Recent Advancements of Magnetic Nanomaterials in Cancer Therapy

Magnetic nanomaterials belong to a class of highly-functionalizable tools for cancer therapy owing to their intrinsic magnetic properties and multifunctional design that provides a multimodal theranostics platform for cancer diagnosis, monitoring, and therapy. In this review article, we have provided an overview of the various applications of magnetic nanomaterials and recent advances in the development of these nanomaterials as cancer therapeutics. Moreover, the cancer targeting, potential toxicity, and degradability of these nanomaterials has been briefly addressed. Finally, the challenges for clinical translation and the future scope of magnetic nanoparticles in cancer therapy are discussed.

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Magnetic nanoparticles: preparation methods, applications in cancer diagnosis and cancer therapy

Artificial Cells Nanomedicine and Biotechnology ◽

10.3109/21691401.2016.1167704 ◽

2016 ◽

Vol 45 (1) ◽

pp. 6-17 ◽

Cited By ~ 40

Author(s):

Saeid Shabestari Khiabani ◽

Masoud Farshbaf ◽

Abolfazl Akbarzadeh ◽

Soodabeh Davaran

Keyword(s):

Magnetic Nanoparticles ◽

Cancer Therapy ◽

Cancer Diagnosis ◽

Preparation Methods

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Chemo-drug controlled-release strategies of nanocarrier in the development of cancer therapeutics.

Current Medicinal Chemistry ◽

10.2174/0929867327666200605153919 ◽

2020 ◽

Vol 27 ◽

Author(s):

Yunyi Liu ◽

Hailong Ou ◽

Xiaming Pei ◽

Bin Jiang ◽

Yihan Ma ◽

...

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Drug Delivery Systems ◽

High Surface ◽

Cancer Therapeutics ◽

Delivery Systems ◽

Magnetic Nanomaterials ◽

Future Application ◽

Stimulus Responsive

: Nanoparticles have been widely used in cancer therapy because of its nanoscale, high surface ratio, multifuntions and so on. With specific construction of nanoparticles, such as choosing magnetic nanomaterials or citric acid coated nanoparticle, scientists can kill tumor cells effectively and accurately，importantly， reducing the side effect of conventional chemotherapy. Currently, they have been continually applied in cancer therapeutics research. Scientists not only designed nanoparticles loading with therapeutic drugs, but also equipped with targeted molecules. These works make nanoparticles become a multifuntional nanocarrier. In the construction of multifunctional nanocarriers, nanoparticles play the important work of drug delivery. Normally, enabling drugs delivery to tumor tissues is a difficult task. During the period of internal circulation, it is hard to keep the nanocarriers stability. As well as not attach to normal cells or serum. With the application of stimulus-responsive nanomaterials, scientists develop many nanocarriers with controllable drug release. These controllable drug delivery systems can quickly respond to microenvironmental changes (PH, enzyme, etc.) or external stimuli (photo, heat, magnetic or electric fields). Thus, it is to overcome the side effects by controllable drug delivery systems in vivo. In this article, we summarize the various kinds of stimulus-responsive nanocarriers for cancer therapy and discuss its possibilities and challenges in future application.

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Magnesium Trisilicate Coated Fe3O4 Nanoparticles as Prompt and Efficient Lactic Acid Removers Potential for Exercise-Induce Fatigue Prevention

Journal of Biomedical Nanotechnology ◽

10.1166/jbn.2020.2903 ◽

2020 ◽

Vol 16 (4) ◽

pp. 531-537

Author(s):

Xiao Huang ◽

Wenhong Wang ◽

Xi Zheng ◽

Xuefei Zhang ◽

Zhuying Wang

Keyword(s):

Magnetic Properties ◽

Lactic Acid ◽

Magnetic Nanoparticles ◽

Fe3o4 Nanoparticles ◽

Magnesium Trisilicate ◽

Sport Injuries ◽

Potential Toxicity ◽

Intensive Exercise ◽

Good Biocompatibility ◽

Exercise Induced

Exercise-induced fatigue is accumulated when lactic acid cannot be timely eliminated after intensive exercise, resulting in sport injuries. Traditional lactic acid removal methods are limited in timeliness, metabolic burden, and potential toxicity. To solve the thorny problems, in this study, nanomedicine was introduced for lactic acid removal. Magnesium trisilicate was coated on the surface of magnetic nanoparticles. These nanoparticles exhibited a prompt and efficient lactic acid adsorbing behavior. Moreover, they have favorable magnetic properties and good biocompatibility. The results showed that the prepared nanoparticles hold great potential in the removal of lactic acid for preventing exercise-induced fatigue.

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Magnetic Nanomaterials for Magnetically-Aided Drug Delivery and Hyperthermia

Applied Sciences ◽

10.3390/app9142927 ◽

2019 ◽

Vol 9 (14) ◽

pp. 2927

Author(s):

Madumali Kalubowilage ◽

Katharine Janik ◽

Stefan H. Bossmann

Keyword(s):

Drug Delivery ◽

Magnetic Nanoparticles ◽

Clinical Translation ◽

Magnetic Nanomaterials ◽

Cancer Therapies ◽

Advantages And Disadvantages ◽

Experimental Approaches

Magnetic nanoparticles have continuously gained importance for the purpose of magnetically-aided drug-delivery, magnetofection, and hyperthermia. We have summarized significant experimental approaches, as well as their advantages and disadvantages with respect to future clinical translation. This field is alive and well and promises meaningful contributions to the development of novel cancer therapies.

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Natural Rubber Latex Assisted Shape-Attuned Synthesis of Intrinsically Radiopaque and Magnetic Bioceramic Nanocomposite with Hyperthermia Potential for Cancer Therapeutics

New Journal of Chemistry ◽

10.1039/d1nj01262b ◽

2021 ◽

Author(s):

Sneha K. R. ◽

Neenu Benny ◽

Balagopal N Nair ◽

G.S. Sailaja

Keyword(s):

Cancer Therapy ◽

Natural Rubber ◽

Saturation Magnetization ◽

Natural Rubber Latex ◽

Cancer Therapeutics ◽

Magnetic Nanomaterials ◽

Targeted Cancer Therapy ◽

Rubber Latex ◽

Time Required

Shape-attuned design plays a remarkable role in modulating the hyperthermia potential of magnetic nanomaterials intended for targeted cancer therapy by tuning the saturation magnetization (Ms) together with the time required...

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Study on Magnetic Properties of Dy0.15Fe1.85O3 Magnetic Nanoparticles at Low Temperature

Journal of Inorganic Materials ◽

10.3724/sp.j.1077.2012.12018 ◽

2013 ◽

Vol 27 (11) ◽

pp. 1174-1178

Author(s):

Mao-Run ZHANG ◽

Jing-Jing SUN ◽

Jing CHEN

Keyword(s):

Magnetic Properties ◽

Magnetic Nanoparticles ◽

Low Temperature

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Evaluation of non-targeting, C- or N-pH (low) insertion peptide modified superparamagnetic iron oxide nanoclusters for selective MRI of liver tumors and their potential toxicity in cirrhosis

RSC Advances ◽

10.1039/c9ra02430a ◽

2019 ◽

Vol 9 (25) ◽

pp. 14051-14059

Author(s):

Abdulrahman Ahmed Mahmood ◽

Jianqi Zhang ◽

Rufang Liao ◽

Xiwei Pan ◽

Dan Xu ◽

...

Keyword(s):

Iron Oxide ◽

Liver Cancer ◽

Contrast Agent ◽

Cancer Diagnosis ◽

Liver Tumors ◽

Superparamagnetic Iron Oxide ◽

Mri Contrast Agent ◽

Potential Toxicity ◽

Mri Contrast ◽

Specific Enhancement

The acid-responsive pHLIP modified SPION as an MRI contrast agent for liver cancer diagnosis requires the validation of both the tumor-specific enhancement and a safe profile in cirrhosis.

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Glycosaminoglycans: Carriers and Targets for Tailored Anti-Cancer Therapy

Biomolecules ◽

10.3390/biom11030395 ◽

2021 ◽

Vol 11 (3) ◽

pp. 395

Author(s):

Aikaterini Berdiaki ◽

Monica Neagu ◽

Eirini-Maria Giatagana ◽

Andrey Kuskov ◽

Aristidis M. Tsatsakis ◽

...

Keyword(s):

Cancer Therapy ◽

Targeted Delivery ◽

Academic Research ◽

Cancer Therapeutics ◽

Disease Evolution ◽

Structure Changes ◽

Recent Developments ◽

Distribution Composition ◽

Membrane Components ◽

Cancer Tissues

The tumor microenvironment (TME) is composed of cancerous, non-cancerous, stromal, and immune cells that are surrounded by the components of the extracellular matrix (ECM). Glycosaminoglycans (GAGs), natural biomacromolecules, essential ECM, and cell membrane components are extensively altered in cancer tissues. During disease progression, the GAG fine structure changes in a manner associated with disease evolution. Thus, changes in the GAG sulfation pattern are immediately correlated to malignant transformation. Their molecular weight, distribution, composition, and fine modifications, including sulfation, exhibit distinct alterations during cancer development. GAGs and GAG-based molecules, due to their unique properties, are suggested as promising effectors for anticancer therapy. Considering their participation in tumorigenesis, their utilization in drug development has been the focus of both industry and academic research efforts. These efforts have been developing in two main directions; (i) utilizing GAGs as targets of therapeutic strategies and (ii) employing GAGs specificity and excellent physicochemical properties for targeted delivery of cancer therapeutics. This review will comprehensively discuss recent developments and the broad potential of GAG utilization for cancer therapy.

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Effect of coverage on the magnetic properties of -COOH, -SH, and -NH2 ligand-protected cobalt nanoparticles

Nanoscale ◽

10.1039/d1nr01081f ◽

2021 ◽

Author(s):

Barbara Farkas ◽

Nora Henriette De Leeuw

Keyword(s):

Magnetic Properties ◽

Magnetic Nanoparticles ◽

Cobalt Nanoparticles ◽

Magnetic Behaviour

Implementation of magnetic nanoparticles in biomedicine requires their passivation, which often comes at a cost of diminished magnetic properties. For the design of nano-agents with targeted magnetic behaviour, it is...

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