scholarly journals The Novel Use of PVP K30 as Templating Agent in Production of Porous Lactose

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 814
Author(s):  
Wei-Feng Zhu ◽  
Lin Zhu ◽  
Zhe Li ◽  
Wen-Ting Wu ◽  
Yong-Mei Guan ◽  
...  
Keyword(s):  
Physical Properties ◽  
Active Ingredient ◽  
Functional Food ◽  
Drug Carrier ◽  
Dissolution Behavior ◽  
The Novel ◽  
Templating Agent ◽  
Operating Process ◽  
Powder Properties ◽  
Pvp K30

It is necessary to prepare porous lactose in order to improve the dissolution behavior of insoluble active ingredient. In this study, polyvinylpyrrolidone K30 (PVP K30) was firstly utilized as a templating agent with different use levels in preparing porous lactose. Then, the physical properties were profoundly characterized. Finally, the porous lactose was also employed as a health functional food/drug carrier to explore the effect on the dissolution behavior of curcumin. The results confirmed that (i) porous lactose was successfully prepared using PVP K30 as templating agent; (ii) PVP K30 significantly improved the yield of lactose in the spray drying; (iii) the improved powder properties of porous lactose were more conducive to the downstream operating process for the preparation of health functional food or drug; and (iv) the porous lactose significantly improved the dissolution behavior of curcumin. Therefore, the results obtained are beneficial to boosting the development of porous materials.

Preparation and Characterization of a Novel Mixed Functional Cationic Exchange Copolymer Microsphere as Drug Carrier

2012 ◽  
Vol 476-478 ◽  
pp. 2288-2291 ◽  
Author(s):  
Kaewnapa Wongsermsin ◽  
Praneet Opanasopit ◽  
Tanasait Ngawhirunpat ◽  
Prasert Akkaramongkolporn
Keyword(s):  
Drug Carrier ◽  
Gastric Ph ◽  
The Novel ◽  
Electron Micrograph ◽  
Scanning Electron Micrograph ◽  
Cationic Exchange ◽  
The Fourier Transform ◽  
Release Characteristic ◽  
Dextromethorphan Hydrobromide

The objective of the present study was to prepare a novel mixed functional cationic exchange copolymer microsphere containing methyl methacrylic acid and sulfonated styrene crosslinked with divinylbenzene. The emulsion polymerization was used to prepare the cationic exchange copolymer microsphere which was characterized by the scanning electron micrograph (SEM) and the fourier transform infrared spectroscopy (FTIR). The release characteristic of the loaded drug i.e. dextromethorphan hydrobromide from the copolymer microsphere was studied under both simulated gastric (pH 1.2) and intestinal (pH 6.8) conditions. The result showed that the drug released from the novel copolymer microsphere depended on the pH of the release media.

scholarly journals Plant Foods and Underutilized Fruits as Source of Functional Food Ingredients: Chemical Composition, Quality Traits, and Biological Properties

Foods ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 1474 ◽  
Author(s):  
Dario Donno ◽  
Federica Turrini
Keyword(s):  
Functional Food ◽  
Biological Activities ◽  
Well Being ◽  
Food Supplement ◽  
Biological Properties ◽  
The Novel ◽  
Food Ingredients ◽  
Health Maintenance ◽  
Plant Foods ◽  
Health Promoting

Changes in lifestyle and demographics, rising consumer incomes, and shifting preferences due to advanced knowledge about the relationships between food and health contribute to generate new needs in the food supply. Today, the role of food is not only intended as hunger satisfaction and nutrient supply but also as an opportunity to prevent nutrition-related diseases and improve physical and mental well-being. For this reason, there is a growing interest in the novel or less well-known plant foods that offer an opportunity for health maintenance. Recently, interest in plant foods and underutilized fruits is continuously growing, and agrobiodiversity exploitation offers effective and extraordinary potentialities. Plant foods could be an important source of health-promoting compounds and functional food ingredients with beneficial properties: the description of the quality and physicochemical traits, the identification and quantification of bioactive compounds, and the evaluation of their biological activities are important to assess plant food efficacy as functional foods or source of food supplement ingredients.

scholarly journals Different BCS Class II Drug-Gelucire Solid Dispersions Prepared by Spray Congealing: Evaluation of Solid State Properties and In Vitro Performances

Pharmaceutics ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 548 ◽  
Author(s):  
Serena Bertoni ◽  
Beatrice Albertini ◽  
Nadia Passerini
Keyword(s):  
Solid State ◽  
Drug Carrier ◽  
Solid Dispersions ◽  
Class Ii ◽  
Water Soluble ◽  
Drug Dissolution ◽  
Crystalline Solid ◽  
Dissolution Behavior ◽  
Bcs Class Ii

Delivery of poorly water soluble active pharmaceutical ingredients (APIs) by semi-crystalline solid dispersions prepared by spray congealing in form of microparticles (MPs) is an emerging method to increase their oral bioavailability. In this study, solid dispersions based on hydrophilic Gelucires® (Gelucire® 50/13 and Gelucire® 48/16 in different ratio) of three BCS class II model compounds (carbamazepine, CBZ, tolbutamide, TBM, and cinnarizine, CIN) having different physicochemical properties (logP, pKa, Tm) were produced by spray congealing process. The obtained MPs were investigated in terms of morphology, particles size, drug content, solid state properties, drug-carrier interactions, solubility, and dissolution performances. The solid-state characterization showed that the properties of the incorporated drug had a profound influence on the structure of the obtained solid dispersion: CBZ recrystallized in a different polymorphic form, TBM crystallinity was significantly reduced as a result of specific interactions with the carrier, while smaller crystals were observed in case of CIN. The in vitro tests suggested that the drug solubility was mainly influenced by carrier composition, while the drug dissolution behavior was affected by the API solid state in the MPs after the spray congealing process. Among the tested APIs, TBM-Gelucire dispersions showed the highest enhancement in drug dissolution as a result of the reduced drug crystallinity.

scholarly journals Pelletization of Sunflower Seed Husks: Evaluating and Optimizing Energy Consumption and Physical Properties by Response Surface Methodology (RSM)

Processes ◽  
2019 ◽  
Vol 7 (9) ◽  
pp. 591 ◽  
Author(s):  
Xuyang Cui ◽  
Junhong Yang ◽  
Xinyu Shi ◽  
Wanning Lei ◽  
Tao Huang ◽  
...  
Keyword(s):  
Response Surface Methodology ◽  
Energy Consumption ◽  
Moisture Content ◽  
Physical Properties ◽  
Response Surface ◽  
Sunflower Seed ◽  
Biomass Energy ◽  
Raw Material ◽  
The Novel ◽  
Seed Husk

Pelletization is a significant approach for the efficient utilization of biomass energy. Sunflower seed husk is a common solid waste in the process of oil production. The novelty of this study was to determine the parameters during production of a novel pellet made from sunflower seed husk. The energy consumption (W) and physical properties (bulk density (BD) and mechanical durability (DU)) of the novel pellet were evaluated and optimized at the laboratory by using a pelletizer and response surface methodology (RSM) under a controlled moisture content (4%–14%), compression pressure (100–200 MPa), and die temperature (70–170 °C). The results show that the variables of temperature, pressure, and moisture content of raw material are positively correlated with BD and DU. Increasing the temperature and moisture content of raw materials can effectively reduce W, while increasing the pressure has an adverse effect on W. The optimum conditions of temperature (150 °C), pressure (180 MPa), and moisture content (12%) led to a BD of 1117.44 kg/m3, DU of 98.8%, and W of 25.3 kJ/kg in the lab. Overall, although the nitrogen content was slightly high, the novel manufactured pellets had excellent performance based on ISO 17225 (International Organization for Standardization of 17225, Geneva, Switzerland, 2016). Thus, sunflower seed husk could be considered as a potential feedstock for biomass pelletization.

scholarly journals The Effect of PVP Molecular Weight on Dissolution Behavior and Physicochemical Characterization of Glycyrrhetinic Acid Solid Dispersions

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Xiaoyu Sui ◽  
Yan Chu ◽  
Jie Zhang ◽  
Honglian Zhang ◽  
Huiyu Wang ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Dissolution Rate ◽  
Solid Dispersions ◽  
Physicochemical Characterization ◽  
Dissolution Behavior ◽  
Enhancement Effect ◽  
Glycyrrhetic Acid ◽  
Equilibrium Solubility ◽  
Drug Molecules ◽  
Pvp K30

The effect of polyvinylpyrrolidone (PVP) as glycyrrhetic acid (GA) solid dispersions carrier at different molecular weights on the dissolution behavior and physicochemical properties was investigated. PVP-GA-SDs prepared with all four molecular weight PVPs displayed good enhancement of dissolution rate and equilibrium solubility compared with pure drug and corresponding physical mixtures. The results showed that the enhancement effect of molecular weight on dissolution rate and equilibrium solubility follows PVP   K 30 > PVP   K 60 > PVP   K 17 > PVP   K 15 . In addition, the dissolution rate and solubility of the SDs with a carrier-drug ratio of 8 : 1 were better than the samples of 4 : 1. The DSC and XRD patterns showed that the crystallization of GA in SDs prepared by PVP K30 and PVP K60 was significantly inhibited, and both were transformed to amorphous. Based on FTIR and Raman detection, a hydrogen-bond between PVP and drug molecules is formed. SEM results showed that there were no significant differences in the appearance of SDs prepared with four PVPs, and no crystalline morphology of GA was seen. In conclusion, the findings of this study demonstrated that the dissolution performance of the PVP-GA-SDs prepared by the solvent method is related to the molecular weight of PVP, and the change in the molecular weight of PVP does not cause a monotonic change in dissolution of GA. The samples with PVP K30 as the carrier have the best dissolution performance.

Physical properties and biological interactions of liposomes developed as a drug carrier in the field of regenerative medicine

2017 ◽  
Vol 27 (2) ◽  
pp. 90-98 ◽  
Author(s):  
Sławomir Lewicki ◽  
Monika Leśniak ◽  
Eugeniusz Krzysztof Machaj ◽  
Małgorzata Antos-Bielska ◽  
Elżbieta Anna Trafny ◽  
...  
Keyword(s):  
Regenerative Medicine ◽  
Physical Properties ◽  
Drug Carrier ◽  
Biological Interactions

scholarly journals Enhancement of Solubility and Dissolution Characteristics of Ibuprofen by Solid Dispersion Technique

2012 ◽  
Vol 11 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Md Abdullah Al Masum ◽  
Florida Sharmin ◽  
S M Ashraful Islam ◽  
Md Selim Reza
Keyword(s):  
Solid Dispersion ◽  
Phosphate Buffer ◽  
Drug Carrier ◽  
Drug Loading ◽  
Solid Dispersions ◽  
Dissolution Behavior ◽  
Dissolution Profile ◽  
Saturation Solubility ◽  
Dispersion Technique ◽  
Physical Mixtures

In this study solid dispersions (SDs) of ibuprofen were prepared by melt dispersion technique using macrogol 4000 and macrogol 6000 as carrier. Physical mixtures (PMs) of ibuprofen were also prepared with the same carrier and in the same drug-carrier ratio (1:0.5, 1:1 and 1:1.5) to compare the dissolution profile. The solid dispersions and physical mixtures were investigated for drug loading, saturation solubility and dissolution behavior. Saturation solubility study was carried out in phosphate buffer (pH 7.2), 0.1 N HCl solution and distilled water. Solid dispersions were found effective to enhance the solubility of ibuprofen significantly in all the media. Dissolution test was carried out in two different media, phosphate buffer (pH 7.2) and 0.1 N HCl. Solid dispersion containing macrogol 6000 at the ratio of 1:1.5 (drug: carrier) showed faster and higher drug release and was found to be most effective among all the solid dispersions. Drug carrier interactions were studied by comparing Fourier Transform Infrared Spectroscopy (FT-IR) of solid dispersions with pure drug which revealed that the SDs were stable. So, solid dispersion may be an effective technique to enhance dissolution rate of ibuprofen. DOI: http://dx.doi.org/10.3329/dujps.v11i1.12480 Dhaka Univ. J. Pharm. Sci. 11(1): 1-6, 2012 (June)

scholarly journals Bioavailability Study of Propranolol Patch

2020 ◽  
Vol 3 (2) ◽  
Author(s):  
Muh Ikhlas Arsul ◽  
Latifah Rahman ◽  
Agnes Lidjajah
Keyword(s):  
Active Ingredient ◽  
Drug Product ◽  
Intravenous Route ◽  
Eudragit Rs ◽  
First Pass Effect ◽  
First Pass ◽  
Site Of Action ◽  
Bioavailability Study ◽  
Pvp K30 ◽  
Made In

Bioavailability is a measure of the rate and amount of drug or active ingredient that is absorbed by a drug product and available at the site of action. By definition, the bioavailability of a drug when administered intravenously is 100%. However, when a drug is given by a different route of administration, its overall bioavailability will decrease (since the drug is not completely absorbed and metabolized first pass effect) or may vary from patient to patient. Bioavailability is very important in pharmacokinetics. One of them is that bioavailability needs to be taken when calculating the doses for administering a drug other than by intravenous route. The aim of this study was to describe the bioavailability of propranolol in patch preparations. Propranolol is made in patch formulations using menthol, PEG, and various combinations of PVP and Eudragit. PVP and Eudragit each dissolved in alcohol and then mixed until homogeneous. Propranolol was dissolved with a menthol solution and then mixed into a solution of PVP and Eudragit. Finally, PEG is added to the solution and stirred until homogeneous and then poured into the patch mold. The patches produced were then measured for each patch and bioavailability assay. The patch formula produced can be used transdermally, but of the three formulas, the F3 formula with a ratio of PVP K30 and Eudragit RS-100 3: 7 gives the best results with a tmax of 2 hours, Cmax 79.33 µg / ml and AUC 49.07 µg hours / ml.

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