scholarly journals Process Modeling and Simulation of Tableting—An Agent-Based Simulation Methodology for Direct Compression

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 996
Author(s):  
Niels Lasse Martin ◽  
Ann Kathrin Schomberg ◽  
Jan Henrik Finke ◽  
Tim Gyung-min Abraham ◽  
Arno Kwade ◽  
...  
Keyword(s):  
Raw Materials ◽  
Pilot Scale ◽  
Physical Models ◽  
Agent Based Simulation ◽  
Validation Data ◽  
Agent Based ◽  
Industrial Processing ◽  
Digital Twins ◽  
Product And Process ◽  
The Impact

In pharmaceutical manufacturing, the utmost aim is reliably producing high quality products. Simulation approaches allow virtual experiments of processes in the planning phase and the implementation of digital twins in operation. The industrial processing of active pharmaceutical ingredients (APIs) into tablets requires the combination of discrete and continuous sub-processes with complex interdependencies regarding the material structures and characteristics. The API and excipients are mixed, granulated if required, and subsequently tableted. Thereby, the structure as well as the properties of the intermediate and final product are influenced by the raw materials, the parametrized processes and environmental conditions, which are subject to certain fluctuations. In this study, for the first time, an agent-based simulation model is presented, which enables the prediction, tracking, and tracing of resulting structures and properties of the intermediates of an industrial tableting process. Therefore, the methodology for the identification and development of product and process agents in an agent-based simulation is shown. Implemented physical models describe the impact of process parameters on material structures. The tablet production with a pilot scale rotary press is experimentally characterized to provide calibration and validation data. Finally, the simulation results, predicting the final structures, are compared to the experimental data.

Modeling Consumer Decisions on Returning End-of-Use Products Considering Design Features and Consumer Interactions: An Agent Based Simulation Approach

2015 ◽  
Author(s):  
Ardeshir Raihanian Mashhadi ◽  
Behzad Esmaeilian ◽  
Sara Behdad
Keyword(s):  
Electronic Waste ◽  
Peer Pressure ◽  
Waste Stream ◽  
Contributing Factors ◽  
Agent Based Simulation ◽  
Design Features ◽  
Agent Based ◽  
Consumer Decisions ◽  
Take Back ◽  
The Impact

As electronic waste (e-waste) becomes one of the fastest growing environmental concerns, remanufacturing is considered as a promising solution. However, the profitability of take back systems is hampered by several factors including the lack of information on the quantity and timing of to-be-returned used products to a remanufacturing facility. Product design features, consumers’ awareness of recycling opportunities, socio-demographic information, peer pressure, and the tendency of customer to keep used items in storage are among contributing factors in increasing uncertainties in the waste stream. Predicting customer choice decisions on returning back used products, including both the time in which the customer will stop using the product and the end-of-use decisions (e.g. storage, resell, through away, and return to the waste stream) could help manufacturers have a better estimation of the return trend. The objective of this paper is to develop an Agent Based Simulation (ABS) model integrated with Discrete Choice Analysis (DCA) technique to predict consumer decisions on the End-of-Use (EOU) products. The proposed simulation tool aims at investigating the impact of design features, interaction among individual consumers and socio-demographic characteristics of end users on the number of returns. A numerical example of cellphone take-back system has been provided to show the application of the model.

scholarly journals Application of Agent-based Modeling for Cultural Information-based Decisions Making

2020 ◽  
Vol 88 ◽  
pp. 8-28
Author(s):  
Rimvydas Laužikas ◽  
Darius Plikynas ◽  
Vytautas Dulskis ◽  
Leonidas Sakalauskas ◽  
Arūnas Miliauskas
Keyword(s):  
Social Capital ◽  
Simulation Model ◽  
Cultural Participation ◽  
Agent Based Simulation ◽  
Research Issues ◽  
Agent Based ◽  
Cultural Events ◽  
The Social ◽  
Cultural Processes ◽  
The Impact

The impact of cultural processes on personal and social changes is one of the important research issues not only in contemporary social sciences but also for simulation of future development scenarios and evidence-based policy decision making. In the context of the theoretical concept of cultural values, based on the system theory and theory of social capital, the impact of cultural events could be analyzed and simulated by focussing on the construction/deconstruction of social capital, which takes place throughout the actor’s cultural participation. The main goal of this research is the development of measuring metrics, and agent-based simulation model aimed at investigation of the social impact of cultural processes.  This paper provides new insights of modeling the social capital changes in a society and its groups, depending on cultural participation. The proposed measurement metrics provide the measurement facility of three key components: actors, cultural events and events flow and social capital. It provides the initial proof of concept simulation results, - simplified agent-based simulation model showcase. The NetLogo MAS platform is used as a simulation environment.  

Agent Based Model to Analyze Consumer Behavior in Consuming the Electricity Energy

2015 ◽  
Vol 72 (4) ◽  
Author(s):  
Erma Suryani ◽  
Rully Agus Hendrawan ◽  
Umi Salama ◽  
Lily Puspa Dewi
Keyword(s):  
Consumer Behavior ◽  
Simulation Model ◽  
Environmental Awareness ◽  
Electricity Consumption ◽  
Point Of View ◽  
Agent Based Model ◽  
Agent Based Simulation ◽  
Agent Based ◽  
Save Energy ◽  
The Impact

Several studies have been conducted regarding save energy in consuming the electricity through the simple changes in routines and habits. In the case of electricity consumption, consumer behavior might influenced by several factors such as consumer profession, season, and environmental awareness. In this paper, we developed an Agent Based Model (ABM) to analyze the behavior of different agents in consuming the electricity energy for each type of profession (agent) as well as their interaction with the environment. This paper demonstrates a prototype agent based simulation model to estimate the electricity consumption based on the existing condition and some scenarios to reduce the electricity consumption from consumer point of view. From the scenario results, we analyzed the impact of the save energy to increase the electrification ratio. 

scholarly journals Multiobjective Decision Making Policies and Coordination Mechanisms in Hierarchical Organizations: Results of an Agent-Based Simulation

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Stephan Leitner ◽  
Friederike Wall
Keyword(s):  
Decision Making ◽  
Performance Improvement ◽  
Coordination Mode ◽  
Agent Based Simulation ◽  
Agent Based ◽  
Multiobjective Decision Making ◽  
Overall Performance ◽  
Hierarchical Organizations ◽  
The Impact ◽  
Adaptive Walk

This paper analyses how different coordination modes and different multiobjective decision making approaches interfere with each other in hierarchical organizations. The investigation is based on an agent-based simulation. We apply a modified NK-model in which we map multiobjective decision making as adaptive walk on multiple performance landscapes, whereby each landscape represents one objective. We find that the impact of the coordination mode on the performance and the speed of performance improvement is critically affected by the selected multiobjective decision making approach. In certain setups, the performances achieved with the more complex multiobjective decision making approaches turn out to be less sensitive to the coordination mode than the performances achieved with the less complex multiobjective decision making approaches. Furthermore, we present results on the impact of the nature of interactions among decisions on the achieved performance in multiobjective setups. Our results give guidance on how to control the performance contribution of objectives to overall performance and answer the question how effective certain multiobjective decision making approaches perform under certain circumstances (coordination mode and interdependencies among decisions).

scholarly journals An Agent-Based Simulation of How Promotion Biases Impact Corporate Gender Diversity

2020 ◽  
Author(s):  
CHIBIN ZHANG ◽  
Paolo Gaudiano
Keyword(s):  
Human Capital ◽  
Gender Diversity ◽  
Agent Based Simulation ◽  
Real World Data ◽  
Agent Based ◽  
Qualitative Approaches ◽  
Powerful Approach ◽  
Invaluable Tool ◽  
Two Parameters ◽  
The Impact

<p>Diversity & Inclusion (D&I) is a topic of increasing relevance across virtually all sectors of our society, with the potential for significant impact on corporations and more broadly on our economy and our society. In spite of the fact that human capital is typically the most valuable asset of every organization, Human Resources (HR) in general and D&I, in particular, are dominated by qualitative approaches. We introduce an agent-based simulation that can quantify the impact of certain aspects of D&I on corporate performance. We show that the simulation provides a parsimonious and compelling explanation of the impact of hiring and promotion biases on the resulting corporate gender balance. We show that varying just two parameters enables us to replicate real-world data about gender imbalances across multiple industry sectors. In addition, we show that the simulation can be used to predict the likely impact of different D&I interventions. Specifically, we show that once a company has become imbalanced, even removing all promotion biases is not sufficient to rectify the situation, and that it can take decades to undo the imbalances initially created by these biases. These and other results demonstrate that agent-based simulation is a powerful approach for managing D&I in corporate settings, and suggest that it has the potential to become an invaluable tool for both strategic and tactical management of human capital. </p>

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