Ultrasound-Responsive Smart Drug Delivery System of Lipid Coated Mesoporous Silica Nanoparticles

The immediate release of chemotherapeutics at the target site, along with no premature release in circulation is always challenging. The purpose of this study was to develop a stimuli responsive drug delivery system, composed of lipid supported mesoporous silica nanoparticles (MSNPs) for triggered drug release at the target site and simultaneously avoiding the premature release. MSNPs with a higher drug loading capacity and very slow release were designed so as to enhance release by FDA approved US-irradiation. Doxorubicin, as a model drug, and perfluoropentane (PFP) as a US responsive material, were entrapped in the porous structure of MSNPs. Lipid coating enhanced the cellular uptake and in addition provided a gatekeeping effect at the pore opening to reduce premature release. The mechanical and thermal effects of US induced the conversion of liquid PFP to a gaseous form that was able to rupture the lipid layer, resulting in triggered drug release. The prolonged stability profile and non-toxic behavior made them suitable candidate for the delivery of anticancer drugs. This smart system, with the abilities of better cellular uptake and higher cytotoxic effects on US-irradiation, would be a good addition to the applied side of chemotherapeutic advanced drug delivery systems.

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An aptamer-targeting photoresponsive drug delivery system using “off–on” graphene oxide wrapped mesoporous silica nanoparticles

Nanoscale ◽

10.1039/c4nr07493a ◽

2015 ◽

Vol 7 (14) ◽

pp. 6304-6310 ◽

Cited By ~ 98

Author(s):

Yuxia Tang ◽

Hao Hu ◽

Molly Gu Zhang ◽

Jibin Song ◽

Liming Nie ◽

...

Keyword(s):

Drug Delivery ◽

Graphene Oxide ◽

Cancer Therapy ◽

Drug Release ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Drug Delivery System ◽

Delivery System ◽

Mesoporous Silica Nanoparticles ◽

Targeted Cancer Therapy

A photoresponsive drug delivery system was developed for light-mediated drug release and aptamer-targeted cancer therapy.

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Smart mesoporous silica nanoparticles gated by pillararene-modified gold nanoparticles for on-demand cargo release

Chemical Communications ◽

10.1039/c6cc08241f ◽

2016 ◽

Vol 52 (95) ◽

pp. 13775-13778 ◽

Cited By ~ 39

Author(s):

Xin Wang ◽

Li-Li Tan ◽

Xi Li ◽

Nan Song ◽

Zheng Li ◽

...

Keyword(s):

Drug Delivery ◽

Gold Nanoparticles ◽

Drug Release ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Drug Delivery System ◽

Delivery System ◽

Mesoporous Silica Nanoparticles ◽

Controlled Drug Release ◽

On Demand

A new drug delivery system, based on mesoporous silica nanoparticles gated by carboxylatopillar[5]arene-modified gold nanoparticles, has been fabricated for controlled drug release.

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Visible-light-triggered supramolecular valves based on β-cyclodextrin-modified mesoporous silica nanoparticles for controlled drug release

RSC Advances ◽

10.1039/c9ra02612f ◽

2019 ◽

Vol 9 (30) ◽

pp. 17179-17182 ◽

Cited By ~ 2

Author(s):

Qing Bian ◽

Zhaolu Xue ◽

Po Sun ◽

Kejing Shen ◽

Shangbing Wang ◽

...

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Mesoporous Silica ◽

Visible Light ◽

Silica Nanoparticles ◽

Drug Delivery System ◽

Delivery System ◽

Mesoporous Silica Nanoparticles ◽

Controlled Drug Release

Visible-light triggered drug delivery system based on tetra-ortho-methoxy-substituted azobenzene (mAzo) and β-cyclodextrin (β-CD) modified mesoporous silica nanoparticles (MSNs-CD).

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Wetting transition in nanochannels for biomimetic free-blocking on-demand drug transport

Journal of Materials Chemistry B ◽

10.1039/c8tb01838c ◽

2018 ◽

Vol 6 (39) ◽

pp. 6269-6277 ◽

Cited By ~ 3

Author(s):

Yaya Cheng ◽

Xiangyu Jiao ◽

Liang Zhao ◽

Yang Liu ◽

Fang Wang ◽

...

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Drug Delivery System ◽

Delivery System ◽

Drug Transport ◽

Mesoporous Silica Nanoparticles ◽

Wetting Transition ◽

On Demand ◽

Inner Surface

Inspired by aquaporins in nature, herein, a biomimetic free-blocking on-demand drug delivery system is proposed, which is constructed by controlling the wettability of the inner surface of nanochannels on mesoporous silica nanoparticles (MSNs).

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ADAM9-Responsive Mesoporous Silica Nanoparticles for Targeted Drug Delivery in Pancreatic Cancer

Cancers ◽

10.3390/cancers13133321 ◽

2021 ◽

Vol 13 (13) ◽

pp. 3321

Author(s):

Etienne J. Slapak ◽

Lily Kong ◽

Mouad el Mandili ◽

Rienk Nieuwland ◽

Alexander Kros ◽

...

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Conditioned Medium ◽

Drug Delivery System ◽

Delivery System ◽

Targeted Drug Delivery ◽

Mesoporous Silica Nanoparticles ◽

Pdac Cell ◽

Targeted Drug

Pancreatic ductal adenocarcinoma (PDAC) has the worst survival rate of all cancers. This poor prognosis results from the lack of efficient systemic treatment regimens, demanding high-dose chemotherapy that causes severe side effects. To overcome dose-dependent toxicities, we explored the efficacy of targeted drug delivery using a protease-dependent drug-release system. To this end, we developed a PDAC-specific drug delivery system based on mesoporous silica nanoparticles (MSN) functionalized with an avidin–biotin gatekeeper system containing a protease linker that is specifically cleaved by tumor cells. Bioinformatic analysis identified ADAM9 as a PDAC-enriched protease, and PDAC cell-derived conditioned medium efficiently cleaved protease linkers containing ADAM9 substrates. Cleavage was PDAC specific as conditioned medium from leukocytes was unable to cleave the ADAM9 substrate. Protease linker-functionalized MSNs were efficiently capped with avidin, and cap removal was confirmed to occur in the presence of PDAC cell-derived ADAM9. Subsequent treatment of PDAC cells in vitro with paclitaxel-loaded MSNs indeed showed high cytotoxicity, whereas no cell death was observed in white blood cell-derived cell lines, confirming efficacy of the nanoparticle-mediated drug delivery system. Taken together, this research introduces a novel ADAM9-responsive, protease-dependent, drug delivery system for PDAC as a promising tool to reduce the cytotoxicity of systemic chemotherapy.

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