Association of Negative Symptoms of Schizophrenia Assessed by the BNSS and SNS Scales With Neuropsychological Performance: A Gender Effect

Objective: The relationship between negative symptoms and neurocognitive performance in schizophrenia is well documented, but the mechanism of these connections remains unclear. The study aims to measure the relationship between the results on the new scales for the assessment of negative symptoms such as Brief Negative Symptom Scale (BNSS) and Self-evaluation of Negative Symptoms (SNS), and the results of some neurocognition tests. The second aim is to assess a possible gender effect on these associations.Methods: The study included 80 patients (40 men, 40 women) with schizophrenia, aged 19–63 (mean 38 years), during the improvement period (total PANSS score <80, unchanged pharmacological treatment in the last 3 weeks). They were assessed using the BNSS, SNS, Personal and Social Performance (PSP) scales, and the tests for neuropsychological performance such as the Trail Making Test (TMT-A, TMT-B), Stroop Color-Word Interference Test, Verbal fluency tests (VFT), Category fluency test (CFT), and Digit Symbol Substitution Test (DSST).Results: Male patients obtained higher scores than females on some PANSS and BNSS items. No gender differences were observed for the SNS scale. Female patients scored better in the PSP and CFT. In male patients, a significant positive correlation between the intensity of negative symptoms measured by the BNSS and the results of PSP with the Trail Making Test was observed. In female patients, we found a positive correlation between the results of BNSS and PSP with the Stroop Color-Word Interference Test.Conclusion: The obtained results confirm the relationship between negative symptoms and neurocognition in schizophrenia patients. However, in male and female patients such association was observed for different cognitive domains. Further research is needed to explain the nature of these differences.

Identification of Patches of Bitumen in a Carbonate Reservoir: A Case Study

Carbonate reservoir X has varying levels of maturity in terms of development. The South/West is highly matured; development activities have recently kicked-off in the Crestal part while the areas towards the Far North is not fully developed and posed the largest uncertainty in terms of reservoir quality, fluid contacts, oil saturation, well injectivity/ productivity, area potential and reserves due to poor well control. In reservoir X with segmented development areas, patches of bitumen have been found in the Far North. The extent of this Bitumen was unknown. In order to expand the CO2 development concept to achieve production target from the Far Northern flank, an understanding and mitigation of the area uncertainties is crucial. Reservoir bitumen is a highly viscous, asphaltene rich hydrocarbon that affects reservoir performance. Distinguishing between producible oil and reservoir bitumen is critical for recoverable hydrocarbon volume calculations and production planning, yet the lack of resistivity and density contrast between the reservoir bitumen and light oil makes it difficult, if not impossible, to make such differentiation using only conventional logs such as neutron, density, and resistivity. This paper highlights the utilization and integration of advanced logging tools such as nuclear magnetic resonance and dielectric, in conjunction with routine logs, pressure points, RCI samples, vertical interference test and core data to differentiate between reservoir bitumen and other hydrocarbon types in the pore space. The major findings from the studies shows bitumen doesn't form as a single layer but occurs in different subzones as patches which is a challenge for static modelling. When high molecular weight hydrocarbons are distributed in the pore space and coexist with light and producible hydrocarbons, reservoir bitumen is likely to block pore throats. The Bitumen present in this reservoir have a log response similar to conventional pore fluids. The outcome of this study has helped in refining the bitumen boundary, optimize well placement, resolved the uncertainties associated with deeper fluid contacts and provided realistic estimate of STOIIP.

Significance of the Diagnosis of Executive Functions in Patients with Relapsing-Remitting Multiple Sclerosis

Multiple sclerosis (MS) is a progressive chronic disease of the Central Nervous System (CNS). Cognitive decline occurs rather rarely in relapsing–remitting multiple sclerosis (RRMS) compared to other types. The present study aimed to assess executive functions (EF) in relation to clinical and demographic variables in patients with RRMS. The study involved 22 individuals with RRMS (aged 23 to 49 years) and 22 matching controls. All the individuals with RRMS were in the remission phase. The assessments were carried out using MoCA, BDI-II, Halstead Category Test, Porteus Maze Test, verbal fluency tasks and Stroop Colour-Word Interference Test. The findings show that the two groups differed significantly in all the tests. All patients with RRMS in the remission phase presented at least one cognitive deficit, observed in general cognitive functioning, abstract reasoning or other executive functions, i.e., fluency, interference suppression, planning, or ability to modify activity in response to feedback. The deficits in most cases (except for those measured with the MoCA, Category Tests and phonemic fluency), are not related to intensity of depression and duration of the disease. Findings suggest that the diagnostic process in the case of patients with RRMS may include psychological assessment focusing on potentially existing cognitive, mainly executive, deficits and their severity.

The Advantages of Having Dedicated Downhole Gauges and Wellhead Meter: A Reservoir Management Perspective from a Massive Tight Gas Reservoir in the Remote Area

Even though the downhole gauges and wellhead meter (wet gas meter) have been invented decades ago, having them installed in every wells are still considered as a luxury for many companies. However, does this view still reasonable for a tight gas reservoir let alone located in a remote area? This study will describe the benefit of having both equipment for reservoir management practice in one of the biggest tight gas reservoirs in Indonesia. Generally, reservoir management is an iterative process that incorporates the analysis of reservoir characterization, development plan, implementation, and monitoring. There are many analyses from the reservoir management process that can be performed using above mentioned equipment. Several analyses have been performed, such as: (i) Interference Test and Pressure Transient Analysis (PTA) after well is completed; (ii) Evolution of connected volume since early production until present day using Dynamic Material Balance (DMB); (iii) Flow regime and reservoir properties using Rate Transient Analysis (RTA); and (iv) Reservoir simulation: regular model update and project opportunity identification. In this study, the above-mentioned analyses are performed in one of the massive tight gas reservoir in Indonesia that is located in the remote area. Having a complete reservoir surveillance tools such as downhole gauges and wellhead meter on each wells is beneficial for reservoir management practice. Precious subsurface data can be obtained anytime without having to wait for equipment mobilization to location. This is critical for managing tight gas reservoir which usually demands robust subsurface data to reduce its uncertainties. There are several findings based on the above mentioned analyses, such as: (i) The interference test indicates there is reservoir connectivity among the production wells; (ii) The PTA indicates that the reservoir has tight properties, although longer buildup/observation time is still needed to better understand the reservoir characteristics in wider scale; (iii) The DMB analysis can be performed even in daily basis to provide the insight on connected gas initial in place (GIIP) evolution through time, as in this case it still shows an increasing GIIP through time which is suspected due to the transient flow regime on the wells; (iv) The RTA can also be performed in similar fashion, if it is combine with other analyses, this analysis able to provide a multi-scale reservoir properties investigation from near wellbore to far field and flow period observation (boundary observation) through time, as in this case the reservoir properties is tight and flow is still in transient period; (v) It increases robustness of reservoir simulation update since it is supported by many analyses, as such, series of hopper can be confidently presented to management, as in this case a project of well stimulation (Acid Fracturing) has been performed successfully and opportunity of further field development plan can be identified. This paper shows that, for the tight reservoir in the remote location, having each well equipped with downhole gauges and dedicated wellhead meter is significantly increasing the robustness of reservoir management process. Thus, providing economic optimization for the managed asset. Regarding the capital that is invested at the beginning, it will simply pay out quickly, looking at the time and resources that need to be spent for having equipment on site.

A-141 Vindicated by Awareness: Acting with Awareness May Compensate for Inhibitory Deficits in ADHD Symptom Burden

Objective To understand the role of trait mindfulness acting-with-awareness in the relationship between inhibitory control and ADHD symptom burden. Method We conducted a cross-sectional study with 103 adults, aged 18 to 86, mean age = 46, mean education = 15 years, 46% male. Participants were recruited in North Western Oregon counties. Eligible individuals were aged >18, fluent in English, and with normal global cognition (Montreal Cognitive Assessment, MoCA>22). The presence of ADHD diagnoses/symptoms was not required. Participants were administered the Adult Investigator Symptom Rating Scale (AISRS), the Five Facet Mindfulness Questionnaire (FFMQ) Acting with Awareness, and the DKEFS Color-Word Interference Test (CWIT). We examined the contribution of CWIT (time/sec), acting-with-awareness (AA), and their interaction in age-adjusted multiple regression predicting AISRS total score. Results Descriptives for the measures of interest were AISRS (M = 19.21, SD = 12.72), CWIT (M = 55.66, SD = 15.27), and FFMQ-AA (M = 25.10, SD = 7.17). Both CWIT and FFMQ-AA predicted AISRS when analyzed independently (B = 0.274, p = 0.14, R2 = 0.13 and B = -0.633, p < 0.001, R2 = 0.45). In the combined model, FFMQ-AA (B = -1.06, p = 0.000) but not CWIT predicted AISRS, R2 = 0.47. The interaction was not significant, p = 0.55. Conclusion AA is a powerful predictor of ADHD symptom burden: it accounts for almost half of the variance, and removes any contribution from inhibitory control. Our finding suggests that trait mindfulness has a more important role in shaping ADHD than cognition.

The Conclusion of the Double-Slit Interference Test Violates the Fundamental Rules of Quantum

The theory of light waves contains a number of errors that violate a fundamental principle of physics: photons can be subdivided indefinitely. Photons can multiply indefinitely. If the phase is shifted π, the electromagnetic, light, or matter waves become negative electromagnetic, negative light, or antimatter waves, respectively, which cancel themselves out. The wavelet sources of light waves are of unknown origin. Photons can be regenerated and reused. The conditions for light waves to interfere do not take into account the effect of polarization direction. The effect of the reflected wave is not represented in the interference fringe. The weak transmittance of the double-slit device will not stand up to close scientific scrutiny. Masks similar to double slit devices do not allow the lithography machine to function properly if the light waves interfere. The pattern of the fringe deduced by the mathematical model is different from that of the double slit interference test. Light waves without bandwidth cannot be accommodated by the theory of electromagnetic waves. The physics of light waves contradicts the principle of the Fourier transform. The spectrum of electromagnetic waves modulated by the transmitted information must produce a modulation effect, but this effect does not occur in optical fiber communication. Because the size is much smaller than the wavelength, the photon is sampled equivalent to the light wave, but the corresponding physical properties are not represented by the photon. The wave-particle duality is incompatible with the Doppler principle. In summary, the conclusion that light waves interfere with each other to produce fringes in the results of the double-slit interference test is reached under the condition that most of the physical properties of waves are stripped away, and this conclusion is divorced from objectivity. The theory of light waves is not correct. In any case, light is not a wave. Light waves are misunderstood.

Numerical Method of Estimating Distance Between Wells

In this study, a simpler numerical model for calculating inter-well distance was developed. This model was developed as an alternative to the Ei-function used for computing pressure drops. The mainobjective of developing this model is tomake resolution of pilfering issues easyto resolve. With the developed model, calculations relating to pressure drops and more specifically, inter-well distance, can be done with greater ease and accuracy. In developing this model, the integral equation of the Eifunction in the pressure drop equation was solved numerically. The numerical solution reduced thepressure drop equation to a polynomial equation which is much easier to solve. The developed model was used to solve real problems. Results generated from it were compared with those obtained using previous approaches. Important informationsuch as well configuration, region of the reservoir, and transient history wherethe work is valid are stated. The development of the correlations and tables forthe range of validity and values of the Ei-function is a major quantum leap in well testing and analysis. It will be quite cumbersome to resolve integrals with unknowns, hence, methods of trials and errors have been resorted to over the years. However, this new approach resolved the pressure drop equation into a systemof polynomials which is much easier to solve. Consequently, the distance betweenpossibly interfering wells (which is an important variable during interference test) can now be gotten with ease. The developed model is valid within the range of validity of the Ei-function. Without doubt, this work will help redefine the pressure drop equation into a polynomial equation which can easily be resolved using any of the known approaches to solving problems involving polynomials. More so, getting the correct distance betweenthe two wells in question is pivotal to the test. With the model developed in this work, getting inter-well distance is now easier and more accurate.

Innovative Use of Injectivity Tests as Interference Tests during Field Development: The EGINA Experience

This paper presents the innovative use of interference tests in the assessment of reservoir connectivity and the field oil production rate during the development phase and prior to the first oil of the EGINA field, which is located in a water depth of 1600 m, deep offshore Niger Delta. The interference test campaign involved 26 pre-first oil wells (13 oil producers and 13 water injectors) to assess and subsequently mitigate reservoir connectivity uncertainties arising from the numerous faults and between the different channels within the complexes. The results proved valuable in confirming or otherwise reservoir connectivity, field oil production rate and the number of wells required at first oil to achieve the production plateau. The tests were designed using the analytical method (PIE software) and the reservoir simulation models enabling to establish the cumulative water injection required, the injection duration and the time a response is expected at the observers. These all had impacts on the planning, OIMR vessel requirements and selection of permanent downhole gauges for the wells. In addition, the tests were performed with the water injectors as pulsers and the oil producers as observers allowing to avoid and the associated environmental impact. Ten interference tests were realized compared to four planned in the FDP partly due to the use of the more cost effective OIMR vessel in addition to the rig.

The Conclusion of the Double-Slit Interference Test Violates the Fundamental Rules of Quantum

The theory of light waves contains a number of errors that violate a fundamental principle of physics: photons can be subdivided indefinitely. Photons can multiply indefinitely. If the phase is shifted π, the electromagnetic, light, or matter waves become negative electromagnetic, negative light, or antimatter waves, respectively, which cancel themselves out. The wavelet sources of light waves are of unknown origin. Photons can be regenerated and reused. The conditions for light waves to interfere do not take into account the effect of polarization direction. The effect of the reflected wave is not represented in the interference fringe. The weak transmittance of the double-slit device will not stand up to close scientific scrutiny. Masks similar to double slit devices do not allow the lithography machine to function properly if the light waves interfere. The pattern of fringe deduced by mathematical model is different from that of double slit interference test. Light waves without bandwidth cannot be accommodated by the theory of electromagnetic waves. The physics of light waves contradicts the principle of the Fourier transform. The spectrum of electromagnetic waves modulated by the transmitted information must produce modulation effect, but this effect does not occur in optical fiber communication. Because the size is much smaller than the wavelength, the photon is sampled equivalent to the light wave, but the corresponding physical properties are not represented by the photon. The wave-particle duality is incompatible with the Doppler principle. To sum up, the conclusion that light waves interfere with each other to produce fringes in the results of double-slit interference test is reached under the condition that most of the physical properties of waves are stripped away, and this conclusion is divorced from objectivity. The theory of light waves is not correct. In any case, light is not a wave. Light waves are misunderstood.