scholarly journals Enzyme-Crosslinked Electrospun Fibrous Gelatin Hydrogel for Potential Soft Tissue Engineering

Polymers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 1977
Author(s):  
Kexin Nie ◽  
Shanshan Han ◽  
Jianmin Yang ◽  
Qingqing Sun ◽  
Xiaofeng Wang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
Tissue Regeneration ◽  
Water Solution ◽  
Cellular Adhesion ◽  
Fibrous Structure ◽  
Electrospun Fibers ◽  
Hydrogel Scaffolds ◽  
Cell Functions ◽  
Soft Tissue Engineering

Soft tissue engineering has been seeking ways to mimic the natural extracellular microenvironment that allows cells to migrate and proliferate to regenerate new tissue. Therefore, the reconstruction of soft tissue requires a scaffold possessing the extracellular matrix (ECM)-mimicking fibrous structure and elastic property, which affect the cell functions and tissue regeneration. Herein, an effective method for fabricating nanofibrous hydrogel for soft tissue engineering is demonstrated using gelatin–hydroxyphenylpropionic acid (Gel–HPA) by electrospinning and enzymatic crosslinking. Gel–HPA fibrous hydrogel was prepared by crosslinking the electrospun fibers in ethanol-water solution with an optimized concentration of horseradish peroxidase (HRP) and H2O2. The prepared fibrous hydrogel held the soft and elastic mechanical property of hydrogels and the three-dimensional (3D) fibrous structure of electrospun fibers. It was proven that the hydrogel scaffolds were biocompatible, improving the cellular adhesion, spreading, and proliferation. Moreover, the fibrous hydrogel showed rapid biodegradability and promoted angiogenesis in vivo. Overall, this study represents a novel biomimetic approach to generate Gel–HPA fibrous hydrogel scaffolds which have excellent potential in soft tissue regeneration applications.

Electrospun fibers of poly(butylene succinate–co–dilinoleic succinate) and its blend with poly(glycerol sebacate) for soft tissue engineering applications

2016 ◽  
Vol 81 ◽  
pp. 295-306 ◽  
Author(s):  
Liliana Liverani ◽  
Agnieszka Piegat ◽  
Agata Niemczyk ◽  
Miroslawa El Fray ◽  
Aldo R. Boccaccini
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
Electrospun Fibers ◽  
Engineering Applications ◽  
Butylene Succinate ◽  
Soft Tissue Engineering

Epoxy-amine synthesised hydrogel scaffolds for soft-tissue engineering

Biomaterials ◽  
2010 ◽  
Vol 31 (25) ◽  
pp. 6454-6467 ◽  
Author(s):  
Zuratul A.A. Hamid ◽  
Anton Blencowe ◽  
Berkay Ozcelik ◽  
Jason A. Palmer ◽  
Geoffrey W. Stevens ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
Hydrogel Scaffolds ◽  
Epoxy Amine ◽  
Soft Tissue Engineering

Fabrication of hydrogel scaffolds using rapid prototyping for soft tissue engineering

2011 ◽  
Vol 19 (7) ◽  
pp. 694-698 ◽  
Author(s):  
Su A. Park ◽  
Su Hee Lee ◽  
WanDoo Kim
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
Rapid Prototyping ◽  
Hydrogel Scaffolds ◽  
Soft Tissue Engineering

Composite hydrogel scaffolds incorporating decellularized adipose tissue for soft tissue engineering with adipose-derived stem cells

Biomaterials ◽  
2014 ◽  
Vol 35 (6) ◽  
pp. 1914-1923 ◽  
Author(s):  
Hoi Ki Cheung ◽  
Tim Tian Y. Han ◽  
Dale M. Marecak ◽  
John F. Watkins ◽  
Brian G. Amsden ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Adipose Tissue ◽  
Soft Tissue ◽  
Composite Hydrogel ◽  
Adipose Derived Stem Cells ◽  
Hydrogel Scaffolds ◽  
Soft Tissue Engineering

Multifunctional poly(glycolic acid-co-propylene fumarate) electrospun fibers reinforced with graphene oxide and hydroxyapatite nanorods

2017 ◽  
Vol 5 (22) ◽  
pp. 4084-4096 ◽  
Author(s):  
Ana M. Díez-Pascual ◽  
Angel L. Díez-Vicente
Keyword(s):  
Tissue Engineering ◽  
Graphene Oxide ◽  
Soft Tissue ◽  
Bactericidal Activity ◽  
Glycolic Acid ◽  
Electrospun Fibers ◽  
Hybrid Nanocomposite ◽  
High Stiffness ◽  
Nanocomposite Fibers ◽  
Soft Tissue Engineering

Biocompatible and biodegradable PGA-co-PPF/HA/GO hybrid nanocomposite fibers with high stiffness and good bactericidal activity have been developed for soft tissue engineering.

scholarly journals Robust alginate/hyaluronic acid thiol–yne click-hydrogel scaffolds with superior mechanical performance and stability for load-bearing soft tissue engineering

2020 ◽  
Vol 8 (1) ◽  
pp. 405-412 ◽  
Author(s):  
Maria M. Pérez-Madrigal ◽  
Joshua E. Shaw ◽  
Maria C. Arno ◽  
Judith A. Hoyland ◽  
Stephen M. Richardson ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Hyaluronic Acid ◽  
Soft Tissue ◽  
Mechanical Performance ◽  
Click Reaction ◽  
Load Bearing ◽  
Hydrogel Scaffolds ◽  
Soft Tissue Engineering

Combining two biopolymers with the efficiency and rapid nature of the thiol–yne click reaction yields biocompatible matrices with superior properties.

scholarly journals Electrospun PCL/PGS Composite Fibers Incorporating Bioactive Glass Particles for Soft Tissue Engineering Applications

Nanomaterials ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 978 ◽  
Author(s):  
Marina Luginina ◽  
Katharina Schuhladen ◽  
Roberto Orrú ◽  
Giacomo Cao ◽  
Aldo R. Boccaccini ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
Bioactive Glass ◽  
Fiber Diameter ◽  
Diameter Distribution ◽  
Electrospun Fibers ◽  
Average Fiber Diameter ◽  
Composite Fibers ◽  
Engineering Applications ◽  
Soft Tissue Engineering

Poly(glycerol-sebacate) (PGS) and poly(epsilon caprolactone) (PCL) have been widely investigated for biomedical applications in combination with the electrospinning process. Among others, one advantage of this blend is its suitability to be processed with benign solvents for electrospinning. In this work, the suitability of PGS/PCL polymers for the fabrication of composite fibers incorporating bioactive glass (BG) particles was investigated. Composite electrospun fibers containing silicate or borosilicate glass particles (13-93 and 13-93BS, respectively) were obtained and characterized. Neat PCL and PCL composite electrospun fibers were used as control to investigate the possible effect of the presence of PGS and the influence of the bioactive glass particles. In fact, with the addition of PGS an increase in the average fiber diameter was observed, while in all the composite fibers, the presence of BG particles induced an increase in the fiber diameter distribution, without changing significantly the average fiber diameter. Results confirmed that the blended fibers are hydrophilic, while the addition of BG particles does not affect fiber wettability. Degradation test and acellular bioactivity test highlight the release of the BG particles from all composite fibers, relevant for all applications related to therapeutic ion release, i.e., wound healing. Because of weak interface between the incorporated BG particles and the polymeric fibers, mechanical properties were not improved in the composite fibers. Promising results were obtained from preliminary biological tests for potential use of the developed mats for soft tissue engineering applications.

scholarly journals Polymer-Based Scaffolds for Soft-Tissue Engineering

Polymers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1566 ◽  
Author(s):  
Victor Perez-Puyana ◽  
Mercedes Jiménez-Rosado ◽  
Alberto Romero ◽  
Antonio Guerrero
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
3D Printing ◽  
Tissue Regeneration ◽  
Freeze Drying ◽  
Future Trends ◽  
Advantages And Disadvantages ◽  
Ancient Times ◽  
Soft Tissue Engineering

Biomaterials have been used since ancient times. However, it was not until the late 1960s when their development prospered, increasing the research on them. In recent years, the study of biomaterials has focused mainly on tissue regeneration, requiring a biomaterial that can support cells during their growth and fulfill the function of the replaced tissue until its regeneration. These materials, called scaffolds, have been developed with a wide variety of materials and processes, with the polymer ones being the most advanced. For this reason, the need arises for a review that compiles the techniques most used in the development of polymer-based scaffolds. This review has focused on three of the most used techniques: freeze-drying, electrospinning and 3D printing, focusing on current and future trends. In addition, the advantages and disadvantages of each of them have been compared.

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