scholarly journals Fabrication of Drug-Eluting Nano-Hydroxylapatite Filled Polycaprolactone Nanocomposites Using Solution-Extrusion 3D Printing Technique

Polymers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 318 ◽  
Author(s):  
Pang-Yun Chou ◽  
Ying-Chao Chou ◽  
Yu-Hsuan Lai ◽  
Yu-Ting Lin ◽  
Chia-Jung Lu ◽  
...  
Keyword(s):  
3D Printing ◽  
Fused Deposition Modeling ◽  
Three Dimensional ◽  
Fused Deposition ◽  
Drug Eluting ◽  
Deposition Modeling ◽  
3D Printed ◽  
Good Biocompatibility ◽  
3D Printing Technique ◽  
Moving Speed

Polycaprolactone/nano-hydroxylapatite (PCL/nHA) nanocomposites have found use in tissue engineering and drug delivery owing to their good biocompatibility with these types of applications in addition to their mechanical characteristics. Three-dimensional (3D) printing of PCL/nHA nanocomposites persists as a defiance mostly because of the lack of commercial filaments for the conventional fused deposition modeling (FDM) method. In addition, as the composites are prepared using FDM for the purpose of delivering pharmaceuticals, thermal energy can destroy the embedded drugs and biomolecules. In this report, we investigated 3D printing of PCL/nHA using a lab-developed solution-extrusion printer, which consists of an extrusion feeder, a syringe with a dispensing nozzle, a collection table, and a command port. The effects of distinct printing variables on the mechanical properties of nanocomposites were investigated. Drug-eluting nanocomposite screws were also prepared using solution-extrusion 3D printing. The empirical outcomes suggest that the tensile properties of the 3D-printed PCL/nHA nanocomposites increased with the PCL/nHA-to-dichloromethane (DCM) ratio, fill density, and print orientation but decreased with an increase in the moving speed of the dispensing tip. Furthermore, printed drug-eluting PCL/nHA screws eluted high levels of antimicrobial vancomycin and ceftazidime over a 14-day period. Solution-extrusion 3D printing demonstrated excellent capabilities for fabricating drug-loaded implants for various medical applications.

Properties and applications of electrically conductive thermoplastics for additive manufacturing of sensors

2017 ◽  
Vol 84 (9) ◽  
Author(s):  
Benedikt Hampel ◽  
Samuel Monshausen ◽  
Meinhard Schilling
Keyword(s):  
3D Printing ◽  
Fused Deposition Modeling ◽  
Electrical Conductance ◽  
Electrically Conductive ◽  
Fused Deposition ◽  
Printing Technique ◽  
Deposition Modeling ◽  
3D Printed ◽  
3D Printing Technique ◽  
Printing Parameters

AbstractIn consequence of the growing diversity of materials in the fused deposition modeling 3D printing technique, electrically conductive materials are commercially available. In this work two filaments based on thermoplastics filled with carbon or metal nanoparticles are analyzed in terms of their electrical conductance. The printing parameters to process the materials with the 3D printer are optimized with the design of experiments (DoE) method. A model to calculate the resistance of such 3D printed structures is presented and a demonstrator as a proof of concept was 3D printed based on these results. In addition, 3D printing of capacitors is investigated.

Analysis of Correlation Between Contrast and Component of Polylatic Acid Composite for Fused Deposition Modeling 3D Printing

2020 ◽  
Vol 20 (8) ◽  
pp. 5107-5111
Author(s):  
Kyu-Hyon Son ◽  
Jung-Hun Kim ◽  
Dong-Eun Kim ◽  
Min-Sik Kang ◽  
Joo-Heon Song ◽  
...  
Keyword(s):  
3D Printing ◽  
Fused Deposition Modeling ◽  
Three Dimensional ◽  
Disruptive Technology ◽  
X Ray ◽  
Fused Deposition ◽  
Potential Applicability ◽  
Deposition Modeling ◽  
3D Printed ◽  
Cie Lab

Additive manufacturing or three-dimensional (3D) printing is considered a disruptive technology for producing components with topologically optimized complex geometries as well as functionalities that are not achievable by traditional methods. 3D printing is expected to revolutionize the manufacturing of components. While several 3D printing systems are available, printing based on fused-deposition modeling (FDM) using thermoplastics is particularly widespread because of the simplicity and potential applicability of the method. In this study, we report the analysis of correlation between contrast and component of polylactic acid (PLA) based composite for FDM 3D printing. The pre-fabricated white composite and black composite were mixed in the fraction of 100:0, 90:10, 75:25, 50:50, 25:75, and 0:100% (v/v) and the obtained mixture was extruded using HX-35 3D filament extrusion line. The samples in different contrast were printed in disk like shape, and the gray scale filaments and 3D printed samples were measured the morphology and components using a field emission scanning electron microscope and energy dispersive X-ray spectroscopy. The CIE-lab values of the samples were measured using a colorimeter and the correlation between CIE-lab values and the components were analyzed. Although the component of Ti was linearly increased, the CIE-lab values show a clear exponential increase by increasing the white composite.

scholarly journals Fabrication and characterization of 3D printed BaTiO3/PVDF nanocomposites

2017 ◽  
Vol 52 (2) ◽  
pp. 197-206 ◽  
Author(s):  
Hoejin Kim ◽  
Torres Fernando ◽  
Mingyue Li ◽  
Yirong Lin ◽  
Tzu-Liang Bill Tseng
Keyword(s):  
3D Printing ◽  
Polyvinylidene Fluoride ◽  
Fused Deposition Modeling ◽  
Fabrication Process ◽  
Piezoelectric Response ◽  
Fused Deposition ◽  
Printing Technique ◽  
Deposition Modeling ◽  
3D Printed ◽  
3D Printing Technique

This paper presents a fabrication process to enhance homogeneous dispersion of BaTiO3 nanoparticles in polyvinylidene fluoride matrix nanocomposites using fused deposition modeling (FDM) 3D printing technique. The nanocomposites integrate the functional property (piezoelectric, pyroelectric, and dielectric) of BaTiO3 with the flexibility and lightweight of polyvinylidene fluoride. Traditionally, the simple yet effective way to fabricate the nanocomposites includes solvent-casting, spin-coating, and hot-embossing. However, these methods have disadvantages such as heterogeneous dispersion of BaTiO3 nanoparticles in polyvinylidene fluoride matrix due to the higher density of BaTiO3 compared with polyvinylidene fluoride and agglomeration during fabrication process. This heterogeneous dispersion could weaken functional and mechanical properties. Herein, fused deposition modeling 3D printing technique was utilized for homogeneous dispersion to alleviate the agglomeration of BaTiO3 in polyvinylidene fluoride through two processes: filament extrusion and 3D printing. In addition, thermal poling was applied to further enhance piezoelectric response of the BaTiO3/polyvinylidene fluoride nanocomposites. It is found that 3D printed BaTiO3/polyvinylidene fluoride nanocomposites exhibit three times higher piezoelectric response than solvent-casted nanocomposites.

Biodegradable 3D Printed Polymer Microneedles for Transdermal Drug Delivery

2018 ◽  
Author(s):  
Michael A. Luzuriaga ◽  
Danielle R. Berry ◽  
John C. Reagan ◽  
Ronald A. Smaldone ◽  
Jeremiah J. Gassensmith
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Transdermal Drug Delivery ◽  
Fused Deposition Modeling ◽  
Fused Deposition ◽  
Modeling Software ◽  
Deposition Modeling ◽  
3D Printed ◽  
Microfabrication Technique ◽  
Mechanical Strengths

Biodegradable polymer microneedle (MN) arrays are an emerging class of transdermal drug delivery devices that promise a painless and sanitary alternative to syringes; however, prototyping bespoke needle architectures is expensive and requires production of new master templates. Here, we present a new microfabrication technique for MNs using fused deposition modeling (FDM) 3D printing using polylactic acid, an FDA approved, renewable, biodegradable, thermoplastic material. We show how this natural degradability can be exploited to overcome a key challenge of FDM 3D printing, in particular the low resolution of these printers. We improved the feature size of the printed parts significantly by developing a post fabrication chemical etching protocol, which allowed us to access tip sizes as small as 1 μm. With 3D modeling software, various MN shapes were designed and printed rapidly with custom needle density, length, and shape. Scanning electron microscopy confirmed that our method resulted in needle tip sizes in the range of 1 – 55 µm, which could successfully penetrate and break off into porcine skin. We have also shown that these MNs have comparable mechanical strengths to currently fabricated MNs and we further demonstrated how the swellability of PLA can be exploited to load small molecule drugs and how its degradability in skin can release those small molecules over time.

Development of three-dimensional printing filaments based on poly(lactic acid)/hydroxyapatite composites with potential for tissue engineering

2021 ◽  
pp. 002199832098856
Author(s):  
Marcela Piassi Bernardo ◽  
Bruna Cristina Rodrigues da Silva ◽  
Luiz Henrique Capparelli Mattoso
Keyword(s):  
Tissue Engineering ◽  
Lactic Acid ◽  
Fused Deposition Modeling ◽  
Three Dimensional ◽  
Poly Lactic Acid ◽  
Scanning Calorimetry ◽  
Three Dimensional Printing ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
3D Printed

Injured bone tissues can be healed with scaffolds, which could be manufactured using the fused deposition modeling (FDM) strategy. Poly(lactic acid) (PLA) is one of the most biocompatible polymers suitable for FDM, while hydroxyapatite (HA) could improve the bioactivity of scaffold due to its chemical composition. Therefore, the combination of PLA/HA can create composite filaments adequate for FDM and with high osteoconductive and osteointegration potentials. In this work, we proposed a different approache to improve the potential bioactivity of 3D printed scaffolds for bone tissue engineering by increasing the HA loading (20-30%) in the PLA composite filaments. Two routes were investigated regarding the use of solvents in the filament production. To assess the suitability of the FDM-3D printing process, and the influence of the HA content on the polymer matrix, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM) were performed. The HA phase content of the composite filaments agreed with the initial composite proportions. The wettability of the 3D printed scaffolds was also increased. It was shown a greener route for obtaining composite filaments that generate scaffolds with properties similar to those obtained by the solvent casting, with high HA content and great potential to be used as a bone graft.

scholarly journals 3D-Printed Soft Structure of Polyurethane and Magnetorheological Fluid: A Proof-of-Concept Investigation of its Stiffness Tunability

Micromachines ◽  
2019 ◽  
Vol 10 (10) ◽  
pp. 655 ◽  
Author(s):  
Seong-Woo Hong ◽  
Ji-Young Yoon ◽  
Seong-Hwan Kim ◽  
Sun-Kon Lee ◽  
Yong-Rae Kim ◽  
...  
Keyword(s):  
Fused Deposition Modeling ◽  
Permanent Magnets ◽  
Thermoplastic Polyurethane ◽  
Three Dimensional ◽  
Magnetorheological Fluid ◽  
Three Dimensional Printing ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
3D Printed ◽  
Dimensional Printing

In this study, a soft structure with its stiffness tunable by an external field is proposed. The proposed soft beam structure consists of a skin structure with channels filled with a magnetorheological fluid (MRF). Two specimens of the soft structure are fabricated by three-dimensional printing and fused deposition modeling. In the fabrication, a nozzle is used to obtain channels in the skin of the thermoplastic polyurethane, while another nozzle is used to fill MRF in the channels. The specimens are tested by using a universal tensile machine to evaluate the relationships between the load and deflection under two different conditions, without and with permanent magnets. It is empirically shown that the stiffness of the proposed soft structure can be altered by activating the magnetic field.

scholarly journals Typography-Like 3D-Printed Templates for the Lithography-Free Fabrication of Microfluidic Chips

2019 ◽  
Vol 25 (1) ◽  
pp. 82-87
Author(s):  
Wenqiong Su ◽  
Yulong Li ◽  
Lulu Zhang ◽  
Jiahui Sun ◽  
Shuopeng Liu ◽  
...  
Keyword(s):  
Processing Time ◽  
Fused Deposition Modeling ◽  
Three Dimensional ◽  
Cost Effective ◽  
Microfluidic Channels ◽  
3D Printer ◽  
Microfluidic Chips ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
3D Printed

Typography-like templates for polydimethylsiloxane (PDMS) microfluidic chips using a fused deposition modeling (FDM) three-dimensional (3D) printer are presented. This rapid and fast proposed scheme did not require complicated photolithographic fabrication facilities and could deliver resolutions of ~100 μm. Polylactic acid (PLA) was adopted as the material to generate the 3D-printed units, which were then carefully assembled on a glass substrate using a heat-melt-curd strategy. This craft of bonding offers a cost-effective way to design and modify the templates of microfluidic channels, thus reducing the processing time of microfluidic chips. Finally, a flexible microfluidic chip to be employed for cell-based drug screening was developed based on the modularized 3D-printed templates. The lithography-free, typography-like, 3D-printed templates create a modularized fabrication process and promote the prevalence of integrated microfluidic systems with minimal requirements and improved efficiency.

scholarly journals An overview on 3D Printed Medicine

2021 ◽  
Vol 18 (1) ◽  
pp. 07-13
Author(s):  
Neha Thakur ◽  
Hari Murthy
Keyword(s):  
3D Printing ◽  
Fused Deposition Modeling ◽  
Low Cost ◽  
Selective Laser Sintering ◽  
Three Dimensional ◽  
Herbal Medicines ◽  
Fused Deposition ◽  
Digitally Controlled ◽  
3D Printed ◽  
Semi Solid

Three-dimensional printing (3DP) is a digitally-controlled additive manufacturing technique used for fast prototyping. This paper reviews various 3D printing techniques like Selective Laser Sintering (SLS), Fused Deposition Modeling, (FDM), Semi-solid extrusion (SSE), Stereolithography (SLA), Thermal Inkjet (TIJ) Printing, and Binder jetting 3D Printing along with their application in the field of medicine. Normal medicines are based on the principle of “one-size-fits-all”. This is not true always, it is possible medicine used for curing one patient is giving some side effects to another. To overcome this drawback “3D Printed medicines” are developed. In this paper, 3D printed medicines forming different Active Pharmaceutical Ingredients (API) are reviewed. Printed medicines are capable of only curing the diseases, not for the diagnosis. Nanomedicines have “theranostic” ability which combines therapeutic and diagnostic. Nanoparticles are used as the drug delivery system (DDS) to damaged cells’ specific locations. By the use of nanomedicine, the fast recovery of the disease is possible. The plant-based nanoparticles are used with herbal medicines which give low-cost and less toxic medication called nanobiomedicine. 4D and 5D printing technology for the medical field are also enlightened in this paper.

scholarly journals Effects of wood flour and MA-EPDM on the properties of fused deposition modeling 3D-printed poly lactic acid composites

BioResources ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. 7122-7138
Author(s):  
Sang-U Bae ◽  
Young-Rok Seo ◽  
Birm-June Kim ◽  
Min Lee
Keyword(s):  
Lactic Acid ◽  
3D Printing ◽  
Fused Deposition Modeling ◽  
Wood Flour ◽  
Poly Lactic Acid ◽  
Common System ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
3D Printed ◽  
Material Composite

Fused deposition modeling (FDM) 3D printing technology is the most common system for polymer additive manufacturing (AM). Recent studies have been conducted to expand both the range of materials that can be used for FDM and their applications. As a filler, wood flour was incorporated into poly lactic acid (PLA) polymer to develop a biocomposite material. Composite filaments were manufactured with various wood flour contents and then successfully used for 3D printing. Morphological, mechanical, and biodegradation properties of FDM 3D-printed PLA composites were investigated. To mitigate brittleness, 5 phr of maleic anhydride grafted ethylene propylene diene monomer (MA-EPDM) was added to the composite blends, and microstructural properties of the composites were examined by scanning electron microscopy (SEM). Mechanical strength tests demonstrated that elasticity was imparted to the composites. Additionally, test results showed that the addition of wood flour to the PLA matrix promoted pore generation and further influenced the mechanical and biodegradation properties of the 3D-printed composites. An excellent effect of wood flour on the biodegradation properties of FDM 3D-printed PLA composites was observed.

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