scholarly journals Polyvinyl Alcohol/Chitosan and Polyvinyl Alcohol/Ag@MOF Bilayer Hydrogel for Tissue Engineering Applications

Polymers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 3151
Author(s):  
Meng Zhang ◽  
Guohui Wang ◽  
Xin Zhang ◽  
Yuqi Zheng ◽  
Shaoxiang Lee ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Polyvinyl Alcohol ◽  
Metal Organic Framework ◽  
A549 Cells ◽  
Hydrogel Scaffold ◽  
Adhesion Ability ◽  
Good Antibacterial Activity ◽  
Metal Organic ◽  
Good Water Retention ◽  
Uniform Pore Size

In this paper, polyvinyl alcohol/Ag-Metal-organic framework (PVA/Ag@MOF) and polyvinyl alcohol/chitosan (PVA/CS) were used as the inner and outer layers to successfully prepare a bilayer composite hydrogel for tissue engineering scaffold. The performance of bilayer hydrogels was evaluated. The outer layer (PVA/CS) has a uniform pore size distribution, good water retention, biocompatibility and cell adhesion ability. The inner layer (PVA/Ag@MOF) has good antibacterial activity and poor biocompatibility. PVA, PVA/0.1%Ag@MOF, PVA/0.5%Ag@MOF, and PVA/1.0%Ag@MOF show anti-microbial activity in ascending order. However, its use as an inner layer avoids direct contact with cells and prevents infection. The cell viability of all samples was above 90%, indicating that the bilayer hydrogel was non-toxic to A549 cells. The bilayer hydrogel scaffold combines the advantages of the inner and outer layers. In summary, this new bilayer composite is an ideal lung scaffold for tissue engineering.

Stable artificial solid electrolyte interphase films for lithium metal anode via metal–organic frameworks cemented by polyvinyl alcohol

2020 ◽  
Vol 8 (1) ◽  
pp. 251-258 ◽  
Author(s):  
Lishuang Fan ◽  
Zhikun Guo ◽  
Yu Zhang ◽  
Xian Wu ◽  
Chenyang Zhao ◽  
...  
Keyword(s):  
Polyvinyl Alcohol ◽  
Metal Organic Framework ◽  
Solid Electrolyte Interphase ◽  
Lithium Metal ◽  
Metal Anode ◽  
Lithium Metal Anode ◽  
Sei Film ◽  
Metal Organic ◽  
Li Metal Anode ◽  
The Stability

Polyvinyl alcohol (PVA) as a “glue” to cement the metal organic framework (Zn-MOF) sheet as a reasonable artificial SEI film. The artificial SEI film can efficiently adapt to the changes of the volume during the cycle, significantly improve the stability of the Li metal anode.

scholarly journals Polypropylene/Polyvinyl Alcohol/Metal-Organic Framework-Based Melt-Blown Electrospun Composite Membranes for Highly Efficient Filtration of PM2.5

Nanomaterials ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 2025
Author(s):  
Ting-Ting Li ◽  
Yujia Fan ◽  
Xixi Cen ◽  
Yi Wang ◽  
Bing-Chiuan Shiu ◽  
...  
Keyword(s):  
Polyvinyl Alcohol ◽  
Metal Organic Framework ◽  
Composite Membranes ◽  
Fibrous Structure ◽  
Electrospinning Technique ◽  
Air Filters ◽  
Highly Efficient ◽  
Metal Organic ◽  
External Forces ◽  
Particulate Matter 2.5

Particulate matter 2.5 (PM2.5) has become a public hazard to people’s lives and health. Traditional melt-blown membranes cannot filter dangerous particles due to their limited diameter, and ultra-fine electrospinning fibers are vulnerable to external forces. Therefore, creating highly efficient air filters by using an innovative technique and structure has become necessary. In this study, a combination of polypropylene (PP) melt-blown and polyvinyl alcohol (PVA)/zeolite imidazole frameworks-8 (ZIF-8) electrospinning technique is employed to construct a PP/PVA/ZIF-8 membrane with a hierarchical fibrous structure. The synergistic effect of hierarchical fibrous structure and ZIF-8 effectively captures PM2.5. The PP/PVA composite membrane loaded with 2.5% loading ZIF-8 has an average filtration efficacy reaching as high as 96.5% for PM2.5 and quality factor (Qf) of 0.099 Pa−1. The resultant membrane resists 33.34 N tensile strength and has a low pressure drop, excellent filtration efficiency, and mechanical strength. This work presents a facile preparation method that is suitable for mass production and the application of membranes to be used as air filters for highly efficient filtration of PM2.5.

scholarly journals Microencapsulated Isoniazid-Loaded Metal–Organic Frameworks for Pulmonary Administration of Antituberculosis Drugs

Molecules ◽  
2021 ◽  
Vol 26 (21) ◽  
pp. 6408
Author(s):  
Cristina Fernández-Paz ◽  
Estefanía Fernández-Paz ◽  
Pablo Salcedo-Abraira ◽  
Sara Rojas ◽  
Sheila Barrios-Esteban ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
A549 Cells ◽  
Aerodynamic Characteristics ◽  
Pulmonary Administration ◽  
Cell Internalization ◽  
Tb Treatment ◽  
Medication Schedule ◽  
Metal Organic ◽  
Vehicle Components ◽  
High Doses

Tuberculosis (TB) is an infectious disease that causes a great number of deaths in the world (1.5 million people per year). This disease is currently treated by administering high doses of various oral anti-TB drugs for prolonged periods (up to 2 years). While this regimen is normally effective when taken as prescribed, many people with TB experience difficulties in complying with their medication schedule. Furthermore, the oral administration of standard anti-TB drugs causes severe side effects and widespread resistances. Recently, we proposed an original platform for pulmonary TB treatment consisting of mannitol microspheres (Ma MS) containing iron (III) trimesate metal–organic framework (MOF) MIL-100 nanoparticles (NPs). In the present work, we loaded this system with the first-line anti-TB drug isoniazid (INH) and evaluated both the viability and safety of the drug vehicle components, as well as the cell internalization of the formulation in alveolar A549 cells. Results show that INH-loaded MOF (INH@MIL-100) NPs were efficiently microencapsulated in Ma MS, which displayed suitable aerodynamic characteristics for pulmonary administration and non-toxicity. MIL-100 and INH@MIL-100 NPs were efficiently internalized by A549 cells, mainly localized in the cytoplasm. In conclusion, the proposed micro-nanosystem is a good candidate for the pulmonary administration of anti-TB drugs.

Metal-organic framework-based nanomaterials for bone tissue engineering and wound healing

2022 ◽  
Vol 23 ◽  
pp. 100670
Author(s):  
M. Asadniaye Fardjahromi ◽  
H. Nazari ◽  
S.M. Ahmadi Tafti ◽  
A. Razmjou ◽  
S. Mukhopadhyay ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Wound Healing ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Organic Framework

Multifunctional metal–organic framework heterostructures for enhanced cancer therapy

2021 ◽  
Author(s):  
Jintong Liu ◽  
Jing Huang ◽  
Lei Zhang ◽  
Jianping Lei
Keyword(s):  
Cancer Therapy ◽  
General Principle ◽  
Biomedical Applications ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Functional Modulation ◽  
Organic Framework

We review the general principle of the design and functional modulation of nanoscaled MOF heterostructures, and biomedical applications in enhanced therapy.

Magnetic Ordering via Itinerant Ferromagnetism in a Metal-Organic Framework

2020 ◽  
Author(s):  
Jesse Park ◽  
Brianna Collins ◽  
Lucy Darago ◽  
Tomce Runcevski ◽  
Michael Aubrey ◽  
...  
Keyword(s):  
Charge Transport ◽  
Magnetic Order ◽  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
Magnetic Ordering ◽  
Double Exchange ◽  
Itinerant Ferromagnetism ◽  
Organic Solids ◽  
Metal Organic ◽  
Organic Framework

<b>Materials that combine magnetic order with other desirable physical attributes offer to revolutionize our energy landscape. Indeed, such materials could find transformative applications in spintronics, quantum sensing, low-density magnets, and gas separations. As a result, efforts to design multifunctional magnetic materials have recently moved beyond traditional solid-state materials to metal–organic solids. Among these, metal–organic frameworks in particular bear structures that offer intrinsic porosity, vast chemical and structural programmability, and tunability of electronic properties. Nevertheless, magnetic order within metal–organic frameworks has generally been limited to low temperatures, owing largely to challenges in creating strong magnetic exchange in extended metal–organic solids. Here, we employ the phenomenon of itinerant ferromagnetism to realize magnetic ordering at <i>T</i><sub>C</sub> = 225 K in a mixed-valence chromium(II/III) triazolate compound, representing the highest ferromagnetic ordering temperature yet observed in a metal–organic framework. The itinerant ferromagnetism is shown to proceed via a double-exchange mechanism, the first such observation in any metal–organic material. Critically, this mechanism results in variable-temperature conductivity with barrierless charge transport below <i>T</i><sub>C</sub> and a large negative magnetoresistance of 23% at 5 K. These observations suggest applications for double-exchange-based coordination solids in the emergent fields of magnetoelectrics and spintronics. Taken together, the insights gleaned from these results are expected to provide a blueprint for the design and synthesis of porous materials with synergistic high-temperature magnetic and charge transport properties. </b>

Sign in / Sign up

Export Citation Format

Share Document