scholarly journals Reckoning the Dearth of Bioinformatics in the Arena of Diabetic Nephropathy (DN)—Need to Improvise

Processes ◽  
2020 ◽  
Vol 8 (7) ◽  
pp. 808
Author(s):  
Jae-Wook Oh ◽  
Manikandan Muthu ◽  
Steve W. Haga ◽  
Vimala Anthonydhason ◽  
Piby Paul ◽  
...  
Keyword(s):  
Renal Function ◽  
Diabetic Nephropathy ◽  
Kidney Function ◽  
Biomarker Discovery ◽  
Total Loss ◽  
Proteomic Research ◽  
Made In ◽  
Abnormal Renal Function

Diabetic nephropathy (DN) is a recent rising concern amongst diabetics and diabetologist. Characterized by abnormal renal function and ending in total loss of kidney function, this is becoming a lurking danger for the ever increasing population of diabetics. This review touches upon the intensity of this complication and briefly reviews the role of bioinformatics in the area of diabetes. The advances made in the area of DN using proteomic approaches are presented. Compared to the enumerable inputs observed through the use of bioinformatics resources in the area of proteomics and even diabetes, the existing scenario of skeletal application of bioinformatics advances to DN is highlighted and the reasons behind this discussed. As this review highlights, almost none of the well-established tools that have brought breakthroughs in proteomic research have been applied into DN. Laborious, voluminous, cost expensive and time-consuming methodologies and advances in diagnostics and biomarker discovery promised through beckoning bioinformatics mechanistic approaches to improvise DN research and achieve breakthroughs. This review is expected to sensitize the researchers to fill in this gap, exploiting the available inputs from bioinformatics resources.

Abstract 215: Adam17 Regulates Renal Function

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_4) ◽  
Author(s):  
Bo Zhang ◽  
Kai Chen ◽  
Zhongjie Sun
Keyword(s):  
Renal Function ◽  
Kidney Function ◽  
Renal Tubule ◽  
Renal Diseases ◽  
Normal Kidney ◽  
Normal Kidney Function ◽  
Membrane Bound ◽  
Tubule Cells ◽  
A Disintegrin And Metalloproteinase

A disintegrin and metalloproteinase 17 (ADAM17) is a ubiquitously expressed membrane-bound sheddase that cleaves a diverse variety of membrane-bound molecules, including cytokines, growth factors, and their receptors to activate or inactivate various cellular signaling pathways. Although it was reported that ADAM17 may mediate renal diseases, the role of ADAM17 in the regulation of normal kidney function has never been identified. The objective of this study is to investigate whether renal ADAM17 plays a role in maintaining normal kidney function and structure. Tamoxifen-inducible kidney-specific cre (Ksp) and ADAM17-floxed mice were cross-bred for generating Ksp/ADAM17-floxed mice. Injection of tamoxifen initiated deletion of the ADAM17 gene in renal tubule cells. We found that conditional kidney-specific knockout of ADAM1 7 gene (Ksp-ADAM17 -/-) decreased urinary creatinine and sodium excretion were decreased in Ksp-ADAM17 -/- mice, indicating that ADAM17 gene deficiency impairs kidney function. H&E staining showed glomerulus collapse and tubule dilation in Ksp-ADAM17 -/- mice. The epithelial cells fall off into the lumen in the renal tubule. Mesangial expansion and fibrosis were found in glomeruli in Ksp-ADAM17 -/- mice. Moreover, apoptosis was increased in tubule cells in both cortex and medulla areas in Ksp-ADAM17 -/- mice. In conclusion, ADAM17 is critical to the maintenance of normal renal function and structure.

Plasma total adiponectin and changes in renal function in a cohort from the community: the prospective Data from an Epidemiological Study on the Insulin Resistance Syndrome study

2020 ◽  
Author(s):  
Frédéric Fumeron ◽  
Ray El Boustany ◽  
Jean-Philippe Bastard ◽  
Soraya Fellahi ◽  
Beverley Balkau ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Renal Function ◽  
Diabetic Nephropathy ◽  
Kidney Disease ◽  
General Population ◽  
Kidney Function ◽  
Insulin Resistance Syndrome ◽  
Plasma Adiponectin ◽  
Kidney Function Decline

Abstract Background High adiponectin levels are associated with diabetic nephropathy. Nevertheless, it is not known whether plasma adiponectin is associated with renal function decline in the general population. We evaluated whether adiponectin concentrations were associated with changes in renal function in a community cohort, the Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) study. Methods Plasma adiponectin concentrations were measured in a random sample of 3284 people from the DESIR study, a 9-year prospective cohort from the general population. Data were analysed for three endpoints during follow-up: incidence of Stage 3 chronic kidney disease (CKD); the Kidney Disease: Improving Global Outcomes (KDIGO) criterion ‘certain drop in eGFR’ and rapid kidney function decline [estimated glomerular filtration rate (eGFR) slope steeper than −3 mL/min/1.73 m2/year]. Results After exclusion of participants with an eGFR <60 mL/min/1.73 m2 at baseline and those with type 2 diabetes or impaired fasting glycaemia at any time during follow-up (remaining n = 2174), there was a 113% higher risk for a rapid decline in kidney function in participants with adiponectin above the third tertile (T3) versus below the first tertile (T1) (Ptrend = 0.004) and a 53% higher risk for kidney function decline as defined by the KDIGO criterion (Ptrend = 0.04). In a cross-sectional analysis, adiponectin was positively associated with urinary albumin:creatinine ratio at baseline (P = 0.009). Conclusions In a healthy cohort from the general population, higher levels of plasma adiponectin were associated with decreased renal function at baseline and at follow-up. This result is similar to what is observed in people with diabetic nephropathy, in contrast with animal models of nephropathy.

scholarly journals The role of bone marrow derived-mesenchymal stem cells in attenuation of kidney function in rats with diabetic nephropathy

2014 ◽  
Vol 6 (1) ◽  
pp. 34 ◽  
Author(s):  
Mohamed Abdel Aziz ◽  
Mohamed Abdel Wassef ◽  
Hanan Ahmed ◽  
Laila Rashed ◽  
Soheir Mahfouz ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Diabetic Nephropathy ◽  
Kidney Function

scholarly journals The potential role of the gut microbiota in modulating renal function in experimental diabetic nephropathy murine models established in same environment

2020 ◽  
Vol 1866 (6) ◽  
pp. 165764
Author(s):  
Yang Li ◽  
Xinhuan Su ◽  
Ying Gao ◽  
Chenxiao Lv ◽  
Zhiwei Gao ◽  
...  
Keyword(s):  
Renal Function ◽  
Diabetic Nephropathy ◽  
Gut Microbiota ◽  
Potential Role ◽  
Murine Models

scholarly journals Histamine and diabetic nephropathy: an up-to-date overview

2019 ◽  
Vol 133 (1) ◽  
pp. 41-54 ◽  
Author(s):  
Alessandro Pini ◽  
Roberta Verta ◽  
Cristina Grange ◽  
Maura Gurrieri ◽  
Arianna Carolina Rosa
Keyword(s):  
Diabetic Nephropathy ◽  
Kidney Function ◽  
Vascular Complication ◽  
Present Review ◽  
Glomerular Hyperfiltration ◽  
Interesting Topic ◽  
Pleiotropic Action

Abstract The classification of diabetic nephropathy (DN) as a vascular complication of diabetes makes the possible involvement of histamine, an endogenous amine that is well known for its vasoactive properties, an interesting topic for study. The aim of the present review is to provide an extensive overview of the possible involvement of histamine in the onset and progression of DN. The evidence collected on the role of histamine in kidney function together with its well-known pleiotropic action suggest that this amine may act simultaneously on glomerular hyperfiltration, tubular inflammation, fibrosis development and tubular hypertrophy.

scholarly journals Advancing the Science and Management of Renal Cell Carcinoma: Bridging the Divide between Academic and Community Practices

2020 ◽  
Vol 9 (5) ◽  
pp. 1508 ◽  
Author(s):  
Nicholas J. Salgia ◽  
Errol J. Philip ◽  
Mohammadbagher Ziari ◽  
Kelly Yap ◽  
Sumanta Kumar Pal
Keyword(s):  
Renal Cell Carcinoma ◽  
Clinical Trials ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Biomarker Discovery ◽  
Tertiary Care ◽  
Patient Recruitment ◽  
Tertiary Care Centers ◽  
Made In

The treatment of metastatic renal cell carcinoma (mRCC) has rapidly evolved; however, the progress made in the field is heavily contingent upon timely and efficient accrual to clinical trials. While a substantial proportion of accrual occurs at tertiary care centers, community sites are playing an increasing role in patient recruitment. In this article, we discuss strategies to optimize collaborations between academic and community sites to facilitate clinical research. Further, as the role of biomarker discovery has become increasingly important in tailoring therapy, we will discuss opportunities to bridge diverse accrual sites for the purpose of translational research.

Monitoring renal function in the critically ill

2016 ◽  
Author(s):  
Paul M. Palevsky
Keyword(s):  
Renal Function ◽  
Critically Ill ◽  
Kidney Function ◽  
Critically Ill Patients ◽  
Continuous Monitoring ◽  
Kidney Injury ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Routine Monitoring

Renal function needs to be monitored in critically-ill patients to detect changes in glomerular filtration rate (GFR) and promptly diagnosis acute kidney injury (AKI). In the absence of reliable bedside techniques for the assessment of GFR, continuous monitoring of urine output and frequent assessment of serum creatinine levels remain the cornerstone of renal functional monitoring. Calculated estimations of GFR should not be relied upon in critically-ill patients, particularly if kidney function is not stable. The role of serum cystatin C as a marker of GFR and biomarkers of tubular injury in routine monitoring of kidney function is uncertain.

Renal Function Affects Prognostic Role of Antiphosphatidylserine Antibodies for Acute Ischemic Stroke Patients

2019 ◽  
Vol 48 (1-2) ◽  
pp. 1-8
Author(s):  
Guangli Wang ◽  
Chongke Zhong ◽  
Hao Peng ◽  
Xiaoqing Bu ◽  
Aili Wang ◽  
...  
Keyword(s):  
Renal Function ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Normal Renal Function ◽  
Primary Outcome ◽  
Estimated Glomerular Filtration Rate ◽  
Spline Regression ◽  
Stroke Patients ◽  
Abnormal Renal Function

Background: Whether the renal function influences the association between antiphosphatidylserine antibodies (aPS) and prognosis of ischemic stroke remains unclear. We aimed to investigate the prognostic value of aPS after ischemic stroke stratified by renal function status. Methods: This prospective study was based on China Antihypertensive Trial in Acute Ischemic Stroke, a randomized clinical trial in 26 hospitals across China from August 2009 to May 2013. A total of 2,874 ischemic stroke patients with blood samples or baseline records of estimated glomerular filtration rate (eGFR) were included in this study. Serum aPS levels were quantitatively measured at baseline, and abnormal renal function in this study was defined as eGFR <90 mL/min per 1.73 m2. The primary outcome was a combination of death and major disability (modified Rankin Scale score ≥3) at 3 months after stroke. Secondary outcomes were death and major disability separately. Results: The association between aPS and primary outcome was significantly modified by renal function status (p for interaction = 0.02). After adjustment for covariates, increased aPS were significantly associated with the primary outcome in the patients with abnormal renal function (OR 2.09; 95% CI 1.24–3.53; p for trend = 0.006), but not in those with normal renal function (OR 0.92; 95% CI 0.69–1.23; p for trend = 0.59), when 2 extreme tertiles were compared. Furthermore, multiple-adjusted spline regression model showed a linear association between aPS and risk of primary outcome in the patients with abnormal renal function (p for linearity = 0.02) but not in those with normal renal function (p for linearity = 0.71). Conclusions: Increased aPS were positively and independently associated with death or major disability after acute ischemic stroke in the patients with abnormal renal function.

Plasma D Dimer: A Useful Marker of Fibrin Breakdown in Renal Failure

1989 ◽  
Vol 61 (03) ◽  
pp. 522-525 ◽  
Author(s):  
M P Gordge ◽  
R W Faint ◽  
P B Rylance ◽  
H Ireland ◽  
D A Lane ◽  
...  
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Acute Renal Failure ◽  
Monoclonal Antibodies ◽  
Diabetic Nephropathy ◽  
Renal Disease ◽  
Plasma Concentrations ◽  
Significant Negative Correlation ◽  
Healthy Controls ◽  
D Dimer

SummaryD dimer and other large fragments produced during the breakdown of crosslinked fibrin may be measured by enzyme immunoassay using monoclonal antibodies. In 91 patients with renal disease and varying degrees of renal dysfunction, plasma D dimer showed no correlation with renal function, whereas FgE antigen, a fibrinogen derivative which is known to be cleared in part by the kidney, showed a significant negative correlation with creatinine clearance. Plasma concentrations of D dimer were, however, increased in patients with chronic renal failure (244 ± 3l ng/ml) (mean ± SEM) and diabetic nephropathy (308 ± 74 ng/ml), when compared with healthy controls (96 ± 13 ng/ml), and grossly elevated in patients with acute renal failure (2,451 ± 1,007 ng/ml). The results indicate an increase in fibrin formation and lysis, and not simply reduced elimination of D dimer by the kidneys, and are further evidence of activated coagulation in renal disease. D dimer appears to be a useful marker of fibrin breakdown in renal failure.

Sign in / Sign up

Export Citation Format

Share Document