scholarly journals Matrix Metalloproteinase-9 (MMP-9) as a Cancer Biomarker and MMP-9 Biosensors: Recent Advances

Sensors ◽  
2018 ◽  
Vol 18 (10) ◽  
pp. 3249 ◽  
Author(s):  
Hao Huang
Keyword(s):  
Extracellular Matrix ◽  
Cell Surface ◽  
Matrix Metalloproteinase ◽  
Surface Proteins ◽  
Biological Processes ◽  
Ecm Remodeling ◽  
Plasma Surface ◽  
Ecm Proteins ◽  
Recent Advances ◽  
Metalloproteinase 9

As one of the most widely investigated matrix metalloproteinases (MMPs), MMP-9 is a significant protease which plays vital roles in many biological processes. MMP-9 can cleave many extracellular matrix (ECM) proteins to regulate ECM remodeling. It can also cleave many plasma surface proteins to release them from the cell surface. MMP-9 has been widely found to relate to the pathology of cancers, including but not limited to invasion, metastasis and angiogenesis. Some recent research evaluated the value of MMP-9 as biomarkers to various specific cancers. Besides, recent research of MMP-9 biosensors discovered various novel MMP-9 biosensors to detect this enzyme. In this review, some recent advances in exploring MMP-9 as a biomarker in different cancers are summarized, and recent discoveries of novel MMP-9 biosensors are also presented.

scholarly journals Lactobacillus Cell Surface Proteins Involved in Interaction with Mucus and Extracellular Matrix Components

2020 ◽  
Vol 77 (12) ◽  
pp. 3831-3841
Author(s):  
Lidia Muscariello ◽  
Barbara De Siena ◽  
Rosangela Marasco
Keyword(s):  
Extracellular Matrix ◽  
Cell Surface ◽  
Intestinal Flora ◽  
Surface Proteins ◽  
Matrix Proteins ◽  
Cell Surface Proteins ◽  
Host Interaction ◽  
Extracellular Matrix Components ◽  
Probiotic Strains ◽  
Matrix Components

AbstractThe gut microbiota is a complex microbial ecosystem where bacteria, through mutual interactions, cooperate in maintaining of wellbeing and health. Lactobacilli are among the most important constituents of human and animal intestinal microbiota and include many probiotic strains. Their presence ensures protection from invasion of pathogens, as well as stimulation of the immune system and protection of the intestinal flora, often exerted through the ability to interact with mucus and extracellular matrix components. The main factors responsible for mediating adhesion of pathogens and commensals to the gut are cell surface proteins that recognize host targets, as mucus layer and extracellular matrix proteins. In the last years, several adhesins have been reported to be involved in lactobacilli–host interaction often miming the same mechanism used by pathogens.

scholarly journals The Diverse Contributions of Fucose Linkages in Cancer

Cancers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1241 ◽  
Author(s):  
Tyler S. Keeley ◽  
Shengyu Yang ◽  
Eric Lau
Keyword(s):  
Cell Surface ◽  
Signaling Pathways ◽  
Cancer Biology ◽  
Surface Proteins ◽  
Biological Processes ◽  
Post Translational Modification ◽  
Therapeutic Approaches ◽  
Cell Surface Proteins ◽  
Clinical Diagnostic

Fucosylation is a post-translational modification of glycans, proteins, and lipids that is responsible for many biological processes. Fucose conjugation via α(1,2), α(1,3), α(1,4), α(1,6), and O’- linkages to glycans, and variations in fucosylation linkages, has important implications for cancer biology. This review focuses on the roles that fucosylation plays in cancer, specifically through modulation of cell surface proteins and signaling pathways. How L-fucose and serum fucosylation patterns might be used for future clinical diagnostic, prognostic, and therapeutic approaches will be discussed.

scholarly journals Emerging Role of Syndecans in Extracellular Matrix Remodeling in Cancer

2020 ◽  
Vol 68 (12) ◽  
pp. 863-870
Author(s):  
Bohee Jang ◽  
Ayoung Kim ◽  
Jisun Hwang ◽  
Hyun-Kuk Song ◽  
Yunjeon Kim ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cell Surface ◽  
Cancer Cells ◽  
Pathological Condition ◽  
Bioactive Molecules ◽  
Structural Basis ◽  
Surface Adhesion ◽  
Ecm Remodeling ◽  
Adhesion Receptor ◽  
Cell Functions

The extracellular matrix (ECM) offers a structural basis for regulating cell functions while also acting as a collection point for bioactive molecules and connective tissue cells. To perform pathological functions under a pathological condition, the involved cells need to regulate the ECM to support their altered functions. This is particularly common in the development of cancer. The ECM has been recognized as a key driver of cancer development and progression, and ECM remodeling occurs at all stages of cancer progression. Thus, cancer cells need to change the ECM to support relevant cell surface adhesion receptor–mediated cell functions. In this context, it is interesting to examine how cancer cells regulate ECM remodeling, which is critical to tumor malignancy and metastatic progression. Here, we review how the cell surface adhesion receptor, syndecan, regulates ECM remodeling as cancer progresses, and explore how this can help us better understand ECM remodeling under these pathological conditions

scholarly journals Thrombin Induces Tumor Invasion through the Induction and Association of Matrix Metalloproteinase-9 and β1-Integrin on the Cell Surface

2007 ◽  
Vol 283 (5) ◽  
pp. 2822-2834 ◽  
Author(s):  
A. Reza Radjabi ◽  
Kenjiro Sawada ◽  
Sujatha Jagadeeswaran ◽  
Alfred Eichbichler ◽  
Hilary A. Kenny ◽  
...  
Keyword(s):  
Cell Surface ◽  
Matrix Metalloproteinase ◽  
Tumor Invasion ◽  
Matrix Metalloproteinase 9 ◽  
Β1 Integrin ◽  
Metalloproteinase 9

scholarly journals Proteomic Analysis Identifies Distinct Glomerular Extracellular Matrix in Collapsing Focal Segmental Glomerulosclerosis

2020 ◽  
Vol 31 (8) ◽  
pp. 1883-1904 ◽  
Author(s):  
Michael L. Merchant ◽  
Michelle T. Barati ◽  
Dawn J. Caster ◽  
Jessica L. Hata ◽  
Liliane Hobeika ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Urinary Excretion ◽  
Cathepsin B ◽  
Glomerular Sclerosis ◽  
Ecm Remodeling ◽  
Ecm Proteins ◽  
Annexin A3 ◽  
Collapsing Fsgs ◽  
Parietal Epithelial Cells ◽  
Normal Controls

BackgroundThe mechanisms leading to extracellular matrix (ECM) replacement of areas of glomerular capillaries in histologic variants of FSGS are unknown. This study used proteomics to test the hypothesis that glomerular ECM composition in collapsing FSGS (cFSGS) differs from that of other variants.MethodsECM proteins in glomeruli from biopsy specimens of patients with FSGS not otherwise specified (FSGS-NOS) or cFSGS and from normal controls were distinguished and quantified using mass spectrometry, verified and localized using immunohistochemistry (IHC) and confocal microscopy, and assessed for gene expression. The analysis also quantified urinary excretion of ECM proteins and peptides.ResultsOf 58 ECM proteins that differed in abundance between cFSGS and FSGS-NOS, 41 were more abundant in cFSGS and 17 in FSGS-NOS. IHC showed that glomerular tuft staining for cathepsin B, cathepsin C, and annexin A3 in cFSGS was significantly greater than in other FSGS variants, in minimal change disease, or in membranous nephropathy. Annexin A3 colocalized with cathepsin B and C, claudin-1, phosphorylated ERK1/2, and CD44, but not with synaptopodin, in parietal epithelial cells (PECs) infiltrating cFSGS glomeruli. Transcripts for cathepsins B and C were increased in FSGS glomeruli compared with normal controls, and urinary excretion of both cathepsins was significantly greater in cFSGS compared with FSGS-NOS. Urinary excretion of ECM-derived peptides was enhanced in cFSGS, although in silico analysis did not identify enhanced excretion of peptides derived from cathepsin B or C.ConclusionsECM differences suggest that glomerular sclerosis in cFSGS differs from that in other FSGS variants. Infiltration of activated PECs may disrupt ECM remodeling in cFSGS. These cells and their cathepsins may be therapeutic targets.

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