Role of Ionic Liquids in Composites in Analytical Sample Preparation

Ionic liquids (ILs) are a group of non-conventional salts with melting points below 100 °C. Apart from their negligible vapor pressure at room temperature, high thermal stability, and impressive solvation properties, ILs are characterized by their tunability. Given such nearly infinite combinations of cations and anions, and the easy modification of their structures, ILs with specific properties can be synthesized. These characteristics have attracted attention regarding their use as extraction phases in analytical sample preparation methods, particularly in liquid-phase extraction methods. Given the liquid nature of most common ILs, their incorporation in analytical sample preparation methods using solid sorbents requires the preparation of solid derivatives, such as polymeric ILs, or the combination of ILs with other materials to prepare solid IL-based composites. In this sense, many solid composites based on ILs have been prepared with improved features, including magnetic particles, carbonaceous materials, polymers, silica materials, and metal-organic frameworks, as additional materials forming the composites. This review aims to give an overview on the preparation and applications of IL-based composites in analytical sample preparation in the period 2017–2020, paying attention to the role of the IL material in those composites to understand the effect of the individual components in the sorbent.

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Evaluation of Sample Preparation Methods for Non-Target Screening of Organic Micropollutants in Urban Waters Using High-Resolution Mass Spectrometry

Molecules ◽

10.3390/molecules26237064 ◽

2021 ◽

Vol 26 (23) ◽

pp. 7064

Author(s):

Nina Huynh ◽

Emilie Caupos ◽

Caroline Soares Peirera ◽

Julien Le Roux ◽

Adèle Bressy ◽

...

Keyword(s):

Sample Preparation ◽

High Resolution Mass Spectrometry ◽

Solid Phase ◽

Extraction Methods ◽

Organic Micropollutants ◽

Preparation Methods ◽

Sample Extraction ◽

Target Screening ◽

Molecular Weight Standard ◽

Sample Preparation Methods

Non-target screening (NTS) has gained interest in recent years for environmental monitoring purposes because it enables the analysis of a large number of pollutants without predefined lists of molecules. However, sample preparation methods are diverse, and few have been systematically compared in terms of the amount and relevance of the information obtained by subsequent NTS analysis. The goal of this work was to compare a large number of sample extraction methods for the unknown screening of urban waters. Various phases were tested for the solid-phase extraction of micropollutants from these waters. The evaluation of the different phases was assessed by statistical analysis based on the number of detected molecules, their range, and physicochemical properties (molecular weight, standard recoveries, polarity, and optical properties). Though each cartridge provided its own advantages, a multilayer cartridge combining several phases gathered more information in one single extraction by benefiting from the specificity of each one of its layers.

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Assessment and refinement of sample preparation methods for deep and quantitative plant proteome profiling

10.1101/273656 ◽

2018 ◽

Author(s):

Gaoyuan Song ◽

Polly Y Yingshan Hsu ◽

Justin W. Walley

Keyword(s):

Mass Spectrometry ◽

Sample Preparation ◽

Protein Extraction ◽

Leaf Tissue ◽

Extraction Methods ◽

Label Free ◽

Preparation Methods ◽

Proteome Profiling ◽

Leaf Tissues ◽

Sample Preparation Methods

SummaryA major challenge in the field of proteomics is obtaining high quality peptides for comprehensive proteome profiling by liquid chromatography mass spectrometry for many organisms. Here we evaluate and modify a range of sample preparation methods using photosynthetically active Arabidopsis leaf tissues from several developmental timepoints. We find that inclusion of FASP-based on filter digestion improves all protein extraction methods tested. Ultimately, we show that a detergent-free urea-FASP approach enables deep and robust quantification of leaf proteomes. For example, from 4-day-old leaf tissue we profiled up to 11,690 proteins from a single sample replicate. This method should be broadly applicable to researchers working on difficult to process samples from a range of plant and non-plant organisms.AbbreviationsChloroMethanol/Chloroform ExtractionFASPFilter Aided Sample PrepGOGene OntologyIAAIodoacetamideLFQLabel Free QuantificationMS/MSTandem mass spectrometryTFTranscription FactorUAUrea Extraction1D1 Dimensional2D2 Dimensional

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Green sample-preparation methods using room-temperature ionic liquids for the chromatographic analysis of organic compounds

TrAC Trends in Analytical Chemistry ◽

10.1016/j.trac.2014.08.018 ◽

2015 ◽

Vol 71 ◽

pp. 144-156 ◽

Cited By ~ 47

Author(s):

Colin F. Poole ◽

Nicole Lenca

Keyword(s):

Ionic Liquids ◽

Sample Preparation ◽

Organic Compounds ◽

Chromatographic Analysis ◽

Room Temperature ◽

Room Temperature Ionic Liquids ◽

Preparation Methods ◽

Green Sample ◽

Sample Preparation Methods

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Improving Sample Preparation Methods For Cannabis-Infused Edible And Topical Products

Planta Medica ◽

10.1055/s-0036-1578645 ◽

2016 ◽

Vol 82 (05) ◽

Author(s):

M Wilcox ◽

M Jacyno ◽

J Marcu ◽

J Neal-Kababick

Keyword(s):

Sample Preparation ◽

Preparation Methods ◽

Sample Preparation Methods

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150. Comparison of Direct and Indirect Sample Preparation Methods for Asbestos Analysis

10.3320/1.2765665 ◽

2001 ◽

Author(s):

L. Burrelli ◽

J. Spencer

Keyword(s):

Sample Preparation ◽

Preparation Methods ◽

Sample Preparation Methods

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Thin-Die Flip Chip Physical-FA Process Flow

ISTFA 2002: Conference Proceedings from the 28th International Symposium for Testing and Failure Analysis ◽

10.31399/asm.cp.istfa2002p0189 ◽

2002 ◽

Author(s):

Andrew J. Komrowski ◽

N. S. Somcio ◽

Daniel J. D. Sullivan ◽

Charles R. Silvis ◽

Luis Curiel ◽

...

Keyword(s):

Sample Preparation ◽

Failure Analysis ◽

Flip Chip ◽

Semiconductor Industry ◽

Organic Substrate ◽

Fault Isolation ◽

Preparation Methods ◽

Chip Technology ◽

Isolation Test ◽

Sample Preparation Methods

Abstract The use of flip chip technology inside component packaging, so called flip chip in package (FCIP), is an increasingly common package type in the semiconductor industry because of high pin-counts, performance and reliability. Sample preparation methods and flows which enable physical failure analysis (PFA) of FCIP are thus in demand to characterize defects in die with these package types. As interconnect metallization schemes become more dense and complex, access to the backside silicon of a functional device also becomes important for fault isolation test purposes. To address these requirements, a detailed PFA flow is described which chronicles the sample preparation methods necessary to isolate a physical defect in the die of an organic-substrate FCIP.

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