scholarly journals Olfactory Disorders in Post-Acute COVID-19 Syndrome

Sinusitis ◽  
2021 ◽  
Vol 5 (2) ◽  
pp. 116-122
Author(s):  
Laura Araújo ◽  
Vanessa Arata ◽  
Ricardo G. Figueiredo
Keyword(s):  
Quality Of Life ◽  
Central Nervous System ◽  
Nervous System ◽  
Cellular Damage ◽  
The Central Nervous System ◽  
Olfactory Impairment ◽  
Underlying Mechanisms ◽  
Complex Scenario

Altered smell is one of the most prevalent symptoms in acute COVID-19 infection. Although most patients recover normal neurosensory function in a few weeks, approximately one-tenth of patients report long-term smell dysfunction, including anosmia, hyposmia, parosmia and phantosmia, with a particularly notable impact on quality of life. In this complex scenario, inflammation and cellular damage may play a key role in the pathogenesis of olfactory dysfunctions and may affect olfactory signaling from the peripheral to the central nervous system. Appropriate management of smell disturbances in COVID-19 patients must focus on the underlying mechanisms and the assessment of neurosensorial pathways. This article aims to review the aspects of olfactory impairment, including its pathophysiology, epidemiology, and clinical management in post-acute COVID-19 syndrome (PACS).

scholarly journals Quality of Life in Carotid Atherosclerosis: The Role of Co-morbid Mood Disorders

2016 ◽  
Vol 12 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Maria Lecca ◽  
Luca Saba ◽  
Roberto Sanfilippo ◽  
Elisa Pintus ◽  
Michela Cadoni ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Central Nervous System ◽  
Nervous System ◽  
Mood Disorders ◽  
Carotid Atherosclerosis ◽  
Short Form ◽  
The Central Nervous System ◽  
Dsm Iv

Introduction/Objective: To study in severe carotid atherosclerosis (CA): the frequency of mood disorders (MD); the impairment of quality of life (QoL); the role of co-morbid MD in such impairment. Methods: Case-control study. Cases: consecutive in-patients with CA (stenosis ≥ 50%). Controls: subjects with no diagnosis of CA randomized from a database of a community survey. Psychiatric diagnosis according to DSM-IV made by clinicians and semi-structured interview, QoL measured by the Short Form Health Survey (SF-12). Results: This is the first study on comorbidity on CA disease and MD in which psychiatric diagnoses are conducted by clinicians according to DSM-IV diagnostic criteria. Major Depressive Disorder (MDD) (17.4% vs 2.72%, P <0.0001) but not Bipolar Disorders (BD) (4.3% vs 0.5%, P = 0.99) was higher in cases (N=46) than in controls (N= 184). SF-12 scores in cases were lower than in controls (30.56±8.12 vs 36.81±6:40; p <0.001) with QoL comparable to serious chronic diseases of the central nervous system. The burden of a concomitant MDD or BD amplifies QoL impairment. Conclusion: Comorbid MD aggravates the impairment of QoL in CA. Unlike autoimmune diseases or degenerative diseases of the Central Nervous System, CA shows a strong risk of MDD than BD.

scholarly journals A Review of the Complex Roles of Glial Cells in Alzheimer’s Disease and Potential Glial-Oriented Therapeutic Targets

2018 ◽  
Author(s):  
Saif Shahriar Rahman Nirzhor ◽  
Rubayat Islam Khan ◽  
Sharmind Neelotpol
Keyword(s):  
Quality Of Life ◽  
Central Nervous System ◽  
Nervous System ◽  
Glial Cells ◽  
Therapeutic Targets ◽  
Concentration Of Ions ◽  
The Central Nervous System

The pathogenesis of Alzheimer&rsquo;s disease (AD) is very complicated and not well-understood. As more and more studies are performed with regards to this disease, new insights are coming to light. Much of the research in AD so far has been very neuron-oriented however, recent studies suggest that certain glial cells i.e. microglia, astrocytes, oligodendrocytes, and NG2 glia are linked to the pathogenesis of AD and may offer several potential therapeutic targets in the long-standing battle against AD. Glial cells are responsible for maintaining homeostasis (i.e. concentration of ions and neurotransmitters) within the neuronal environment of the central nervous system (CNS) and are crucial to the integrity of neurons. This review explores the (1) role of glial cells in AD pathogenesis, (2) complex functionalities of the components involved and (3) potential therapeutic targets that it could eventuate leading to a better quality of life for AD patients.

scholarly journals Fatigue and Affective Manifestations in Multiple Sclerosis—A Cluster Approach

2019 ◽  
Vol 10 (1) ◽  
pp. 10 ◽  
Author(s):  
Samar S. Ayache ◽  
Moussa A. Chalah
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Central Nervous System ◽  
Nervous System ◽  
Economic Cost ◽  
Cluster Approach ◽  
High Prevalence ◽  
The Central Nervous System ◽  
Chronic Autoimmune Disease

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system, characterized by a high prevalence in young people, a drastic impact on the quality of life, and an important economic cost to society [...]

scholarly journals Neuroendocrine Changes during Menopausal Transition

Endocrines ◽  
2021 ◽  
Vol 2 (4) ◽  
pp. 405-416
Author(s):  
Andrea Giannini ◽  
Marta Caretto ◽  
Andrea R. Genazzani ◽  
Tommaso Simoncini
Keyword(s):  
Quality Of Life ◽  
Central Nervous System ◽  
Nervous System ◽  
Target Therapy ◽  
Menstrual Cycles ◽  
Mood Changes ◽  
The Central Nervous System ◽  
Urogenital Symptoms ◽  
Follicular Activity

Menopause is the permanent cessation of menstrual cycles following the loss of ovarian follicular activity. Quality of life of postmenopausal woman is the result of a series of psychobiological transformations, that see in the reduction of sex hormones and steroids the etiopathogenetic determinant moment. Symptoms of menopause range from somatic side such as metabolic changes, increased cardiovascular disease, irregular vaginal bleeding, urogenital symptoms, vaginal dryness, osteoporosis and risk of bones fractures to changes of central nervous system as vasomotor symptoms, sleep disruption, mood changes, migraine, sexual dysfunctions. It is fundamental to know the mechanisms underlying changes in the central nervous system during menopause, related to hypoestrogenism, to be able to create appropriate target therapy for patients, improving their quality of life. In fact, the central nervous system is now one of the major targets of sex steroids that cannot be achieved disregard when dealing with the problem of choice of a particular type of MHT.

scholarly journals ANALYSIS OF THE PHYSIOTHERAPEUTIC TREATMENT FOR CEREBRAL PALSY BASED ON THE BOBATH NEURODEVELOPMENTAL TREATMENT THROUGH THE GMFM

2019 ◽  
Vol 7 (8) ◽  
pp. 01-11
Author(s):  
João Pedro Euriques Batista ◽  
Denize Moura de Souza ◽  
Vanessa Ghattás Testoni ◽  
Viviane Carla Pereira
Keyword(s):  
Quality Of Life ◽  
Central Nervous System ◽  
Nervous System ◽  
Cerebral Palsy ◽  
Quantitative Data ◽  
Descriptive Statistics ◽  
Before And After ◽  
The Central Nervous System ◽  
Efficacy Of Treatment

INTRODUCTION: Cerebral palsy (CP) is characterized by postural, functional and tonus dysfunctions due to lesions in the Central Nervous System in the maturation phase. Physiotherapy inserts itself in the treatment of CP aiming to normalize dysfunctions, providing higher quality of life and autonomy. One of the most used methods for the treatment of these patients is the Bobath Neurodevelopmental Treatment (NDT). The prognosis and efficacy of treatment can be measured through instruments such as GMFM. OBJECTIVES: To evaluate the physiotherapeutic treatment based on NDT through the GMFM-88 scale in children with CP before and after intervention, quantitatively observing the evolution. METHODOLOGY: 8 patients were submitted to the GMFM scale before and after physiotherapeutic treatment. The treatment was carried out in the discipline of Pediatrics of a Community University. Quantitative data were tabulated and analyzed using simple descriptive statistics and GMAE-2 Software. RESULTS: A general evolution was observed in the neuropsychomotor development of patients or the maintenance of their condition. CONCLUSION: The results demonstrate that the physiotherapeutic treatment based on the Bobath Neurodevelopmental Treatment is effective for the evolution or maintenance of the gross motor function of the patients and that the GMFM instrument is effective in showing these results quantitatively. KEYWORDS: motor activity, cerebral palsy, proprioception, physiotherapy.

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