scholarly journals A Coronavirus (COVID-19) Triage Framework for (Sub)National Public–Private Partnership (PPP) Programs

2020 ◽  
Vol 12 (13) ◽  
pp. 5253
Author(s):  
David Baxter ◽  
Carter B. Casady
Keyword(s):  
Public Private Partnership ◽  
The Novel ◽  
Private Partnership ◽  
The World ◽  
Project Failures ◽  
Novel Coronavirus ◽  
Financial Losses ◽  
Triage Decisions ◽  
Command Center

Around the world, countries are struggling to address the immediate and long-term impacts of the novel coronavirus (COVID-19) pandemic on their (sub)national public–private partnership (PPP) programs. Burdened with the real possibility of widespread project failures and constrained budgets, governments are searching for ways to prioritize projects in need of relief and bolster post-pandemic recovery plans. To meet this need, this article conceptualizes a triage system for PPP programs based on five categories: (1) projects without a need for economic stimulus (blue); (2) projects experiencing minor economic/financial losses (green); (3) projects needing temporary/stop-gap support or restructuring (yellow); (4) projects unable to survive without significant economic relief (red); and (5) projects that cannot survive, even with government intervention (black). This research also stresses the importance of launching and sustaining a crisis command center to support PPP triage decisions and encourages PPP stakeholders to collectively craft win–win solutions for post-pandemic recovery efforts.

scholarly journals Addressing the Impacts of the Covid-19 Pandemic on Public - Private Partnership (PPP) Contracts

2021 ◽  
Vol 12 (2) ◽  
pp. 368-397
Author(s):  
George Nwangwu
Keyword(s):  
Public Private Partnership ◽  
Private Partnership ◽  
Contractual Arrangements ◽  
The World ◽  
Project Failures ◽  
Legal Outcomes ◽  
The Impact ◽  
Legal Consequences

The Covid-19 pandemic has significantly impacted the health and economy of the world. The pandemic has also frustrated the execution of public-private partnership (PPP) projects across the world, with economic and legal consequences for contracting parties. The impacts of the pandemic have, and may continue to, result in uncertainties and even project failures. PPPs are underpinned by long term contracts which should ordinarily determine the rights, obligations and remedies arising out of the impact of the pandemic. However, the legal outcomes are never always certain or determinable and might not augur well for any of the parties. This article examines legal and contractual tools for managing uncertainties and risks arising from the pandemic. It suggests that, as much as possible, parties should rely on extra-contractual arrangements to resolve the issues that are likely to arise out of the pandemic. This article discusses the possible legal outcomes of the pandemic on PPP arrangements and suggests creative ways of mitigating its impacts.

scholarly journals The Covid-19 Pandemic and its Effect on the Elderly: A Review

2020 ◽  
Vol 5 (3) ◽  
Author(s):  
Maimoona Nadri ◽  
Ujala Zubair
Keyword(s):  
The Elderly ◽  
Medical Community ◽  
Health Concern ◽  
The Novel ◽  
Global Public Health ◽  
Public Health Concern ◽  
The World ◽  
Long Term Consequences ◽  
Novel Coronavirus

In 2019, the world experienced a global public health concern when the novel coronavirus originated from China and affected around fifty-seven thousand people around the world by March 2020. The quick rise in the number of cases and the death toll overwhelmed the scientific and medical community. While all the focus was driven towards finding the epidemiology, the treatment and the management, the mental health aspect of the quarantine was being overlooked. The purpose of this review is to create awareness about the long-term consequences of quarantine, with the focus on the elderly community in Pakistan. 

scholarly journals Concession as a Form of Implementation of Public-Private Partnership Projects in Ukraine and World-Wide

2021 ◽  
Vol 2 (517) ◽  
pp. 56-61
Author(s):  
B. S. Shuliuk ◽  
Keyword(s):  
Waste Treatment ◽  
Public Private Partnership ◽  
Transport Sector ◽  
Quality Of Services ◽  
Private Partnership ◽  
The World ◽  
Characteristic Features ◽  
Concession Projects

The article is aimed at examining the peculiarities of implementation of public-private partnership concession projects in various sectors of the economy in both Ukraine and the world. The main approaches to understanding the essence of the concept of «concession» are considered and its characteristic features are defined. The procedure of operation of the concession mechanism is disclosed. Risks of public-private partnership participants in the process of implementation of concession projects in Ukraine are determined. The need to provide the State support to stimulate the participation of a private partner in long-term projects is substantiated. It is specified that such support should be provided in order to implement the most necessary public-private partnership projects to significantly improve the living conditions of the population in a particular region. It is determined that, unlike Ukraine, the concession mechanism is actively used in various sectors of the world economy, in particular, successfully implemented projects in the transport sector (roads, railways, ports, airports, pipeline transport), housing and communal services (water supply, water purification, electricity supply). At that, the transport industry dominates, while heat supply and waste treatment are the least popular. Prospects for further research in this direction are the search for ways to improve the domestic concession mechanism in the process of implementing public-private partnership projects, taking into account the best achievements of world experience. This will allow to attract financial resources of business in various forms of cooperation in terms of public-private partnerships, and, consequently, to improve the quality of services provided to the population.

scholarly journals COVID-19 and Its Current Trends with Long Term Implication

2021 ◽  
Vol 58 (2) ◽  
pp. 454-460
Author(s):  
Akshada Mahadik
Keyword(s):  
The Novel ◽  
Current Trends ◽  
Major Study ◽  
The World ◽  
Novel Coronavirus

BACKGROUND The coronavirus disease 2019 or COVID-19 is a serious medical threat that is posed before since more than a year. Scientists and researchers from all over the world are working on the solution on the ongoing problem. SUMMARY The mutated strain of the novel coronavirus has been successful in creating a buzz around the circuit of concerned people. The COVID-19 is being uncertain throughout its stay and any prediction would possibly go wrong. Long term implications may lack some major study but many lessons and parallels can be drawn from the previous similar outbreaks of SARS and MERS. CONCLUSION More fact based along with broad based study is needed to understand and correlate the COVID-19 and its long-term implications.

scholarly journals Drug Repurposing for Prevention and Treatment of COVID-19: A Clinical Landscape

Discoveries ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. e121
Author(s):  
Md. Shahadat Hossain ◽  
◽  
Ithmam Hami ◽  
Md. Sad Salabi Sawrav ◽  
Md. Fazley Rabbi ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Treatment Plan ◽  
Drug Repurposing ◽  
The Novel ◽  
Long Term Effects ◽  
Novel Therapy ◽  
Worldwide Distribution ◽  
The World ◽  
Novel Coronavirus

SARS-CoV-2, the novel coronavirus strain responsible for the current pandemic of COVID-19, has rendered the entire humanity suffering. Several months have passed since the pandemic has struck. However, the world is still looking for an effective treatment plan to battle the viral infection. The first vaccine just received emergency approval in December 2020 for use in USA and UK. These are excellent news, however, the worldwide distribution of such vaccine, the possibility of virus mutation and the lack of data regarding the long-term effects of such vaccines are a significant concern. In addition, although remdesivir was recently approved by the FDA to be used as a clinical drug against COVID-19, it hasn’t stood out yet as a proven form of therapeutics. Such inability to produce a novel therapy has caused enough inconveniences for the affected people worldwide. Repurposing the already available drugs to fight against the virus seems to be a reasonable option amidst such uncertainty. Given the vast collection of potential treatment candidates to be explored against COVID-19, there is a decent chance that a success in this regard will serve the intermediary purpose of clinically treating the infection until a COVID-19 vaccine is widely distributed worldwide and will be able to treat COVID-19 patients that do not adequately respond to vaccines. Such treatments may prove very useful in future coronavirus outbreaks too. Proper research into these repurposing treatments may yield a certain insight into the field of novel treatment production as well. This review study accumulates a relevant set of information about drugs and vaccines against COVID-19, in terms of their repurposing properties and the specific phases of clinical trials they are undergoing across the world. A potential timeline is also suggested to estimate when an effective result can be expected from the ongoing clinical trials for a better anticipation of the drug landscape. This study will hopefully help accelerate investment of resources into development and discovery of drugs and vaccines against the infection.

Comparative docking of SARS-CoV-2 receptors antagonists from repurposing drugs

2020 ◽  
Author(s):  
Micael Davi Lima de Oliveira ◽  
Kelson Mota Teixeira de Oliveira
Keyword(s):  
World Health Organisation ◽  
World Health ◽  
Lung Cells ◽  
The Novel ◽  
High Modulation ◽  
Main Protease ◽  
The World ◽  
Novel Coronavirus ◽  
Viral Receptors ◽  
Theoretical Results

According to the World Health Organisation, until 16 June, 2020, the number of confirmed and notified cases of COVID-19 has already exceeded 7.9 million with approximately 434 thousand deaths worldwide. This research aimed to find repurposing antagonists, that may inhibit the activity of the main protease (Mpro) of the SARS-CoV-2 virus, as well as partially modulate the ACE2 receptors largely found in lung cells, and reduce viral replication by inhibiting Nsp12 RNA polymerase. Docking molecular simulations were performed among a total of 60 structures, most of all, published in the literature against the novel coronavirus. The theoretical results indicated that, in comparative terms, paritaprevir, ivermectin, ledipasvir, and simeprevir, are among the most theoretical promising drugs in remission of symptoms from the disease. Furthermore, also corroborate indinavir to the high modulation in viral receptors. The second group of promising drugs includes remdesivir and azithromycin. The repurposing drugs HCQ and chloroquine were not effective in comparative terms to other drugs, as monotherapies, against SARS-CoV-2 infection.

Association and treatment of diabetes in patients affected by Covid-19

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1198-1201
Author(s):  
Syed Yasir Afaque
Keyword(s):  
Diabetes Mellitus ◽  
Prognostic Value ◽  
Heart Diseases ◽  
The Novel ◽  
The World ◽  
Treatment Of Diabetes ◽  
Coronavirus Infection ◽  
Composite Outcomes ◽  
Novel Coronavirus ◽  
The Impact

In December 2019, a unique coronavirus infection, SARS-CoV-2, was first identified in the province of Wuhan in China. Since then, it spread rapidly all over the world and has been responsible for a large number of morbidity and mortality among humans. According to a latest study, Diabetes mellitus, heart diseases, Hypertension etc. are being considered important risk factors for the development of this infection and is also associated with unfavorable outcomes in these patients. There is little evidence concerning the trail back of these patients possibly because of a small number of participants and people who experienced primary composite outcomes (such as admission in the ICU, usage of machine-driven ventilation or even fatality of these patients). Until now, there are no academic findings that have proven independent prognostic value of diabetes on death in the novel Coronavirus patients. However, there are several conjectures linking Diabetes with the impact as well as progression of COVID-19 in these patients. The aim of this review is to acknowledge about the association amongst Diabetes and the novel Coronavirus and the result of the infection in such patients.

USE OF THE WORLD EXPERIENCE OF PUBLIC-PRIVATE PARTNERSHIP IN UKRAINE

2019 ◽  
pp. 41-47
Author(s):  
Natalia Tretyak ◽  
Olga Kalenska
Keyword(s):  
World Bank ◽  
Economic Activity ◽  
Spatial Development ◽  
Public Private Partnership ◽  
Private Capital ◽  
Private Partnership ◽  
The World Bank ◽  
The World ◽  
Area Of Application

The article investigates the world experience of public-private partnership in the economic activity of different countries. Different models and forms of contracts of public-private partnership are covered. The link between public-private partnership projects with the country and area of application is noted. The models of public-private partnership proposed by the World Bank for attracting private capital are covered. The main directions of realization of world forms of public-private partnership for Ukraine are proposed for the effective provision of sustainable spatial development, their further adaptation to the realities of our time.

Synthetic and semi-synthetic drugs as promising therapeutic option for the treatment of COVID-19

2020 ◽  
Vol 20 ◽  
Author(s):  
Ekta Shirbhate ◽  
Preeti Patel ◽  
Vijay K Patel ◽  
Ravichandran Veerasamy ◽  
Prabodh C Sharma ◽  
...  
Keyword(s):  
Therapeutic Option ◽  
Antiviral Treatment ◽  
The Novel ◽  
Clinical Experiences ◽  
Synthetic Compounds ◽  
Synthetic Drugs ◽  
Global Pandemic ◽  
The World ◽  
Novel Coronavirus

: The novel coronavirus disease-19 (COVID-19), a global pandemic that emerged from Wuhan, China has today travelled all around the world, so far 216 countries or territories with 21,732,472 people infected and 770,866 deaths globally (as per WHO COVID-19 update dated August 18, 2020). Continuous efforts are being made to repurpose the existing drugs and develop vaccines for combating this infection. Despite, to date, no certified antiviral treatment or vaccine prevails. Although, few candidates have displayed their efficacy in in vitro studies and are being repurposed for COVID-19 treatment. This article summarizes synthetic and semi-synthetic compounds displaying potent activity in their clinical experiences or studies against COVID-19 and also focuses on mode of action of drugs being repositioned against COVID-19.

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