Association between Levels of Urine Di-(2-ethylhexyl)phthalate Metabolites and Heart Rate Variability in Young Adults

Phthalate exposure is associated with cardiovascular risk. Among the various phthalates, di-(2-ethylhexyl) phthalate (DEHP) is a deleterious plasticizer in our daily lives. This study investigated the association between DEHP exposure and the alteration of heart rate variability (HRV). During 2017–2019, we recruited 974 young adults to investigate the effects of living environments and dietary habits on cardiometabolic disorders in Taiwan. We quantitatively analyzed urinary metabolites of DHEP. A continuous electrocardiogram was recorded to obtain a 5-min ECG. Time-domain and frequency-domain HRV analyses were performed. Multiple linear regression showed that urinary oxidized DEHP metabolites MEHHP and MEOHP were associated with decreased HRV after controlling for associated cardiovascular risk factors. A higher MEHHP level was associated with a lower triangular interpolation of NN interval histogram (TINN), very low frequency (VLF), and low frequency/high frequency (LF/HF) ratio. A higher MEOHP level was associated with a decreased LF/HF ratio. In addition, trend analysis showed that higher MEHHP and MEOHP quantiles were significantly associated with a decreased LF/HF ratio. DEHP is a potentially harmful and invisible chemical. The urinary DEHP metabolites MEHHP and MEOHP are associated with decreased HRV, indicating an adverse effect on autonomic balance in young adults in Taiwan.

Download Full-text

Association Between Levels of Urine Di-(2-ethylhexyl)phthalate Exposure, a Potentially Harmful and Invisible Chemical, and Heart Rate Variability in Young Adults

10.21203/rs.3.rs-927128/v1 ◽

2021 ◽

Author(s):

Ching-Way Chen ◽

Jin-Shiang Hwang ◽

Cheng-Chih Hsu ◽

Chien-Yu Lin ◽

Ta-Chen Su

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Young Adults ◽

Cardiovascular Risk ◽

Dietary Habits ◽

Low Frequency ◽

Urinary Metabolites ◽

Daily Lives ◽

Cardiometabolic Disorders ◽

Ethylhexyl Phthalate

Abstract BackgroundPhthalate exposure is associated with cardiovascular risk. Among the various phthalates, di-(2-ethylhexyl) phthalate (DEHP) is the most important plasticizer in our daily lives. This study investigated the association between DEHP exposure and the alteration of heart rate variability (HRV).MethodsDuring 2017-2019, we recruited 974 young adults to investigate the effects of living environments and dietary habits on cardiometabolic disorders in Taiwan. We quantitatively analyzed urinary metabolites of phthalates, including mono-(2-ethylhexyl) phthalate (MEHP), mono-(ethyl-5-hydroxyhexyl) phthalate (MEHHP), and mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP). A continuous electrocardiogram was recorded to obtain a 5-minute ECG. Time-domain and frequency-domain HRV analyses were performed.ResultsMultiple linear regression showed that urinary oxidized DEHP metabolites MEHHP and MEOHP were associated with decreased HRV after controlling for associated cardiovascular risk factors. A higher MEHHP level was associated with a lower TINN (triangular interpolation of NN interval histogram), very-low-frequency (VLF), and low frequency/high frequency (LF/HF) ratio. A higher MEOHP level was associated with a decreased LF/HF ratio. In addition, trend analysis showed that higher MEHHP and MEOHP quantiles were significantly associated with a decreased LF/HF ratio.ConclusionsDEHP is a potentially harmful and invisible chemicals. The urinary DEHP metabolites MEHHP and MEOHP are associated with decreased HRV, indicating an unfavorable autonomic balance in young adults in Taiwan.

Download Full-text

Relationship between Malocclusion and Heart Rate Variability Indices in Young Adults

Methods of Information in Medicine ◽

10.3414/me10-01-0045 ◽

2011 ◽

Vol 50 (04) ◽

pp. 358-363 ◽

Cited By ~ 4

Author(s):

N. Takeuchi ◽

M. Furuta ◽

T. Tomofuji ◽

M. Morita ◽

D. Ekuni

Keyword(s):

Quality Of Life ◽

Heart Rate ◽

Heart Rate Variability ◽

Young Adults ◽

Chronic Stress ◽

High Frequency ◽

Low Frequency ◽

The Relationship ◽

Oral Impacts

Summary Objectives: Heart rate variability (HRV) has been used to assess sympathetic and parasympathetic modulation of heart rate. Chronic stress relates to reduced HRV. Malocclusion has effects on quality of life, which can lead to chronic stress. Therefore, we hypothesized that malocclusion, as chronic stress, may contribute to reduced HRV. The aim of this study was to investigate the relationship between malocclusion and HRV indices in healthy young adults. Methods: Thirty-seven non-smoking healthy subjects, aged 22 to 25 years, were examined. Malocclusion was defined by Angle classification. HRV indices included root mean square of successive differences, low frequency (LF), high frequency (HF) and ratio of LF to HF. The effects of malocclusion on quality of life and mental health were assessed using self-reported questionnaires, the condition-specific Oral Impacts on Daily Performances index (CS-OIDP) and the Hopkins Symptoms Checklist (HSCL), respectively. Results: Significantly lower score of HF and higher heart rate (HR) level and CS-OIDP score were observed in subjects with malocclusion (n = 17) compared to those in the control subjects (n = 20) (P < 0.05). There was a positive correlation between HR and score of “anxiety” in HSCL (P < 0.05). Conclusions: The data showed an association between malocclusion and lower HRV. Based on our results, orthodontic treatment might contribute not only to improvement of oral esthetic and functional problems but also to improvement of stress and HRV indices.

Download Full-text

Cardiovascular risk and heart rate variability in young adults with type 2 diabetes and arterial stiffness: The SEARCH for Diabetes in Youth Study

Journal of Diabetes and its Complications ◽

10.1016/j.jdiacomp.2020.107676 ◽

2020 ◽

Vol 34 (10) ◽

pp. 107676

Author(s):

Amy Sanghavi Shah ◽

Mamta Jaiswal ◽

Dana Dabelea ◽

Jasmin Divers ◽

Scott Isom ◽

...

Keyword(s):

Type 2 Diabetes ◽

Heart Rate ◽

Heart Rate Variability ◽

Young Adults ◽

Cardiovascular Risk ◽

Arterial Stiffness ◽

Youth Study ◽

Diabetes In Youth

Download Full-text

Heart Rate Variability in Patients with Hypertension: the Effect of Metabolic Syndrome and Antihypertensive Treatment

Cardiovascular Therapeutics ◽

10.1155/2020/8563135 ◽

2020 ◽

Vol 2020 ◽

pp. 1-9

Author(s):

Małgorzata Maciorowska ◽

Paweł Krzesiński ◽

Robert Wierzbowski ◽

Grzegorz Gielerak

Keyword(s):

Metabolic Syndrome ◽

Heart Rate ◽

Heart Rate Variability ◽

Cardiovascular Risk ◽

Antihypertensive Treatment ◽

Low Frequency ◽

Total Power ◽

Autonomic Nervous System Dysfunction ◽

Ambulatory Electrocardiography ◽

The Mean

Metabolic syndrome (MetS) is a combination of factors which, collectively, increase cardiovascular risk to a greater extent than each of them separately. Previous studies showed high cardiovascular risk to be associated with autonomic nervous system dysfunction. The purpose of this study was to assess the effects of antihypertensive treatment on heart rate variability (HRV) in patients with hypertension (HTN), depending on cooccurrence of MetS. 118 patients with uncontrolled HTN were enrolled to the study. HRV was compared among patients with and without MetS (MetS [+], n = 70 ) at baseline and following 12 months antihypertensive treatment. The HRV indices measured from RR intervals recorded form using 24-hour ambulatory electrocardiography. The measured HRV domains were the standard deviation of the average of NN intervals [SDNN], square root of the mean of the sum of the squares of differences between adjacent NN intervals [rMSSD], percentage of NN50 [pNN50], low frequency [LF], high frequency [HF], total power of variance of all NN intervals [TP], and LF/HF ratio. Baseline parameters: SDNN, rMSSD, pNN50, and HF were significantly lower in the MetS[+] compared to the MetS[-] subgroup ( p < 0.05 ). After a 12-month antihypertensive treatment, MetS[+] patients achieved a significant improvement in parameters: SDNN, rMSSD, pNN50, and TP ( p < 0.05 ), while the changes in HRV observed in the MetS[-] subgroup were not statistically significant. The cooccurrence of HTN and other components of MetS is associated with disturbances of the autonomic balance. HTN control has a beneficial effect on HRV, with the effect being more evident in patients with MetS.

Download Full-text

Heart Rate Variability, Emotions, and Music

Journal of Psychophysiology ◽

10.1027/0269-8803/a000021 ◽

2010 ◽

Vol 24 (2) ◽

pp. 112-119 ◽

Cited By ~ 9

Author(s):

F. Riganello ◽

A. Candelieri ◽

M. Quintieri ◽

G. Dolce

Keyword(s):

Data Mining ◽

Heart Rate ◽

Heart Rate Variability ◽

Vegetative State ◽

Low Frequency ◽

Emotional Reactions ◽

Heart Beat ◽

Healthy Controls ◽

Frequency Spectra ◽

Emotional Value

The purpose of the study was to identify significant changes in heart rate variability (an emerging descriptor of emotional conditions; HRV) concomitant to complex auditory stimuli with emotional value (music). In healthy controls, traumatic brain injured (TBI) patients, and subjects in the vegetative state (VS) the heart beat was continuously recorded while the subjects were passively listening to each of four music samples of different authorship. The heart rate (parametric and nonparametric) frequency spectra were computed and the spectra descriptors were processed by data-mining procedures. Data-mining sorted the nu_lf (normalized parameter unit of the spectrum low frequency range) as the significant descriptor by which the healthy controls, TBI patients, and VS subjects’ HRV responses to music could be clustered in classes matching those defined by the controls and TBI patients’ subjective reports. These findings promote the potential for HRV to reflect complex emotional stimuli and suggest that residual emotional reactions continue to occur in VS. HRV descriptors and data-mining appear applicable in brain function research in the absence of consciousness.

Download Full-text