scholarly journals Risk Assessment and Virological Monitoring Following an Accidental Exposure to Concentrated Sabin Poliovirus Type 3 in France, November 2018

Vaccines ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 331
Author(s):  
Marion Jeannoël ◽  
Denise Antona ◽  
Clément Lazarus ◽  
Bruno Lina ◽  
Isabelle Schuffenecker
Keyword(s):  
Risk Assessment ◽  
Accidental Exposure ◽  
Exposed Worker ◽  
Poliovirus Type ◽  
Viral Culture ◽  
Short Period ◽  
National Response ◽  
Response Plan ◽  
Virological Monitoring ◽  
Type 3

The safe and secure containment of infectious poliovirus (PV) in facilities where live PV are handled is the condition to achieve and maintain poliomyelitis eradication. Despite precautions to minimize the risk of release of PV from such facilities to the environment, breaches of containment have already been documented. Here, we report the management of an incident that occurred on 30 November 2018 in a French vaccine manufacturing plant. Five adequately vaccinated operators were exposed to a Sabin poliovirus type 3 (PV3) spill. A microbiological risk assessment was conducted and the operators were monitored for PV shedding. On day 5 after exposure, Sabin PV3 was detected only in the stool sample of the most exposed worker. Shedding of Sabin PV3 (as detected by viral culture) was restricted to a very short period (less than 15 days). Monitoring of this incident was an opportunity to assess the relevance of our national response plan. We concluded that the measures undertaken and reported here were appropriate and proportional.

OUTBREAK OF PARALYTIC POLIOMYELITIS IN FINLAND: WIDESPREAD CIRCULATION OF ANTIGENICALLY ALTERED POLIOVIRUS TYPE 3 IN A VACCINATED POPULATION

The Lancet ◽  
1986 ◽  
Vol 327 (8495) ◽  
pp. 1427-1432 ◽  
Author(s):  
T. Hovi ◽  
A. Huovilainen ◽  
T. Kuronen ◽  
T. Pöyry ◽  
N. Salama ◽  
...  
Keyword(s):  
Paralytic Poliomyelitis ◽  
Poliovirus Type ◽  
Type 3

Molecular cloning of the genomes of poliovirus type 3 strains by the cDNA: RNA hybrid method

1984 ◽  
Vol 81 (1-2) ◽  
pp. 67-78 ◽  
Author(s):  
G. Stanway ◽  
R. C. Mountford ◽  
S. D. J. Cox ◽  
G. C. Schild ◽  
P. D. Minor ◽  
...  
Keyword(s):  
Molecular Cloning ◽  
Hybrid Method ◽  
Poliovirus Type ◽  
Type 3

Comparison of neuropathogenicity of poliovirus type 3 in transgenic mice bearing the poliovirus receptor gene and cynomolgus monkeys

Vaccine ◽  
2001 ◽  
Vol 19 (23-24) ◽  
pp. 3201-3208 ◽  
Author(s):  
Noriyo Nagata ◽  
Takuya Iwasaki ◽  
Yasushi Ami ◽  
Ayako Harashima ◽  
Ikuyoshi Hatano ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Receptor Gene ◽  
Poliovirus Type ◽  
Cynomolgus Monkeys ◽  
Poliovirus Receptor ◽  
Type 3

Cancer risk assessment of polycyclic aromatic hydrocarbons in the soil and sediments of Iran: a systematic review study

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Roshanak Rezaei Kalantary ◽  
Neamatollah Jaafarzadeh ◽  
Mohammad Rezvani Ghalhari ◽  
Mohsen Hesami Arani
Keyword(s):  
Risk Assessment ◽  
Polycyclic Aromatic Hydrocarbons ◽  
Cancer Risk ◽  
Human Health ◽  
Aromatic Hydrocarbons ◽  
Dermal Exposure ◽  
Carcinogenic Risk ◽  
Cancer Risk Assessment ◽  
Accidental Exposure ◽  
Polycyclic Aromatic

Abstract Polycyclic aromatic hydrocarbons (PAHs) are organic pollutants containing several hydrocarbon rings affecting human health according to the published monitoring data. Most of these compounds can be absorbed by the soil and sediments due to the abundance of production resources of these compounds in the soil around the cities and sediments of the Iranian coast. Cancer risk assessment (CRA) is one of the most effective methods for quantifying the potentially harmful effects of PAHs on human health. In this study, the published papers that monitored PAHs in Iran’s soil and sediments were reviewed. The extraction of different data and their equivalent factors were performed according to BaP equivalent, which is the main factor for calculating CRA of PAHs. The highest concentrations of PAHs were found in the sediments of Assaluyeh industrial zones (14,844 μg/kg), Khormousi region (1874.7 μg/kg), and Shadegan wetland (1749.5 μg/kg), respectively. Dermal exposure to sediments was 96% in adults, and 4% in children, and ingestion exposure to sediment was 99% in adults and 99.2% in children. Children dermal exposure to soil was 53%, and the accidental exposure to soil was 47%. In adults, dermal exposure to soil was 96% and the accidental exposure was 4%. The results of the present study indicated a significant, the carcinogenic risk of Polycyclic Aromatic Hydrocarbons in sediments of southern regions and soils of central regions of Iran is significant.

scholarly journals Case of Poliomyelitis Caused by Significantly Diverged Derivative of the Poliovirus Type 3 Vaccine Sabin Strain Circulating in the Orphanage

Viruses ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 970
Author(s):  
Ekaterina A. Korotkova ◽  
Maria A. Prostova ◽  
Anatoly P. Gmyl ◽  
Liubov I. Kozlovskaya ◽  
Tatiana P. Eremeeva ◽  
...  
Keyword(s):  
Genome Sequencing ◽  
Mucosal Immunity ◽  
Neutralizing Antibodies ◽  
Oral Poliovirus Vaccine ◽  
Paralytic Poliomyelitis ◽  
Epidemiological Investigation ◽  
Poliovirus Type ◽  
Complete Rejection ◽  
Type 3

Significantly divergent polioviruses (VDPV) derived from the oral poliovirus vaccine (OPV) from Sabin strains, like wild polioviruses, are capable of prolonged transmission and neuropathology. This is mainly shown for VDPV type 2. Here we describe a molecular-epidemiological investigation of a case of VDPV type 3 circulation leading to paralytic poliomyelitis in a child in an orphanage, where OPV has not been used. Samples of feces and blood serum from the patient and 52 contacts from the same orphanage were collected twice and investigated. The complete genome sequencing was performed for five polioviruses isolated from the patient and three contact children. The level of divergence of the genomes of the isolates corresponded to approximately 9–10 months of evolution. The presence of 61 common substitutions in all isolates indicated a common intermediate progenitor. The possibility of VDPV3 transmission from the excretor to susceptible recipients (unvaccinated against polio or vaccinated with inactivated poliovirus vaccine, IPV) with subsequent circulation in a closed children’s group was demonstrated. The study of the blood sera of orphanage residents at least twice vaccinated with IPV revealed the absence of neutralizing antibodies against at least two poliovirus serotypes in almost 20% of children. Therefore, a complete rejection of OPV vaccination can lead to a critical decrease in collective immunity level. The development of new poliovirus vaccines that create mucosal immunity for the adequate replacement of OPV from Sabin strains is necessary.

scholarly journals Human enterovirus infection in stray dogs. Some aspects of interest to public health

1996 ◽  
Vol 38 (2) ◽  
pp. 157-161 ◽  
Author(s):  
Eliseu Alves Waldman ◽  
Regina C. Moreira ◽  
Sueli G. Saez ◽  
Denise F.C. Souza ◽  
Rita de C.C. Carmona ◽  
...  
Keyword(s):  
Neutralizing Antibodies ◽  
Neutralizing Antibody ◽  
Human Enterovirus ◽  
Poliovirus Type ◽  
Stray Dogs ◽  
Wild Poliovirus ◽  
Antibody Titres ◽  
Global Eradication ◽  
Type 3 ◽  
Echovirus Type

To investigate the possible role of domestic animals as reservoirs of human enteroviruses, we studied 212 stray dogs captured in different areas of the municipality of São Paulo. The captured animals were divided into 19 groups of 10 to 20 dogs each; faeces of 126 of the 212 dogs were processed for enterovirus isolation. The following viruses were isolated from 12 dogs: poliovirus type 1 (2 dogs), poliovirus type 3 (1 dog), echovirus type 7 (8 dogs) and echovirus type 15 (1 dog). Of the 12 infected animals, four had specific homotypic neutralizing antibody titres > 16. All 212 animals were tested for the presence of neutralizing antibodies to human enteroviruses. The frequency of neutralizing antibodies present in titres of > 16 was 10.3%, 3,8% and 4.3% for vaccinal prototypes of polioviruses 1, 2 and 3 respectively; 1,9%, 1.4% and 1.5% for wild prototypes of the same viruses, 11.3% for echovirus 7, and 2.4% for echovirus 15. The proportion of dogs with neutralizing antibodies varied with the virus studied. Some indication of the susceptibility of dogs to infection with human enteroviruses was demonstrated, and the importance of this fact for the Plan for Global Eradication of the Wild Poliovirus is discussed.

Protecting Disaster Site, Support, and Recovery Workers

2008 ◽  
Vol 18 (3) ◽  
pp. 329-332 ◽  
Author(s):  
James Celenza
Keyword(s):  
Occupational Safety ◽  
Worker Safety ◽  
Federal State ◽  
Incident Management ◽  
Health Administration ◽  
Gulf Region ◽  
Safety And Health ◽  
National Response ◽  
Response Plan ◽  
State And Local

When a disaster strikes, FEMA activates the worker safety and health provisions (annex document) of the National Response Plan (NRP). The annex describes actions needed to ensure that threats to safety and health are recognized, evaluated, and controlled consistently so that responders are properly protected during incident management operations. The activation of the Worker Safety and Health Annex gives the Occupational Safety and Health Administration (OSHA) the responsibility to coordinate a comprehensive response involving federal, state, and local agencies and private-sector organizations to ensure the safety and health needs of responders are met. There is confusion, however, as to whether OSHA is acting as an advisory “coordinator” or as an enforcement agency. OSHA personnel at the WTC and the Gulf region reported they were not clear what role they must perform (and the language in the National Response Plan is not explicit). Thus, the need for a clear and comprehensive mandatory program.

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