Dynamics of indicators of reparative regeneration of the oral mucosa in patients with lichen planus

Relevance: red lichen planus refers to a long, protracted disease with a chronic course. There are a lot of root causes, it is quite diﬃcult to diﬀerentiate them. Therefore, pharmacotherapy of this pathology is reduced to the appointment of local drugs that have only symptomatic eﬀects that help accelerate the healing of the oral mucosa.Purpose – to study reparative regeneration based on the analysis of clinical and cytological examination on the background of the appointment of various methods of pharmacotherapy.Materials and methods: all patients were divided into two groups using simple randomization: in patients of the ﬁrst group, betamethasone B was used to treat erosive-ulcerative lesions, which were delivered to the lesion using Tisol, which has conductive transcutaneous activity, using the sandwich technique. The second group of patients used the drug delivery system in the form of a ﬁlm, which ﬁxed betamethasone B in the lesion area.Results: were evaluated before treatment, on day 7 and 14. The area and intensity of healing of the oral mucosa were determined, a qualitative and quantitative analysis of cytograms was carried out, which characterizes the dynamics of reparative regeneration of erosions and ulcers.Conclusion: based on the obtained clinical and laboratory data, it can be concluded that it is advisable to include betamethasone applications in the pharmacotherapy of patients with erosive and ulcerative forms of lichen planus. However, preference should be given to the method of layer-by-layer application of betamethasone B in combination with Tezol.

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Ulcerative Lichen Planus in Childhood

Case Reports in Dentistry ◽

10.1155/2013/874895 ◽

2013 ◽

Vol 2013 ◽

pp. 1-4

Author(s):

Chiyadu Padmini ◽

K. Yellamma Bai ◽

Vinil Chaitanya ◽

M. Shilpa Reddy

Keyword(s):

Differential Diagnosis ◽

Lichen Planus ◽

Oral Mucosa ◽

Clinical Examination ◽

Unusual Case ◽

Local Treatment ◽

Oral Lesion ◽

Ulcerative Lesion ◽

Histopathological Features ◽

Ulcerative Lesions

Lichen planus (LP) is a chronic inflammatory mucocutaneous condition which is relatively common in adults but rarely affects children. The present study is a report on an unusual case of ulcerative oral LP involving the dorsum of tongue in a 12-year-old boy. Patient complained of painful oral lesion on the tongue which was burning in nature and obstructing talking and eating spicy foods. On intraoral examination, a white ulcerative lesion on the dorsum of tongue was observed. Diagnosis was made based on clinical examination and histopathological features. We instituted local treatment and patient responded well to the treatment. Although rarely reported in childhood, lichen planus should be considered in a differential diagnosis of hyperkeratotic, reticular, and ulcerative lesions of the oral mucosa in children.

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Use of Physiotherapy in the Treatment of Oral Muco-sa (brief message)

Journal of New Medical Technologies ◽

10.12737/5001 ◽

2014 ◽

Vol 21 (2) ◽

pp. 65-68

Author(s):

Сериков ◽

N. Serikov ◽

Серикова ◽

O. Serikova ◽

Щербаченко ◽

...

Keyword(s):

Lichen Planus ◽

Oral Mucosa ◽

The Body ◽

Physical Factors ◽

Development Of Resistance ◽

Extremely High Frequency ◽

Urgent Task ◽

Inflammatory Processes ◽

Dental Diseases ◽

Chronic Course

Lichen planus is one of the most common diseases of the oral mucosa, which is characterized by a chronic course, clinical polymorphism, resistant to treatment, the possibility of malignancy. For treatment of the red lichen planus, the modern medicines are used: neurotropic, corticosteroids, aminoquinolinic preparations, antibiotics, retinoids, drugs, vitamins that have impact on different stages of pathogenesis. However, the prescription of these drugs is often inefficient, and is associated with the development of complications and the development of resistance to the therapy. The phenomena of toxic and allergic reactions in the use of drugs are frequent. Improvement of non-drug methods of treatment of the red lichen planus in mucous membranes of the mouth is an urgent task. Combined methods of physiotherapy are one way of treatment. Combined physiotherapy is physiotherapy, based on simultaneously (coinfection) use of two or more physical factors on the same area of the body. These factors were selected with the aim of increasing their physical activity and therapeutic effectiveness. One of the variants of combined physical therapy of diseases of the oral mucosa is the use of a device for the treatment of dental diseases «Radadent», in which there are two types of physical factors: the extremely high frequency electromagnetic and ultraviolet radiation. In the clinic of the Department of stomatology the apparatus «Radadent» was used in the complex treatment of 12 patients with erosive and ulcerative forms of red lichen planus. The reduction or elimination of inflammatory processes of the mucous membrane and the regeneration of tissues trophism of the mouth, elimination of pain, cell regeneration, the acceleration of healing of ulcers and ero-sions were identified.

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Ulcerative Lesions of the Oral Mucosa

Handbook of Oral Pathology and Oral Medicine ◽

10.1002/9781119781172.ch27 ◽

2021 ◽

pp. 403-412

Keyword(s):

Oral Mucosa ◽

Ulcerative Lesions

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Malignant development of lichen planus-affected oral mucosa

Journal of Oral Pathology and Medicine ◽

10.1111/j.1600-0714.1988.tb01528.x ◽

1988 ◽

Vol 17 (5) ◽

pp. 219-225 ◽

Cited By ~ 156

Author(s):

P. Holmstrup ◽

J. J. Thorn ◽

J. Rindum ◽

J. J. Pindborg

Keyword(s):

Lichen Planus ◽

Oral Mucosa

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The Lichenoid Tissue Reactions of the Oral Mucosa: Oral Lichen Planus and Other Lichenoid Lesions

Surgical Pathology Clinics ◽

10.1016/j.path.2011.07.001 ◽

2011 ◽

Vol 4 (4) ◽

pp. 1005-1026 ◽

Cited By ~ 7

Author(s):

Susan Müller

Keyword(s):

Lichen Planus ◽

Oral Mucosa ◽

Oral Lichen Planus ◽

Tissue Reactions ◽

Oral Lichen

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Criteria for assessing severity of oral lichen planus

MedAlliance ◽

10.36422/23076348-2021-9-1-73-81 ◽

2021 ◽

Vol 9 (1) ◽

pp. 73-81

Keyword(s):

Lichen Planus ◽

Oral Mucosa ◽

Severity Score ◽

Oral Lichen Planus ◽

Unknown Etiology ◽

Altered Level ◽

Doppler Flowmetry ◽

Serum Free ◽

Control Subjects ◽

Oral Lichen

Introduction. Oral lichen planus (OLP) is an autoim- mune disease of unknown etiology, manifested in vari- ous clinical forms. A correlation between intensity of OLP local manifestations and severity of general disturbances predisposing to altered oral mucosa have been poorly investigated. The aim of our study was to identify criteria for assessing OLP severity score. Methods. OLP patients and control subjects (not OLP) matched by hepatobiliary disease and type IIa dyslipidemia were examined. Samples collected during the study were as- sessed by way clinical examination, gas chromatographic analysis of serum free fatty acids (FFA), oral fluid, serum and fecal microbial marker analysis by gas chromatogra- phy/mass spectrometry, laser Doppler flowmetry of the oral mucosa, immunohistochemistry staining with an- ti-CD68 monoclonal antibody specific to apolipoprotein B-100-bearing macrophages. Results. It was found that OLP patients significantly differed from control subjects in the three FFA levels (lauric acid, eicosopentaenoic/ lauric and eicosopentaenoic/linoleic ratios), displayed four pathologic factors matching the altered level of mi- crobial markers. In addition, OLP patients were found to differ in oral mucosa blood filling both inside and outside lesions paralleled with oxidative changes immediately in oral mucosa highlighted as elevated amount of apo- lipoprotein B-100-bearing CD68-positive macrophages. Conclusion. OLP severity score is an integrate parameter which reflects oxidative changes and alterations in oral mucosa microhemocirculation primarily in serum free fat- ty acid composition, altered oral and gut microbiota as well as intensity score of clinical picture.

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Evaluation of Cellular Proliferative Activity in Patients with Oral Lichen Planus and Hepatitis C through AgNOR Method

Brazilian Dental Journal ◽

10.1590/0103-6440201302379 ◽

2014 ◽

Vol 25 (6) ◽

pp. 461-465

Author(s):

João Paulo De Carli ◽

Soluete Oliveira da Silva ◽

Maria Salete Sandini Linden ◽

Carmen Silvia Busin ◽

Luiz Renato Paranhos ◽

...

Keyword(s):

Hepatitis C ◽

Lichen Planus ◽

Oral Mucosa ◽

Oral Lichen Planus ◽

Clinical Signs ◽

Hcv Infection ◽

Control Group ◽

Proliferative Potential ◽

Group 2 ◽

Oral Lichen

The objective of this study was to evaluate the cellular proliferative potential of oral lichen planus (OLP) lesions from patients without hepatitis C virus (HCV) by means of AgNOR method, as well as the cellular proliferative potential of the normal oral mucosa from patients with HCV, treated or untreated by interferon and ribavirin. A cross-sectional study was developed to investigate four groups: 10 HCV+ patients without clinical signs of OLP who had never been treated for HCV infection - Group 1; 10 HCV+ patients that were under interferon and ribavirin treatment - Group 2; 15 patients with reticular OLP lesions histopathologically confirmed, without HCV - Group 3; and 15 blood donors without HCV infection and no clinical signs of OLP GROUP 4 Control Group. The cytological material of all groups was collected by the liquid-based cytology technique. Then, the sedimented material from each patient was filled with the Nucleolar Organizer Regions impregnation by silver method (AgNOR). The count of NORs was performed on 100 epithelial cell nuclei per patient using the Image Tool(tm) software. The Tukey HSD test was used to compare the median value of NORs among the groups and showed that the oral mucosa of HCV+ patients previously treated with anti-HCV drugs (GROUP 2), presented a higher average number of NORs in relation to others (p<0.05). The anti-HCV treatment may be related to increased cell proliferation of oral mucosa, indicating a possible relationship between OLP and HCV+ patients treated with interferon and ribavirin.

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THE IMPACT OF NUTRITION ON THE COURSE OF LICHEN PLANUS

The actual problems in dentistry ◽

10.18481/2077-7566-2015-0-2-19-23 ◽

2015 ◽

Vol 11 (2) ◽

pp. 19-23 ◽

Cited By ~ 2

Author(s):

Г. Ронь ◽

G. Ron ◽

А. Епишова ◽

A. Yepishova

Keyword(s):

Lichen Planus ◽

Oral Mucosa ◽

Feeding Habits ◽

The Impact

<p>The feeding habits of patients with manifestations of lichen planus on the oral mucosa are demonstrated in the article).</p>

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Role of apoptosis in erosive and reticular oral lichen planus exhibiting variable epithelial thickness

Brazilian Dental Journal ◽

10.1590/s0103-64402008000300001 ◽

2008 ◽

Vol 19 (3) ◽

pp. 179-185 ◽

Cited By ~ 21

Author(s):

Juliana M. Caldeira Brant ◽

Anilton C. Vasconcelos ◽

Luciana V. Rodrigues

Keyword(s):

Lichen Planus ◽

Oral Mucosa ◽

Oral Lichen Planus ◽

Chronic Inflammatory Disease ◽

Mechanical Trauma ◽

Epithelial Thickness ◽

Healthy Mucosa ◽

Toxic Agents ◽

Oral Lichen

Oral lichen planus (OLP) is a chronic inflammatory disease with different clinical types. Reticular and erosive forms are the most common. Although the cause of OLP remains speculative, many findings suggest auto-immune involvement, mediated by T lymphocytes against the basal keratinocytes. Inflammation, mechanical trauma or toxic agents can affect the epithelial homeostasia. Increased apoptosis may cause a decrease in epithelial thickness reflecting in the activity of the lesion. The objective of this study was to evaluate the occurrence of apoptosis and epithelial thickness in reticular and erosive forms of OLP. 15 samples of OLP each type (reticular and erosive) plus 10 of healthy mucosa were collected and processed. After morphometry, the apoptotic index and epitelial thickness were obtained. TUNEL and M30 CytoDEATH immunohistochemical assay were used to validate the morphologic criteria used. Apoptosis in the erosive OLP was significantly more intense than in the reticular type and both forms of OLP presented more apoptosis than the healthy oral mucosa. Healthy oral mucosa was thicker than both OLP forms and thicker in OLP reticular form than in the erosive one. The clinical differences between reticular and erosive forms of OLP are related to variations in epithelial thickness and in intensity of apoptosis.

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