Low-Level Laser Therapy Approach of Bilateral Necrotizing Sialometaplasia of the Hard and Soft Palates

Introduction: Necrotizing sialometaplasia (NS) is a rare locally destructive inflammatory benign disease that commonly affects the minor salivary glands. It is frequently associated with the glands located in the posterior portion of the hard and soft palates. Low-level laser therapy (LLLT), also called photobiomodulation therapy (PBMT), has been deemed a substantial method for the regenerative wound process. Case Presentation: A 32-year-old male patient was referred with a chief complaint of two asymptomatic crater-like ulcers measuring approximately 1.5 cm wide on the right side of the hard and soft palates, and another measuring 0.3 cm wide on the left side of the hard palate. The lesion had two weeks of evolution followed by a previous infectious "sore throat" event that kept the patient hospitalized for 4 days. A clinical diagnosis of NS was made. LLLT was applied during 2 sessions per week, favoring the total wound healing within 2 weeks. At 3 months of clinical followup, the patient did not present any complication or relapse and was thus released. Conclusion: This is, to our knowledge, the first clinical report of LLLT applied for the management of NS. Large palatal ulcers caused by NS usually have long healing periods. The shortened healing period observed in this case encourages the inclusion of LLLT in any treatment protocol for similar lesions.

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Low-Level Laser Therapy as a Coadjuvant in Sodium Hypochlorite Extrusion Management

Journal of Dentistry and Oral Sciences ◽

10.37191/mapsci-2582-3736-2(1)-023 ◽

2020 ◽

Author(s):

Diana Ened Rodríguez Zaragoza

Keyword(s):

Laser Therapy ◽

Sodium Hypochlorite ◽

Conventional Treatment ◽

Soft Tissues ◽

Treatment Protocol ◽

Low Level Laser Therapy ◽

Low Level ◽

Low Level Laser ◽

Level Laser ◽

Severe Tissue

Aim: The extrusion of sodium hypochlorite through the apical foramen is an accident that can occur during the endodontic treatment although is relatively uncommon, Due to the severe tissue damage that is caused by the solution, the management becomes important to prevent serious sequalae. Low-level laser therapy might be useful to treat damaged soft tissues because of its bio modulatory effects, which may reduce edema and prevent infection. Methods: In this clinical case, the accidental leakage of 5% sodium hypochlorite during the preparation of the root canal of an upper left canine is reported. The accident caused immediate and intense pain and severe edema and ecchymosis. The conventional treatment protocol was applied along with low-level laser therapy. Results: Clinical examination revealed the healing of soft tissue in thirteen days, besides a significant pain reduction in three days after laser therapy was applied. Conclusion: The combination of low-level laser therapy with a conventional treatment protocol could be a useful tool to manage such an accident.

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Low-level laser therapy, at 830 nm, for pain reduction in experimental model of rats with sciatica

Arquivos de Neuro-Psiquiatria ◽

10.1590/s0004-282x2011000300017 ◽

2011 ◽

Vol 69 (2b) ◽

pp. 356-359 ◽

Cited By ~ 20

Author(s):

G R F Bertolini ◽

E L Artifon ◽

T S Silva ◽

D M Cunha ◽

P R Vigo

Keyword(s):

Laser Therapy ◽

Pain Reduction ◽

Low Level Laser Therapy ◽

Painful Condition ◽

Low Level ◽

Low Level Laser ◽

Level Laser ◽

Before And After ◽

Common Clinical Presentation ◽

The Right

Chronic pain, resulting from nerve compression, is a common clinical presentation. One means of conservative treatment is low-level laser therapy, although controversial. The aim of this study was to evaluate the effects of two doses of low-level laser, at 830 nm, on pain reduction in animals subjected to sciatica. Eighteen rats were used, divided into three groups: GS (n=6), sciatica and simulated treatment; G4J (n=6), sciatica and treatment with 4 J/cm²; and G8J (n=6), sciatica and irradiation with 8 J/cm². The right sciatic nerve was exposed and compressed using catgut thread. Five days of treatment were started on the third postoperative day. Pain was assessed by means of the paw elevation time during gait: before sciatica, before and after the first and second therapies, and the end of the fifth therapy. Low-level laser was effective in reducing the painful condition.

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Low-level laser on femoral growth plate in rats

Acta Cirurgica Brasileira ◽

10.1590/s0102-86502012000200004 ◽

2012 ◽

Vol 27 (2) ◽

pp. 117-122 ◽

Cited By ~ 6

Author(s):

Sidney Piesco de Oliveira ◽

Sheila Canevese Rahal ◽

Elenize Jamas Pereira ◽

Paulo Ricardo de Oliveira Bersano ◽

Fabio de Almeida Vieira ◽

...

Keyword(s):

Laser Therapy ◽

Growth Plate ◽

Low Level Laser Therapy ◽

Low Level ◽

Low Level Laser ◽

Calcified Cartilage ◽

Level Laser ◽

Longitudinal Length ◽

Male Wistar Rats ◽

The Right

PURPOSE: To determine the influence of low-level laser therapy on femoral growth plate in rats. METHODS: Thirty male Wistar rats aged 40 days were divided into two groups, G1 and G2. In G1 the area of the distal growth plate of the right femur was irradiated at one point using GaAlAs laser 830 nm wavelength, output power of 40 mW, at an energy density of 10 J/cm². The irradiation was performed daily for a maximum of 21 days. The same procedure was done in G2, but the probe was turned off. Five animals in each group were euthanized on days 7, 14 and 21 and submitted to histomorphometric analysis. RESULTS: In both groups the growth plate was radiographically visible at all moments from both craniocaudal and mediolateral views. On the 21st day percentage of femoral longitudinal length was higher in G2 than G1 compared to basal value while hypertrophic zone chondrocyte numbers were higher in G1 than G2. Calcified cartilage zone was greater in G1 than in G2 at all evaluation moments. Angiogenesis was higher in G1 than in G2 at 14th and 21st days. CONCLUSION: The low-level laser therapy negatively influenced the distal femoral growth plate.

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Medication-Related Osteonecrosis of Jaws: A Low-Level Laser Therapy and Antimicrobial Photodynamic Therapy Case Approach

Case Reports in Dentistry ◽

10.1155/2016/6267406 ◽

2016 ◽

Vol 2016 ◽

pp. 1-4 ◽

Cited By ~ 2

Author(s):

Mariana Comparotto Minamisako ◽

Guilherme Henrique Ribeiro ◽

Mariáh Luz Lisboa ◽

Mabel Mariela Rodríguez Cordeiro ◽

Liliane Janete Grando

Keyword(s):

Photodynamic Therapy ◽

Laser Therapy ◽

Alveolar Bone ◽

Treatment Protocol ◽

Low Level Laser Therapy ◽

Therapeutic Approaches ◽

Systemic Complications ◽

Low Level ◽

Low Level Laser ◽

Level Laser

Medication-related osteonecrosis of the jaws (MRONJ) can be considered an inability of the alveolar bone to respond to an injury, which frequently leads to severe local and systemic complications. Once the problem is installed, dentist must use all therapeutic approaches recommended. This manuscript reports a successful management of MRONJ handled with antibiotics, conservative debridement, low-level laser therapy (LLLT), and photodynamic therapy (PDT) up to 12 months. As healing of MRONJ may be very slow, combined therapeutic approaches are required. Besides the recommended conventional treatment protocol, LLLT and PDT are important tools to contribute to healing and improvement of patient’s quality of life.

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Evaluation of Aquaporins 1 and 5 Expression in Rat Parotid Glands After Volumetric Modulated Arc Radiotherapy and Use of Low-Level Laser Therapy at Different Times

Journal of lasers in medical sciences ◽

10.34172/jlms.2020.44 ◽

2020 ◽

Vol 11 (3) ◽

pp. 262-267

Author(s):

Gabriel Francisco Krueger ◽

Milene Castilhos de Oliveira ◽

Humberto Thomazi Gassen ◽

Juliana Tomaz Sganzerla ◽

Daniel Simon ◽

...

Keyword(s):

Gene Expression ◽

Parotid Gland ◽

Laser Therapy ◽

Low Level Laser Therapy ◽

Parotid Glands ◽

Low Level ◽

Low Level Laser ◽

Level Laser ◽

The Right ◽

Experimental Group

Introduction: This experimental study investigated the mRNA expression of aquaporins (AQPs) 1 and 5 in the parotid glands of rats irradiated with volumetric modulated arc therapy (VMAT) and subjected to low-level laser therapy (LLLT) at different time points. Methods: The sample consisted of 30 Wistar rats (Rattus norvegicus) divided into the following groups: control, LLLT alone (LG), radiotherapy alone (RG), and experimental groups that received LLLT at 24 hours (early experimental group [EEG], n=12) and 120 hours (late experimental group [LEG], n=12) after radiotherapy. VMAT was delivered at a single dose (12 Gy) and LLLT was performed with an aluminium-gallium-arsenide diode laser (660 nm, 100 mW), spot area of 0.0028 cm2, energy of 2 J/cm2 applied to 3 spots in the region corresponding to the right parotid gland, for 10 consecutive days. The right parotid gland was resected and prepared for RNA extraction. The gene expression of AQPs was evaluated by quantitative polymerase chain reaction (qPCR) using specific TaqMan probes, with the HPRT gene as an internal control. Results: The lowest AQP1 gene expression was 0.83 (0.27) with the use of LLLT 24 hours after radiotherapy (EEG), and the highest was 1.56 (0.80) with the use of LLLT alone (LG). Likewise, the lowest AQP5 gene expression was found in the EEG (mean = 0.88; SD = 0.49) and the highest in the LG (mean = 1.29; SD = 0.33). Conclusion: The use of LLLT after radiotherapy may contribute to the maintenance and an increase of these proteins, even when used at a later time point after radiotherapy.

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Treatment of severe oral mucositis in a pediatric patient undergoing chemotherapy

RGO - Revista Gaúcha de Odontologia ◽

10.1590/1981-863720150003000143007 ◽

2015 ◽

Vol 63 (4) ◽

pp. 467-471 ◽

Cited By ~ 1

Author(s):

Isabella Lima Arrais RIBEIRO ◽

Ana Maria Gondim VALENÇA ◽

Paulo Rogério Ferreti BONAN

Keyword(s):

Laser Therapy ◽

Oral Mucositis ◽

Lymphoblastic Leukemia ◽

Treatment Protocol ◽

Low Level Laser Therapy ◽

Low Level ◽

Low Level Laser ◽

Level Laser ◽

Chondroblastic Osteosarcoma ◽

Severe Oral Mucositis

This article reports the resolution of a case of severe oral mucositis and the treatment protocol that promoted complete remission of the lesions. A male 13-year-old patient with chondroblastic osteosarcoma in the left distal thigh and acute lymphoblastic leukemia undergoing cancer treatment with methotrexate presented with severe oral mucositis. The treatment protocol included the use of 10ml of a mucositis mouthwash and low-level laser therapy. The lesions remitted after five days of gargling with the mucositis mouthwash and two sessions of low-level laser therapy on the lesions. The use of a treatment protocol consisting of a mucositis solution associated with low-level laser therapy effectively resolved a case of severe chemotherapy-induced oral mucositis. The monitoring and treatment of oral mucositis lesions in children and adolescents undergoing chemotherapy are necessary to prevent the patient from suffering from induced comorbidities.

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The Effects of Low-Level Laser Therapy, 670 nm, on Epiphyseal Growth in Rats

The Scientific World JOURNAL ◽

10.1100/2012/231723 ◽

2012 ◽

Vol 2012 ◽

pp. 1-5 ◽

Cited By ~ 4

Author(s):

Adriana Regina de Andrade ◽

Anamaria Meireles ◽

Elisangela Lourdes Artifon ◽

Rose Meire Costa Brancalhão ◽

José Roberto Leonel Ferreira ◽

...

Keyword(s):

Laser Therapy ◽

Histological Analysis ◽

Low Level Laser Therapy ◽

Total Thickness ◽

Low Level ◽

Low Level Laser ◽

Level Laser ◽

Final Length ◽

The Right ◽

Different Doses

The longitudinal growth of long bones is attributed to epiphyseal growth. However, the effects of low-level laser therapy (LLLT) in such structures has still not been studied extensively in the literature. Therefore, the aim of this study was to evaluate the use of LLLT, 670 nm, at three different doses on the epiphyseal growth of the right tibia of rats. Twenty-one Wistar rats, aged four weeks, were subjected to the application of LLLT, with dosage according to the group (G4: were submitted to the application of 4 J/cm2; G8: were submitted to the application of 8 J/cm2; G16: were submitted to the application of 16 J/cm2). After completion of protocol they were kept until they were 14 weeks of age and then submitted to a radiological examination (evaluation of limb length) and euthanised. The histological analysis of the growth plates (total thickness and hypertrophic and proliferative zones) was then performed. Comparisons were made with the untreated left tibia. No differences were observed in any of the reviews (radiological and histological), when comparing the right sides (treated) to the left (untreated). It was concluded that the treatment with LLLT within the parameters used caused changes neither in areas of the epiphyseal cartilage nor in the final length of limbs.

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The Effects of Photobiomodulation Therapy on Post-Surgical Pain

Journal of lasers in medical sciences ◽

10.15171/jlms.2019.13 ◽

2019 ◽

Vol 10 (2) ◽

pp. 79-85 ◽

Cited By ~ 5

Author(s):

Kamran Ezzati ◽

Reza Fekrazad ◽

Zeinab Raoufi

Keyword(s):

Laser Therapy ◽

Effect Size ◽

Treatment Protocol ◽

Case Series ◽

Low Level Laser Therapy ◽

Low Level ◽

Positive Effects ◽

Low Level Laser ◽

Level Laser ◽

Wide Range

Introduction: One of the major complains after surgery is pain. Recent advances in the prevention and reduction of postoperative pain have provided several modalities. One of them is the use of laser irradiation on the surgical area. Objectives: To evaluate the effects of low level laser therapy (LLLT) on pain and side effects after surgery. Methods: In this research, databases such as: PubMed, Science Direct, Google Scholar, Springer and Cochrane were used and the words of laser therapy, photobiomodulation, therapeutic laser, low level laser therapy, surgery and pain were searched. Articles, including systematic reviews, original articles, case series, and clinical intervention studies related to these words, were studied. The language of all articles was English and consists of papers from 2009 until 2017. Results: A total of 370 papers were studied and 10 articles that met inclusion criteria were selected for this review. Few of these articles were followed up. Surgery included a wide range of surgeries including mastectomy, breast augment post-fracture, episiotomy, tonsillectomy and hernia. The methodological quality score on the PEDro scale was between 5 and 11. 8 trials reported positive effects and 2 trials reported negative effects. In order to study clinical effect size of laser therapy after surgery, only 4 papers met entry criteria and the mean effect sizes were 0.13 to 2.77. Accordingly, the best treatment protocol included a red laser dose of 4 J/cm2 for the post-operative pain of tonsillectomy, which was irradiated through the infra mandibular angle on the tonsils. Conclusion: LLLT may be an appropriate modality for reducing pain after surgery, nevertheless the effect size of this modality is variable. Therefore, further research based on proper protocols for these patients and follow-up of therapeutic course should be designed and implemented.

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Assessment of healing of dental implant surgical site following Low-Level Laser Therapy using Bio-Clinical parameters: An Exploratory Study

Journal of Oral Implantology ◽

10.1563/aaid-joi-d-18-00316 ◽

2020 ◽

Author(s):

VARSHA PALLED ◽

DR. JITENDRA RAO ◽

DR. RAGHUWAR DAYAL SINGH ◽

DR. SHUCHI TRIPATHI ◽

DR. KALPANA SINGH ◽

...

Keyword(s):

Laser Therapy ◽

Test Group ◽

Low Level Laser Therapy ◽

Control Group ◽

Clinical Parameters ◽

Implant Stability ◽

Low Level ◽

Implant Stability Quotient ◽

Low Level Laser ◽

Level Laser

The purpose of this study was to evaluate whether Low-Level Laser Therapy (LLLT) improves the healing of the implant surgical site with clinical and biochemical parameters.Thirty patients with an edentulous space spanning a single tooth were selected. The patients were randomly allocated to two groups - the control group and the test group. The test group received laser energy at a power of 2J/cm 2 with a total of 4-6J energy over each implant. Clinical parameters (Implant Stability Quotient, probing index, modified sulcus bleeding index)and osteoprotegerin (OPG) were assessed at baseline and follow-up intervals (2 weeks, 6 weeks, and 3 months).The test group showed significantly higher implant stability quotient compared to thecontrol group at 2 weeks(57.93±3.95 and 35.67±3.08; p<0.01) and 3months(58.86±3.75 and 67.06±3.78; p<0.01). A significant rise in OPG levels of the test group(686.30±125.36pg/ml at baseline and 784.25±108.30pg/ml at 3months;p<0.01) was seen contrary to significant decline in the control group (839.50±249.08pg/ml at baseline,415.30±78.39pg/ml at 3months;p<0.01). Within the limitations of the study, the study suggests that the healing of peri-implant hard and soft tissues may be enhanced with the use of LLLT as an explicit modality during the post-operative period.

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