scholarly journals EXPERIMENTAL INVESTIGATION OF THE EFFECT OF PHARMACEUTICAL COMPOSITION ON THE CENTRAL NERVOUS SYSTEM

2019 ◽  
Vol 6 (3) ◽  
Author(s):  
G. Syrova ◽  
L. Lukianova ◽  
V. Sinelnik ◽  
Yu. Krasnikova ◽  
Logina Salam
Keyword(s):  
Central Nervous System ◽  
Experimental Investigation ◽  
Nervous System ◽  
Open Field ◽  
Behavioral Reactions ◽  
Formalin Edema ◽  
The Central Nervous System ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Pharmaceutical Composition

Abstract EXPERIMENTAL INVESTIGATION OF THE EFFECT OF PHARMACEUTICAL COMPOSITION ON THE CENTRAL NERVOUS SYSTEM Syrova G.A., Lukianova L.V., Sinelnik V.V., Krasnikova Yu.M., Salam Logina It is known that when non-steroidal anti-inflammatory drugs combine with other drugs it can cause complementary effects, or potentiate the effects of each other. Object and methods The objective of this experiment is to analyze the use of a new pharmaceutical composition consisting of nonsteroidal anti-inflammatory drug of the coxib group (rofecoxib) and an immunomodulator of lycopid (glucosaminylmuramyl dipeptide). An experiment on laboratory animals was conducted in order to view the effect of rofecoxib, licopid and their pharmacological composition on the central nervous system and on emotional-behavioral reactions in an "open field" test under formalin edema conditions. Results Previously, we studied the pharmaceutical compositions of nonsteroidal anti-inflammatory drugs of different chemical structure with the psychostimulant caffeine. The results indicated that caffeine potentiated the pharmacological effects of nonsteroidal anti-inflammatory drugs. In this study, we set a goal to create a pharmaceutical composition of rofecoxib with licopid and investigated its effect on the emotional-behavioral reactions of rats under formalin edema conditions. Аnalysis of the experimental results show that the addition of licopid to rofecoxib contributed to an increase rat’s locomotor and orienting-research activities and also an increase in the indicators of their emotional reactions (urination and defecation) compared to the mono-administration of rofecoxib. Conclusions The pharmaceutical composition of rofecoxib and licopid is expedient and promising for the study of anti-inflammatory and analgesic effects.  Keywords: formalin edema, licopid, "open field", pharmaceutical composition, rofecoxib.   Резюме ЕКСПЕРИМЕНТАЛЬНЕ ДОСЛІДЖЕННЯ ВПЛИВУ ФАРМАЦЕВТИЧНОЇ КОМПОЗИЦІЇ НА ЦЕНТРАЛЬНУ НЕРВОВУ СИСТЕМУ Сирова Г.О., Лук’янова Л.В., Синельник В.В., Краснікова Ю.М., Салам Логіна Відомо, що нестероїдні протизапальні засоби комбінують з іншими препаратами, які можуть викликати взаємодоповнюючу дію, або потенціювати ефекти один одного. Об’єкт і методи. Експериментальне обґрунтування застосування нової фармацевтичної  композиції, що містить нестероїдний протизапальний засіб групи коксиби (рофекоксиб) і імуномодулятор лікопід (глюкозамінілмурамілдипептид). В експерименті на лабораторних тваринах проведено дослідження впливу рофекоксибу, лікопіду та їх фармацевтичної композиції на центральну нервову систему за емоційно-поведінковими реакціями у тесті «відкрите поле» в умовах формалінового набряку. Результати. Раніше нами вивчалися фармацевтичні композиції нестероїдних протизапальних засобів різної хімічної будови з психостимулятором кофеїном. Отримані результати вказували на потенціювання кофеїном фармакологічних ефектів нестероїдних протизапальних засобів. В даному дослідженні ми поставили за мету створити фармацевтичну композицію рофекоксибу з лікопідом та дослідили її вплив на емоційно-поведінкові реакції щурів в умовах формалінового набряку. Аналіз результатів експериментальних досліджень вказує на те, що додавання лікопіду до рофекоксибу сприяло підвищенню локомоторної та орієнтовно-дослідницької діяльності щурів, показників емоційних реакцій (уринацій та дефекацій) у порівнянні з моновведенням рофекоксибу. Висновки. Фармацевтична композиція рофекоксибу з лікопідом доцільна та перспективна щодо вивчення протизапальної та протибольової дії.  Ключові слова: «відкрите поле», лікопід, рофекоксиб, фармацевтична композиція, формаліновий набряк.   Резюме ЭКСПЕРИМЕНТАЛЬНОЕ ИССЛЕДОВАНИЕ ВЛИЯНИЯ ФАРМАЦЕВТИЧЕСКОЙ КОМПОЗИЦИИ НА ЦЕНТРАЛЬНУЮ НЕРВНУЮ СИСТЕМУ Сыровая А.О., Лукьянова Л.В., Синельник В.В., Красникова Ю.Н., Салам Логина Резюме. Известно, что нестероидные противовоспалительные средства комбинируют с другими препаратами, которые могут вызвать взаимодополняющее действие или усиливать эффекты друг друга. Объект и методы. Экспериментальное обоснование применения новой фармацевтической композиции, содержащей нестероидные противовоспалительные средства группы коксибы (рофекоксиб) и иммуномодулятор ликопид (глюкозаминилмурамилдипептид). В эксперименте на лабораторных животных проведено исследование влияния рофекоксиба, ликопида и их фармацевтической композиции на центральную нервную систему поэмоционально-поведенческим реакциям в тесте «открытое поле» в условиях формалиновых отека. Результаты. Ранее нами изучались фармацевтические композиции нестероидных противовоспалительных средств разного химического строения с психостимулятором кофеином. Полученные результаты указывали на потенцирование кофеином фармакологических эффектов нестероидных противовоспалительных средств. В данном исследовании мы поставили цель создать фармацевтическую композицию рофекоксиба с ликопидом и исследовали ее влияние на эмоционально-поведенческие реакции крыс в условиях формалиновых отека. Анализ результатов экспериментальных исследований указывает на то, что добавление ликопида к рофекоксибу способствовало повышению локомоторной и ориентировочно-исследовательской деятельности крыс, показателей эмоциональных реакций (уринаций и дефекаций) по сравнению с моновведением рофекоксиба. Выводы. Фармацевтическая композиция рофекоксиба с ликопидом целесообразна и перспективная для изучения противовоспалительного и противоболевого действий.  Ключевые слова: ликопид, «открытое поле», рофекоксиб, фармацевтическая композиция, формалиновый отек.

Non-steroidal anti-inflammatory drugs and their effect on the nervous system: neurotoxicity, types, mechanism of occurrence

2021 ◽  
pp. 459-464
Author(s):  
Elmira Erfanovna Alimova ◽  
Elena Evgenievna Al-Rabadi
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Hearing Loss ◽  
Side Effects ◽  
World Health ◽  
The World ◽  
The Central Nervous System ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Health Organization

Currently, according to the World Health Organization, about 20% of the world's population takes non-steroidal anti-inflammatory drugs (NSAIDs). NSAIDs are lipophilic substances that easily penetrate the blood-brain barrier and can cause side effects from the central nervous system. Neurotoxicity (headache, dizziness, insomnia, depression, depersonalization, psychosis, and tremor occur during the treatment with indomethacin; visual impairment, drowsiness - during the treatment with meloxicam; hearing loss - when taking salicylates) ranks second after gastrotoxicity. The article describes the mechanisms of neurotoxicity that occur when taking NSAIDs.

scholarly journals XII. An experimental investigation of the central motor innervation of the larynx. Part I. Excitation experiments

1891 ◽  
Vol 48 (292-295) ◽  
pp. 341-342 ◽  
Keyword(s):  
Central Nervous System ◽  
Experimental Investigation ◽  
Nervous System ◽  
Internal Capsule ◽  
Laryngeal Nerve ◽  
Motor Innervation ◽  
Corona Radiata ◽  
Cortical Areas ◽  
The Central Nervous System

In this paper the authors communicate the first part of a series of researches in which they have been engaged from time to time since 1886, on the nature of the representation of the intrinsic laryngeal movements in the central nervous system. Briefly stated, the anatomical arrangement of the laryngeal nerve; centres they believe to be as follows:— a . Cortical areas of representation. b . Connecting fibres in the corona radiata and the internal capsule. c . Bulbar areas of representation.

The effect of Qing Huan Ling combined risperidone on the open field behavior of schizophrenic mice model

2016 ◽  
Vol 33 (S1) ◽  
pp. s289-s289
Author(s):  
Y. Zhang ◽  
F. Liu ◽  
Z. Dai ◽  
B. Wu ◽  
Q. Wu
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Locomotor Activity ◽  
Open Field ◽  
Open Field Test ◽  
Model Group ◽  
Mice Model ◽  
Blank Group ◽  
The Central Nervous System ◽  
Risperidone Group

ObjectiveTo observe the effect of Qing Huan Ling and (or) risperidone on locomotor activity and explorative behavior of schizophrenia mice model by open field test.MethodsSeventy kunming mice were randomly divided into 5 groups, one group as blank group. The rest groups ip MK-801 continuously 14 day, then randomly numbered: model group, risperidone group, Qing Huan Ling group and risperidone combined Qing Huan Ling group. Ig give corresponding drugs for each group 4 weeks, observe the change of locomotor activity and explorative behavior by open field test.ResultsAfter Ig 4 weeks, compared with the blank group, there were no obvious difference in locomotor activity and explorative behavior between risperidone group, Qing Huan Ling group and the combined group. Compared with the model group, risperidone had statistics meaning in the repression of explorative behavior (P < 0.05),the combined group has statistics meaning in the repression of locomotor activity and explorative behavior (78.92 ± 36.18 m vs. 186.92 ± 41.08 m, P < 0.01).ConclusionQing Huan Ling regulate the central nervous system of schizophrenia mice model; when combined with risperidone, it restrain the central nervous system of schizophrenia mice model and the effect is stronger than risperidone alone.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals The impact of a binary catalyst system «tereftal + ascorbic acid» on the central nervous system

2017 ◽  
Vol 16 (2) ◽  
pp. 42-49
Author(s):  
N. P. Ermakova ◽  
S. S. Trofimov ◽  
N. Y. Kulbachevskaya ◽  
O. I. Konyaeva ◽  
V. M. Bukhman ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Ascorbic Acid ◽  
Nervous System ◽  
Body Temperature ◽  
Open Field ◽  
Catalytic System ◽  
Catalyst System ◽  
Emotional Status ◽  
The Central Nervous System ◽  
Binary Catalyst

Introduction. Neurotoxicity is one of the specific systemic complications of anticancer chemotherapy. Detection in experimental animals complications of psychotropic or neurotropic action of the new drug is one of the most difficult challenges of preclinical toxicology. Preclinical toxicological study of the effect of a binary catalyst system «tereftal + ascorbic acid» on the central nervous system (CNS). Objective. The prediction of toxic effects of binary catalytic system in clinical application in patients. Materials and methods. The study was conducted on 300 male mice hybrids (CBA х C57 Bl/6J) F1. Have terephtal - russian drug. A binary catalyst system was injected intravenously once at close to the maximum tolerated dose - 50 mg/kg tereftal + 110 mg/kg ascorbic acid and in therapeutic dose - 20 mg/kg tereftal + 44 mg/kg ascorbic acid. The obtained data were compared with a control animal treated with saline solution and with the data of animals treated with one tereftal and one ascorbic acid in equivalent doses. To assess neurotoxicity tests used standard neuropharmacological screening. An assessment of emotional status, muscle tone were undertaken. Behavior was evaluated in the tests «open field» and «aggression». We evaluated the response to pain stimulation, the change in rectal body temperature. Higher integrative brain functions were investigated on the model of the conditioned reflex of passive avoidance. Estimated effect on convulsive readiness of the CNS. Results. The catalytic system changed the general condition of the animals. This was manifested, on the one hand, in the suppression of their overall activity (sluggishness, inactivity until weakness, muscle relaxation, the lowering side, the slowing of breathing), the other - to increase their excitability (when in group, some animals adopted a characteristic aggressive stands, in some cases seizures). These animals were observed exophthalmos, the appearance of the position «frog», posture «praying mouse», the desire to hide. The inhibitory effect of the catalytic system was dose-dependent. Observed inhibition of various forms of behavior, emotional status, decrease in body temperature and pain sensitivity, in the test for aggression - reducing the number of fights, in open field test - locomotor activity suppression. Spontaneous seizures in the provocation corazol binary catalytic system was not strengthened. Conclusion. The obtained data allow to predict toxic effects from the CNS during clinical use of binary catalytic system «tereftal + ascorbic acid»: total confusion, lethargy, physical inactivity, decrease in body temperature, increased anxiety and aggression and, in very rare cases, the occurrence of seizures.

scholarly journals The impact of the new derivative of nicotinic acid with anti-hypoxic activity on the functions of the central nervous system

2019 ◽  
Vol 17 (1) ◽  
pp. 45-52 ◽  
Author(s):  
Igor M. Gneushev ◽  
Natalia P. Katunina ◽  
Vasiliy E. Novikov ◽  
Elena V. Pozhilova
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Open Field ◽  
Emotional Reactivity ◽  
Antihypoxic Activity ◽  
Defensive Reflex ◽  
The Central Nervous System ◽  
Nervous System Function ◽  
The Impact ◽  
Defense Reflex

The aim of the work was to study the effect of the complex compound of nicotine acid with antihypoxic activity under the code πQ-1043 on the function of the central nervous system. The experiments were performed on male mice of the SHR line. Influence of the compound on the function of the central nervous system was evaluated in the tests “open field”, conditioned-defense reflex of avoidance and corazole seizures. It was found that the compound πQ-1043 at a dose of 25 mg/kg increases emotional reactivity and reduces the coefficient of mobility of mice in the “open field” test, increases the latent time of the conditionally defensive reflex of avoidance, inhibits the development of seizures and increases the life expectancy of animals after administration of corazole. Such changes in the studied parameters indicate that the compound πQ-1043 has a depressing effect on the central nervous system function. It is assumed that the identified effect may be one of the components in the mechanism of antihypoxic action of the compound.

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