scholarly journals State-of-the-art molecular genetic techniques in surveillance over intensity of enterovirus infection epidemic process in some constituent entities of the Siberian Federal District of the Russian Federation

2019 ◽  
pp. 42-50
Author(s):  
E.Yu. Sapega ◽  
L.V. Butakova ◽  
Trotsenko ◽  
Lapa ◽  
Perezhogin ◽  
...  
Keyword(s):  
Russian Federation ◽  
State Of The Art ◽  
Molecular Genetic ◽  
Clinical Manifestations ◽  
Federal District ◽  
Enterovirus Infection ◽  
Siberian Federal District ◽  
Epidemic Process ◽  
Epidemiologic Surveillance ◽  
The Russian Federation

Background. Enterovirus infection is widely spread around the world. It has different epidemiologic and clinical manifestations. However, to date, the amount of accumulated information on the epidemic process of enterovirus infection in different constituent entities of the Siberian Federal district of the Russian Federation is insufficient. Objectives. Our objectives were to investigate characteristics of the enterovirus infection epidemic process in Siberian constituent entities subjected to surveillance using the innovative molecular genetic analysis. Materials and methods. The analysis of long-term enterovirus infection incidence in the investigated constituent entities of Siberia was performed. The total number of 237 enterovirus strains circulating during 2017-2018 epidemic seasons in the analyzed regions were isolated using sequencing technique. A phylogenetic analysis of the obtained nucleotide sequences was performed. Results. The epidemiologic situation related to enterovirus infection was unfavorable in the majority of the Siberian constituent entities in the past two years. A significant increase in incidence rates was registered in the Irkutsk Region, Zabaykalsky Krai and Altai Republic. We distinguished major manifestations of the enterovirus infection epidemic process including a years-long excess of the national average and a rising trend in the annual incidence rate, prevalence of herpangina, exanthema and enterovirus meningitis in the clinical course of the disease among children aged 3–6. Prevalence of Coxsackievirus A-6 and Coxsackievirus A-9 in the landscape of circulation was revealed in a number of Siberian regions. Group incidence and imported cases were also registered. Discussion. Our results demonstrated the importance of molecular genetic monitoring of circulating enteroviruses as part of the epidemiologic surveillance. This state-of-the-art approach can reveal potential epidemiologic links between cases of the disease.

scholarly journals Molecular-Genetic Monitoring of SARS-CoV-2 Genovariants in the Territory of the Volga Federal District of the Russian Federation. Communication 1

2021 ◽  
pp. 122-127
Author(s):  
N. A. Osina ◽  
Ya. M. Krasnov ◽  
N. P. Guseva ◽  
E. G. Boolgakova ◽  
I. V. Domanina ◽  
...  
Keyword(s):  
Russian Federation ◽  
Molecular Genetic ◽  
Clinical Manifestations ◽  
Federal District ◽  
Genetic Monitoring ◽  
Antigenic Structure ◽  
Three Samples ◽  
Sequencing Method ◽  
The Russian Federation

Emergence of various genovariants of the SARS-CoV-2 virus, which are characterized by a higher ability to spread and a more severe clinical manifestations compared to the initial variants, require molecular-genetic monitoring of strains circulating in the Russian Federation.The aim of the work was to identify the VOC SARS-CoV-2 genovariants in the territory of the Republics of Bashkortostan, Tatarstan, Udmurtia, and Samara, Penza, Saratov, Ulyanovsk, and Orenburg Regions.Materials and methods. The identification of genovariants and the determination of the type of mutations was carried out by the Sanger fragment sequencing method.Results and discussion. The study examined 298 samples of clinical material obtained from the Centers for Hygiene and Epidemiology in the Republics of Bashkortostan, Tatarstan, Udmurtia, Samara, Penza, Saratov, Ulyanovsk, and Orenburg Regions. In 17 % of cases, the variability of the SARS-CoV-2 virus was observed for one or more markers: in three samples, a new coronavirus of the B. 1.1.7 line (“British”) was detected; in a number of cases, only one mutation was detected in the virus found in samples – deletion Y144 or substitution D138Y, E484K, N501Y, and very rarely two mutations – deletion Y144 and substitution E484K. The presence of the L141-G142-V143 deletion localized in the recurrent deletion region RDR2 of the S-gene was shown in 10 % of the cases. The data obtained indicate the heterogeneity in macroorganism of the population of the new coronavirus with the deletion L141-G142-V143, which leads to a change in the antigenic structure of the virus, which probably allows the virus to evade the immune response.

Molecular Epidemiological Monitoring of Circulation of Coxsackievirus A10

2021 ◽  
pp. 43-49
Author(s):  
LN Golitsyna ◽  
VV Zverev ◽  
NV Ponomareva ◽  
NI Romanenkova ◽  
Thao Thanh Thi Nguyen ◽  
...  
Keyword(s):  
Russian Federation ◽  
Molecular Genetic ◽  
Clinical Manifestations ◽  
Foot And Mouth Disease ◽  
Sewage Water ◽  
Epidemiological Surveillance ◽  
Molecular Monitoring ◽  
South Vietnam ◽  
Epidemiological Monitoring ◽  
The Russian Federation

Background: Coxsackievirus A10 (CV-A10) is currently one of the most common etiological agents of enterovirus infection (EVI). Over the past decade, severe and fatal cases of CV-A10 infection have become more frequent while clinical manifestations of the disease are similar to those of Enterovirus A71 infection. The objective of our study was to characterize circulation of Coxsackievirus A10 in the Russian Federation in 2008–2019 and to study the phylogenetic relationships of strains isolated in Russia and Vietnam. Materials and methods: In 2008–2019, 220 CV-A10 strains were isolated from patients with various clinical manifestations of EVI and from sewage water samples taken in the Russian Federation and then studied using molecular genetic methods. In addition to that, we analyzed 26 CV-A10 strains isolated from patients with hand, foot, and mouth disease (HFMD) and acute flaccid paralysis in South Vietnam in 2018–2019. Results: We established a two-year periodicity of CV-A10 active circulation in Russia. In the structure of clinical forms of CV-A10 infection, herpetic angina prevailed (30.8 %), followed by minor illness (25.25 %), respiratory diseases (15.66 %), exanthema (14.65 %), gastrointestinal disorders (8.08 %), and asymptomatic infections (2.02 %). Symptoms of CNS damage (meningitis, meningoencephalitis) were observed in 3.53 % of cases. Most CV-A10 strains from Vietnam were isolated from patients with CNS affection of varying degrees of severity. During the study period, CV-A10 strains of genotypes C, E, and F3 circulated in the territory of the Russian Federation whereas the strains from South Vietnam were represented by genotypes F3 and F1. The studied strains showed a genetic relationship with those of CV-A10 circulating in different countries. Vietnamese and some Russian strains of the F3 genotype were genetically close to the strains isolated from severe cases. Conclusions: Molecular monitoring of CV-A10 circulation is an important component of the global epidemiological surveillance of EVI.

scholarly journals The prevalence of arterial hypertension as a risk factor of cardiovascular diseases in one of the cities in Siberian Federal District

2013 ◽  
Vol 10 (4) ◽  
pp. 30-37
Author(s):  
I E Chazova ◽  
I A Trubacheva ◽  
Yu V Zhernakova ◽  
E V Oshchepkova ◽  
V N Serebriakova ◽  
...  
Keyword(s):  
Arterial Hypertension ◽  
Russian Federation ◽  
Vascular Diseases ◽  
Federal District ◽  
Siberian Federal District ◽  
Hypertension Prevention ◽  
Population Strategy ◽  
The Russian Federation ◽  
Cardio Vascular ◽  
Epidemiological Situation

The present article analizes the prevalence of arterial hypertension, features of distribution of the various BP levels, efficiency of its medicamental control in the adult unorganized population of 25–64 years old of the Western Siberian city during one-stage epidemiological research carried out within the framework of the ESSAY Russian Federation-2012 (Epidemiology of Cardio Vascular diseases in regions of the Russian Federation). The unfavorable epidemiological situation was established concerning arterial hypertension in the surveyed population. The received results prove expediency of population strategy of arterial hypertension prevention in the studied group of the population.

scholarly journals MIGRATION AND INVESTMENT ACTIVITY IN THE REGIONS OF THE SIBERIAN FEDERAL DISTRICT OF THE RUSSIAN FEDERATION

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Kseniya PARFENOVA ◽  
Olga GUROVA
Keyword(s):  
Economic Development ◽  
Russian Federation ◽  
Federal District ◽  
Activity Level ◽  
Siberian Federal District ◽  
Investment Activity ◽  
Irkutsk Region ◽  
Social And Economic Development ◽  
Visual Reference ◽  
The Russian Federation

This article analyses the migration and investment activity processes in constituent entities of the Russian Federation located in the Siberian Federal District (SFD). The research was performed on the basis of official statistical data with geographical visual reference. The study was performed in the mono-specialized cities of SFD regions on the basis of official statistics within the context of the creation of Priority Social and Economic Development Areas (PSEDA). A negative migration balance is registered in SFD regions and mono-specialized settlements. Investment activity in SFD territories, their regional potentials and risks were analyzed. Krasnoyarsk Territory, Tomsk Region, Irkutsk Region, Novosibirsk Region, and Kemerovo Region stand out among the SFD regions by their investment activity level and social and economic development. At the current stage of social and economic development, Priority Social and Economic Development Areas can be successfully created in the regions which are the most developed both industrially and innovatively and in the mono-specialized settlements with the most favorable start conditions.

scholarly journals Priority social and economic development areas as an economic development tool for the Siberian mono-settlements

2022 ◽  
Vol 962 (1) ◽  
pp. 012015
Author(s):  
O Gurova
Keyword(s):  
Economic Development ◽  
Russian Federation ◽  
Baikal Region ◽  
Federal District ◽  
Siberian Federal District ◽  
Development Tool ◽  
Social And Economic Development ◽  
The Russian Federation ◽  
The City

Abstract The article is discussing the Priority Social and Economic Development Areas (PSEDAs) which are formed in the Siberian part of the Russian Federation (Siberian Federal District and the Baikal region). One of the goals for the PSEDAs formation is the diversification of mono-specialized towns and the reduction of their reliance on the city-forming enterprises. A typology of mono-settlements was carried out and the areas of activity that receive support within the framework of this mechanism in Siberia were presented.

Mapping nature management risk in the Russian Federation Districts

2020 ◽  
Vol 963 (9) ◽  
pp. 14-29
Author(s):  
S.B. Kuzmin ◽  
D.A. Lopatkin
Keyword(s):  
Environmental Management ◽  
Natural Disasters ◽  
Russian Federation ◽  
Federal District ◽  
Comprehensive Analysis ◽  
Nature Management ◽  
Siberian Federal District ◽  
Psychological Indicators ◽  
The Will ◽  
The Russian Federation

The authors present a method of assessing the risk of nature management and its mapping in the Russian Federation constituent entities and those of the Siberian Federal District. The assessments were carried out for a comprehensive analysis of the Russian Federation Districts as a single administrative-territorial entity according to their own established factors of environmentally dangerous processes and the parameters of protection against natural disasters. The risk of nature management equally depends on both the type of the danger and the protection against natural disasters, in other words – on both the natural and socio-economic situation in the Russian Federation Districts. In many cases, the indicator of protection against natural disasters plays even a leading part, since its assessment includes current socio-economic characteristics that determine the real ability of management structures to predict and deal with the consequences of natural disasters, as well as psychological indicators, i.e. the will and sequence of the managers’ actions in making specific resolutions on environmental management under risky conditions.

scholarly journals Medical care for children with cancer in the Siberian Federal District

2019 ◽  
Vol 18 (1) ◽  
pp. 5-12
Author(s):  
M. Yu. Rykov
Keyword(s):  
Mortality Rate ◽  
Medical Care ◽  
Russian Federation ◽  
Federal District ◽  
Siberian Federal District ◽  
Children With Cancer ◽  
Aim Analysis ◽  
Incidence And Mortality ◽  
Hospital Beds ◽  
The Russian Federation

background. The analysis of the quality of medical care for children with cancer is based on statistical data. Evaluation of the results obtained is also the basis of the strategy for the development of medical care for this category of patients. aim: analysis of the main parameters characterizing medical care for children with cancer in the Siberian Federal District. material and methods. The reports for 2017 on the health protection of 11/12 (91.6 %) constituent entities of the Russian Federation belonging to the Siberian Federal District were analyzed (Irkutsk Region did not provide data). results. In 2017 the number of children aged 0–17 years was 3 722 470, the number of pediatric hospital beds for children with cancer (ages 0–17 years) was 260 (0,7 per 10,000), and the average number of bed-days per year was 342.2. In 3 (25 %) constituent entities of the Russian Federation, there were no departments of pediatric oncology and in 1 (8,3 %) there were no hospital beds for children with cancer. The number of physicians, who specialized in children’s cancer was 49, of them 32 (65,3 %, 0,08 per 10,000, ages 0–17 years) had a certificate of a pediatric oncologist. In 1 (8,3 %) constituent entity of the Russian Federation, there were no pediatric oncologists. For children aged 0–17 years, the cancer incidence rate was 11.7 per 100,000 children, the cancer mortality rate was 2,2 per 100,000, and one-year mortality rate was 7,4 %. 188 (43,2 %) primary cancer patients were referred to medical institutions of the Federal District, and 17 (3,9 %) primary patients left the territory of the Russian Federation. conclusion. The low incidence and mortality rates can be explained by the lost of reliable follow-up data. It is advisable to introduce electronic health record systems. For reliable estimation of hospital bed supply for children with cancer and percent of patients referred to medical centers for treatment, it is necessary to carry out a clinical audit. Deficiency of pediatric oncologists should be eliminated by reforming the training of medical personnel.

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