scholarly journals HUBUNGAN LINGKAR PINGGANG DENGAN PROFIL LIPID PADA PASIEN DIABETES MELITUS TIPE 2

e-CliniC ◽  
2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Mentari Simbar ◽  
Karel Pandelaki ◽  
M. C.P Wongkar
Keyword(s):  
Diabetes Mellitus ◽  
Waist Circumference ◽  
High Density Lipoprotein ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Cross Sectional ◽  
Diabetes Melitus

Abstract: Waist circumference is often used to evaluate abdominal fat mass. Waist circumference is correlated with abdominal mass and is a predictor of type 2 diabetes mellitus compared to BMI. Diabetes Mellitus Type 2 (T2DM) is more common in individuals with overweight and obesity. T2DM is not only occured due to carbohydrate metabolism disorder of lipid metabolism but also due to dyslipidemia. Dyslipidemia caused by substances called lipoprotein VLDL (Very Low Density Lipoprotein) or triglycerides, decreased HDL cholesterol (High Density Lipoprotein) and the formation of small dense LDL (Low Density Lipoprotein) which are atherogenic. This study aimed to determine the relationship of waist circumference with the lipid profile in T2DM patients Prof. R.D. Kandou Hospital Manado. This was a descriptive cross sectional analytic study. There were 53 respondents that met the inclusion criteria. This study was conducted for three months starting from September – November 2013 in the Endocrine Clinic. Conclusions: There was no significant correlation between waist circumference and total cholesterol, LDL, and triglycerides levels. However, there is a significant correlation between waist circumference and HDL levels.Keywords: Waist circumference, total cholesterol, HDL, LDL, Triglycerides, T2DMAbstrak: Lingkar pinggang sering digunakan sebagai penilai massa lemak abdominal, karena lingkar pinggang berkorelasi dengan massa lemak abdominal dan merupakan prediktor Diabetes Melitus Tipe 2 (DMT2) yang paling kuat dibandingkan dengan IMT. DMT2 lebih sering terjadi pada individu dengan berat badan lebih dan obesitas. Pada DMT2 bukan saja terjadi gangguan metabolisme karbohidrat melainkan juga terdapat metabolisme lipid, keadaan ini disebut dislipidemia. Dislipidemia terjadi akibat gangguan metabolisme lipoprotein yaitu Very Low Density Lipoprotein (VLDL), trigliserida, penurunan kolesterol High Density Lipoprotein (HDL), dan terbentuknya small dense Low Density Lipoprotein (LDL) yang bersifat aterogenik. Penelitian ini bertujuan untuk mengetahui hubungan lingkar pinggang dengan profil lipid pada pasien DMT2 di RSUP Prof. R.D. Kandou Manado. Jenis penelitian ini ialah deskriptif analitik dengan pendekatan cross sectional. Responden penelitian sebanyak 53 pasien yang memenuhi kriteria inklusi. Penelitian ini dilakukan selama tiga bulan yaitu dari bulan September – November 2013 di Poliklinik Endokrin Bagian/SMF Ilmu Penyakit Dalam RSUP. Prof. R.D. Kandou Manado. Simpulan: Tidak terdapat hubungan yang bermakna antara lingkar pinggang dengan kadar kolesterol total, kadar LDL, dan trigliserida. Terdapat hubungan bermakna antara lingkar pinggang dan kadar HDL.Kata kunci: Lingkar Pinggang, Kolesterol Total, HDL, LDL, Trigliserida, DMT2

Non-HDL-Cholesterin

2020 ◽  
Vol 18 (06) ◽  
pp. 242-246
Author(s):  
Leonie Adam ◽  
Thomas Bobbert
Keyword(s):  
Diabetes Mellitus ◽  
High Density Lipoprotein ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Intermediate Density Lipoprotein ◽  
Intermediate Density ◽  
Niedriges Hdl ◽  
Ldl Cholesterin

ZUSAMMENFASSUNGDie diabetische Stoffwechsellage korreliert häufig mit einer Dyslipidämie, die sich typischerweise durch erhöhte Triglyzeride, niedriges HDL-Cholesterin und eine hohe Konzentration an small dense LDL-Cholesterin (LDL: low-density lipoprotein) auszeichnet. Zur kardiovaskulären Risikostratifizierung bei Diabetes mellitus Typ 2 eignet sich die Verwendung von Non-HDL-Cholesterin (HDL: high-density lipoprotein), um sämtliche potenziell atherogene Lipoproteine – VLDL (very-low-density lipoprotein), IDL (intermediate-density lipoprotein), LDL, Lipoprotein(a), Chylomikronen, Remnants – zu erfassen.

scholarly journals Dyslipidemia in Type 2 Diabetes mellitus

2017 ◽  
Vol 7 (2) ◽  
pp. 1149-1154 ◽  
Author(s):  
Subarna Dhoj Thapa ◽  
Shiva Raj K.C ◽  
Santosh Gautam ◽  
Deepika Gyawali
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
High Density Lipoprotein ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
Increased Risk

Background: In type 2 diabetes mellitus lipid abnormalities are very common and is associated with increased risk of cardiovascular diseases.  This study was conducted to find association of type 2 diabetes and dyslipidemia.Materials and Methods: This cross-sectional study was conducted at KISTMCTH. All the necessary data of patient with type 2 diabetes in the period between December 2016 and May 2017 were studied.Results: Out of 199 patients with diabetes mellitus 30.7% had total cholesterol >200 mg/dl, 64.4% had elevated low density lipoprotein, 53.77% patient had elevated triglyceride and 64% patients had low high density lipoprotein level. Cholesterol showed significant correlation with triglyceride (P < 0.001), low density lipoprotein (P < 0.001). Triglyceride showed a significant negative correlation with high density lipoprotein (P < 0.01), while a highly significant positive correlation was observed with cholesterol and high density lipoprotein (P < 0.001).Conclusion: Diabetes is associated with high incidence of dyslipidemia with elevated level of low density lipoprotein, cholesterol and triglyceride.

scholarly journals Hubungan Antara Tekanan Darah Sistolik Dengan Kadar Ldl (Low Density Lipoprotein) Padapasien Diabetes Melitus Tipe 2 Di Klinik Arafah, Lampung Tengah

2021 ◽  
Vol 1 (3) ◽  
pp. 134-141
Author(s):  
Avi Hurriyatus Sholihah ◽  
Firhat Esfandiari ◽  
Sandhy Arya Pratama ◽  
Resti Arania
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Systolic Blood Pressure ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Diabetes Melitus

ABSTRACT: RELATIONSHIP BETWEEN SYSTOLIC BLOOD PRESSURE WITH LDL (LOW DENSITY LIPOPROTEIN) IN DIABETES MELLITUS TYPE 2 PATIENTS IN ARAFAH CLINIC, CENTRAL LAMPUNG  Background: According to the 2017 World Health Organization (WHO), type 2 diabetes mellitus and hypertension ( HT) is a common disease among older adults aged> 60 years in developing and developed countries. One of the factors of hypertension is high levels of fat at high levels of fat, levels of LDL (Low Density Lipoprotein) are very influential and can lead to atherosclerosis that triggers hypertension. Of the 46 subjects, the frequency distribution of the sexes was male as many as 16 people (34.8%), female 30 people (65.2%). According to age <30 years as many as 2 people (4.3%), 30-50 years as many as 8 people (17.4%),> 50 years as many as 36 (78.3%). According to normal systolic blood pressure <140 mmHg as many as 34 people (73.9%), Height> 140 mmHg as many as 12 people (26.1%). And according to normal LDL levels <100 mg / dl as many as 8 people (17.4%), height> 100 mmHg as many as 38 people (2.6%). Objectives: to determine the relationship between systolic blood pressure and LDL (Low Density Lipoprotein) levels in patients with type 2 diabetes mellitus at the Arafah clinic, Central Lampung, 2020. Methods: This study used a cross sectional approach, namely by collecting data at the same time as one time. The data will be processed and analyzed with the help of a computer using the SPSS for Windows version 20.0 program. Results: Based on the Chi-Square analysis, it was found that there was no relationship with the value of p = 0.336 (p> 0.05). Conclusion: There is no relationship between systolic blood pressure and LDL (Low Density Lipoprotein) levels in patients with type 2 diabetes mellitus.                                                                                                 Keywords: Systolic blood pressure, LDL Levels, Diabetes Mellitus type 2.        INTISARI: HUBUNGAN ANTARA TEKANAN DARAH SISTOLIK DENGAN KADAR LDL (LOW DENSITY LIPOPROTEIN) PADA PASIEN DIABETES MELITUS TIPE 2 DI KLINIK ARAFAH, LAMPUNG TENGAH.Latar Belakang: Menurut World Health Organization tahun 2017 (WHO), diabetes melitus tipe 2 dan hipertensi (HT) adalah penyakit yang umum dikalangan orang dewasa tua berusia > 60 tahun di negara berkembang dan negara maju. Salah satu faktor hipertensi ialah tingginya kadar lemak pada tingginya kadar lemak, kadar LDL (Low Density Lipoprotein) sangat berpengaruh dan dapat mengakibatkan sebuah aterosklerosis pemacu hipertensi. Dari 46 subjek didapatkan distribusi frekuensi jenis kelaminnya laki laki sebanyak 16 orang (34,8%), perempuan 30 orang (65,2%). Menurut umurnya <30 tahun sebanyak 2 orang (4,3%), 30 – 50 tahun sebanyak 8 orang (17,4%), >50 tahun sebanyak 36 (78,3%). Menurut Tekanan darah sistoliknya Normal <140 mmHg sebanyak 34 orang (73,9%), Tinggi >140 mmHg sebanyak 12 orang (26,1%). Dan Menurut Kadar LDLnya normal <100 mg/dl sebanyak 8 orang (17,4%), tinggi >100 mmHg sebanyak 38 orang (2,6%).Tujuan: untuk mengetahui hubunganan antara tekanan darah sistolik dengan kadar LDL (Low Density Lipoprotein) pada pasien diabetes melitus tipe 2 di klinik Arafah, Lampung tengah tahun 2020.Metode: Penelitian ini menggunakan pendekatan cross sectional, yaitu dengan cara pengumpulan data sekaligus pada satu waktu. Data akan diolah dan dianalisa dengan bantuan komputer dengan menggunakan program SPSS for Windows versi 20,0.Hasil: Berdasarkan analisa Chi-Square didapatkan tidak adanya hubungan dengan nilai nilai p =0,336 (p>0,05).Kesimpulan: Tidak terdapat hubungan antara tekanan darah sistolik dengan kadar LDL (Low Density Lipoprotein) pada pasien diabetes melitus tipe 2. Kata Kunci : Tekanan darah sistolik, Kadar LDL, Diabetes Melitus tipe 2.

Studies on the Thromboplastic Effect of Human Plasma Lipoproteins

1976 ◽  
Vol 35 (01) ◽  
pp. 178-185 ◽  
Author(s):  
Helena Sandberg ◽  
Lars-Olov Andersson
Keyword(s):  
High Density Lipoprotein ◽  
Human Plasma ◽  
Platelet Rich Plasma ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Plasma Lipoproteins ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Free Plasma ◽  
Good Agreement

SummaryHuman plasma lipoprotein fractions were prepared by flotation in the ultracentrifuge. Addition of these fractions to platelet-rich, platelet-poor and platelet-free plasma affected the partial thromboplastin and Stypven clotting times to various degrees. Addition of high density lipoprotein (HDL) to platelet-poor and platelet-free plasma shortened both the partial thromboplastin and the Stypven time, whereas addition of low density lipoprotein and very low density lipoprotein (LDL + VLDL) fractions only shortened the Stypven time. The additions had little or no effect in platelet-rich plasma.Experiments involving the addition of anti-HDL antibodies to plasmas with different platelet contents and measuring of clotting times produced results that were in good agreement with those noted when lipoprotein was added. The relation between structure and the clot-promoting activity of various phospholipid components is discussed.

scholarly journals Impact of Adoption of Directly Measured Low-Density Lipoprotein-Cholesterol (LDL-C) on Targets of Lipid Control and Its Comparison With Friedewald Formula-Calculated LDL Cholesterol in People With Type-2 Diabetes Mellitus

2020 ◽  
pp. 263246362097804
Author(s):  
Rejitha Jagesh ◽  
Mathew John ◽  
Manju Manoharan Nair Jalaja ◽  
Tittu Oommen ◽  
Deepa Gopinath
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Atherosclerotic Cardiovascular Disease ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Friedewald Formula

Objectives: The accurate and precise measurement of low-density lipoprotein-cholesterol (LDL-C) is important in the assessment of atherosclerotic cardiovascular disease risk (ASCVD) in people with diabetes mellitus. This study aimed at comparing directly measured LDL-C with Friedewald formula (FF)-calculated LDL-C (c-LDL-C) in people with type-2 diabetes. Methods: Fasting lipid profiles of 1905 people with type-2 diabetes, whose LDL-C was estimated by direct LDL assay, were chosen for the study. In the same group, LDL-C was calculated with FF. Correlation and agreement between these methods were analyzed at various strata of triglycerides (TGs). The possibility of misclassifying people at various levels of LDL-C targets proposed in literature was calculated. Results: The mean LDL-C levels were lower in the c-LDL-C group across various TG strata. A significant correlation was found between c-LDL-C and direct LDL-C for all the study samples ( r = 0.948, P < .001) and across all TG strata. Analysis of agreement showed a positive bias for direct LDL-C which increased at higher strata of TGs. c-LDL-C underestimated ASCVD by misclassifying people at various LDL-C target levels. Conclusion: There is a difference between direct LDL-C and c-LDL-C values in people with diabetes and this may result in misclassifying ASCVD especially at lower levels of LDL-C and higher levels of TGs.

scholarly journals Correlation of Serum Low Density Lipoprotein Cholesterol and High Density Lipoprotein Cholesterol with Type 2 Diabetes Mellitus

2018 ◽  
Vol 26 (2) ◽  
pp. 140-147
Author(s):  
Nahid Yeasmin ◽  
Qazi Shamima Akhter ◽  
Sayeeda Mahmuda ◽  
Sultana Yeasmin ◽  
Rumana Afroz ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Fasting Serum ◽  
Medical College

Background: Diabetes mellitus is one of the most widespread endocrine disorders in female and its complications are increasing all over the world, leading to life threatening medical problems like cardiovascular diseases, stroke and end stage renal diseases. A correlation between hyperlipidemia and type 2 diabetes mellitus has been identified. The study was carried out to observe the correlation of serum low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) level with type 2 diabetes mellitus in adult female subjects.Method: This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka, during the period of January 2011 to December 2011. Total sixty female subjects were selected with age ranging from 30 to 50 years. Among them 30 female subjects with diabetes mellitus were included from out-patient department of Endocrinology, Dhaka Medical College Hospital, Dhaka as study group (B) and 30 apparently healthy females were taken as control group (A) for comparison. Estimation of serum fasting serum LDL-C and HDL-C levels was done by enzymatic method in the department of Physiology, Dhaka Medical College Dhaka in both groups. Fasting serum insulin level was measured by ELISA method in the laboratory of National Institute of ENT, Dhaka and fasting blood glucose was estimated by glucose oxidase method in the department of Physiology, Dhaka Medical College in both groups. Data were analyzed by Unpaired Student’s- test and Pearson’s correlation co-efficient (r) test as applicable.Results: The value of fasting serum LDL-C level was significantly higher in study subjects than those of control. Again, fasting serum HDL-C level was significantly lower in study subjects in comparison to controls. In study subjects fasting serum LDL showed positive correlation and fasting serum HDL-C levels showed negative correlation with fasting blood glucose and serum insulin level.Conclusion: Present study reveals that serum insulin and blood glucose level have positive relationship with low density lipoprotein cholesterol (LDL-C) and negative relationship with high density lipoprotein cholesterol (HDL-C) levels.J Dhaka Medical College, Vol. 26, No.2, October, 2017, Page 140-147

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