scholarly journals DEDIFFERENTIATED LIPOSARCOMA PAYUDARA (LAPORAN KASUS)

2013 ◽  
Vol 3 (3) ◽  
Author(s):  
Poppy M. Lintong ◽  
Eddy H. Tambajong
Keyword(s):  
Lymph Nodes ◽  
Alcian Blue ◽  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Histopathological Examination ◽  
Breast Tumors ◽  
The Body ◽  
Dedifferentiated Liposarcoma ◽  
Cystosarcoma Phyllodes ◽  
Tumor Tissues

Abstrak: Liposarkoma primer pada payudara termasuk salah satu tumor payudara yang sa-ngat jarang, insidennya kurang dari 1% dari semua tumor ganas payudara. Umumnya liposarkoma pada payudara jarang atau tidak menyebar ke kelenjar getah bening aksila. Gambaran histologik liposarkoma pada payudara sama dengan liposarkoma di ekstrimitas atau tubuh. Suatu liposarkoma yang sejati pada payudara ditegakkan bilamana gambaran cystosarcoma phyllodes tidak ditemukan dalam potongan-potongan  jaringan tumor. Satu kasus dilaporkan pada seorang wanita usia 49 tahun dengan tumor payudara besar. Gambaran Dedifferentiated Liposarcoma secara makroskopik menunjukkan massa multinoduler besar, warnanya bervariasi dari kuning, kuning kecoklatan bercampur coklat keabu-abuan. Mikroskopik terdiri dari 2 komponen yaitu lipogenik, menunjukkan gambaran  liposarkoma diferensiasi baik; dan nonlipogenik (dedifferentiated). Daerah dedifferentiated menunjukkan gambaran fibrosarkoma, malignant fibrous histiocytoma, dan liposarkoma miksoid. Daerah yang menyerupai malignant fibrous histiocytoma menunjukkan gambaran sitologik pleo-morfisme, arsitektur storiform, dan sel-sel datia. Fokus-fokus  liposarkoma miksoid telah dibuat pulasan dengan Alcian blue hasilnya positip. Kata kunci: dedifferentiated liposarcoma,  payudara.     Abstract: Primary liposarcoma of the breast belongs to very rarely found breast tumors, hav-ing an incidence of less than 1% of all malignant breast tumors. In general, this liposarcoma rarely or does not spread to axillar lymph nodes. Histopathologically, liposarcoma of the breast is similar to liposarcoma in extremities and other parts of the body. A true liposarcoma of the breast is diagnosed if there is no cystosarcoma phyllodes in the tumor tissues. We re-ported a 49-year-old female with a huge breast tumor (21x18x15cm), associated  with four lymph nodes in the ipsilateral axilla.  Histopathological examination of the tumor tissues showed a dedifferentiated liposarcoma, and of the four lymph nodes, as well as reactive hyperplasia with no metastase. Macroscopically, this dedifferentiated liposarcoma, appeared as large multinodular masses ranging in color from yellow to yellow-tan admixed with firm tan-gray areas. Microscopically, it consisted of two components: lipogenic, a well differen-tiated liposarcoma; and nonlipogenic, dedifferentiated one. These dedifferentiated areas showed a fibrosarcoma, malignant fibrous histiocytoma, and mixoid liposarcoma. Areas of malignant fibrous histiocytoma looked  cytologic pleomorphisme, storiform architecture, and multinucleate cells. Foci of mixoid liposarcoma were stained with Alcian blue, and showed positive results. Key words: dedifferentiated liposarcoma, breast.

scholarly journals Histopathological Evaluation of Lymph Node Biopsies: A Hospital Based Study

2012 ◽  
Vol 2 (1) ◽  
pp. 8-14
Author(s):  
Md Atiqur Rahman ◽  
Md Mamun Ali Biswas ◽  
Syeda Tasfia Siddika ◽  
Abdul Mannan Sikder
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Hodgkin Lymphoma ◽  
Histopathological Examination ◽  
Age Groups ◽  
The Body ◽  
Cross Sectional ◽  
Cervical Lymph Nodes ◽  
Female Ratio ◽  
Histopathological Evaluation

Background: Lymphadenopathy is a common manifestation of a large variety of disorders,both benign and malignant. It is essential to define the pattern of disorders presenting primarily as lymph node enlargement in a particular environment. Histopathological examination of the lymph node biopsies is a gold standard test in the distinction between reactive and malignant lymphoid proliferations as well as for detailed subtyping oflymphomas. We designed this study in our population for histopathological evaluation of lymph nodes that might be helpful for clinical management of these lesions. Objective: Histopathological evaluation of lymphadenopathy from excised specimen, in relation to ageand sex of the patients, and distribution of the lymph nodes. Materials and Methods: It was a retrospective cross sectional study conducted in the department of Pathology, Enam MedicalCollege & Hospital, Savar, Dhaka during the period from January 2006 to December 2010. Lymph node biopsies of all patients of both sexes and all age groups were included.Metastatic lymph nodes associated with evidence of primaries elsewhere in the body were excluded from the study. Total 191 lymph node biopsies were selected for histopathological evaluation. Among these 90 (47.12%) were from males and 101 (52.88%) were from females with male to female ratio being 1:2.1. The age of the patients ranged from 2 to 85 years with a mean age of 35.73 ± 18 years. Results: Cervical lymph nodes were the most common (56%) biopsied group. Of the 191 cases 59 cases (30.89%) were reactive lymphadenitis, 64 cases (33.5%) were tuberculosis, 2 cases (1.05%) were non-caseous granuloma, 11 cases (5.76%) were Hodgkin lymphoma, 22 cases (11.52%) were non-Hodgkin lymphoma, 24 cases (12.57%) were metastatic neoplasm and 9 cases (4.7%) were other lesions.Conclusion: Tuberculosis was the most common cause of lymphadenopathy, followed by reactive lymphadenitis and the cervical group of lymph nodes was most frequently affected. DOI: http://dx.doi.org/10.3329/jemc.v2i1.11915 J Enam Med Col 2012; 2(1):8 -14

scholarly journals Case for diagnosis

2012 ◽  
Vol 87 (4) ◽  
pp. 647-648
Author(s):  
Mariana Hammerschmidt ◽  
Luciana Menezes de Azevedo ◽  
Anelisa Ruaro ◽  
Betina Werner ◽  
Alexandre do Nascimento ◽  
...  
Keyword(s):  
Elderly People ◽  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Skin Tumors ◽  
The Body ◽  
Neoplastic Cells ◽  
Atypical Fibroxanthoma ◽  
Cutaneous Tumor

Atypical fibroxanthoma is a rare cutaneous tumor found mainly in elderly people on sun-exposed areas of the body. Histologically, atypical fibroxanthoma is considered a malignant fibrous histiocytoma with bizarre neoplastic cells, marked pleomorphism, hyperchromatic nuclei and abundant mitoses. It must be differentiated from other skin tumors, usually by immunohistochemistry, since its diagnosis is made by exclusion.

Malignant Fibrous Histiocytoma of The Larynx

1979 ◽  
Vol 87 (5) ◽  
pp. 599-603 ◽  
Author(s):  
Joseph P. Keenan ◽  
G. Gordon Snyder ◽  
James M. Toomey
Keyword(s):  
Lymph Nodes ◽  
Local Excision ◽  
Malignant Fibrous Histiocytoma ◽  
Wide Local Excision ◽  
Normal Tissue ◽  
Fibrous Histiocytoma ◽  
Mesenchymal Tumor ◽  
Clinical Behavior ◽  
Regional Block ◽  
Degree Of Malignancy

Fibrous histiocytoma is a rare mesenchymal tumor. The origin is believed to be a pleuripotential cell, histiocytic in type, which can evolve into a facultative fibroblast under certain conditions. A case of a malignant fibrous histiocytoma in the subglottic larynx is reported. At present, the clinical behavior and degree of malignancy cannot be predicted. It appears that wide, local excision of the tumor with a margin of normal tissue is the treatment of choice. Regional block dissection of lymph nodes is not indicated unless clinically palpable nodes are present.

IgG4-related Lung Disease With Recurrent Pulmonary Lesions During Steroid Therapy and Difficulty in Differentiating From Malignancy: Case Report and Literature Review

2021 ◽  
Author(s):  
Tomohito Okubo ◽  
Nariyasu Nakashima ◽  
Yoshimasa Tokunaga ◽  
Nobuyuki Kita ◽  
Hiroyuki Nakamura ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Lung Disease ◽  
Steroid Therapy ◽  
Histopathological Examination ◽  
Lung Resection ◽  
The Body ◽  
Maximum Diameter ◽  
Mediastinal Lymph Nodes ◽  
Pulmonary Lesions ◽  
Partial Lung Resection

Abstract Background: Immunoglobulin G4-related disease (IgG4-RD) is characterized by the formation of inflammatory lesions with fibrosis and infiltration of IgG4-positive plasma cells and lymphocytes in various organs of the body. Since the first report of IgG4-related autoimmune pancreatitis, IgG4-RD affecting various organs has been reported; however, there are still only a few reports of IgG4-related lung disease (IgG4-RLD). In this report, we describe a case of IgG4-RLD with recurrent pulmonary lesions during steroid therapy that were difficult to differentiate from malignancy.Case presentation: A 61-year-old man was referred to our hospital after an abnormal chest shadow on X-ray was noted during his visit to his previous doctor for asthma treatment. Chest computed tomography (CT) revealed a middle lobe hilar mass with irregular margins and swelling of the right hilar and mediastinal lymph nodes. 18F-fluorodeoxyglucose-positron emission tomography revealed a mass lesion with a maximum diameter of 5.5 cm, maximum standardized uptake value (SUVmax) of 11.0, and areas with high SUV in the hilar and mediastinal lymph nodes. We suspected lung cancer or malignant lymphoma and performed a thoracoscopic lung biopsy to confirm the diagnosis. A total of five tumor sites and an enlarged lymph node (LN#10) were biopsied; histopathological examination revealed no malignant findings, and IgG4-RLD was diagnosed. One month after treatment with prednisolone (PSL), the tumor had shrunk, but a CT scan during the third month of PSL treatment revealed multiple nodular shadows in both lungs. Considering the possibility of malignant complications and multiple lung metastases, we performed thoracoscopic partial lung resection of the new left lung nodules to determine the treatment strategy. Histopathological examination revealed no malignant findings in any of the lesions, and the patient was diagnosed with IgG4-RLD refractory to PSL monotherapy. We are considering the combination of azathioprine and PSL as future treatment.Conclusions: IgG4-RLD refractory to PSL monotherapy showed changes from a solitary large mass (pseudotumor) to multiple nodules on chest CT. It was difficult to distinguish malignancy from IgG4-RLD based on imaging tests and blood samples alone, and performing thoracoscopic lung biopsies and partial lung resection were useful in determining the diagnosis and treatment plan.

scholarly journals Primary Malignant Fibrous Histiocytoma of Proximal Humerus with Pathological Fracture- Case Report

2021 ◽  
pp. 148-153
Author(s):  
Malkesh D. Shah ◽  
Ajinkya Arun Naik ◽  
Sai Sabharish Reddy ◽  
Sarvang M. Desai
Keyword(s):  
Malignant Fibrous Histiocytoma ◽  
Pathological Fracture ◽  
Mononuclear Cells ◽  
Proximal Humerus ◽  
Fibrous Histiocytoma ◽  
Histopathological Examination ◽  
Giant Cells ◽  
Left Shoulder ◽  
Intralesional Curettage ◽  
Operative Specimen

Malignant fibrous histiocytoma (MFH) is a tumor of late adulthood that occurs in men more commonly than women. Proximal humerus involvement in PMFH is comparatively rare. A 45 year old female presented with complain of pain and mild swelling over the left shoulder with restricted range of movement since 15 days. Radiography of the affected part was suggestive of an osteolytic eccentric lesion with a pathological fracture. A trucut needle biopsy showed minimal tumour tissue with abundant necrosis and showed giant cells with pleomorphic mononuclear cells. So intralesional curettage followed by osteosynthesis with PHILLOS plating and bone cementing was done. Intra operative specimen sent for histopathological examination showed presence of fibroblast cells arranged in storiform pattern s/o MFH along with occasional multinucleated giant cells. Postoperatively patient was started with adjuvant chemotherapy. Patient had good results functionally and clinically with no signs of recurrence till follow up of 1.5 years.

scholarly journals Some epidemiological characteristics of malignant fibrous histiocytoma in the Province of Vojvodina

2005 ◽  
Vol 13 (1) ◽  
pp. 16-17 ◽  
Author(s):  
Borislava Nikolin ◽  
Tihomir Dugandzija ◽  
Svetlana Salma ◽  
Jasna Trifunovic ◽  
Dragana Vojnovic
Keyword(s):  
Incidence Rate ◽  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Adult Life ◽  
The Body ◽  
Lower Limbs ◽  
Deep Fascia ◽  
Surgical Removal ◽  
Incidence And Mortality ◽  
Epidemiological Characteristics

BACKGROUND: Malignant fibrous histiocytoma is most common soft tissue sarcoma occurring in late adult life, most in the extremities and in the retroperitoneum, usually developing in deep fascia or skeletal muscle. Because of the aggressive nature of the tumor early and complete surgical removal is indicated. The overall survival rate of patients with malignant fibrous histiocytoma ranges from 36% to 58% at 5 years. Malignant fibrous histiocytoma in Vojvodina is still rare malignancy either in incidence or in mortality in both sexes. The population of Vojvodina is about 2 100 000. METHODS: We used a descriptive epidemiological method to analyze incidence and mortality from malignant fibrous histiocytoma in Vojvodina. This study is based on the Cancer Registry data for the ten-year period from 1993 to 2002. RESULTS: During the observed period 37 cases of malignant fibrous histiocytoma were reported (19 men and 18 women). The average age of patients was 50 years. The body site distribution differed between sexes and malignant fibrous histiocytoma was more common on the trunk (retroperitoneum) in men and on the lower limbs in women. The average annual incidence rate for the observed period was 1.82 per 1 000 000 for both sexes. The incidence rate changed irregularly over the observed period with the peak of 9 cases (4.55 per 1 000 000) in 2001. The overall linear trends of incidence and of mortality showed a slight increasing tendency in both sexes, but not significantly. Concerning mortality, the similar patterns were noticed. The mortality rate was 0.83 per 1 000 000. CONCLUSION: According to epidemiological data we obtained it can be concluded that Province of Vojvodina is not a region with an important risk for malignant fibrous histiocytoma; however, the increase of incidence appearing in both men and women should be taken into account very seriously in future.

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