scholarly journals Primary Malignant Fibrous Histiocytoma of Proximal Humerus with Pathological Fracture- Case Report

2021 ◽  
pp. 148-153
Author(s):  
Malkesh D. Shah ◽  
Ajinkya Arun Naik ◽  
Sai Sabharish Reddy ◽  
Sarvang M. Desai
Keyword(s):  
Malignant Fibrous Histiocytoma ◽  
Pathological Fracture ◽  
Mononuclear Cells ◽  
Proximal Humerus ◽  
Fibrous Histiocytoma ◽  
Histopathological Examination ◽  
Giant Cells ◽  
Left Shoulder ◽  
Intralesional Curettage ◽  
Operative Specimen

Malignant fibrous histiocytoma (MFH) is a tumor of late adulthood that occurs in men more commonly than women. Proximal humerus involvement in PMFH is comparatively rare. A 45 year old female presented with complain of pain and mild swelling over the left shoulder with restricted range of movement since 15 days. Radiography of the affected part was suggestive of an osteolytic eccentric lesion with a pathological fracture. A trucut needle biopsy showed minimal tumour tissue with abundant necrosis and showed giant cells with pleomorphic mononuclear cells. So intralesional curettage followed by osteosynthesis with PHILLOS plating and bone cementing was done. Intra operative specimen sent for histopathological examination showed presence of fibroblast cells arranged in storiform pattern s/o MFH along with occasional multinucleated giant cells. Postoperatively patient was started with adjuvant chemotherapy. Patient had good results functionally and clinically with no signs of recurrence till follow up of 1.5 years.

scholarly journals Ultrastructure of a Feline Extraskeletal Giant Cell Tumor (Malignant Fibrous Histiocytoma)

1981 ◽  
Vol 18 (6) ◽  
pp. 738-744 ◽  
Author(s):  
A. W. Confer ◽  
F. M. Enright ◽  
G. B. Beard
Keyword(s):  
Endoplasmic Reticulum ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Rough Endoplasmic Reticulum ◽  
Malignant Fibrous Histiocytoma ◽  
Mononuclear Cells ◽  
Fibrous Histiocytoma ◽  
Giant Cells ◽  
Cell Tumor ◽  
Multinucleated Giant Cells

A subcutaneous extraskeletal giant cell tumor (malignant fibrous histiocytoma) was excised repeatedly from a 9-year-old Domestic Shorthair cat. Ultrastructurally, the mass was composed of fibroblast-like, histiocyte-like, and multinucleated giant cells, and some undifferentiated cells and mononuclear cells intermediate between the fibroblast-like and histiocyte-like cells. Fibroblast-like cells were characterized by abundant well-developed rough endoplasmic reticulum, relatively smooth cytoplasmic membranes, few lysosomal structures, and finely granular chromatin. Histiocyte-like cells resembled immature macrophages. The cell membranes had many villous projections. Rough endoplasmic reticulum varied in quantity. Lysosomes were numerous. Multinucleated giant cells had characteristics of both the fibroblast-like and histiocyte-like cells. No viral particles were seen.

scholarly journals DEDIFFERENTIATED LIPOSARCOMA PAYUDARA (LAPORAN KASUS)

2013 ◽  
Vol 3 (3) ◽  
Author(s):  
Poppy M. Lintong ◽  
Eddy H. Tambajong
Keyword(s):  
Lymph Nodes ◽  
Alcian Blue ◽  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Histopathological Examination ◽  
Breast Tumors ◽  
The Body ◽  
Dedifferentiated Liposarcoma ◽  
Cystosarcoma Phyllodes ◽  
Tumor Tissues

Abstrak: Liposarkoma primer pada payudara termasuk salah satu tumor payudara yang sa-ngat jarang, insidennya kurang dari 1% dari semua tumor ganas payudara. Umumnya liposarkoma pada payudara jarang atau tidak menyebar ke kelenjar getah bening aksila. Gambaran histologik liposarkoma pada payudara sama dengan liposarkoma di ekstrimitas atau tubuh. Suatu liposarkoma yang sejati pada payudara ditegakkan bilamana gambaran cystosarcoma phyllodes tidak ditemukan dalam potongan-potongan  jaringan tumor. Satu kasus dilaporkan pada seorang wanita usia 49 tahun dengan tumor payudara besar. Gambaran Dedifferentiated Liposarcoma secara makroskopik menunjukkan massa multinoduler besar, warnanya bervariasi dari kuning, kuning kecoklatan bercampur coklat keabu-abuan. Mikroskopik terdiri dari 2 komponen yaitu lipogenik, menunjukkan gambaran  liposarkoma diferensiasi baik; dan nonlipogenik (dedifferentiated). Daerah dedifferentiated menunjukkan gambaran fibrosarkoma, malignant fibrous histiocytoma, dan liposarkoma miksoid. Daerah yang menyerupai malignant fibrous histiocytoma menunjukkan gambaran sitologik pleo-morfisme, arsitektur storiform, dan sel-sel datia. Fokus-fokus  liposarkoma miksoid telah dibuat pulasan dengan Alcian blue hasilnya positip. Kata kunci: dedifferentiated liposarcoma,  payudara.     Abstract: Primary liposarcoma of the breast belongs to very rarely found breast tumors, hav-ing an incidence of less than 1% of all malignant breast tumors. In general, this liposarcoma rarely or does not spread to axillar lymph nodes. Histopathologically, liposarcoma of the breast is similar to liposarcoma in extremities and other parts of the body. A true liposarcoma of the breast is diagnosed if there is no cystosarcoma phyllodes in the tumor tissues. We re-ported a 49-year-old female with a huge breast tumor (21x18x15cm), associated  with four lymph nodes in the ipsilateral axilla.  Histopathological examination of the tumor tissues showed a dedifferentiated liposarcoma, and of the four lymph nodes, as well as reactive hyperplasia with no metastase. Macroscopically, this dedifferentiated liposarcoma, appeared as large multinodular masses ranging in color from yellow to yellow-tan admixed with firm tan-gray areas. Microscopically, it consisted of two components: lipogenic, a well differen-tiated liposarcoma; and nonlipogenic, dedifferentiated one. These dedifferentiated areas showed a fibrosarcoma, malignant fibrous histiocytoma, and mixoid liposarcoma. Areas of malignant fibrous histiocytoma looked  cytologic pleomorphisme, storiform architecture, and multinucleate cells. Foci of mixoid liposarcoma were stained with Alcian blue, and showed positive results. Key words: dedifferentiated liposarcoma, breast.

Benign Fibrous Histiocytoma: Report of Case

2003 ◽  
Vol 4 (2) ◽  
pp. 74-79 ◽  
Author(s):  
Ümit Ertaş ◽  
M. Cemil Büyükkurt ◽  
Yasin Çiçek
Keyword(s):  
Soft Tissue ◽  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Panoramic Radiograph ◽  
Giant Cells ◽  
Benign Fibrous Histiocytoma ◽  
Multinucleated Giant Cells ◽  
Caucasian Male ◽  
Storiform Pattern ◽  
Radiolucent Lesion

Abstract Benign fibrous histiocytoma is a rare and usually painless oral neoplasm found in adults that may affect either soft tissue or bone typically noted in their fifth decade. This case was found in a 32 year-old Caucasian male who presented with a fairly well circumscribed unilocular radiolucent lesion extending from the mandibular right first incisor to the left first premolar and reaching the inferior mandible on a panoramic radiograph. A bony window was created and the intrabony lesion was curetted. Multiple sections revealed a cellular tumor composed of uniform spindle-shaped cells arranged in a prominent whorled or storiform pattern. Scattered xanthoma cells, multinucleated giant cells, lymphocytes, and deposits of hemosiderin were noted throughout the lesional stroma. Although malignant fibrous histiocytoma of the bone is relatively well known, benign fibrous histiocytoma of the bone is very rare. Citation Ertas U, Büyükkurt MC. Benign Fibrous Histiocytoma: Report of Case. J Contemp Dent Pract 2003 May;(4)2:074-079.

Malignant fibrous histiocytoma of the meninges

1981 ◽  
Vol 55 (6) ◽  
pp. 957-962 ◽  
Author(s):  
Uma P. Kalyanaraman ◽  
John J. Taraska ◽  
Joshua A. Fierer ◽  
Patrick W. Elwood
Keyword(s):  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Giant Cells ◽  
Cell Of Origin ◽  
Left Frontal Lobe ◽  
Content Type ◽  
Undifferentiated Cells ◽  
The Central Nervous System ◽  
Meningeal Tumors ◽  
Fibroblastic Cells

✓ A case of malignant fibrous histiocytoma arising from the meninges in a 12-year-old boy is reported. This tumor presented as an extracerebral hemorrhagic mass in the left frontal lobe without obvious invasion of the underlying brain. Histologically, a malignant tumor with the characteristic storiform pattern of malignant fibrous histiocytoma with focal areas of hemorrhage was observed. Ultrastructurally, fibroblastic cells, undifferentiated cells, histiocytic-type cells, multinucleated tumor giant cells, and xanthomatous cells were distinctly seen. The possible cell of origin of these meningeal tumors and their prognosis are discussed. The significance of considering this entity in the differential diagnosis of those tumors of the central nervous system with a spindle-cell or xanthomatous component is discussed, and the value of ultrastructural and immunocytochemical study with glial fibrillary acidic protein in the diagnosis is stressed.

scholarly journals Plasma Cell Rich Osteomyelitis: A Rare Entity

2020 ◽  
Author(s):  
Prakhar Maheshwari ◽  
Rajesh Kumar Maheshwari ◽  
Anuradha Kusum ◽  
Digvijay Agarwal
Keyword(s):  
Clinical Features ◽  
Plasma Cell ◽  
Pathological Fracture ◽  
Plasma Cells ◽  
Histopathological Examination ◽  
Correct Diagnosis ◽  
Left Shoulder ◽  
Correct Treatment ◽  
Cortical Irregularity ◽  
Post Traumatic

Plasma cell rich osteomyelitis is a rare finding characterised by a plethora of plasma cells localised in the affected bone without the typical clinical features of infection. It usually affects the metaphysis of long bones with a radiological appearance as a dense thickening of bone without sequestrum formation. We present an atypical case of plasma cell osteomyelitis with a lesion in the metaphysis as well as the diaphysis of the humerus without sclerosis but with sequestrum formation. An 11-year-old girl was brought to OutPatient Department (OPD) with complaints of post-traumatic pain and swelling at left shoulder and proximal arm since one and a half months with aggravation of symptoms since last 10 days. Patient had also been treated for Urinary Tract Infection (UTI) by a paediatrician who prescribed antibiotics and antipyretics because of which fever subsided but the pain persisted. The x-ray of left shoulder with arm revealed a fracture of surgical neck of humerus with cortical irregularity noted in the mid-shaft of humerus along with lamellated periosteal reaction suggestive of post-traumatic osteomyelitis with a pathological fracture. Clinicoradiologic diagnosis of pathological fracture of left neck of humerus was made with an underlying neoplastic or infective aetiology. An open biopsy was taken from left proximal humerus. Histopathological examination showed plasma cells in sheets having abundant basophilic cytoplasm, round to eccentric nuclei and perinuclear hoff along with lymphocytes and few polymorphs with surrounding area showing fibrosis, oedema and hyperemia. A diagnosis of chronic plasma cell osteomyelitis was rendered, which is an uncommon condition without specific clinical findings and an ambigious cause. Histopathology is the definitive tool for obtaining an accurate diagnosis and we strongly recommend a meticulous histopathological examination correlated with clinico-radiological description for a correct diagnosis in order to avoid an increased frequency of diagnosis of neoplastic plasma cell lesion as well as for advocating the correct treatment. This case is discussed for presentation of plasma cell osteomyelitis and also to report a case of chronic primary plasma cell rich osteomyelitis with atypical clinical features.

scholarly journals Gaint cell tumour of phalynx: have you seen it?

2020 ◽  
Vol 8 (6) ◽  
pp. 2309
Author(s):  
Nuthan Jagadeesh ◽  
Sachin H. G. ◽  
Vishwanath M. S. ◽  
Arjun Mandri
Keyword(s):  
Giant Cell ◽  
Mononuclear Cells ◽  
Histopathological Examination ◽  
Giant Cells ◽  
Pain Scale ◽  
Giant Cell Tumors ◽  
Foot Function Index ◽  
Function Index ◽  
Foot Function ◽  
Scale 8

Giant cell tumors are rarely seen in the foot. Only 1-2% cases of GCT occur in the foot. They can cause a significant amount of pain and deformity due to their aggressive and recurrent nature whenever it occurs in foot. We present an unusual case of a giant cell tumor of proximal phalynx of middle toe of left foot. 26 year old male came with complaints of pain and swelling over the middle toe of left foot since 6 months. Clinical and radiological features showed features consistent with GCT. Foot Function Index revealed a) Pain scale: 29 / 50 = 58%, b) Disability scale: 56 / 90 = 62%, c) Activity limitation scale: 8 / 30 = 27%. Authors performed enbloc resection with ray amputation of 3rd toe. Histopathological examination of excised specimen revealed classic findings of mononuclear cells with interspersed fibro-collagenous strands and numerous multinucleated osteoclast-like giant cells which confirmed our diagnosis. Patient was serially followed up and at 6 months followup, there were no signs of recurrence with markedly improved foot function index.

scholarly journals Intramedullary Nailing for Pathological Fractures of the Proximal Humerus Caused by Multiple Myeloma: A Case Report and Literature Review

2021 ◽  
Author(s):  
guoqiang xu ◽  
gang wang ◽  
xiaodong bai ◽  
zhenyu liu ◽  
xinjia wang ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Proximal Humeral Fracture ◽  
Pathological Fracture ◽  
Proximal Humerus ◽  
Combined Treatment ◽  
Bone Destruction ◽  
Humeral Fracture ◽  
Whole Body ◽  
Left Shoulder ◽  
Im Nailing

Abstract Background: Multiple myeloma bone disease(MMBD) is indicative of multiple myeloma (MM), and it will reduce patient life quality. In addition to oncological, antineoplastic systemic therapy, surgical therapy in patients with MM represents an essential treatment pillar within the framework of supportive therapy measures and is the task of orthopedic tumor surgery. Nevertheless, there are few reports about applying intramedullary (IM) nailing in treating MM-induced proximal humeral fracture to prevent fixation loss. This paper aims to describe a case of pathological fracture of the proximal humerus caused by multiple myeloma effectively treated with IM nailing without removal of tumors and review the current literature.Case presentation: This study reported a 64-year-old male patient complaining of serious left shoulder pain and limited movement. X-ray films showed left proximal humeral fracture accompanying with osteoporosis and bone destruction. During the preoperative examinations, tumor markers, whole-body bone imaging and bone marrow biopsy were performed. The patient was finally diagnosed with multiple myeloma (IgAλ, IIIA/II). After the treatment of pathological fracture with IM nailing, the patient's function recovered and the pain was relieved rapidly. The visual analogue scale (VAS) reduced by 7 points to 2 points postoperatively compared with that preoperatively. Histopathological examination results presented plasma cell myeloma. Next, the patient received chemotherapy in the hematology department. Humeral fracture displayed good union in the 40-month follow-up, with complete healing of fracture, and the clinical outcome was still satisfactory.Conclusion: The pathological fracture of proximal humerus caused by multiple myeloma should be treated by surgery early. IM nail can be used for this kind of fracture without removal of tumors, bone cement augmentation for bone defect or local adjuvant therapy was also employed. Under the combined treatment, the proximal humerus fracture can eventually heal.

Malignant Fibrous Histiocytoma of the Left Atrium

1996 ◽  
Vol 4 (4) ◽  
pp. 230-232
Author(s):  
Rajendar Krishan Suri ◽  
Ratna S Manjari ◽  
Neerod Kumar Jha ◽  
Vaiphei Kim ◽  
Rajnish Juneja ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Malignant Fibrous Histiocytoma ◽  
Left Atrial ◽  
Fibrous Histiocytoma ◽  
Giant Cells ◽  
Atrial Myxoma ◽  
Postoperative Course ◽  
Left Atrial Myxoma ◽  
The Right

A 25-year-old female presented with symptoms resembling those of critical mitral stenosis. Echocardiography revealed a left atrial mass without a stalk, which was suspected to be a left atrial myxoma. An irregular soft friable mass was found at surgery. It measured 10 × 8 cm, with finger-like extensions and occupied almost the entire left atrial cavity, extending into the three tributaries of the right pulmonary vein. Histopathology of the excised tumor including electron microscopy showed a pleomorphic cytology interlaced with bundles, areas of necrosis, and occasional bizarre tumor giant cells. Characteristic histiocytes containing lysosomes identified the tumor as malignant fibrous histiocytoma. A postoperative course of radiotherapy with a dose of 4,000 cGy/20 fractions was applied to the mediastinum. At follow-up 4 months later the patient was asymptomatic. This case is reported because of the extreme rarity of left atrial malignant fibrous histiocytoma.

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