PENGARUH VIRGIN COCONUT OIL TERHADAP KADAR KOLESTEROL HDL DARAH

Abstract: High Density Lipoprotein Cholesterol (HDL-C) has some protective roles in minimizing cardiovascular diseases. The risks of cardiovascular diseases decrease 2-3% by increasing 1 mg/dL of HDL-C. Although the blood levels of triglyceride, total cholesterol, and low density lipoprotein (LDL) are low, these risks are still high if the HDL-C is low. The purpose of this study was to find out whether the consumption of virgin coconut oil (VCO) could increase the HDL-C level. This study used pre and post tests in a randomized control group design. Samples consisted of 39 male students at the ages of 19 ± 1.6 years. Nineteen students who were administered VCO 20 ml twice daily (pre-breakfast and pre-dinner) for two weeks belonged to the VCO group, while the others belonged to the control group. The result showed that the mean HDL-C level of the VCO group at day 15 was significantly higher (P < 0.05) than at day 1 before VCO administration, with an increase of 10.45%. The mean HDL-C increase of the VCO group at day 15 was also significantly higher (P < 0.05) than the difference of the HDL-C level at day 1 and day 15 of the control group. Conclusion: two-week administration of VCO twice daily could increase HDL-C levels.Keywords: virgin coconut oil, High Density LipoproteinAbstrak: Kolesterol high density lipoprotein (HDL-C) berperan protektif terhadap penyakit kardiovaskular. Setiap peningkatan kadar HDL-C 1 mg/dL, terjadi penurunan 2-3% risiko terkena penyakit kardiovaskular. Walaupun kadar trigliserida, kolesterol total, kolesterol low density lipoprotein (LDL-C) rendah, risiko penyakit kardiovaskular tetap tinggi bila kadar kolesterol HDL juga rendah. Penelitian ini bertujuan untuk mendapatkan apakah konsumsi virgin coconut oil (VCO) dapat meningkatkan kadar kolesterol HDL darah. Rancangan penelitian yang digunakan yaitu randomized control group pre-test and post-test. Sampel penelitian sebanyak 39 orang mahasiswa laki-laki dengan usia rata-rata 19 ± 1,6 tahun. Sembilan belas mahasiswa mengonsumsi VCO 20 mL dua kali sehari sebelum makan pagi dan malam selama dua minggu; sampel lainnya menjadi kelompok kontrol. Rerata kadar kolesterol HDL darah setelah mengonsumsi VCO (hari ke-15) lebih tinggi secara bermakna (P < 0,05) dibandingkan dengan rerata kadar HDL-C darah sebelum mengonsumsi VCO (hari ke-1), dengan peningkatan sebesar 10,45%. Rerata kenaikan kadar HDL-C darah hari ke-15 setelah mengonsumsi VCO (p < 0,05) lebih tinggi secara bermakna (P < 0,05) dibandingkan selisih antara kadar kolesterol HDL darah hari ke-1 dan ke-15 kelompok kontrol. Simpulan: konsumsi VCO selama dua minggu dapat meningkatkan kadar HDL-C.Kata kunci: virgin coconut oil, High Density Lipoprotein

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Effect of Some Strains of Lactic Acid Bacteria and Their Mixture on the Level of Fats and Cholesterol in Albino Rats (Rattus norvegicus) Male with Hypothyroidism Induced Using Carbimazole

Basrah Journal of Agricultural Sciences ◽

10.37077/25200860.2021.34.1.12 ◽

2021 ◽

Vol 34 (1) ◽

pp. 139-146

Author(s):

Elham K. Nasser ◽

Kithar R. Majeed ◽

Hayder I. Ali

Keyword(s):

High Density Lipoprotein ◽

Low Density Lipoprotein ◽

Control Sample ◽

Density Lipoprotein ◽

High Density ◽

Control Group ◽

Albino Rats ◽

Very Low Density Lipoprotein ◽

Low Density ◽

Fortified Milk

Fortified milk containing Lactobacillus plantarum, L. casei, and L. acidophilus isolates and their mixture were used in dosing the male albino rats at an age of 9-12 weeks at an average of 23 g with induced hypothyroidism at a concentration of 0.6 g.kg-1 of carbimazole. Total cholesterol, triglycerides, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very-low-density lipoprotein (VLDL) were estimated. The results showed a significant increase in the level of triglycerides (TG), cholesterol and triglycerides. Low-density lipoprotein (LDL) and very-low-density lipoprotein (VLDL), with a significant decrease in the level of high-density lipoprotein (HDL) in infected male mice, compared to the control sample, and upon dosing with liquid milk fortified, it returned to its normal level without significant differences from the control group.

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Hypertriglyceridemia is associated with the incidence of preeclampsia

Indonesian Journal of Obstetrics and Gynecology ◽

10.32771/inajog.v6i4.844 ◽

2018 ◽

pp. 218-221

Author(s):

Intje S Dahlan ◽

Mardiah Tahir ◽

Efendi Lukas ◽

St. Maisuri T Chalid

Keyword(s):

High Density Lipoprotein ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Mean Value ◽

High Density ◽

University Teaching ◽

Low Density ◽

Hospital Department ◽

Exact Test ◽

The Mean

Abstract Objective: to find out the correlation between lipid profille at trimester II of pregnancy and the incidence.of preeclampsia Method : The research was conducted in the Polyclinic of Hasanuddin University Teaching Hospital, Department of Obstetrics and Gynecology of the Faculty of Medicine, and it network in Makassar city from March, 2015 through March, 2016. The research used was the prospective cohort design. Results : The examination of the lipid levels of 115 pregnant mothers, aged 24-28 weeks. The mothers were then observed whether they experienced preeclampsia up to the time they gave birth or not. In the end, 8 subjects (6.9%) experienced preeclampsia and 107 subjects (93.1%) have no preeclampsia. The statistical analyses used Fisherâ€™s Exact test and Mann Whitney test. The research results indicated that the mean value of the total cholesterol and Low Density Lipoprotein (LDL) was higher in the preeclampsia group compared to the non-preeclampsia group: 267.37 Â± 64.12 : 238 Â± 37.98; 177.38 Â± 55.38 : 157.24 Â± 35.08 (p>0.05). The mean value of High Density Lipoprotein (HDL) was lower in the preeclampsia group compared to the non-preeclampsia group: 64.75 Â± 14.64 : 67.86 Â± 16.72 (p>0,05). The mean value of trigliserida in preeclampsia group was significantly higher (19,5%) compared thanin the non-preeclampsia group: 260.12 Â± 58.86 vs 209.14 Â± 65.10 (p=0,027). Conclusion : The hypertrigliseridemia was correlated with the preeclampsia incidence. Keywords:preeclampsia, lipid profile, trimester II of pregnancy Abstrak Tujuan: mengetahui hubungan antara profil lipid kehamilan trimester II dengan kejadian preeklamsia. Metode : Penelitian dilaksanakan di Poliklinik RS jejaring pendidikan Departemen Obstetri dan Ginekologi Fakulltas Kedokteran Universitas Hasanuddin dan Poliklinik Kesehatan Ibu dan Anak di beberapa Puskesmas Kota Makassar selama Maret 2015 sampai dengan Maret 2016. Rancangan penelitian yang digunakan adalah prospektif kohort. Hasil: dari 115 ibu hamil dilakukan pemeriksaan kadar lipid, 115 ibu hamil pada usia kehamilan 24 â€“ 28 minggu, kemudian diamati apakah subyek mengalami preeklamsia hingga proses persalinan. Terdapat delapan subyek (6,9%) berkembang menjadi preeklampsia dan 107 subyek tidak preeklamsia. Data dianalisis secara statistik dengan menggunakan uji Fisherâ€™s Exact dan uji Mann Whitney. Hasil penelitian menunjukkan bahwa nilai mean kolesterol total dan Low Density Lipoprotein (LDL) lebih tinggi pada kelompok preeklampsia dibandingkan kelompok tidak preeklamsia, yaitu 267,37 Â± 64,12 : 238,01 Â± 37,98; 177,38 Â± 55,38 : 157,24 Â± 35,08 (p>0,05). Nilai mean High Density Lipoprotein (HDL) lebih rendah pada kelompok preeklamsia dibandingkan tidak preeklamsia yaitu 64,75 Â± 14,64 : 67,86 Â± 16,72 (p>0,05). Nilai mean trigli seri daripada kelompok preeklamsia secara signifikan lebih tinggi 19,5 % dibandingkan kelompok tidak preeklamsia, yaitu 260,12 Â± 58,86 : 209,14 Â± 65,10 (p=0,027). Kesimpulan : Hiper trigli seridemia berhubungan dengan kejadian preeklamsia. Kata kunci : preeklamsia, profil lipid, kehamilan trimester II

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JUS PEPAYA (CARICA PAPAYA L) DAPAT MENURUNKAN KADAR LDL DAN KOLESTEROL TOTAL PADA USIA 40-70 TAHUN

Jurnal Kesehatan Kusuma Husada ◽

10.34035/jk.v9i2.274 ◽

2018 ◽

pp. 153-161

Author(s):

Junendri Ardian ◽

Ari Natalia Probandari ◽

K Kusnandar

Keyword(s):

High Density Lipoprotein ◽

Carica Papaya ◽

Low Density Lipoprotein ◽

Intervention Group ◽

Density Lipoprotein ◽

High Density ◽

Control Group ◽

Low Density ◽

Post Test ◽

Research Show

ABSTRAK Hiperkolesterolemia merupakan suatu kondisi dimana kolesterol dalam darah meningkat melebihi ambang normal yang ditandai dengan meningkatnya kadar kolesterol total terutama Low Density Lipoprotein (LDL) dan diikuti dengan penurunan kadar High Density Lipoprotein (HDL) darah, Tujuan penelitian adalah menganalisis pengaruh pemberian asupan jus pepaya terhadap kadar LDL dan kolesterol total pada ibu rumah tangga usia 40-70 tahun yang menderita hiperkolesterolemia. Metode: Jenis penelitian ini merupakan penelitian true eksperimental dengan desain penelitian pre and post test with control group. Total subjek sebanyak 20 orang yang dibagi kedalam dua kelompok, yaitu Intervensi Jus pepaya dan kelompok kontrol. Hasil penelitian menunjukkan bahwa kadar kolesterol total pada kelompok jus pepaya mengalami penurunan yang bermakna (p<0,05). Sedangkan pada kelompok kontrol tidak bermakna (p>0,05). Kadar LDL pada kelompok jus pepaya mengalami penurunan yang bermakna (p<0,05). Sedangkan pada kelompok kontrol tidak bermakna (p>0,05). Kesimpulan jus pepaya (carica papaya l) dapat menurunkan kadar LDL (Low Density Lipoprotein) dan kolesterol total. Kata kunci: jus pepaya, kolesterol total, LDL. ABSTRACT Hypercholesterolemia is a conditions where cholesterol in the bloods increased beyond the normal standard, its showed with cholesterol total level’s was increased especially Low Density Lipoprotein (LDL) and followed by the decreasing of High Density Lipoprotein (HDL) in blood, The purpose of this research is analyzing the influence’s of papaya juice intake for LDL’s levels and cholestrol’s total at the age of 40 – 70 years old for housewives with hypercholesterolemia. The method this research is true experimental researchs with pre and post test control group designs. The subject in this research are 20 people and separated into two groups, the first group is papaya juice’s intervention group, and the second is control group. The result of this research show that papaya juice’s has significant result for decreasing cholesterol’s total with p value’s < 0,05 , while the control group has no significant result because its p value’s >0,05. The result for LDL’s levels show that papaya juice’s has significant result too for decreasing LDL’s levels with p value’s < 0,05, while the control group has no significant result because its p value’s >0,05. The conclusion in this research is papaya juice (carica papaya l) can decreased ldl’s levels and cholesterol’s total. Keywords: cholesterol’s total, LDL, papaya juice.

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Dyslipidemia in Psoriasis: A Case - Controlled Study

Nepal Journal of Dermatology Venereology & Leprology ◽

10.3126/njdvl.v19i2.38556 ◽

2021 ◽

Vol 19 (2) ◽

pp. 39-43

Author(s):

Monique Kafle ◽

Madhu Gyawlee ◽

Amit Amatya ◽

Bhaskar Mohan Meher Kayastha ◽

Smarika Upadhyaya

Keyword(s):

High Density Lipoprotein ◽

Lipid Profile ◽

Total Cholesterol ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

High Density ◽

Controlled Study ◽

Control Group ◽

Low Density ◽

Chronic Inflammatory Condition

INTRODUCTION: Psoriasis is a chronic inflammatory condition of skin which can be associated with other ailments including dyslipidemia which is an abnormal serum lipid profile. OBJECTIVE: The aim of present study was to determine correlation between dyslipidemia and Psoriasis of patients visiting the Out-patient Department of Patan Hospital METHODS: Ninety patients were selected for study. Among them 30 patients with psoriasis were taken as cases and 60 patients that matched for age and sex with Psoriasis patients were taken as controls. The lipid profile that comprised four parameters: serum High-density Lipoprotein, Low-density Lipoprotein, Total Cholesterol and Triglyceride were determined and compared for both case and control groups. RESULTS: More than 95% of the psoriatic patients had dyslipidemia. The odds of dyslipidemia among Psoriatic patients were 1.709 times higher compared to control group (p <0.001). Among the parameters, results showed High-density lipoprotein was significantly lower while Triglyceride was significantly higher among the cases compared to controls with p value of 0.012 and 0.001 respectively. The risk factors like smoking and alcohol were present in higher proportions among the patients with dyslipidemia but it failed to reach statistical significance. With increase in duration of Psoriasis and PASI scores, lipid parameters i.e., Total cholesterol, triglyceride and Low-density lipoprotein increased while High density lipoprotein decreased but this correlation was insignificant. CONCLUSION: This study showed Dyslipidemia is significantly higher among patients with Psoriasis especially lipid profile parameters Triglyceride and total cholesterol. Thus, timely screening and management of dyslipidemia among Psoriatic patients might be helpful in prevention of future cardiovascular events.

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TO ASSESS THE POTENTIAL OF CURCUMIN AGAINST GUT MICROBIOTA-INDUCED ALTERATION IN CHOLINE METABOLISM IN C57BL/6J MICE

International Journal of Pharmacy and Pharmaceutical Sciences ◽

10.22159/ijpps.2017v9i3.15966 ◽

2017 ◽

Vol 9 (3) ◽

pp. 215

Author(s):

Himani Joshi ◽

Uma Bhandari ◽

Bibhu Prasad Panda

Keyword(s):

High Density Lipoprotein ◽

Total Cholesterol ◽

Inhibitory Concentration ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

High Density ◽

Very Low Density Lipoprotein ◽

Low Density ◽

Choline Metabolism ◽

The Mean

Objective: The present study was focused on assessing the antimicrobial activity of curcumin against Providencia rettgeri, a gut microbe, which was further corelated to the effect of curcumin on choline metabolism and its role in preventing atherosclerosis and on the evaluation of potential of curcumin on the inhibition of conversion of choline to trimethylamine (TMA), and further its conversion to trimethylamine-N-oxide (TMAO) in liver.Methods: The minimum inhibitory concentration of curcumin was determined using Cup-plate method. The estimation of trimethylamine was performed using high performance thin layer chromatography (HP-TLC) technique. Estimation of blood serum parameters were performed using kits supplied by Span-diagnostics for estimation of triglycerides, total cholesterol and high density lipoprotein (HDL) cholesterol. All surgical procedures on animals including blood withdrawal and isolation of livers were carried out in accordance with CPCSEA guidelines.Results: The minimum inhibitory concentration of curcumin was found to be 10 µg/ml. There was a significant increase (p<0.001) in the mean triglyceride, total cholesterol, low-density and very low-density lipoprotein, along with a significant decrease (p<0.001) in high-density lipoprotein in choline-fed mice. Also, there was significant decrease (p<0.001) in the mean triglyceride, total cholesterol, low-density and very low-density lipoprotein, along with a significant increase (p<0.001) in high-density lipoprotein cholesterol in choline-fed mice treated with curcumin. Further, there was a decrease in the Flavin mono-oxygenase (FMO3) activity in the mice livers treated with curcumin by 21.57%.Conclusion: It was concluded that curcumin has the potential to inhibit gut microbiota thus prevention the conversion of choline to trimethylamine, has serum lipid lowering effect in female C57BL/6J mice and has an inhibitory effect on hepatic FMO3 thus preventing the conversion of trimethylamine to trimethylamine-N-oxide.

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MODIFIKASI TAI CHI DAN SENAM JANTUNG SEHAT PADA PROFIL LIPIDA DAN KEBUGARAN PRA LANSIA The Tai Chi Modification (Mtc) And Gymnastics (Senam Jantung Sehat) Upon Lipid Profile And Physical Fitness At Middle Age.

Jurnal Insan Cendekia ◽

10.35874/jic.v1i1.6 ◽

2014 ◽

Vol 1 (1) ◽

Author(s):

M. Zainul Arifin

Keyword(s):

Physical Fitness ◽

High Density Lipoprotein ◽

Lipid Profile ◽

Tai Chi ◽

Middle Age ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Control Group ◽

Low Density ◽

Randomized Control

Penelitian ini bertujuan untuk menciptakan Modifikasi Tai Chi (MTC) berupa gerakan yang sesuai dan efektif bagi pra lansia dalam hal perbaikan profil lipida dan kebugaran tubuh disamping Senam Jantung Sehat (SJS). Jenis penelitian ini adalah penelitian eksperimen dengan menggunakan desain Randomized Control Group Pretest Posttest. Populasi penelitian adalah laki-laki pra lansia (40 th s/d 49 th) dan sehat di Puri Mojobaru RW 03, Canggu, Mojokerto berjumlah 300 orang. Melalui rumus Lemeshow ditentukan jumlah sampel 27 orangyang dibagi tiap kelompok 9 orang secara random, ada tiga kelompok yaitu kelompok 1 diberi perlakuan Modifikasi Tai Chi berjumlah 9 orang, kelompok 2 diberi perlakuan Senam Jantung Sehat berjumlah 9 orang dan kelompok 3 adalah kontrol berjumlah 9 orang. Perlakuan pada kelompok Modifikasi Tai Chi dan Senam Jantung Sehat berdurasi 60 menit per latihan, frekuensi 3 x per minggu, selama 8 minggu. Variabel yang akan diukur adalah: 1) total colesterol (TC), 2)trigliserida (TG), 3) low density lipoprotein (LDL), 4) high density lipoprotein (HDL), 5) perbandingan HDL/TC dan kebugaran terdiri atas: 1) kapasitas aerobic maksimal (VO2max), 2) efisiensi ambilan oksigen saat ventilasi (VO2/VE). Data variabel terikat diukur sebelum perlakuan (pretest) dan sesudah perlakuan (posttest). Selanjutnya data diolah menggunakan analisis statistik meliputi : Anova, LSD (α=0,05) dengan menggunakan program komputer SPSS versi 16. Hasil penelitian menunjukkan bahwa : 1) MTC memperbaiki TC (p=0,000, TG (p=0,000), LDL (p=0,005), HDL (p=0,000), HDL/TC (p=0,000), VO2max (p=0,000), VO2/VE (p=0,019). 2) SJS memperbaiki TC (p=0,000), TG (p=0,000), LDL (p=0,005), HDL (p=0,000), HDL/TC (p=0,000), VO2max (p=0,019), VO2/VE(p=0,006). 3) Perbedaan perbaikan profil lipida dan peningkatan kebugaran antara MTC dengan SJS adalah TC(p=0,000), TG (p=0,000), LDL (p=0,000), HDL (p=0,000), HDL/TC (p=0,000), VO2max (p=0,000), VO2/VE (p=0,645) . sehingga diketahui MTC lebih efektif memperbaiki profil lipida dan kebugaran tubuh pra lansia dari pada SJS. Jadi Modifikasi Tai Chi dapat dijadikan sebagai alternatif yang lebih baik dari pada Senam Jantung Sehat dalam hal memperbaiki profil lipida dan meningkatkan kebugaran tubuh, terutama pada pra lansia, walaupun VO2/VE antara MTC dan SJS tidak ada beda.

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