scholarly journals The Effect of Helicobacter Pylori Eradication on Migraine: A Randomized, Double Blind, Controlled Trial

2012 ◽  
Vol 6;15 (6;12) ◽  
pp. 495-498 ◽  
Author(s):  
Nader Zarinfar
Keyword(s):  
Helicobacter Pylori ◽  
Treatment Group ◽  
Migraine Headache ◽  
Treatment Result ◽  
Control Group ◽  
Migraine Treatment ◽  
Double Blind ◽  
Significant Difference ◽  
H Pylori ◽  
And Control

Background: Recent studies have shown a positive correlation between Helicobacter pylori (H. pylori)infection and migraine headache. Objective: To study the impact of H. pylori eradication on migraine headache. Study Design: Double blind, randomized, controlled clinical trial. Setting: Sixty-four patients diagnosed with migraine-type headache were included in the study. The patients were randomly allocated into 2 groups: a treatment group that received migraine treatment and H.pylori eradication treatment, and a control group that received migraine treatment and a placebo in place of H. pylori eradication treatment. Methods: There were 25 women and 7 men in the treatment group and 22 women and 10 men in the control group. The MIDAS (Migraine Disability Assessment) questionnaire was used to assess the severity of symptoms, before and after treatment. Result: There was no significant difference between treatment group patients and control group patients with respect to age (44.6 ± 8.8 vs. 43.8 ± 13.8), clinical symptoms and signs. In the beginning of the study, patients in the treatment group had a higher MIDAS compared to patients in the control group (28.87 ± 6.18 vs. 25.43 ± 7.13, P < 0.05). There was no significant difference between the treatment and control groups, with respect to the MIDAS, after treatment (20.09 ± 1.14 vs. 20.00 ± 1.150, P = 0.5). General linear model, repeated measures demonstrated that the reduction in the MIDAS score was more prominent in the treatment group (Mean Square 164.25, F: 2.02, P = 0.05). Limitations: Short-term follow up. Conclusion: H. pylori eradication may have a beneficial role on migraine headache. This shows the significance of H. pylori treatment in the management of migraine headache among Iranian patients. Key words: Helicobacter pylori, migraine headache

scholarly journals Ganji Formulation for Patients with Hepatocellular Carcinoma Who Have Undergone Surgery: A Multicenter, Randomized, Double-Blind, Controlled Trial

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Jing-Hao Zhang ◽  
Chao Zheng ◽  
Xiao-Jun Zhu ◽  
Xin Zhang ◽  
Zhi-Jun Hou ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Treatment Group ◽  
Liver Resection ◽  
Controlled Trial ◽  
Disease Free Survival ◽  
Control Group ◽  
Double Blind ◽  
Local Ablation ◽  
Significant Difference ◽  
And Control

Objective. To ascertain the efficacy and safety of Ganji Formulation (GF) for patients with Hepatocellular carcinoma (HCC) who had undergone surgery. Materials and Methods. A total of 262 HCC patients who had undergone liver resection, local ablation, or transcatheter arterial chemoembolization (TACE) were divided randomly into the treatment group and control group. The former was treated with GF and the later with placebo, both for 6 months. The primary endpoint was overall survival (OS). Second endpoints were disease-free survival (DFS) or time to disease progression (TTP). Results. OS of the treatment group was significantly longer than that of the control group (P < 0.05). Subgroup analysis showed that, for patients who received TACE, the TTP was significantly longer in the treatment group than in the control group (P < 0.05). However, for patients who underwent liver resection or local ablation, there was no significant difference in DFS between the two groups (P > 0.05). Conclusion. GF could improve postoperative cumulative survival and prolong the TTP. This clinical trial number is registered with ChiCTR-IOR-15007349.

scholarly journals Comparison of combination of probiotic and standard therapy compared to standard therapy on eradication of Helicobacter pylori infection in children

2016 ◽  
Vol 50 (1) ◽  
pp. 38
Author(s):  
Fransisca Theresia Aryani ◽  
Agus Firmansyah ◽  
Abdul Latief
Keyword(s):  
Helicobacter Pylori ◽  
Treatment Group ◽  
Side Effects ◽  
Standard Therapy ◽  
Eradication Rate ◽  
Controlled Trial ◽  
Control Group ◽  
Double Blind ◽  
Cancer Management ◽  
H Pylori

Background Helicobacter pylori (H. pylori) infection is thought to be the etiology of chronic gastritis, peptic ulcer, and risk factor for gastric cancer. Management of H. pylori infection in children is associated with several problems such as compliance to therapy, untolerated side effects, and antibiotic resistance. Probiotic is reported to give beneficial effect in the management of H. pylori infection and there is no study yet on the effect of probiotic in eradication of H. pylori infection in Indonesian children.Objectives To study the effect of additional probiotic in the standard therapy on the rate of H. pylori infection eradication in children and its side effect.Methods This was a double blind randomized controlled trial performed in 23 children with H. pylori infection at Kampung Melayu and Rawa Bunga District. The diagnosis was determined based on Helicobacter pylori stool antigen test (HpSA). Subjects were randomly assigned to either receive receive amoxiycilin, clarithromycin, omeprazole, and probiotic (2 x 109 cfu of Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12) or amoxicillin, clarithromycin, omeprazole dan placebo (maltodextrin). HpSA examination was evaluated again after 2 weeks of therapy.Results Two of 13 subjects in the treatment group and 6 of 10 subjects in the control group experienced side effects. Eradication rate in the treatment group is higher than the control group (13/13 vs 7/10) but the correlation between additional probiotic with the eradication rate of H. pylori is not statistically significant.Conclusions Probiotic can reduce the incidence of side effects due to antibiotic used in H. pylori eradication (2/13 vs 6/10, p < 0.012). [Paediatr Indones. 2010;50:38-41].

scholarly journals The Relationship Between Infertility and Infection with Clarithromycin Resistant Strain of Helicobacter Pylori in Iraq

2020 ◽  
pp. 1874-1879
Author(s):  
Shiamaa G. Abid ◽  
Rana S. Aboud
Keyword(s):  
Helicobacter Pylori ◽  
Seminal Fluid ◽  
Control Group ◽  
Control Groups ◽  
Significant Difference ◽  
Polymerase Chain ◽  
H Pylori ◽  
And Control ◽  
The Relationship ◽  
Infertile Patients

The relationship between infertility and Helicobacter pylori infection was investigated; samples from thirty-five infertile patients (aged 20-49 years) were collected from Kamal Al-Samaraei hospital , Baghdad, Iraq during the period from the first of February until April 2018. These patients were compared with 10 apparently fertile individuals who served as a control. The study was carried out to detect the DNA of H.pylori in both serum and seminal fluid of male infertile patients and for the control group by Real-Time Polymerase Chain Reaction (RT-PCR) technique. The results revealed that there was a significant difference (P<0.01) in the detection of DNA of H.pylori between patients and control groups. thereby the percentage level of H.pylori DNA in serum was 80% and in the seminal fluid was 0 %. As a result, we strongly suggest that the infection with H. pylori plays an important role in male infertility.

Treatment of Chronic Idiopathic Urticaria with Levamisole: A Multicentre, Randomized, Double-Blind, Controlled Trial

2009 ◽  
Vol 37 (4) ◽  
pp. 1167-1172 ◽  
Author(s):  
H Zhang ◽  
C Shan ◽  
Z Hua ◽  
P Zhao ◽  
H Zhang
Keyword(s):  
Treatment Group ◽  
Controlled Trial ◽  
Chronic Idiopathic Urticaria ◽  
Response To Therapy ◽  
Control Group ◽  
Efficacy Rate ◽  
Control Groups ◽  
Double Blind ◽  
Significant Difference ◽  
And Control

The objective of this study was to evaluate the efficacy of treating chronic idiopathic urticaria (CIU) with levamisole in combination with levocetirizine. This was a multicentre, randomized, double-blind, controlled trial that included 132 patients with active CIU who were treated for 6 weeks with either levocetirizine alone (control group; n = 65) or levamisole plus levocetirizine (treatment group; n = 67). Response to therapy was evaluated by measuring the efficacy rate. After 2 weeks of treatment, there was no significant difference in the efficacy rate between the treatment and control groups (54.84% and 42.37%, respectively). After 6 weeks of treatment, a statistically significant difference in the efficacy rate was observed between the groups (76.27% and 54.39% for the treatment and control groups, respectively). This study demonstrated that a combination of levamisole plus levocetirizine is more effective than levocetirizine alone and potentially provides a new, promising approach to the treatment of CIU.

scholarly journals Evaluation of the Relationship Between Childhood Asthma and Helicobacter pylori Sero-Prevalence

2019 ◽  
Author(s):  
Rasoul Nasiri ◽  
Pedram Ataee ◽  
Azad Abdi ◽  
Ghobad Moradi ◽  
Borhan Moradveisi ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Cigarette Smoke ◽  
Childhood Asthma ◽  
Control Group ◽  
Case Group ◽  
Significant Difference ◽  
History Of ◽  
H Pylori ◽  
And Control ◽  
The Relationship

In recent years, the prevalence of asthma and allergic rhinitis has increased in developed countries. Helicobacter pylori (H. pylori) infection can exacerbate asthma. The purpose of this study was to investigate the relationship between asthma and H. pylori seroprevalence in children. In this cross-sectional study, 100 children aged 5-15 years hospitalized in Besat hospital in Sanandaj were investigated from 2015 to 2016. Fifty children with asthma were considered as the case group and 50 non-asthmatic children as the control group. The questionnaires were completed, including demographic information, history of asthma, exposure to cigarette smoke, and family history of gastric and duodenal ulcers. Blood samples were collected from the children, and the serum level of specific antibodies (IgG) of H. pylori was measured. There were 42 and 31 boys in the case and control group, respectively. The mean age in the case group was 8.12±2.29 and in the control group was 8.9±2.52 years. In the case group, 48% were exposed to cigarette smoke and in the control group, 18%. There was a statistically significant difference between the groups in terms of gender and exposure to cigarette smoke (P=0.001 and P=0.013, respectively). There was no significant difference between the case and control groups in terms of H. pylori seroprevalence. (P=0.211). There was no significant association between asthma and H. pylori seroprevalence. (P=0.22). According to our study, there no correlation between childhood asthma and H. pylori seroprevalence. © 2019 Tehran University of Medical Sciences. All rights reserved. Acta Med Iran 2019;57(5):299-302.

The evaluation of nasal mucociliary clearance in patients with Helicobacter pylori infection

2019 ◽  
Vol 133 (03) ◽  
pp. 220-223
Author(s):  
S Üstün Bezgin ◽  
T Çakabay ◽  
K Irak ◽  
M Koçyiğit ◽  
B Serin Keskineğe ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Mucociliary Clearance ◽  
Endoscopic Examination ◽  
Control Group ◽  
Clearance Time ◽  
Saccharine Test ◽  
Significant Difference ◽  
And Gender ◽  
H Pylori ◽  
Nasal Mucociliary Clearance

AbstractObjectiveThis study aimed to examine nasal mucociliary clearance time in patients with Helicobacter pylori infection.MethodsFifty patients who were newly diagnosed with H pylori infection using gastric biopsy in the gastroenterology out-patient clinic, and 50 age- and gender-matched healthy adults who were admitted to the otorhinolaryngology out-patient clinic, were included in this study. After an otorhinolaryngological examination (anterior rhinoscopy and nasal endoscopic examination), the nasal mucociliary clearance time of each subject was calculated using the saccharine test.ResultsThe mean mucociliary clearance time was 06:29 ± 3:31 minutes (range, 00:55–15:19 minutes) in the control group and 10:12 ± 06:09 minutes (range, 01:28–32:00 minutes) in the study group. Comparisons of the two groups revealed a statistically significant difference (p = 0.002).ConclusionNasal mucociliary clearance time was significantly increased in patients with H pylori infection. The results suggest that H pylori infection may have an unfavourable effect on nasal mucociliary clearance.

scholarly journals Effects of Mangosteen pericarp Extract to Clinical Improvements, The Plasma Level of IL-6 and Malondialdehyde in Acute Exacerbation of COPD Patients

2018 ◽  
Vol 38 (3) ◽  
pp. 164-172
Author(s):  
Khilyatul Baroroh ◽  
Suradi Suradi ◽  
Ade Rima
Keyword(s):  
Treatment Group ◽  
Plasma Level ◽  
Length Of Stay ◽  
Acute Exacerbation ◽  
Clinical Symptoms ◽  
Control Group ◽  
Chronic Obstructive ◽  
Copd Patients ◽  
Significant Difference ◽  
And Control

Background: Amplification of inflammation in acute exacerbation of chronic obstructive pulmonary disease (COPD) increases inflammatory mediators and oxidative stress in the airways, pulmonary and systemic circulation that are characterized by increased plasma level of IL-6 and MDA, resulting in worsening of clinical symptoms. Xanthones in mangosteen pericarp have anti-inflammatory and antioxidant effects, potentially as an adjuntive therapy in acute exacerbations of COPD. Methods: The aim of this study was to determine the effect of mangosteen pericarp extract to clinical improvements, plasma level of IL-6 and MDA of acute exacerbation COPD patients. A clinical trial of experimental with pretest and posttest was conducted on 34 acute exacerbation of COPD patients in Dr. Moewardi Hospital Surakarta and Dr. Ario Wirawan Lung Hospital Salatiga from April until May 2016. The sample was taken by consecutive sampling. Subjects were divided by randomized double blind technique into the treatment group (n=17) received mangosteen pericarp extract 2x1100mg/day and control group (n = 17) received placebo. Clinical improvements were measured in CAT score and length of stay. CAT score, plasma level of IL-6 and MDA were measured on admission and at discharge. Length of stay based on the number of days of care in hospitals. Results: There was significant difference (p=0,011) towards decreased of IL-6 plasma level between treatment group (-2,17 ± 3,46 pg/ mL) and control group (+1,67 ± 6,81 pg/mL). There were no significant difference towards decreased of length of stay (p=0,34) between treatment group (4,12 ± 1,54 days) and control group (5,24 ± 2,49 days), towards decreased of CAT score (p=0,252) between treatment group (-19,18 ± 3,96) and control group (-18,24 ± 2,75), and towards decreased of MDA plasma level (p=0,986) between treatment group (+0,03 ± 0,36μmol/L) and control group (+0,35 ± 1,58). Conclusions: The addition of mangosteen pericarp extract 2x1100mg/day during hospitalization was significantly lowered plasma levels of IL-6, but were not significant in lowering the CAT score, shortening the length of stay, and reducing the increase in plasma level of MDA.

scholarly journals Pengaruh suplementasi Zn terhadap perubahan indeks TB/U anak stunted usia 24-36 bulan

2017 ◽  
Vol 5 (2) ◽  
pp. 98-104
Author(s):  
Dewi Pertiwi Dyah Kusudaryati ◽  
Siti Fatimah Muis ◽  
Laksmi Widajanti
Keyword(s):  
Treatment Group ◽  
Dietary Intake ◽  
Child Growth ◽  
Control Group ◽  
Control Group Design ◽  
Dietary Allowance ◽  
Significant Difference ◽  
Before And After ◽  
And Control ◽  
Height For Age

Background : Zn supplementation on stunted children in multiple research get the result inconsistent concerning the effect of Zn on children’s growth.Objective : To examine the effect of Zn supplementation to the change in height for index among stunted children age between 24-36 months.Methods: The research design is randomized pretest posttest control group design. The total of thirty six stunted children are divided into two groups. The treatment group is received syrup with 20 mg ZnSO4 twice a week for three months. The control group received placebo without Zn. Height for age z score (HAZ) on WHO Child Growth 2006 is used to measure height for age index while dietary intake and infection diseases are used as confounding variables.Result : There is significant difference in HAZ before and after supplementation at treatment group (p<0.001) and control group (p<0.001). There is a significant difference of the change in HAZ between the treatment group and control group (p=0.006). Percentage Achievement of Energy, Protein, and Zn Dietary Allowance have significant difference between the treatment group and control group (p=0.009; p<0.001; p<0.001, respectively). The change in HAZ, Percentage Achievement of Energy, Protein, and Zn Dietary Allowance are higher in treatment group than control group. Duration of diarrhea (p=0.045) and morbidity (p=0.019) are lower in treatment group than control group. Conclusion : Zn Supplementation among stunted children have significant effect on the change in HAZ, dietary intake, and infection.

scholarly journals Efficacy of a herbal toothpaste on patients with established gingivitis: a randomized controlled trial

2006 ◽  
Vol 20 (2) ◽  
pp. 172-177 ◽  
Author(s):  
Fabiana Ozaki ◽  
Claudio Mendes Pannuti ◽  
Ana Vitória Imbronito ◽  
Wellington Pessotti ◽  
Luciana Saraiva ◽  
...  
Keyword(s):  
Adverse Reactions ◽  
Controlled Trial ◽  
Test Group ◽  
Experimental Period ◽  
Positive Control ◽  
Control Group ◽  
Control Groups ◽  
Double Blind ◽  
Significant Difference ◽  
And Control

The aim of this randomised, double blind controlled trial was to verify the efficacy of a herbal dentifrice on the reduction of plaque and gingivitis. Forty eight volunteers with established gingivitis were randomly assigned to either a test group (herbal dentifrice) or positive control group (dentifrice with triclosan and fluoride). The dentifrices were distributed in plain white tubes by an independent pharmacy, which revealed the contents of each tube only after the experimental period. Plaque and gingivitis assessments were carried out on baseline and after 28 days of product use. All examinations were conducted by the same calibrated investigator. Subjects were instructed to brush their teeth three times daily using their assigned dentifrice for 28 days. There was a significant reduction in plaque levels in both the test and control groups. However, there was no significant difference between the groups. A significant reduction in gingivitis was observed in both groups, although there was no significant difference between them. No adverse reactions were reported. The authors concluded that both dentifrices were effective in reducing plaque and gingivitis in subjects with established gingivitis.

Seroprevalence of Helicobacter pylori infection in patients with chronic nonspecific pharyngitis: preliminary study

2007 ◽  
Vol 122 (1) ◽  
pp. 61-64 ◽  
Author(s):  
İ Aladag ◽  
Y Bulut ◽  
M Guven ◽  
A Eyibilen ◽  
K Yelken
Keyword(s):  
Helicobacter Pylori ◽  
Treatment Strategies ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Control Groups ◽  
Chi Square ◽  
Control Subjects ◽  
The Difference ◽  
H Pylori ◽  
And Control

AbstractBackground and objectives:Chronic nonspecific pharyngitis is a chronic inflammation of the pharynx. It is found worldwide, and treatment is difficult. The underlying aetiopathogenesis is still controversial. The aim of this study was to investigate Helicobacter pylori seroprevalence in chronic nonspecific pharyngitis patients without other possible causative factors for chronic pharyngeal irritation and without H pylori gastric mucosal infection.Materials and methods:Forty-one patients with symptoms of chronic nonspecific pharyngitis and 30 healthy control subjects were enrolled in this prospective, controlled, clinical study. In both study and control groups, selected patients were shown to have gastric mucosa uninfected by H pylori, as demonstrated by the 14C-urea breath test. Comprehensive otorhinolaryngological examination did not elicit any factor contributing to the chronic pharyngeal complaint. Serum H pylori immunoglobulin G antibody titres were assayed using serum enzyme-linked immunosorbent assay. The difference between the study and control groups was analysed by the chi-square test (the likelihood ratio was used).Results:Thirty-two of the 41 patients (78 per cent) and 14 of the 30 control subjects (46.7 per cent) were found to be H pylori positive. Patients with chronic nonspecific pharyngitis were found to have a significantly higher rate of H pylori seropositivity than the control group (p = 0.016).Conclusion:These data may be important in developing future treatment strategies for chronic nonspecific pharyngitis.

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