scholarly journals COMPARATIVE STUDY OF TRAMADOL WITH THAT OF BUTORPHANOL FOR THE CONTROL OF SHIVERING IN PATIENTS UNDERGOING NEURAXIAL BLOCKADE

2020 ◽  
pp. 70-72
Author(s):  
Prabhat Kumar Choudhary ◽  
Sadab Faisal Ansari ◽  
Namita Saraswat ◽  
Debarshi Jana
Keyword(s):  
Spinal Anesthesia ◽  
Lower Limb ◽  
Oral Anticoagulant Therapy ◽  
Double Blind Study ◽  
Double Blind ◽  
Neuraxial Blockade ◽  
Group I ◽  
Lower Limb Surgery ◽  
History Of ◽  
Group Ii

Aim: To compare the efficacy of Tramadol with that of Butorphanol for the control of shivering in patients undergoing neuraxial blockade. Materials And Methods: A randomized, double blind study of 60 patients undergoing lower abdominal and lower limb surgery under spinal anesthesia who got shivering during intra operative period up to 60minutes. Out of which 60 patients, who will develop shivering after neuraxial blockade will be randomly allocated to one of the following groups. Each group contains 30 patients. Group I: (Tramadol Group) Patients received tramadol intravenously (50mg) Group II: (Butorphanol Group) Patients received butorphanol intravenously (1mg) Inclusion criteria: ASA Grade I Or II, age 18 to 60 years, weight 30 to 70 kg, lower abdominal and lower limb surgery under spinal anesthesia. Exclusion Criteria: Patients not willing to take part in study, ASA grade >2, significant systemic illness, patients with fever, pregnancy, patients with history of seizure, patient on oral anticoagulant therapy, emergency surgeries, conditions where neuraxial blockade will be contraindicated. Result: Time taken to control Shivering was significantly lower in Group I (Tramadol) as compared to group II (Butorphanol), more patients with higher sedation score with Butorphanol group compared to Tramadol Group, Nausea and vomiting higher in Tramadol Group compared to Butorphanol Group. Conclusion: Tramadol is most rapid acting & effective in control of shivering with neauraxial block without any significant side effects and least reappearance of shivering as compared to Butorphanol.

scholarly journals PREVENTION OF SHIVERING DURING LOWER SEGMENT CESAREAN SECTION;

2013 ◽  
Vol 20 (03) ◽  
pp. 409-415
Author(s):  
ASHFAQ AHMED ◽  
MOHAMMAD ASLAM
Keyword(s):  
Cesarean Section ◽  
Spinal Anesthesia ◽  
Carbon Dioxide Production ◽  
Double Blind Study ◽  
Lower Segment ◽  
Chi Square ◽  
Double Blind ◽  
Lower Segment Cesarean Section ◽  
Group I ◽  
Group Ii

Objectives: To compare the efficacy of low-dose prophylactic use of ketamine with ketamine plus midazolam for theprevention of shivering caused by spinal anesthesia, during lower segment cesarean section. Main Outcome Measures: Heamodynamicmonitoring, avoidance of lactic acidosis/ increased carbon dioxide production and patient satisfaction. Design: Prospective RandomizedControlled trial. Place: Department of Anesthesia and ICU PNS Shifa Karachi. Duration of study: March 2010 to June 2010. Patients andMethods: 100 ASA-I & II consecutive patients who reported for LSCS in PNS Shifa Hospital were studied. In this double-blind study,patients were randomly allocated to receive ketamine alone (Group I, n= 50), and ketamine plus midazolam (Group II, n = 50). Afterstandardized Spinal anesthesia, a shivering was recorded at 5 min intervals for 15 minutes. Results: Shivering was observed in 9/50(18%) patients of group I (Ketamine only) as compared to only 2/50 (4%) patients in Group II (ketamine + midazolam) (p=0.025) whichis statically significant. The two groups were comparable regarding distribution of age (p=0.37), BMI (p=0.27) and duration of surgery.Results were analyzed by using chi square test. Conclusions: The efficacy of i.v. ketamine plus midazolam is better as compared to lowdosei.v. ketamine alone in preventing shivering in lower segment Cesarean Section patients, during spinal anesthesia.

scholarly journals Clinical Comparative Study between Fentanyl and Dexmedetomidine with Bupivacaine for Lower Limb Surgery in Spinal Anaesthesia

2020 ◽  
Vol 5 (1) ◽  
pp. 126-130
Author(s):  
Tuhin Vashishth ◽  
Sangeeta Varun
Keyword(s):  
Spinal Anesthesia ◽  
Lower Limb ◽  
Motor Block ◽  
Sensory Block ◽  
Double Blind Study ◽  
Hyperbaric Bupivacaine ◽  
Double Blind ◽  
Block Time ◽  
Lower Limb Surgery ◽  
Group D

Background: Spinal anesthesia is a preferred technique of choice in infraumbilical surgeries. The spinal anesthesia effect can be improved by adding various adjuvant like Fentanyl, clonidine, dexmedetomidine. Dexmedetomidine is a highly selective alpha 2 adrenergic agonists. The aim of study to compare efficacy and safety between Dexmedetomidine and Fentanyl with Bupivacaine.Subjects and Methods:A prospective randomized, double-blind study was conducted on 100 patient by dividing them into two groups. Group D: 2.5ml (12.5mg) of 0.5% hyperbaric bupivacaine with 5mcg (0.5ml) dexmedetomidine and Group F : 2.5ml(12.5mg) of 0.5% hyperbaric bupivacaine with 2 5mcg(0.5ml)  fentanyl. The total volume injected intrathecally was 3.0ml in ASA I and II grade patient undergoing lower limb surgery.Results:Patients in dexmedetomidine groupD had a significantly longer sensory and motor block time than patients in fentanyl group F.The mean time of sensory regression to level S1 was 306.00 ± 13 .32 in group D and 206.14± 16.69 in group F(P<0.001). The regression time of motor block to reach modified Bromage 0 was 257.70±14.61 in group D and 178.54±14.23 in group F(P<0.001).Conclusion:Intrathecal Dexmedetomidine is associated with prolonging motor and sensory block as compare to Fentanyl.

scholarly journals COMPARATIVE EVALUATION OF TRAMADOL AND FENTANYL FOR EPIDURAL ANALGESIA IN LOWER LIMB SURGERIES

2020 ◽  
Vol 8 (12) ◽  
pp. 811-816
Author(s):  
Hp Singhl ◽  
◽  
Naveen Jindal ◽  
Jaspreet Singh ◽  
◽  
...  
Keyword(s):  
Lower Limb ◽  
Comparative Evaluation ◽  
Epidural Block ◽  
Epidural Fentanyl ◽  
Epidural Administration ◽  
Double Blind ◽  
Sensory Blockade ◽  
Catheter Technique ◽  
Lower Limb Surgery ◽  
History Of

Background:Epiduralandspinalblocksaremajorregionaltechniques with along history of effectiveuseforavarietyofsurgicalprocedures and pain relief. Epidural block with the catheter technique gives a better control of the level of analgesia and can be used for providingpost-operativepainreliefbyopioidsorlocalanaestheticagents.The purposeofthepresentstudywastocomparethe safetyandefficacyofepiduraltramadolversusepiduralfentanylas adjuvantstobupivacaineforlowerlimbsurgeries. Materials and methods:100 patients werer an domisedin to two groups with50 patient sineach group: Group BB-epidural administration of 20mL 0.5% plain bupivacaine with [50 mg (1 mL) tramadol + 1 mL NS= 2 mL].Group BF- epidural administration of 20 mL 0.5% plain bupivacainewith100mcg(2mL)of fentanyl.Settings and Design- Randomised double-blind trial. Results:The mean onset of sensory blockade and time for maximum sensory blockade was observed to be significantly reduced with the addition of fentanyl to bupivacaine as compared to tramadol and bupivacaine. The results showed statistically significant increase in the duration of analgesia with the addition of fentanyl to bupivacaine as compared to tramadol and bupivacaine. Conclusion:We can conclude that tramadol and fentanyl were effective adjuvants to bupivacaine when used epidurally in patients undergoing lower limb surgery. Although, epidural fentanyl with bupivacaine produces significantly faster onset of sensory blockadecompared to epiduralhowever,epiduraltramadolwithbupivacaineproducessignificantlyprolonged durationofanalgesiacomparedtoepiduralfentanyl.

scholarly journals Oral midazolam versus oral triclofos for sedation of children for computed tomography scan - a randomized clinical trial

2015 ◽  
Vol 2 (2) ◽  
pp. 41-45
Author(s):  
Anushu Gupta ◽  
Maitree Pandey ◽  
Lalita Choudhry ◽  
Aruna Jain ◽  
Harish Pemde
Keyword(s):  
Computed Tomography ◽  
Double Blind Study ◽  
Computed Tomography Scan ◽  
Double Blind ◽  
Comparable Rate ◽  
Group I ◽  
Oral Midazolam ◽  
Group Ii ◽  
Student’S T ◽  
Tomography Scan

Background: Effective and safe pediatric procedural sedation is still a concern especially in areas outside operation theatres. The aim of the study was to compare the efficacy and safety of oral triclofos and oral midazolam in children undergoing computed tomography.Methods: A prospective randomized double blind study was conducted in 100 children aged one to five years. Group-I (n=50) received oral triclofos 100 mg/kg and Group-II (n=50) oral midazolam 0.75 mg/kg. Both groups were given oral atropine 0.03 mg/kg and supplemented with intravenous midazolam upto 0.1 mg/kg in case of inadequate effect. Onset and duration of sedation, success for completion of procedure and time to recovery were noted. Student’s t test and Z test of proportions were used for statistical analysis.Results Majority of children 36(72%) in Group-I achieved Ramsay Sedation Score >4 as compared to 25(50%) in Group-II. Computed tomography scan could be successfully completed at comparable rate (52% vs 56%). Success rate improved to 96% vs 80% after supplementing intravenous midazolam in Group I & II respectively (p< 0.05). Onset (37.91minutes ± 7.96 vs 26 ± 10), duration of sedation ( 117.91minutes ± 72.41 vs 66.2minutes ± 33) were significantly shorter and recovery (98.19minutes ± 72.58 vs 47.4minutes ± 31.42) in Group I & II respectively was faster in children who received oral midazolam (p< 0.05).Conclusion We conclude that both drugs were equally effective and safe for computed tomography scan in children. However better recovery profile of midazolam makes it more suitable for day care procedures.Journal of Society of Anesthesiologists of Nepal 2015; 2(2): 41-45

scholarly journals A comparative study of hemodynamic changes and adverse effects of intrathecal bupivacaine with fentanyl and intrathecal bupivacaine with clonidine in infra-umbilical abdominal and lower limb surgery

2019 ◽  
Vol 6 (11) ◽  
pp. 4048
Author(s):  
Krishna Prasad G. V. ◽  
Vipin Jaishree Sharma
Keyword(s):  
Adverse Effects ◽  
Lower Limb ◽  
Analgesic Effects ◽  
Anesthetic Agents ◽  
Group I ◽  
Significant Difference ◽  
Lower Limb Surgery ◽  
Hemodynamic Profile ◽  
Group Ii ◽  
Intrathecal Clonidine

Background: Adjuvants prolong the action of intrathecal local anesthetic agents. They have shown to have significant analgesic effects in the postoperative period much after the regression of the sensory and motor blockade. Our objective of the current study was to compared the hemodynamic profile and adverse effects (nausea, pruritus, sedation and respiratory depression) in two groups of adult patients undergoing infra-umbilical and lower limb surgery under spinal anaesthesia using either intrathecal clonidine or intrathecal fentanyl as an adjuvant to intrathecal bupivacaine (0.5% heavy).Methods: This randomized, prospective and observational study was undertaken in the Department of Anaesthesiology and Critical Care, 5 Airforce Hospital, Kanpur from the period of January 2014 to February 2016 on 120 patients fulfilling the inclusion criteria. Study patients were randomly allocated to the two groups Group I: Cases who received intrathecal 0.5% heavy bupivacaine (2.5 ml) + fentanyl (50 mcg/ml) (0.5 ml) (n=60 patients) and Group II: cases who received intrathecal 0.5% heavy bupivacaine (2.5 ml) + clonidine (60 mcg/ml) (0.5 ml) (n=60 patients).Results: Mean age of patients in Group I and Group II was 42.60±5.93 and 42.03±7.16 years, respectively. Mean BMI of patients in Group I and Group II was 22.0±1.92 and 21.54±2.14 kg/m2, respectively. Comparison of baseline hemodynamic parameters (heart rate (bpm), mean arterial pressure (mmhg), respiratory rate (/min) and oxygen saturation (%) did not show a significant difference between two groups.Conclusions: With respect to the side effects like nausea and pruritus, these are significantly more in fentanyl group as compared to clonidine group.

scholarly journals The Effect of Nitroglycerine Infusion on Postoperative Pain in Lower Limb Surgery: A Clinical Double-Blind Study

2019 ◽  
Vol 9 (4) ◽  
Author(s):  
Poupak Rahimzadeh ◽  
Seyed Hamid Reza Faiz ◽  
Farnad Imani ◽  
Atoosa Soltani ◽  
Pooya Derakhshan
Keyword(s):  
Postoperative Pain ◽  
Lower Limb ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Lower Limb Surgery

scholarly journals Hemodynamic Changes During Spinal Anesthesia with Different Bupivacaine Concentrations in Elderly Cardiac Patients Undergoing Transurethral Resection of Prostate

2021 ◽  
pp. 99-108
Author(s):  
Omar Mohamed Fathy Elkady ◽  
Naglaa Khalil Mohamed ◽  
Ahmed Esam-Eldein Salim ◽  
Ahmed Ali Eldaba
Keyword(s):  
Spinal Anesthesia ◽  
Stress Test ◽  
Chronic Stable Angina ◽  
Cardiac Patients ◽  
Control Group ◽  
Transurethral Resection Of Prostate ◽  
Arterial Blood ◽  
Group I ◽  
History Of ◽  
Group Ii

Background: Spinal anesthesia produces hypotension more often in elderly patients than in younger patients due to decrease systemic vascular resistance mainly. Limiting the dose (and thus, extent of anesthetic spread) to the necessary dermatomes reduces the likelihood of side effects. The aim of the study was to compare hemodynamic effects of spinal anesthesia by using different bupivacaine concentrations in elderly cardiac patients undergoing TURP. Methods: This prospective randomized controlled double-blinded study was carried out on 60 male patients aged 65 years and above, American Society of Anesthesiologists (ASA) III, with IHD (history of MI, a history of a positive treadmill test result (ECG stress test), use of nitroglycerin, chronic stable angina for more than two months, or an ECG with abnormal Q waves), with ejection fraction (EF) 35%-50%, undergoing TURP with prostate from 100-150 gm by using bipolar resection technique and normal saline wash during surgical procedure. Patients were randomly allocated into two equal groups: Group I (Control group): received 2.5 ml bupivacaine 0.5% + 0.5 ml fentanyl (25 mcg). Group II: received 1.75ml bupivacaine 0.5% + 0.75 ml distilled water + 0.5 ml fentanyl (25 mcg). Results: Mean arterial blood pressure was significantly decreased in group I than group II at 6, 9, 12, 15 and 30 minutes. Heart rate and peripheral oxygen saturation were insignificantly different between both groups. Ischemia occurred in 3 (10%) patients in group I and no patients in group II & the difference between both groups was insignificant. Hypotension was found significantly higher in group I than group II (P = 0.021) while PONV, bradycardia, headache, backache and shivering were insignificantly different between both groups. TURP syndrome didn’t occur in any case of our study. Conclusions: Hyperbaric bupivacaine 8.75 mg injected at L4-L5 is sufficient to provide adequate sensory and motor block, while maintaining hemodynamic stability during TURP procedures.

scholarly journals Isobaric levobupivacaine a better and safer substitute for spinal anaesthesia in patients undergoing prolonged lower abdominal and lower limb surgeries

2018 ◽  
Vol 6 (9) ◽  
pp. 3111
Author(s):  
Wasimul Hoda ◽  
Abhishek Kumar ◽  
Priodarshi Roychoudhury
Keyword(s):  
Spinal Anesthesia ◽  
Spinal Anaesthesia ◽  
Lower Limb ◽  
Motor Block ◽  
Sensory Block ◽  
Double Blind Study ◽  
Double Blind ◽  
Sensory Blockade ◽  
Group A ◽  
Group B

Background: Bupivacaine being the drug of choice for spinal anaesthesia is associated with serious cardiac toxicity. Levobupivacaine and ropivacaine, both being the two S enantiomers of bupivacaine can be a safer alternatives with better cardiovascular safety. Hence, the clinical efficacy of both were assessed and compared in patients undergoing spinal anesthesia.Methods: A prospective randomized controlled double blind study was done in 68 adult posted for elective lower abdominal and lower limb surgeries under spinal anesthesia. They were randomized into 2 groups. About 3ml isobaric levobupivacaine 0.5% (15mg) was given in group A and 3ml isobaric ropivacaine 0.5% (15mg) was given in group B. Onset, duration of sensory and motor blocks, time for maximum sensory and motor block, time for 2 segment sensory regression and haemodynamic parameters were recorded and analyzed.Results: All patients achieved a sensory block of T10 dermatome. Onset of sensory blockade at T10 was similar in both groups, group A (5.71±1.31min) and group B (5.94±1.72min). Time from injection to two dermatomal regression was 129.68±15.54min in group A and 111.38±22.35min in group B. Onset of Bromage score of 1 in group A was 4.68±1.27min and in group B was 6.44±1.64min. The mean duration of motor and complete motor block was prolonged in group A patients (197.74±18.51min, 168.82±17.90 min) as compared to group B (131.88±20.41min, 106.71±10.85min).Conclusions: Isobaric levobupivacaine was found to be a better and safer substitute for spinal anesthesia in patients undergoing prolonged lower abdominal and lower limb surgeries.

scholarly journals Comparison between intrathecal nalbuphine and butorphanol as adjuvants to isobaric ropivacaine in elective lower limb orthopedic surgeries: A prospective, randomized, double blind study

2020 ◽  
Author(s):  
Akash Nirmal ◽  
Yashpal Singh ◽  
Sharad Kumar Mathur ◽  
Satish Patel
Keyword(s):  
Postoperative Analgesia ◽  
Lower Limb ◽  
Primary Outcome Measure ◽  
Blind Study ◽  
Double Blind Study ◽  
Motor Blockade ◽  
Chi Square ◽  
Double Blind ◽  
Lower Limb Surgery ◽  
To Receive

Background: Intrathecal ropivacaine is now routinely used for lower limb surgery. Adjuvants e.g. fentanyl, dexmedetomidine or morphine etc. are commonly used to prolong the intraoperative anesthesia or postoperative analgesia. The available literature lacks information on use of butorphanol and nalbuphine as adjuvants with 0.75% isobaric ropivacaine. We aimed to compare nalbuphine and butorphanol as adjuvant with isobaric ropivacaine in lower limb orthopedic surgeries. Methodology: After institutional ethical committee approval and informed written consent, a total of 108 patients of ages between 18 to 65 y, of either sex, American Society of Anesthesiologists (ASA) grade ӏ & ӏӏ, scheduled for elective lower limb orthopedic surgeries, were enrolled and  randomly allocated into two groups: Group RN; to receive isobaric ropivacaine (0.75%, 7.5 mg/ml) 2.5 ml plus nalbuphine 500 µg (0.5 ml), and Group RB; to receive isobaric ropivacaine 2.5 ml plus butorphanol 100 µg (0.5 ml) intrathecally. Primary outcome measure was the duration of sensory‑motor blockade from the time of intrathecal drug administration. Statistical analysis was performed by using t-test and chi-square test as applicable. A p < 0.05 was considered as significant. Results: Duration of sensory (p < 0.001) and motor blockade (p = 0.02) was significantly prolonged in nalbuphine group than butorphanol group. Onset of blockade was earlier in nalbuphine group. Duration of motor block and sensory analgesia was prolonged in group RN (p < 0.001). Perioperative hemodynamic parameters and the observed side effects including bradycardia, hypotension, nausea and vomiting, sedation and shivering were comparable between the two groups (p = 0.77). Conclusion: Intrathecal nalbuphine produces prolonged motor blockade as well as postoperative analgesia than intrathecal butorphanol when used as adjuvants to isobaric 0.75% ropivacaine. Citation: Nirmal A, Singh Y, Mathur SK, Patel S. Comparison between intrathecal nalbuphine and butorphanol as adjuvants to isobaric ropivacaine in elective lower limb orthopedic surgeries: A prospective, randomized, double blind study. Anaesth pain & intensive care 2019;23(4)__ Received: 22 August 2019; Reviewed: 8, 9 October 2019; 6, 7 November 2019; Revised: 18 November 2019; Reviewed: 19 November 2019; Accepted: 20 November 2019

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