HOW TOPICAL BETA-BLOCKER DID WONDER IN THE MANAGEMENT OF RESIDUAL HEMANGIOMA AFTER PROPRANOLOL THERAPY

2021 ◽  
pp. 44-46
Author(s):  
Zaheer hasan ◽  
Vinit kumar Thakur ◽  
Rakesh kumar ◽  
Digamber chaubey ◽  
Rupesh keshri
Keyword(s):  
Retrospective Study ◽  
Side Effects ◽  
Beta Blocker ◽  
Complete Resolution ◽  
Pediatric Patients ◽  
Β Blocker ◽  
One Year ◽  
Propranolol Therapy ◽  
Therapy Result

Background: To determine the role of topical β- blocker in the management of residual hemangioma after propranolol therapy. Method: A retrospective study of all pediatric patients presenting with hemangioma from April 2014 to March 2019 was performed. Topical timolol gel was applied over the residual hemangioma which persisted even after one year of propranolol therapy. Result: Out of 68 patients included in this study 45 (70.3%), patients had complete resolution by one year using the treatment with propranolol. In 14 patients (21.8%) had residual lesion even after 1 year of treatment, upon which we applied topical timolol 0.5% gel for further 4 to 6 months. (Mean 5.35 months). At the end of the treatment, hemangioma was almost resolved. Conclusion: Timolol is a safer alternative to propranolol for residual hemangioma as a sequential treatment. It augments the regression of residual hemangioma with minimal side effects.

Beta-Blocker Attenuates Cardiotoxicity Related Anthracycline Usage

2021 ◽  
Vol 104 (8) ◽  
pp. 1389-1392
Keyword(s):  
Side Effects ◽  
Cancer Therapy ◽  
Mortality Rate ◽  
Cancer Patients ◽  
Beta Blocker ◽  
The Other ◽  
Large Numbers ◽  
Therapy Effectiveness ◽  
Chemotherapy Agents

To summarize the recent trials and studies of the role of beta-blocker on the treatment for cancer patients treated with anthracycline to decrease morbidity and mortality rate. Good management of cancer will result in large numbers of cancer survivors. On the other hand, cancer therapy also has side effects, one of which is cardiotoxicity. Cardiotoxicity could reduce therapy effectiveness, hence, increase disease progression and mortality rate. Anthracyclines is one of the chemotherapy agents with cardiotoxicity as a side effect. Beta-blocker has the ability to reduce cardiotoxicity due to anthracyclines usage. Keywords: Beta-blocker; Cardiotoxicity; Anthracyclines

Bleeding patterns and weight gain in users of injectable progestogen-only contraceptives: A retrospective study

2015 ◽  
Vol 1 (2) ◽  
pp. 27-34
Author(s):  
JO Sotunsa ◽  
A Inofomoh ◽  
AK Akinseku ◽  
FI Ani ◽  
AO Olatunji
Keyword(s):  
Retrospective Study ◽  
Weight Gain ◽  
Side Effects ◽  
Menstrual Cycle ◽  
Menstrual Bleeding ◽  
Modern Contraceptive ◽  
Contraceptive Methods ◽  
The Mean ◽  
One Year ◽  
Injectable Contraceptives

Objective: Modern contraceptive methods have been very effective in family planning and well-being. The injectable contraceptives, though effective, had been discontinued by some users because of side effects like abnormal menstrual bleeding and weight gain. This study compared the pattern of menstrual bleeding and weight gain in users of Depot Medroxyprogesterone Acetate (DMPA) and Norethisterone-Enanthate (Noristerat) in Sagamu. Method: A retrospective study of 323 patients who used either DMPA or Noristerat over a 7-year period (January 2007 to December 2013). Data extracted from case notes included bio-data, parity, previous contraceptive methods and reasons for discontinuation of the contraceptives. Clients' weights, pattern of menstrual cycle and side effects were also documented for the rst, second and third visits, and up to 1 year after commencing the injectable contraceptives. Results: The mean age of the participants was 32.72± 5.47 years. About 13.5% experienced no change in their menstrual cycle, but 55.9% and 58.9% of those who used Noristerat and DMPA respectively, had amenorrhoea by the end of one year. The mean weight was 62.89kg±12.84 for Noristerat group and  0.93kg±9.94 for DMPA group at commencement and 65.15kg±13.70 for Noristerat group and 64.05kg±10.30 for DMPA group at the end of one year. There was significant weight gain (p<0.05) in both groups by the end of the First year. Weight gain was perceived as a problem by 2% of Noristerat users and 0.9% users of DMPA. Conclusion: There were significant weight changes with use of injectable contraceptives. However, very few clients perceived this as a problem. Amenorrhoea was the commonest menstrual change experienced by clients over the period. 

scholarly journals Procedural Pediatric Sedation by Nurses: Available, Competent, and Safe

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Laetiscia Lavoie ◽  
Catherine Vezina ◽  
Emilie Paul-Savoie ◽  
Claude Cyr ◽  
Sylvie Lafrenaye
Keyword(s):  
Retrospective Study ◽  
Pediatric Patients ◽  
Standard Of Care ◽  
Centre Hospitalier ◽  
Major Complications ◽  
Centre Hospitalier Universitaire ◽  
Pediatric Sedation ◽  
One Year ◽  
Physician Availability ◽  
Sedation Program

Sedation and/or analgesia are standard of care for pediatric patients during painful intervention or medical imaging requiring immobility. Physician availability is frequently insufficient to allow for all procedural sedation. A nurse-led sedation program was created at the Centre Hospitalier Universitaire de Sherbrooke (CHUS) to address this problem.Objective. To evaluate the effectiveness and the safety of our program.Methods. A retrospective study of all the procedural sedations done over one year was performed. Complications were separated in four categories: (1) major complications (call for help; unexpected admission, aspiration, and code); (2) reportable sedation events (oxygen saturation <90%, bradycardia (more than 2 SD below normal for the age of the child), and hypotension (more than 2 SD below normal for the age of the child); (3) difficult sedation (agitation, inadequate sedation, and failure to perform the procedure), (4) minor complications.Results. 448 patients, 249 boys and 199 girls; received sedation for 555 procedures. Overall, 78% (432) of interventions were successfully accomplished: 0% of major complications, 8% of reportable sedation events; 5% of difficult sedation; 9% of minor complications.Conclusion. Our nurse-led sedation program compares favorably to other similar systems.

scholarly journals Fertility outcomes following myomectomy in infertile patients at our centre: a retrospective analysis

2020 ◽  
Vol 9 (6) ◽  
pp. 2249
Author(s):  
Nidhi Goyal ◽  
K. Jayakrishnan
Keyword(s):  
Retrospective Study ◽  
Retrospective Analysis ◽  
Young Patients ◽  
Pregnancy Rates ◽  
Active Management ◽  
Multiple Factors ◽  
One Year ◽  
Infertile Patients

Background: Fibroids have been known to cause infertility due to multiple factors. However, the role of myomectomy in patients with intramural and subserosal fibroids has been a topic of debate. This study evaluates outcomes following myomectomy in patients seeking treatment for infertility at study centre.Methods: This was hospital based retrospective study which evaluated 92 infertile patients who took treatment for infertility.Results: A total 41.3% patients conceived within one year of myomectomy. Pregnancy rates were better in patients with intramural combined with submucous fibroids, age between 30 and 35 years, size of largest fibroid between 3 and 6 cm and when number of fibroids were between 3 and 6 and conception was maximum after ovulation induction.Conclusions: Pregnancy rates after myomectomy are better in young patients with large fibroids. Active management for infertility needs to be done after myomectomy.

scholarly journals Hyponatremia During Induction Therapy in Distinct Pediatric Oncological Cohorts: A Retrospective Study

2021 ◽  
Vol 11 ◽  
Author(s):  
Christina Salvador ◽  
Robert Salvador ◽  
Peter Willeit ◽  
Christine Kuntner ◽  
Alexandra Haid ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Childhood Leukemia ◽  
Pediatric Patients ◽  
Wilms Tumor ◽  
Lymphoblastic Leukemia ◽  
Elementary School Age ◽  
Oncological Patients ◽  
High Incidence ◽  
Male Patients

BackgroundHyponatremia is a well-known adverse event of repeated therapy with vincristine in oncological patients. However, to date, data in pediatric patients with malignant diseases other than acute lymphoblastic leukemia (ALL) are sparse or lacking.Materials and MethodsA retrospective study of 98 pediatric patients was conducted to analyze the incidence of hyponatremia in a Caucasian cohort of newly diagnosed ALL. For comparison, we further examined five other pediatric oncological cohorts (Hodgkin’s disease, Ewing sarcoma, Wilms tumor, benign glioma of the CNS, Langerhans cell histiocytosis) that receive alkaloids in their induction regimes.ResultsWe found a high incidence of hyponatremia (14.7%) in our ALL cohort with a trend toward male patients of elementary school age. None of the affected patients showed neurological symptoms. By comparison, patients from other malignancy groups did not show significant hyponatremia, regardless of their comparable therapy with alkaloids. We here show a noticeable coincidence of hyponatremia and hypertriglyceridemia in ALL patients, indicating a possible role of L-asparaginase-related hypertriglyceridemia in the development of severe hyponatremia in such patients.ConclusionWe report a higher incidence of hyponatremia following vincristine therapy in Caucasian children with ALL than published before. This hyponatremia could not be demonstrated in other oncologic cohorts treated with alkaloids. L-Asparaginase-induced hypertriglyceridemia may play a role in the certainly multifactorial development of hyponatremia in childhood leukemia.

scholarly journals Neurovascular Decompression for Trigeminal Neuralgia in 17-year-old Girl

2018 ◽  
Vol 24 (4) ◽  
pp. 349-352
Author(s):  
Gustavo Simiano Jung ◽  
Leonardo Gilmone Ruschell ◽  
Luis Fernando Moura Da Silva Junior ◽  
Erasmo Barros Da Silva Jr. ◽  
Jerônimo Buzetti Milano ◽  
...  
Keyword(s):  
Trigeminal Neuralgia ◽  
Complete Resolution ◽  
Pediatric Patients ◽  
The Elderly ◽  
Vascular Compression ◽  
Venous Compression ◽  
Neurovascular Decompression

Trigeminal neuralgia in general is a disease of the elderly. Rarely, the disease presents during childhood. Therefore we sought to explore the role of vascular compression in pediatric patients with medically refractory trigeminal neuralgia. A case of venous compression related to trigeminal neuralgia is presented in a 17-year-old girl. Upper petrous vein was found to be related to aneurovascular conflict with unusual response to neurovascular decompression with complete resolution of symptoms in postoperativeperiod. 

Role of irradiation in the suppression of parotid secretions

1989 ◽  
Vol 103 (6) ◽  
pp. 594-595 ◽  
Author(s):  
A. C. R. Robinson ◽  
G. G. Khoury ◽  
P. M. Robinson
Keyword(s):  
Side Effects ◽  
Parotid Gland ◽  
Drug Treatment ◽  
Complete Resolution ◽  
Salivary Flow ◽  
Primary Treatment ◽  
Low Doses ◽  
Failed Surgery

AbstractSuppression of salivary flow is of value in the management of salivary fistulae and sialectasia. It may also be beneficial in mentally defective patients and those with neurological palsies lacking control of their salivation. Nine patients were treated by irradiation to the parotid gland to control salivary flow; eight had complete resolution of symptoms and one had partial relief. Irradiation was effective as primary treatment and after failed surgery and/or drug treatment. Low doses were effective and there were no significant acute or long-term side effects. Its use avoids long-term medication and their potential side effects and may reduce the need for surgery.

scholarly journals Obstetric and neonatal outcome in women with epilepsy

2017 ◽  
Vol 6 (6) ◽  
pp. 2593
Author(s):  
Roopa Malik ◽  
Viral Kumar ◽  
Susheela Chaudhary ◽  
Nirmala Duhan
Keyword(s):  
Retrospective Study ◽  
Side Effects ◽  
Psychiatric Disorders ◽  
Congenital Malformation ◽  
Neonatal Outcome ◽  
Antenatal Clinic ◽  
Newly Diagnosed ◽  
Major Malformation ◽  
Major Congenital Malformation ◽  
One Year

Background: Epilepsy is the second most common neurological disorder complicating pregnancy next to migraine. Both mother and fetus stay at risk due to epilepsy and side effects of antiepileptic’s. This retrospective study was conducted to study fetal and maternal outcome in WWE.Methods: This study was conducted on 55 patients of epilepsy with pregnancy who attended antenatal clinic of our hospital from January 2016 to December 2016. Data was collected using antenatal registers in outdoor settings and medical case sheets in indoor patients and was analyzed statistically.Results: There were a total of 55 WWE in one year duration. Incidence of epilepsy being 0.4% in this study. 11 WWE were not on ante epileptic drug when conceived, while 34 WWE were on ante epileptic drugs when conceived, 8 WWE were newly diagnosed and 2 patients had both psychiatric disorders along with epilepsy. There were 3 IUDs, 4 major congenital malformation and 2 minor malformations. 2 major malformation occurred in patients taking both antipsychotic and ante epileptics since conception.Conclusions: There were a total of 55 WWE in one year duration. Incidence of epilepsy being 0.4% in this study. 11 WWE were not on ante epileptic drug when conceived, while 34 WWE were on ante epileptic drugs when conceived, 8 WWE were newly diagnosed and 2 patients had both psychiatric disorders along with epilepsy. There were 3 IUDs, 4 major congenital malformation and 2 minor malformations. 2 major malformation occurred in patients taking both antipsychotic and ante epileptics since conception.

scholarly journals The Effectiveness and Side Effects of Conscious Sedation using Chloral hydrate, Hydroxyzine, and Nitrous oxide

2020 ◽  
Vol 47 (2) ◽  
pp. 109-119
Author(s):  
Gyeongmin Kim ◽  
Jaesik Lee ◽  
Hyunjung Kim ◽  
Soonhyeun Nam
Keyword(s):  
Body Mass Index ◽  
Nitrous Oxide ◽  
Retrospective Study ◽  
Side Effects ◽  
Chloral Hydrate ◽  
Pediatric Patients ◽  
Conscious Sedation ◽  
Several Variables ◽  
Associated Variables ◽  
Over Time

This retrospective study assessed the effectiveness and side effects of conscious sedation using chloral hydrate, hydroxyzine, and N<sub>2</sub>O/O<sub>2</sub> in the sedation of 149 pediatric patients over 188 sedation sessions, and to identify associated variables.<br/>The effectiveness of the sedation was evaluated using the Houpt scale, and was considered effective for scale categories of excellent or good. Effectiveness and side effects were assessed every 15 minutes. The effectiveness decreased and side effects increased over time. The effectiveness of sedation during 60 minutes was 57.4%, and one or more side effects occurred in 18.1% of sessions. Effectiveness of sedation increased with body mass index (BMI). When patients were sedated at the beginning of the procedure, the effectiveness was greater. Side effects increased with patient age. When sedation was divided into two sessions, the number of sedation did not affect the effectiveness or side effects.<br/>It can be suggested that sedation should be performed over two separate sessions, as a single prolonged session may lead to reduced effectiveness and increased side effects. To maximize effectiveness and minimize side effects, several variables such as BMI, whether to sedate at the beginning of the procedure and age should be considered thoroughly before sedation.

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