Fertility outcomes following myomectomy in infertile patients at our centre: a retrospective analysis

Background: Fibroids have been known to cause infertility due to multiple factors. However, the role of myomectomy in patients with intramural and subserosal fibroids has been a topic of debate. This study evaluates outcomes following myomectomy in patients seeking treatment for infertility at study centre.Methods: This was hospital based retrospective study which evaluated 92 infertile patients who took treatment for infertility.Results: A total 41.3% patients conceived within one year of myomectomy. Pregnancy rates were better in patients with intramural combined with submucous fibroids, age between 30 and 35 years, size of largest fibroid between 3 and 6 cm and when number of fibroids were between 3 and 6 and conception was maximum after ovulation induction.Conclusions: Pregnancy rates after myomectomy are better in young patients with large fibroids. Active management for infertility needs to be done after myomectomy.

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Study of the role of an infectious factor in the development of stroke in children. Results of a 5-year retrospective analysis

CHILDREN INFECTIONS ◽

10.22627/2072-8107-2021-20-2-10-15 ◽

2021 ◽

Vol 20 (2) ◽

pp. 10-15

Author(s):

A. A. Ivanova ◽

O. V. Shamsheva ◽

I. O. Shchederkina

Keyword(s):

Bacterial Infection ◽

Viral Infection ◽

Retrospective Analysis ◽

Bacterial Infections ◽

Sinus Thrombosis ◽

Risk Groups ◽

Additional Risk Factor ◽

Additional Risk ◽

One Year

Objective: Determine the role of infectious diseases in the development of strokes in children and to identify risk groups for its progression.Materials and Methods: A retrospective analysis of 660 case histories of children aged 1 months to 1 8 years old, hospitalized in Morozov Children's City Clinical Hospital with stroke in the period from 201 6 to July 2020 was carried out.Results. An infectious disease or fever 4 weeks before stroke is diagnosed in 78 (1 2%) cases. Infections more often act as a stroke trigger in children under 7 years old (28% in children under one year old). The incidence of strokes against a background of a bacterial infection is higher than against a background of a viral infection (47% versus 35%). Among bacterial infections, meningitis (35%), otitis media (24%), pneumonia (1 8%) prevailed. With a viral infection, viruses of Herpes are more common (44%), as well as respiratory viruses (37%). Two cases of cerebrovascular accident were revealed in children who have undergone a new coro-navirus infection SARS-CoV-2 (7%). Among the types of stroke, with bacterial infection, sinus thrombosis was more common (50%), among viral infection, the most common was ischemic stroke (60%). The presence of an additional risk factor was revealed in 72%, most often these were prothrombotic conditions (35%).

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HOW TOPICAL BETA-BLOCKER DID WONDER IN THE MANAGEMENT OF RESIDUAL HEMANGIOMA AFTER PROPRANOLOL THERAPY

10.36106/ijsr/2726749 ◽

2021 ◽

pp. 44-46

Author(s):

Zaheer hasan ◽

Vinit kumar Thakur ◽

Rakesh kumar ◽

Digamber chaubey ◽

Rupesh keshri

Keyword(s):

Retrospective Study ◽

Side Effects ◽

Beta Blocker ◽

Complete Resolution ◽

Pediatric Patients ◽

Β Blocker ◽

One Year ◽

Propranolol Therapy ◽

Therapy Result

Background: To determine the role of topical β- blocker in the management of residual hemangioma after propranolol therapy. Method: A retrospective study of all pediatric patients presenting with hemangioma from April 2014 to March 2019 was performed. Topical timolol gel was applied over the residual hemangioma which persisted even after one year of propranolol therapy. Result: Out of 68 patients included in this study 45 (70.3%), patients had complete resolution by one year using the treatment with propranolol. In 14 patients (21.8%) had residual lesion even after 1 year of treatment, upon which we applied topical timolol 0.5% gel for further 4 to 6 months. (Mean 5.35 months). At the end of the treatment, hemangioma was almost resolved. Conclusion: Timolol is a safer alternative to propranolol for residual hemangioma as a sequential treatment. It augments the regression of residual hemangioma with minimal side effects.

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Effects of thrombocytopenia in pregnancy

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20180889 ◽

2018 ◽

Vol 7 (3) ◽

pp. 1044 ◽

Cited By ~ 1

Author(s):

Shital N. Kapadia ◽

Harsh S. Patel ◽

Kartikey G. Parmar

Keyword(s):

Platelet Count ◽

Retrospective Study ◽

Gestational Age ◽

Antenatal Visit ◽

Civil Hospital ◽

Multiple Factors ◽

Gestational Thrombocytopenia ◽

Common Etiology ◽

One Year ◽

In Pregnancy

Background: Thrombocytopenia defined as platelet count of less than 1,50,000/cu.mm. Thrombocytopenia is divided according to severity into mild moderate and severe types. Multiple factors are responsible.Methods: This is a retrospective study of one-year period including 120 pregnant patients irrespective of their gestational age at civil hospital Ahmedabad. Etiology of this condition are identified and analyzed.Results: Gestational Thrombocytopenia is the most common etiology. This condition is self-limiting usually.Conclusions: Platelet count estimation should be a routine at first antenatal visit for timely diagnosis and to achieve favorable fetomaternal outcome.

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P–028 Single centre retrospective analysis of endocrine stimulation therapy prior to microsurgical testicular sperm retrieval (mTESE) in men with hypogonadism and non-obstructive azoospermia (NOA)

Human Reproduction ◽

10.1093/humrep/deab130.027 ◽

2021 ◽

Vol 36 (Supplement_1) ◽

Author(s):

G Chiriaco ◽

K Naylor ◽

V Talaulikar ◽

E Williamson ◽

G Conway ◽

...

Keyword(s):

Retrospective Study ◽

Success Rate ◽

Retrospective Analysis ◽

Klinefelter Syndrome ◽

Serum Testosterone ◽

Obstructive Azoospermia ◽

Sperm Retrieval ◽

Infertile Men ◽

Before And After

Abstract Study question What is the role of endocrine stimulation therapy prior to mTESE in men with hypogonadism and non obstructive azoospermia (NOA)? Summary answer In hypogonadal men there is a positive correlation between change of serum Testosterone (ΔT) before and after stimulation, and a successful mTESE. What is known already NOA is the most common cause of azoospermia and it is often associated with hypogonadism and testicular failure. It is common practice for endocrine stimulation therapies such as gonadotropines or selective estrogens receptor modulators to be used prior mTESE; however there is currently paucity of data regarding their efficacy. Study design, size, duration Retrospective analysis on infertile men with hypogonadism (defined as T < 12nmol/L) and NOA who underwent mTESE with or without prior endocrine stimulation therapy (clomiphene or human chorionic gonadotropin). Retrospective data from 2015–2020, total number of patient: 71; stimulated group (N:40) vs unstimulated group (N:31). Participants/materials, setting, methods Retrospective study on infertile men who underwent mTESE with or without prior endocrine stimulation therapy. Hypogonadism was defined as serum testosterone (T) level <12nm/L. We recorded demographic data, cause of testicular failure, previous testosterone therapy, duration and type of endocrine stimulation, pre-and post-stimulation hormone levels(T, FSH, LH), pre-operative hormone levels, successful sperm retrieval rate (at least 1 vial of viable sperm), average Johnsen score and total number of vials of sperm retrieved. Main results and the role of chance One-hundred-sixty-eight men underwent mTESE out of which 59 men received endocrine stimulation therapy for NOA between 2015–2020. Among them, we selected men with hypogonadism defined as serum T < 12nmol/L which comprised 43% of the entire patient cohort. The hypogonadal group included 71 men, 28/71 had Klinefelter syndrome and 40/71 received endocrine stimulation for 13.9±9.2 months. Testosterone levels significantly increased after endocrine stimulation (6.3±3.3nm/L vs 11.7±7.4nm/L) with mean change in serum testosterone (ΔT) of 5.7 nm/L (–5.5–23.3, N35). In the stimulated group, pre-operative serum T levels were significantly higher (11.7±7.4 vs 7.8±3.0 p:0.007) as compared to unstimulated men but the success rate of mTESE did not differ significantly (16/40–40%) vs 13/31–42%). Men with Klinefelter syndrome demonstrated significant differences with regards to age, lower T levels, higher FSH and LH levels, lower Johnsen score and success rates compared to other causes of NOA. Comparing men who had successful mTESE vs unsuccessful mTESE - higher T and lower FSH and LH seemed to correlate with successful sperm retrieval. Among men who received endocrine stimulation therapy the ΔT before and after stimulation seemed to correlate with successful sperm retrieval (AUC:0.701, SE:0.089, p:0.043). In the stimulated group a ΔT>3.5nm/L showed a significant association with successful mTESE(p:0.041). Limitations, reasons for caution Retrospective study limitations. Wider implications of the findings: Our study shows a significant improvement of serum T following endocrine stimulation therapy. Overall, in hypogonadal men, the hormonal stimulation seems not to be related to a higher success rate of mTESE but our data do suggest a positive correlation between ΔT before and after stimulation, and a successful mTESE. Trial registration number Not applicable

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Believing that transferring more embryos will result in increased pregnancy rates: a flawed concept: a SWOT analysis

Middle East Fertility Society Journal ◽

10.1186/s43043-020-00042-3 ◽

2020 ◽

Vol 25 (1) ◽

Author(s):

Michael H. Dahan ◽

Samer Tannus

Keyword(s):

Decision Making ◽

Swot Analysis ◽

Clinical Decision Making ◽

Clinical Decision ◽

Endometrial Receptivity ◽

Pregnancy Rates ◽

Multiple Factors ◽

Accessory Factors

Abstract A belief exists that transferring multiple embryos can improve pregnancy rates. However, this concept is flawed. Multiple factors affect outcomes when transferring embryos, endometrial receptivity, and rates of aneuploidy among them. In this article, we will discuss how factors can affect outcomes at IVF that are independent of the number of embryos transferred. It is important to understand the role of accessory factors on pregnancy rates to be able to counsel patients as per the number of embryos that should be transferred. An understanding of this concept will also lead to a realistic understanding of how multiple embryo transfers may result in better cumulative pregnancy rates than a single transfer of multiple embryos. Finally, we will present a SWOT analysis diagram to help guide clinical decision-making.

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Success of embryo transfer in mice with freshly collected and cryopreserved two-cell embryos with different genetic backgrounds correlated with the number of transferred embryos: A 5-year retrospective analysis

Laboratory Animals ◽

10.1177/0023677219832922 ◽

2019 ◽

Vol 53 (6) ◽

pp. 577-586 ◽

Cited By ~ 1

Author(s):

Martina Dorsch ◽

Isabell Wittur ◽

Wiebke Garrels

Keyword(s):

Retrospective Study ◽

In Vitro Fertilization ◽

Retrospective Analysis ◽

Embryo Transfer ◽

Genetic Modification ◽

Genetic Background ◽

Pregnancy Rates ◽

Vitro Fertilization ◽

Cryopreserved Embryos

Embryo transfer of pre-implantation embryos to surrogate dams is a key technique for the hygienic sanitation of strains, cryopreservation, in vitro fertilization, genetic modification and engineering. However, the effects of several parameters, such as the number of transferred embryos, on the success of embryo transfer are not well studied. In this retrospective study, we reanalysed 1320 embryo transfers of two-cell embryos originating from genetically altered donors, which were performed under routine conditions in our facility over a period of 5 years. Of them, 453 embryo transfers were done with freshly collected embryos and 867 transfers were performed with cryopreserved embryos. Despite the fact that the genetic background of the embryo donors was quite heterogeneous, we found that the transfer of ≥ 21 embryos reduced the success of embryo transfers for freshly collected embryos in correlation with the number of pregnancies and born pups, whereas this was not the case for transfer in the cryopreservation group. Most pregnancies were achieved after embryo transfer of 10–20 freshly collected embryos (90.4%), which dropped to 37.5% if more embryos were transferred. The highest pregnancy rates in the cryopreservation group were achieved if 15–17 embryos were transferred (62.9%). Despite the fact that the precise substrains were only rarely defined, we confirmed that beside the number of transferred embryos, the genetic background of the donors had an influence on the success of embryo transfer. Significantly more embryos in a C57BL/6 background developed to term than embryos on a BALB/c background.

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Role of ovarian markers in predicting pregnancy rates in infertile patients undergoing ICSI cycle

Benha Medical Journal ◽

10.21608/bmfj.2021.77413.1421 ◽

2021 ◽

Vol 0 (0) ◽

pp. 0-0

Author(s):

Ahmed Nasef ◽

Mohamed Abdelsalam ◽

Mohamed El noury ◽

Tarek Idris

Keyword(s):

Pregnancy Rates ◽

Icsi Cycle ◽

Infertile Patients

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Experience of negative pressure wound therapy over sternal wound healing: A retrospective review

WCET Journal ◽

10.33235/wcet.39.2.9-18 ◽

2019 ◽

Vol 39 (2) ◽

pp. 9-18

Author(s):

Wai Sze Ho ◽

Wai Kuen Lee ◽

Ka Kay Chan ◽

Choi Ching Fong

Keyword(s):

Wound Healing ◽

Negative Pressure ◽

Negative Pressure Wound Therapy ◽

Assessment Tool ◽

Wound Care ◽

Wound Therapy ◽

Treatment Pathways ◽

Wound Assessment ◽

One Year

Objectives The aim of this study was to retrospectively review the effectiveness of negative pressure wound therapy (NPWT) in sternal wound healing with the use of the validated Bates-Jensen Wound Assessment Tool (BWAT), and explore the role of NPWT over sternal wounds and future treatment pathways. Methods Data was gathered from patients' medical records and the institution's database clinical management system. Seventeen subjects, who had undergone cardiothoracic surgeries and subsequently consulted the wound care team in one year were reviewed. Fourteen of them were included in the analysis. Healing improvement of each sternal wound under continuous NPWT and continuous conventional dressings was studied. In total, 23 continuous NPWT and 13 conventional dressing episodes were analysed with the BWAT. Results Among conventional dressing episodes, sternal wound improvement was 2.5–3% over 10 days to 3.5 weeks, whereas 4–5% sternal healing was achieved in 5 days to 2 weeks with sternal wire presence. Better healing at 11% in 1 week by conventional dressing was attained after sternal wire removal. In NPWT episodes, 8–29%, 13–24%, and 15–46% of healing was observed in 2 weeks, 3.5 to 5 weeks and 6 to 7 weeks, respectively. Only 39% wound healing was acquired at the 13th week of NPWT in one subject. With sternal wire present, 6%–29% wound healing progress was achieved by NPWT in 1–4 weeks, and 16–23% wound improvement in 2 to 4.5 weeks by NWPT after further surgical debridement. After sternal wire removal, 6–34% sternal wound healing occurred by continuous NPWT for 1–2 weeks, and maximum healing at 46% after 2.5 weeks of NPWT were observed. Conclusions Better wound healing was achieved in the NPWT group in comparison to conventional dressings alone. However, suboptimal sternal wound healing by NPWT alone was observed. Removal of sternal wire may improve the effectiveness of NPWT. Successful tertiary closure after NPWT among subjects supports the important bridging role of NPWT in sternal wound healing. Factors causing stagnant sternal wound healing by NPWT alone are discussed.

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ANDROST-5-ENE-3β,17β-DIOL IN OVARY OF POST-MENOPAUSAL HYPEROESTROGENIC WOMEN

Acta Endocrinologica ◽

10.1530/acta.0.0580364 ◽

1968 ◽

Vol 58 (3) ◽

pp. 364-376 ◽

Cited By ~ 5

Author(s):

S. Pesonen ◽

M. Ikonen ◽

B-J. Procopé ◽

A. Saure

Keyword(s):

Ovarian Tissue ◽

Cortical Layer ◽

Vaginal Smears ◽

Incubation Experiments ◽

Cell Groups ◽

Post Menopause ◽

Reducing Activity ◽

Post Menopausal ◽

One Year

ABSTRACT The ovaries of ten patients, at least one year after the post-menopause, were incubated with two Δ5-C19-steroids and also studied histochemically. All these patients had post-menopausal uterine bleeding and increased oestrogen excretion of the urine. The urinary estimations of gonadotrophins, 17-KS, 17-OHCS and pregnanediol were carried out on all patients. Vaginal smears were read according to Papanicolaou, and the endometrium and ovaries were studied histologically. The incubation experiments indicate the presence of Δ5-3β-hydroxysteroid-dehydrogenase. When androst-5-ene-3β,17β-diol was used as precursor the formation of testosterone occurred without any concomitant production of DHA and/or androstenedione. This seems to indicate the possible role of the Δ5-pathway in the formation of testosterone by post-menopausal ovarian tissue. The histochemical reactions indicated a reducing activity on NADH, lactate and glucose-6-phosphate, in certain corpora albicantia, atretic follicles and in diffuse thecoma regions in the cortical layer of the ovary. Steroid-3β-ol-dehydrogenase and β-hydroxybutyrate-dehydrogenase were found only at the edges of certain corpora albicantia, in some individual stroma cell groups and in some atretic follicles. Our studies, both biochemical and histochemical, suggest that the observed increase in the urinary oestrogens of the patients studied might in part at least, be of ovarian origin. This opinion is also supported by the postoperative oestrogen values.

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