EVALUATION OF SERUM C-PEPTIDE AND SERUM INSULIN LEVEL IN INDIVIDUAL WITH HIGH BMI/ SEDENTARY LIFE STYLE; NEWLY DIAGNOSED CASES OF HYPERTENSION/ TYPE2DM; AND OLD CASES OF DIABETES MELLITUS.

2021 ◽  
pp. 19-21
Author(s):  
Shipra Singh ◽  
Dipti Debbarma ◽  
Harishankar Mishra
Keyword(s):  
Diabetes Mellitus ◽  
Serum Insulin ◽  
P Value ◽  
Strong Positive Correlation ◽  
Fasting Insulin ◽  
Newly Diagnosed ◽  
Strong Negative Correlation ◽  
C Peptide ◽  
Sedentary Life ◽  
Sedentary Life Style

Introduction: Diabetes mellitus is the commonest endocrine disorder in population. This clinical syndrome is due to either absolute or relative insulin deciency. Currently number of diabetics worldwide is 422 million. In India the projected increase is from 20 to 62 million, The term diabetes is derived from Greek words Dia meaning “through”, and Bainein meaning “to go”. This disease causes loss of weight as if the body mass is passed through urine. It is a disease known from ancient times. Charaka in his treatise, elaborated this disorder as “Madhumeha” (meaning sweet urine) around 400 BC. Aim & Objective: The level of fasting insulin and serum c-peptide in individual with high BMI /sedentary life style; newly diagnosed cases of hypertension / type2 DM; and old cases of diabetes mellitus. Raised level of serum insulin and c-peptide as a cause of progressive diabetes which can lead to cardiovascular complications and help to prepare patient. Materials And Methods: It is an observational cross sectional study done in the diabetic outpatient clinic of our hospital. 60 diabetic patients were evaluated for fasting plasma glucose level, post prandial glucose level, Glycosalated haemoglobin HbA1c, fasting Insulin and fasting C-peptide level. Results And Analysis: From the above table it was inferred that there is very strong positive correlation of HbA1c with C-PEPTIDE and INSULIN ( r > 0.7 and p value = .000 ). From the table it is inferred that there is a very strong positive correlation of INSULIN with C-PEPTIDE ( r > 0.7 and p value =.000 ). From table it is inferred that C-PEPTIDE has a strong negative correlation with SBPand DBP. (r value > 0.7 and p = .000 ). From table it is inferred that INSULIN has a strong negative correlation with SBPand DBP. ( r value > 0.7 and p =.000). Summary & Conclusion: The level of serum insulin and c-peptide is found to be higher in “newly diagnosed” cases than that of “old diagnosed” cases and this can be explained by the fact that treatment modies the course of disease and slows its progression. With passage of duration, hypertension starts to build up in established cases of diabetes. C-peptide and serum insulin testing should be done in patients with poor blood glucose control to decide treatment modalities and to create awareness about lifestyle modications and education to Prevent progression of prediabetic stage to diabetic and further to its complicated stage.

scholarly journals Study of fasting & PP C- peptide & its correlation with HbA1c in T2 Diabetes mellitus in population of Uttarakhand

2022 ◽  
Vol 8 (4) ◽  
pp. 245-247
Author(s):  
Farah Ahsan ◽  
Naeem Qureshi ◽  
Sumera Samreen ◽  
Sonali Kukreti
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Secretion ◽  
P Value ◽  
Newly Diagnosed ◽  
Predominant Role ◽  
Serum Samples ◽  
Medicine Department ◽  
C Peptide ◽  
Insulin Resistence

We aimed to provide correlation of Fasting & PP C-peptide with HbA1C in patients of T2 Diabetes Mellitus.: 50 patients admitted in IPD of Medicine department in Shri Mahant Indresh Hospital from April-August 2021. Serum samples taken for fasting & PP C-peptide and HbA1C for patients of T2 Diabetes Mellitus and run on VITROS 5600/7600 which is based on dry chemistry. : We took 50 patients who were T2DM then we did fasting C peptide & PP C-peptide and HbA1c. Out of 50, 15 were females &35 were males. Out of 50, 45 patients had raised HbA1C maximum around 8-10.Mean & SD for fasting C-Peptide for males was 1.346±1.070 & for females 2.442±2.57.Mean & SD for Post prandiol C-Peptide for males was 4.208±5.020 & for females 2.993±2.130.It was significant for fasting C- Peptide with P value 0.0371 and non significant for PP C peptide with p value 0.3731.: Insulin secretion estimated by measurement of Fasting C-Peptide was either normal or raised in newly diagnosed T2DM subjects in my study indicating predominant role of insulin resistence in the etiology. Further research can explore the exact contribution of insulin resistence and insulin secretory defects in this area.

Prevalence of Hypertension and Associated Factors among Bank Workers in Harar Town, Eastern Ethiopia 2018

2020 ◽  
Vol 2 (3) ◽  
pp. 1-6
Author(s):  
Gosaye Teklehaymanot Zewde ◽  
Keyword(s):  
Risk Factor ◽  
Heart Disease ◽  
Life Style ◽  
Associated Factors ◽  
Study Participant ◽  
P Value ◽  
Eastern Ethiopia ◽  
Sedentary Life ◽  
Sedentary Life Style

Background: Hypertension clinically defined as a blood pressure of 140/90 mmHg or more on at least two readings on separated time. It is one of the most prevalent non communicable diseases and the most important preventable risk factor for premature death worldwide, due to heart disease and stroke. It is the most important modifiable risk factor for coronary heart disease, stroke, congestive heart failure, end stage renal disease and peripheral vascular diseases. Objective: To assess the prevalence of hypertension and its associated factors among bank workers in Harar town, Eastern Ethiopia 2018. Methods and material: Institutions based cross sectional study was conducted on 149 Bank workers in 6 governmental and 19 private banks which were found in Harar Town. Sample was allocated proportionately and study participant was selected by simple random sampling. Collected and checked data were entered in to Epi Data software version 3.02 and exported and analyzed using SPSS version 21. Descriptive statistics were used to determine prevalence such as frequency, percentage, mean and ratio. Both Bivariate and multiple logistic regressions were used to observe the association between the outcome variable and associated factors. P value less than 0.2 in Bivariate analysis was transferred to multivariate analysis and P value less than or equal to 0.05 was considered as level of statistically significance. Result: The prevalence of hypertension on this study was 27.5 %. Among study participant 6(4%) had diagnosed with hypertension and only 3 (2%) had on treatment and follow- up. 26(17.4%) bank workers BMI Was obsessed. In multivariable logistic regression analysis Age, Sedentary life style and BMI of bank workers had significant association with hypertension. Conclusion and recommendation: The prevalence of Hypertension in the study was 27.5% Age, Sedentary life style and BMI (Obesity) in this study was positively associated with higher odds of having hypertension. Regular blood monitoring, conducting physical exercise and reduction of Alcohol consumption and street Treatment care and follow-up strategy need to be maintained.

scholarly journals Kidney manifestations of diabetes mellitus – A Review

2018 ◽  
Vol 9 (4) ◽  
pp. 126
Author(s):  
Swaminathan S. ◽  
Rajeswari S. ◽  
Wasim Mohideen
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Kidney Disease ◽  
Delayed Diagnosis ◽  
Review Article ◽  
Metabolic Disturbances ◽  
Research Findings ◽  
Sedentary Life ◽  
Sedentary Life Style ◽  
Prevalence Of Diabetes Mellitus

    The prevalence of diabetes mellitus, especially T2DM is on the increase worldwide and in a developing country like india, as of date approximately 30 – 40% of population are identified as having DM. Sedentary life style, obesity, increased BMI, insulin resistance, hyperlipidemia, delayed diagnosis and metabolic syndrome are some of the factors  that lead to the development of DM. Extensive research have been conducted in this field and still more studies are being undertaken. The first organ affected in all uncontrolled DM patients is the kidney, followed by liver and cardiac. Kidney disease predominantly account for increased mortality among T2DM and is the main cause of CKD as well as DN. Treatment of CKD  due to  uncontrolled T2DM is still controversial because of the scarcity of evidence available. MA plays a significant role in screening pre and established DM.  Increased levels of urate is identified as one of the metabolic disturbances in T2DM. This review article summaries the research findings during the last two decades on the manifestations of kidney disease in T2DM.

scholarly journals Prevalence of Hypertension and Associated Factors among Bank Workers in Harar Town, Eastern Ethiopia 2018

2020 ◽  
Vol 3 (2) ◽  
pp. 01-06
Author(s):  
Gosaye Teklehaymanot Zewde
Keyword(s):  
Risk Factor ◽  
Heart Disease ◽  
Life Style ◽  
Associated Factors ◽  
Study Participant ◽  
P Value ◽  
Eastern Ethiopia ◽  
Sedentary Life ◽  
Sedentary Life Style

Background: Hypertension clinically defined as a blood pressure of 140/90 mmHg or more on at least two readings on separated time. It is one of the most prevalent non communicable diseases and the most important preventable risk factor for premature death worldwide, due to heart disease and stroke. It is the most important modifiable risk factor for coronary heart disease, stroke, congestive heart failure, end stage renal disease and peripheral vascular diseases Objective: To assess the prevalence of hypertension and its associated factors among bank workers in Harar town, Eastern Ethiopia 2018 Methods and material: Institutions based cross sectional study was conducted on 149 Bank workers in 6 governmental and 19 private banks which were found in Harar Town. Sample was allocated proportionately and study participant was selected by simple random sampling. Collected and checked data were entered in to Epi Data software version 3.02 and exported and analyzed using SPSS version 21. Descriptive statistics were used to determine prevalence such as frequency, percentage, mean and ratio. Both Bivariate and multiple logistic regressions were used to observe the association between the outcome variable and associated factors. P value less than 0.2 in Bivariate analysis was transferred to multivariate analysis and P value less than or equal to 0.05 was considered as level of statistically significance. Result: The prevalence of hypertension on this study was 27.5 %. Among study participant 6(4%) had diagnosed with hypertension and only 3 (2%) had on treatment and follow- up. 26(17.4%) bank workers BMI Was obsessed. In multivariable logistic regression analysis Age, Sedentary life style and BMI of bank workers had significant association with hypertension Conclusion and recommendation: The prevalence of Hypertension in the study was 27.5% Age, Sedentary life style and BMI (Obesity) in this study was positively associated with higher odds of having hypertension. Regular blood monitoring, conducting physical exercise and reduction of Alcohol consumption and street Treatment care and follow-up strategy need to be maintained.

scholarly journals Comparison of Insulin Resistance in Lean and Obese Adults with Type 2 Diabetes Mellitus- A Cross-sectional Study

2020 ◽  
Author(s):  
Sandinti Deepa ◽  
V Lakshmaiah ◽  
K Prabhakar ◽  
A Raveesha ◽  
CR Vidyasagar ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Fasting Insulin ◽  
Obese Adults ◽  
Cross Sectional ◽  
Univariate Logistic Regression Analysis ◽  
C Peptide

Introduction: Insulin Resistance (IR) can develop into type 2 diabetes mellitus and is closely associated with obesity. However, the non-obese population has also shown a predisposition to the risk of IR due to genetics. Aim: To assess the relationship between IR and obesity in Type 2 Diabetes Mellitus (T2DM) by comparing the proportion of subjects with IR in lean and obese T2DM and to identify the factors predicting IR in T2DM. Materials and Methods: A cross-sectional, hospital-based study was done at Department of Medicine of RL Jalappa hospital, Kolar, Karnataka on 106 T2DM patients aged >18 years. The study population was grouped into lean (BMI <19 kg/m2) and obese adults (BMI >30 kg/m2). IR was calculated using Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) and was considered as primary outcome variable. Obesity was considered as primary explanatory variable. Age, Gender, fasting insulin, C-peptide, Fasting Blood Sugar, Glycated haemoglobin (GHB or HbA1c) were the other explanatory variables. Descriptive analysis was carried out using mean and standard deviation for quantitative variables, frequency and proportion for categorical variables. Chi-square test was used to test statistical significance between the groups. Univariate logistic regression analysis was done to identify the predictors of IR. IBM Statistical Package for Social Sciences (SPSS) version 22 was used for statistical analysis. The p-value <0.05 was considered to be statistically significant. Results: The 106 subjects involved in the study had a mean age of 53.88±9.21 years. 44 subjects (41.5%) had IR. Obese to lean diabetic patients were in the ratio of 1:4. The proportion of obese diabetic subjects was (n=84, 79.2%) whereas lean diabetics were (n=22, 20.8%). The proportion of obese diabetic subjects with IR was 38.1% while the proportion of lean diabetic subjects with IR was 54.55%, but this difference was statistically not significant (p=0.163). On univariate logistic regression analysis, fasting insulin (odds ratio of 2.442 with 95% CI of 1.665 to 3.851, p<0.001**) and C-peptide (odds ratio of 1.446 with 95% CI of 1.123, p=0.004) were statistically significant factors attributing to IR. Conclusion: There was no significant relationship between IR and obesity. IR was independently associated with Fasting insulin levels and C-peptide levels.

scholarly journals Insulin Resistance and Hypogonadism

2013 ◽  
Vol 1 (1) ◽  
pp. 3-7
Author(s):  
Md Ruhul Amin ◽  
Md Faruque Pathan ◽  
AHM Aktaruzzaman ◽  
Nazmul Kabir Qureshi ◽  
Fahmida Akter ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Age Groups ◽  
Visceral Obesity ◽  
Cross Sectional Study ◽  
P Value ◽  
Age Group ◽  
Cross Sectional ◽  
Sedentary Life ◽  
Sedentary Life Style ◽  
Male Subjects

Backgound: The number of hypogonads is increasing day by day. It may be due to sedentary life style with increased obesity, increased tension or stressed lifestyle among all groups of populations. Visceral obesity is associated with insulin resistance, diabetes mellitus and also with hypogonadism. Objective: This study was carried out to determine the proportion of insulin resistance among male subjects with hypogonadism in different age groups along with status of erectile quality among diabetics and non diabetics. Materials and method: This cross sectional study among 161 adult male subjects aged ? 20 to ? 60 years were purposively selected from Bangladesh Institute of Research and Rehabilitation in Diabetes Endocrine and Metabolic Disorders (BIRDEM), Dhaka, Bangladesh between May 2009 to September 2010. Glycemic status and insulin resistance (by HOMA-R) were done and relevant history were documented. Results: The highest proportion (38.9%) of hypogonadism was in ? 50 years age group whereas highest proportion (39.6%) of the eugonads was in the age group of 40 to 49 years. More than half of the hypogonad subjects had weak erectile quality (54.0%) which were followed by absent erectile quality in 32.7% and 13.3% subjects had normal erectile quality. Among the eugonad subjects 41.7% had normal erectile quality, 41.6% subjects had weak erectile quality and 16.7% subjects had no erectile quality. More than ninety percent of the hypogonad subjects and about 60% of the eugonad subjects had insulin resistance. The average HOMA-R was more in the subjects with hypogonadism with diabetes which was highly significant (p-value < 0.001). Conclusion: Hypogonadism is associated with insulin resistance.DOI: http://dx.doi.org/10.3329/dmcj.v1i1.14968 Delta Med Col J. Jan 2013;1(1):3-7 

scholarly journals The association of glucose metabolism and kidney function in middle-aged adults

2021 ◽  
Author(s):  
Marielle A Schroijen ◽  
Renée de Mutsert ◽  
Friedo W Dekker ◽  
Aiko P J de Vries ◽  
Eelco J P de Koning ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Glucose Metabolism ◽  
Kidney Function ◽  
Odds Ratio ◽  
Fasting Glucose ◽  
Reference Group ◽  
Population Based ◽  
Glomerular Hyperfiltration ◽  
Fasting Insulin ◽  
Newly Diagnosed

ABSTRACT Background Previous clinical studies showed that various measures of glucose metabolism are associated with risk of chronic kidney disease in different populations, but results were not consistent in all aspects. In the present study we assessed measures of glucose metabolism and their association with kidney function in a population-based study. Methods The Netherlands Epidemiology of Obesity (NEO) study is a population-based cohort study of middle-aged men and women. We categorized the study population according to glycaemic levels into normoglycemia (reference group), pre-DM, known DM, and newly diagnosed DM. Outcome variables were serum creatinine, estimated glomerular filtration rate (eGFR), glomerular hyperfiltration (defined as an eGFR &gt;90th percentile; &gt; 102 ml/min/1.73 m2) and micro-albuminuria. We examined the association between measures of glucose metabolism (fasting glucose, HbA1c, fasting insulin, glucose area under the curve (AUC), insulin AUC, HOMA-IR, HOMA-B, Disposition index) and measures of kidney function. Results Of the total population (N = 6338), 55% participants were classified as normoglycemic (reference), 35% as pre-diabetes, 7% as diabetes mellitus, and 4% as newly diagnosed diabetes mellitus. Compared to the reference group, diagnosed and newly diagnosed DM was associated with a slightly higher trend in eGFR (+ 2.1 ml/min/1.73 m2 (95% CI -0.2, 4.4) and + 2.7 ml/min/1.73 m2 (95% CI -0.3, 5.7)) respectively. A 1% higher HbA1c was associated with an increased odds of hyperfiltration: odds ratio 1.41 (95% CI 1.06, 1.88). Higher levels of fasting plasma glucose, AUC glucose, and HOMA-B, were associated hyperfiltration. Fasting insulin, AUC insulin and HOMA-IR were not associated with hyperfiltration. Per mmol/l higher fasting glucose concentrations the odds ratio of micro-albuminuria was 1.21 (95% CI 1.04, 1.42). Conclusions Both fasting and post-prandial glucose and HOMA-B, but not measures of insulin resistance, were associated with glomerular hyperfiltration, while fasting glucose was also associated with micro-albuminuria.

scholarly journals Study on Association of Serum Uric Acid and Calcium with Insulin and its Resistance in Newly Diagnosed Type 2 Diabetes Mellitus Patients

2021 ◽  
Author(s):  
Saffalya Nayak ◽  
Roma Rattan ◽  
Manmath Kumar Mandal ◽  
Debjyoti Mohapatra
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Serum Insulin ◽  
Model Assessment ◽  
Newly Diagnosed

Introduction: Type 2 Diabetes Mellitus (T2DM) is a multifactorial pathological condition associated with insulin resistance and insulin deficiency. Uric acid and calcium have shown inconsistent association with occurrence of diabetes. Aim: To evaluate the role of uric acid and calcium in development of T2DM. Materials and Methods: This was a case-control study conducted in Department of Biochemistry from March to November 2019 in Sriram Chandra Bhanja, Medical College and Hospital, Cuttack, Odisha, India. A 180 subjects undertaken with the objective of finding any association of serum uric acid and calcium with insulin and its resistance in newly diagnosed T2DM cases. Newly diagnosed T2DM patients were taken as cases. Age and sex matched healthy individuals were taken as controls. Fasting Plasma Glucose (FPG), serum insulin, serum uric acid and ionised calcium were measured in autoanalyser and insulin resistance was calculated using Homeostasis Model Assessment for Insulin Resistance (HOMA- IR). Other confounding risk factors for T2DM like Body Mass Index (BMI), family history was taken into account. Results: A significant positive correlation of serum uric acid with serum insulin (p=0.029) and its resistance (p=0.032) in cases. Serum calcium was negatively associated with insulin and its resistance in both cases and controls. Regression models showed serum uric acid as a strong independent risk factor for levels of insulin and its resistance. Conclusion: The findings of the study showed that regular evaluation of serum uric acid and calcium should be done in those who are at risk of developing T2DM. Larger prospective studies will be required for definite assessment.

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