COMPARATIVE STUDY OF NIFEPIDINE AND ISOXSUPRINE IN SUPPRESSION OF PRETERM LABOUR IN THIRD TRIMESTER

Background: A prospective study was conducted to compare the efficacy of nifedipine against isoxsuprine in preventing preterm labour in third trimester and also to evaluate maternal side effects and neonatal outcome. Methods: This prospective comparative study was conducted at JLNMCH, Bhagalpur, Bihar. 75 antenatal women with gestational age between 28 to 36 weeks wereselected who fulfilled the inclusion criteria for the study, were given nifedipine and were monitored throughout thecourse of treatment. Results: Groups were compared with mean prolongation of delivery, side effects, neonatal outcome, parity, cervicaleffacements. Nifedipine was twice more effective than isoxsuprine hydrochloride as a uterine tocolytic agent whileside effects were comparable with fewer side effects in nifedipine group. Neonatal outcome was better with nifedipinein comparison to isoxsuprine. Conclusions: There is a high incidence of preterm labour in India. The present study found that nifedipine has bettertocolytic efficacy, less side effects and better tolerability as compared to isoxsuprine in third trimester.

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Comparison of safety, efficacy and perinatal outcome of isoxsuprine and nifedipine in women with preterm labour

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20164845 ◽

2017 ◽

Vol 6 (2) ◽

pp. 400

Author(s):

Seema BN ◽

Tejaswi V. Pujar

Keyword(s):

Side Effects ◽

Neonatal Outcome ◽

Preterm Labour ◽

Study Groups ◽

Research Centre ◽

Maternal Complications ◽

Uterine Contractions ◽

Group B ◽

A Prospective Study ◽

Maternal Side

Background: Over the last 50 years, extensive research has been conducted with the objective of preventing, predicting and optimizing the outcome of patients with preterm labour. Currently, the therapeutic foundation for treating preterm labour involves the use of tocolysis. An attempt is made to study the tocolytic effect of Isoxsuprine and nifedipine in suppression of preterm labour.Methods: This is a prospective study, carried out in the department of Obstetrics and Gynaecology of S S institute of medical sciences and research centre, Davangere, over a period of 15 months- from October 2014 to January 2016.Results: 60 antenatal cases with 28-36 weeks of gestation with painful intermittent uterine contractions were considered for the study. Subjects were randomly allotted into two groups - Group A (Isoxsuprine) and Group B (Nifedipine) 30 patients each. Main outcomes include prolongation of pregnancy, maternal side effects and neonatal outcome were compared. Baseline characteristics were well matched in both study groups. Mean prolongation of pregnancy was 31.68 days in Nifedipine and 27.54 days in Isoxsuprine group which was statistically significant. Success rate with Nifedipine was found to be 96% as compared to Isoxsuprine which was 75%. Maternal side effects like hypotension (13.33%) and tachycardia (6.66%) were common in Isoxsuprine group, while facial flushing was seen in16.66% patients in Nifedipine group. Neonatal outcome was similar in the both groups.Conclusions: Nifedipine is a safe and effective tocolytic agent than Isoxsuprine with less maternal complications.

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Comparative Study Between Clean Intermittent Self-Catheterization (Cisc) and Continuous Indwelling Catheterization (Cidc) in Relieving Acute Refractory Retention of Urine Due to Benign Enlargement of Prostate (Bep)

Bangladesh Journal of Urology ◽

10.3329/bju.v21i2.49882 ◽

2020 ◽

Vol 21 (2) ◽

pp. 105-110

Author(s):

Md Shawkat Alam ◽

Sudip Das Gupta ◽

Hadi Zia Uddin Ahmed ◽

Md Saruar Alam ◽

Sharif Muhammod Wasimuddin

Keyword(s):

Comparative Study ◽

Acute Urinary Retention ◽

Bladder Capacity ◽

Inclusion Criteria ◽

College Hospital ◽

Medical College ◽

High Incidence ◽

Group A ◽

Group B ◽

Better Than

Objective: To compare the clean intermittent self-catheterization (CISC) with continuous indwelling catheterization (CIDC) in relieving acute urinary retention (AUR) due to benign enlargement of prostate (BEP). Materials and Methods :A total 60 patients attending in urology department of Dhaka Medical college hospital were included according to inclusion criteria ,Patients were randomized by lottery into two groups namely group –A and group –B for CISC and IDC drainage respectively . Thus total 60 patients 30 in each group completed study. Results : Most men can safely be managed as out-patients after AUR due to BPH. The degree of mucosal congestion and inflammation within the bladder was found to be lower in those using CISC and the bladder capacity in these patients was also found higher.Patients with an IDC had a high incidence of UTIs then that of patients with CISC. During the period of catheterization the incidence of UTI was 43.3% in group B in comparison to 40% in group A; before TURP 36% in group B in comparison to 10% incidence in group A.According to patient’s opinion CISC is better than IDC in the management of AUR. Experiencing bladder spasm, reporting blood in urine, management difficulties, incidence and severity of pain were less in CISC group, and the method of CISC was well accepted by patients as well as their family members. Conclusion: From the current study it may be suggested that CISC is better technique for management of AUR patient due to BPH than IDC. It can also be very helpful when surgery must be delayed or avoided due to any reasons in this group of patients. Bangladesh Journal of Urology, Vol. 21, No. 2, July 2018 p.105-110

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Comparative study between endoscopic cartilage myringoplasty and endoscopic temporalis fascia myringoplasty

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20185116 ◽

2018 ◽

Vol 5 (1) ◽

pp. 24 ◽

Cited By ~ 1

Author(s):

P. Chozhan ◽

M. Sankara Subramanian ◽

D. Kannathal ◽

R. Malarvizhi

Keyword(s):

Comparative Study ◽

Prospective Study ◽

Temporalis Fascia ◽

Ear Surgery ◽

Medical College ◽

The World ◽

Prospective Comparative Study ◽

Patient Series ◽

A Prospective Study

Background: Myringoplasty is a common ear surgery performed all over the world. This study is focused on prospective comparative study using two different graft materials.Methods: This was a prospective study done in the Department of ENT Stanley Medical College, Chennai during the period from March 2013 to September 2013. Sample size was 60 patients. Follow up was done till 6 months. Results: Graft acceptance was achieved in 28 patients (93%) who underwent palisade cartilage myringoplasty, whereas it was achieved in 24 patients (80%) in the temporalis fascia myringoplasty group.Conclusions: The outcomes in our patient series indicate that cartilage myringoplasty achieves good results. Cartilage, a very effective material for the reconstruction of the TM and grafts can provide an excellent anatomical result, perfect stability and good functional outcome.

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A comparative study between nifedipine and isoxsuprine in the suppression of preterm labor pain

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20202727 ◽

2020 ◽

Vol 9 (7) ◽

pp. 2886

Author(s):

Susheela Khoiwal ◽

Vandana Patidar ◽

Radha Rastogi ◽

Bharat Tailor

Keyword(s):

Preterm Labor ◽

Preterm Labour ◽

Neonatal Morbidity ◽

Labour Pain ◽

Labor Pain ◽

Morbidity And Mortality ◽

Medical College ◽

Uterine Contractions ◽

High Incidence ◽

A Prospective Study

Background: A prospective study was conducted to compare the effectiveness of Nifedipine and Isoxsuprine in suppression of preterm labour pain as tocolytics drug. As preterm labour pain is major contributor for perinatal morbidity and mortality. The aims of this study were to assess the effect of nifedipine and isoxsuprine in threatened preterm labour with the aim of preventing preterm birth and its sequelae.Methods: This study was conducted on 100 patients coming to Pannadhay Rajkiya Mahila Chikitsalaya, RNT Medical College, Udaipur and attending OPD and IPD with complain of uterine contractions between 28-36 weeks of gestation.Results: Nifedipine was more effective than isoxsuprine hydrochloride as tocolytic agent.Conclusions: There is high incidence of preterm labour in India which leads to neonatal morbidity and mortality. Nifedipine is a better tocolytic drug compared to isoxsuprine hydrochloride.

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Prospective comparative study of third trimester serum retinol binding Protein 4 as a potential adipokine marker of pre-eclampsia

Cumhuriyet Medical Journal ◽

10.7197/223.vi.506381 ◽

2019 ◽

Author(s):

Handan Çelik ◽

Samettin Çelik ◽

Canan Soyer Çalışkan ◽

Miğraci Tosun ◽

Bahattin Avcı

Keyword(s):

Comparative Study ◽

Binding Protein ◽

Retinol Binding Protein ◽

Serum Retinol ◽

Third Trimester ◽

Retinol Binding Protein 4 ◽

Prospective Comparative Study

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Comparative study of efficacy of nifedipine, nitroglycerin dermal patches and isoxsuprine as tocolytic agents in suppression of preterm labour 1-year study at navodaya medical college hospital and research centre Raichur

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20212672 ◽

2021 ◽

Vol 10 (7) ◽

pp. 2806

Author(s):

Rita D. ◽

V. Haripriya

Keyword(s):

Side Effects ◽

Preterm Labour ◽

Research Centre ◽

College Hospital ◽

Treatment Groups ◽

Medical College ◽

Uterine Contractions ◽

Significant Difference ◽

Tocolytic Agent ◽

Tocolytic Agents

Background: Tocolytic agents are used to reduce preterm deliveries. Very few studies documenting the comparison of tocolytic agents viz. nifedipine, nitroglycerin dermal patches and isoxsuprine. Other drugs are not used due to their adverse effects. Objective was to study and compare the safety efficacy of nifedipine, nitroglycerin dermal patches and isoxsuprine as tocolytic agents in suppression of preterm labour 1 year study.Methods: This was a prospective case control study was conducted for a period of 1 year. Total 90 cases selected to study were randomly distribute in to three treatment groups viz. A, B, and C nifedipine, nitroglycerin and isoxsuprine respectively. Subjects in all three groups were evaluated for maternal pulse rate, palpitation uterine contractions and fetal heart rate in order to assess efficacy of each drug under investigation.Results: There was no statistically significant difference in age of woman’s in three different groups. Among (100%) subjects, majority of the cases i.e. (27.8%) primi gravida followed by multi (72.2%). Side effects of nifedipine was less when compared to nitroglycerine dermal patch and isoxsuprine i/v/o of headache (8.9%), nausea (1.1%), vomiting (1.1%), tachycardia (3.3%), palpitation (3.3%), hypotension (1.1%). side effects were statistically significant different between the treatment groups. There was no statistically significant difference with respect to APGAR score at 1 minute and 5 minutes.Conclusions: Oral nifedipine was found to be superior and efficacious as tocolytic agent as compared to transdermal nitroglycerin and intravenous isoxsuprine.

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Efficacy of oral nifedipine as a tocolytic agent

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20213468 ◽

2021 ◽

Vol 10 (9) ◽

pp. 3450

Author(s):

Veena Bikkolli Teekappa Gowda ◽

Madhubala Kalidoss

Keyword(s):

Side Effects ◽

Preterm Labour ◽

Mortality And Morbidity ◽

Minimal Dose ◽

Tocolytic Agent ◽

Maternal Monitoring ◽

Infant Outcome ◽

The Mean ◽

Randomized Control

Background: Preterm birth is defined as birth at less than 37 weeks period of gestation, is the most important single determinant of adverse infant outcome in terms of both survival and quality of life. The need for tocolysis in terms of safety and efficacy is necessary to decrease perinatal mortality and morbidity in preterm labour. This study was aimed to evaluate the effectiveness of nifedipine as a tocolytic for inhibiting uterine contraction in threatened preterm labour.Methods: It was a prospective, nonblinded, single centred, randomized control trial. This study included 100 cases of preterm labour admitted in department of obstetrics and gynaecology, KIMSH, Bangalore, who satisfied the inclusion and exclusion criteria and were administered with nifedipine tocolysis.Results: 100 cases of preterm were evaluated for the prolongation of pregnancy for more than 48 hours. Prolongation of pregnancy till term was observed in 88% of the cases administered with nifedipine tocolysis. The mean gestational age in each group was 32.58±1.95 weeks. Nifedipine had very few side effects, namely tachycardia and headache and no changes in fetal heart rate.Conclusions: In this study oral nifedipine was found to be efficacious in prolongation of pregnancy for more than 48 hours with the ease of oral administration and with minimal dose tocolytic effect was achieved. It had minimal maternal and neonatal side effects and eliminate the need for intensive maternal monitoring.

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Study on role of magnesium Sulphate as a Tocolytic agent in preventing preterm labour

Journal of Dhaka Medical College ◽

10.3329/jdmc.v22i2.21538 ◽

2015 ◽

Vol 22 (2) ◽

pp. 179-184

Author(s):

Lutfa Begum Lipi ◽

Nasima Begum ◽

Ummum Khair Alam ◽

Rounak Jahan ◽

Mohammed Mizanur Rahman ◽

...

Keyword(s):

Blood Pressure ◽

Preterm Birth ◽

Magnesium Sulphate ◽

Preterm Labour ◽

Medical College ◽

Uterine Contractions ◽

Tocolytic Agent ◽

Study Population ◽

A Prospective Study

A prospective study was done to assess the effectiveness of magnesium sulphate therapy given to women in preterm labour with the aim preventing preterm birth and its sequel. The place of study was the Department of Obstetrics & Gynecology, Sir Salimullah Medical College & Mitford Hospital, Dhaka. The study population were all primi and multigravida with preterm labour admitted in the above mentioned hospital, from January to December, 2009. Gestational age, maternal pulse, blood pressure, temperature, urine output, respiratory rate, uterine contractions, cervical effacement, dilatation and amniotic membrane status were elicited. Data were collected by questionnaire and analyzed with SPSS version 12.0. The results showed that magnesium sulphate injection is an effective method for tocolysis and appears to be safe for the mother and fetus and is a promising option for the treatment of preterm labour in a low resourced setting. DOI: http://dx.doi.org/10.3329/jdmc.v22i2.21538 J Dhaka Medical College, Vol. 22, No.2, October, 2013, Page 179-184

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Anterior inferior plating versus superior plating for middle 1/3rd clavicle fracture: a prospective comparative study

International Journal of Research in Orthopaedics ◽

10.18203/issn.2455-4510.intjresorthop20214960 ◽

2021 ◽

Vol 8 (1) ◽

pp. 48

Author(s):

Girish H. Rudrappa ◽

Deepak B. V. ◽

Gowthama Pradhaban

Keyword(s):

Surgical Technique ◽

Comparative Study ◽

Functional Outcome ◽

Outcome Measure ◽

Clavicle Fracture ◽

Delayed Union ◽

Demographic Analysis ◽

Inclusion Criteria ◽

Plating Technique ◽

Prospective Comparative Study

Background: Fractures of the clavicle are common injuries that may result from direct blow or transmitted forces. Deformities are shortening and depression of lateral fragments. Various techniques are performed out of which superior and anteroinferior plating are widely used with each having its own merits and drawbacks. Our study compares the outcome between above mentioned techniques.Methods: We conducted a prospective comparative study of 60 patients who has met inclusion criteria and out of which 30 patients were treated with anteroinferior technique and 30 patients were treated with superior plating technique. Outcome measure were assessed through constant and murley score.Results: The demographic analysis of our study showed that the incidence of fracture is predominant among males (63.3%) with RTA being the most common mode of injury. AO/OTA classification which was used in our study revealed A1 as the most frequently involved group. Each group had 2 patients with infection post operatively which was managed with appropriate antibiotics. Increased incidence of delayed union was found in anterioinferior group (13.3%) with decreased hardware prominence in comparison with superior plating.Conclusions: There were no significant differences in functional outcome between both the groups except the fact that superior plating had higher chances of plate prominence. So either of the surgical technique can be employed depending upon the feasibility of surgeon.

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