scholarly journals Comparison of safety, efficacy and perinatal outcome of isoxsuprine and nifedipine in women with preterm labour

2017 ◽  
Vol 6 (2) ◽  
pp. 400
Author(s):  
Seema BN ◽  
Tejaswi V. Pujar
Keyword(s):  
Side Effects ◽  
Neonatal Outcome ◽  
Preterm Labour ◽  
Study Groups ◽  
Research Centre ◽  
Maternal Complications ◽  
Uterine Contractions ◽  
Group B ◽  
A Prospective Study ◽  
Maternal Side

Background: Over the last 50 years, extensive research has been conducted with the objective of preventing, predicting and optimizing the outcome of patients with preterm labour. Currently, the therapeutic foundation for treating preterm labour involves the use of tocolysis. An attempt is made to study the tocolytic effect of Isoxsuprine and nifedipine in suppression of preterm labour.Methods: This is a prospective study, carried out in the department of Obstetrics and Gynaecology of S S institute of medical sciences and research centre, Davangere, over a period of 15 months- from October 2014 to January 2016.Results: 60 antenatal cases with 28-36 weeks of gestation with painful intermittent uterine contractions were considered for the study. Subjects were randomly allotted into two groups - Group A (Isoxsuprine) and Group B (Nifedipine) 30 patients each. Main outcomes include prolongation of pregnancy, maternal side effects and neonatal outcome were compared. Baseline characteristics were well matched in both study groups. Mean prolongation of pregnancy was 31.68 days in Nifedipine and 27.54 days in Isoxsuprine group which was statistically significant. Success rate with Nifedipine was found to be 96% as compared to Isoxsuprine which was 75%. Maternal side effects like hypotension (13.33%) and tachycardia (6.66%) were common in Isoxsuprine group, while facial flushing was seen in16.66% patients in Nifedipine group. Neonatal outcome was similar in the both groups.Conclusions: Nifedipine is a safe and effective tocolytic agent than Isoxsuprine with less maternal complications.

scholarly journals Comparative study of efficacy of nifedipine, nitroglycerin dermal patches and isoxsuprine as tocolytic agents in suppression of preterm labour 1-year study at navodaya medical college hospital and research centre Raichur

2021 ◽  
Vol 10 (7) ◽  
pp. 2806
Author(s):  
Rita D. ◽  
V. Haripriya
Keyword(s):  
Side Effects ◽  
Preterm Labour ◽  
Research Centre ◽  
College Hospital ◽  
Treatment Groups ◽  
Medical College ◽  
Uterine Contractions ◽  
Significant Difference ◽  
Tocolytic Agent ◽  
Tocolytic Agents

Background: Tocolytic agents are used to reduce preterm deliveries. Very few studies documenting the comparison of tocolytic agents viz. nifedipine, nitroglycerin dermal patches and isoxsuprine. Other drugs are not used due to their adverse effects. Objective was to study and compare the safety efficacy of nifedipine, nitroglycerin dermal patches and isoxsuprine as tocolytic agents in suppression of preterm labour 1 year study.Methods: This was a prospective case control study was conducted for a period of 1 year. Total 90 cases selected to study were randomly distribute in to three treatment groups viz. A, B, and C nifedipine, nitroglycerin and isoxsuprine respectively. Subjects in all three groups were evaluated for maternal pulse rate, palpitation uterine contractions and fetal heart rate in order to assess efficacy of each drug under investigation.Results: There was no statistically significant difference in age of woman’s in three different groups. Among (100%) subjects, majority of the cases i.e. (27.8%) primi gravida followed by multi (72.2%). Side effects of nifedipine was less when compared to nitroglycerine dermal patch and isoxsuprine i/v/o of headache (8.9%), nausea (1.1%), vomiting (1.1%), tachycardia (3.3%), palpitation (3.3%), hypotension (1.1%). side effects were statistically significant different between the treatment groups. There was no statistically significant difference with respect to APGAR score at 1 minute and 5 minutes.Conclusions: Oral nifedipine was found to be superior and efficacious as tocolytic agent as compared to transdermal nitroglycerin and intravenous isoxsuprine.

scholarly journals COMPARATIVE STUDY OF NIFEPIDINE AND ISOXSUPRINE IN SUPPRESSION OF PRETERM LABOUR IN THIRD TRIMESTER

2020 ◽  
pp. 1-2
Author(s):  
Priyanka Kumari ◽  
Anupama Sinha ◽  
Debarshi Jana
Keyword(s):  
Side Effects ◽  
Comparative Study ◽  
Neonatal Outcome ◽  
Preterm Labour ◽  
Inclusion Criteria ◽  
Third Trimester ◽  
Tocolytic Agent ◽  
High Incidence ◽  
Prospective Comparative Study ◽  
A Prospective Study

Background: A prospective study was conducted to compare the efficacy of nifedipine against isoxsuprine in preventing preterm labour in third trimester and also to evaluate maternal side effects and neonatal outcome. Methods: This prospective comparative study was conducted at JLNMCH, Bhagalpur, Bihar. 75 antenatal women with gestational age between 28 to 36 weeks wereselected who fulfilled the inclusion criteria for the study, were given nifedipine and were monitored throughout thecourse of treatment. Results: Groups were compared with mean prolongation of delivery, side effects, neonatal outcome, parity, cervicaleffacements. Nifedipine was twice more effective than isoxsuprine hydrochloride as a uterine tocolytic agent whileside effects were comparable with fewer side effects in nifedipine group. Neonatal outcome was better with nifedipinein comparison to isoxsuprine. Conclusions: There is a high incidence of preterm labour in India. The present study found that nifedipine has bettertocolytic efficacy, less side effects and better tolerability as compared to isoxsuprine in third trimester.

scholarly journals A comparative study of magnesium sulphate and isoxsuprine as a tocolytic in preterm labour

2021 ◽  
Vol 10 (3) ◽  
pp. 950
Author(s):  
Gayatri Mathuriya ◽  
Ritu Tarware
Keyword(s):  
Side Effects ◽  
Magnesium Sulphate ◽  
Perinatal Outcome ◽  
Neonatal Outcome ◽  
Preterm Labour ◽  
Later Life ◽  
Neuroprotective Effects ◽  
Medical College ◽  
Preterm Babies ◽  
Group B

Background: Preterm birth is a significant health problem across the world because of associated neonatal mortality and short-and long-term morbidity in later life. The incidence in India is higher than developed countries.Methods: The present study conducted in the Department of Obstetrics and Gynaecology, MGM Medical College and M. Y. Hospital. Indore, (Madhya Pradesh). The patients selected from labour rooms.100 antenatal women of gestational age between 28 weeks to 37 weeks presenting with preterm labor, 50 in each group. Group A consisted women receiving magnesium sulphate, group B had women receiving isoxsuprine. Efficacy of the two tocolytics, prolongation of pregnancy and neonatal outcome in preterm labour was assessed.Results: Intravenous magnesium sulphate was much effective in postponement of preterm labour for at least 48 hours (74%) as compared to isoxsuprine (50%). As a cervical dilatation, effacement increased the success rate of both the drugs came down. Magnesium sulphate side effects were better monitored clinically and tolerated. Also, better neonatal outcome and lesser perinatal mortality were noticed in this group (24%) compared to isoxsuprine (54%).Conclusions: Prematurity is the one of the major risk factor determing perinatal outcome. There is no ideal tocolytic, short term prolongation till steroid coverage for lung maturit with minimum side effects and to achieve better perinatal outcome recommended. The number of nursery admissions of preterm babies with better perinatal outcome were observed with magnesium sulphate. Also, the number of nursery admissions of preterm babies were less when treated with magnesium sulphate as tocolytic (also found to have neuroprotective effects in various studies), as compared to isoxsuprine.

scholarly journals A PROSPECTIVE STUDY TO ANALYSE THE SIDE EFFECTS OF OLMESARTAN MEDOXOMIL AND ENALAPRIL IN HYPERTENSIVE SUBJECTS

2018 ◽  
Vol 11 (12) ◽  
pp. 258
Author(s):  
Parminderpal Singh ◽  
Kiranjit Kiranjit
Keyword(s):  
Drug Therapy ◽  
Side Effects ◽  
Postural Hypotension ◽  
Olmesartan Medoxomil ◽  
National Commission ◽  
Group A ◽  
Group B ◽  
Taste Alteration ◽  
A Prospective Study

Objective: The present study was aimed to analyze the side effects of olmesartan medoxomil and enalapril in hypertensive subjects.Methods: The study consisted of newly diagnosed hypertension categorized according to 7th report of Joint National Commission on prevention, detection, evaluation, and treatment of high blood pressure. The subjects were divided into two groups. The Group A subjects received olmesartan, and Group B subjects received enalapril. Pressure was recorded both in supine and sitting positions. The appearance of side effects was observed in the follow-up, i.e., dry cough, headache, postural hypotension, angioedema, dizziness, skin rashes, taste alterations, and urticaria. A statistical data were prepared on the basis of information obtained and analyzed thoroughly for antihypertensive effects and side effects of olmesartan and enalapril. SPSS software was used for analysis.Results: There was observed an increase in the incidence of taste alteration with drug therapy in Group B (Enalapril). There was observed an increase in the incidence of postural hypotension with drug therapy in both groups. In Group A (Olmesartan), the incidence of postural hypotension at the beginning of trial, 4 weeks, and 8 weeks was 0%, 2%, and 2%, respectively. In Group A (Olmesartan), there was no incidence of a headache at the beginning of trial, at 4 weeks and 8 weeks.Conclusion: From the study, it can be concluded that both olmesartan and enalapril are effective in Stage I and Stage II hypertension, but olmesartan is tolerated well with lesser side effects.

scholarly journals Comparison of efficacy & safety of Blue Light vs topical application of 1% Clindamycin solution in the treatment of mild to moderate inflammatory Acne Vulgaris

2021 ◽  
Vol 15 (7) ◽  
pp. 1475-1480
Author(s):  
Saira Mohsin ◽  
Muhammad Nadeem ◽  
Shahbaz Aman ◽  
Zaib . ◽  
Shehbaz Ali
Keyword(s):  
Side Effects ◽  
Blue Light ◽  
Topical Application ◽  
Acne Vulgaris ◽  
Severity Index ◽  
Study Groups ◽  
P Value ◽  
Group B ◽  
Light Group ◽  
Efficacy Of Treatment

Aim: To compare the efficacy & safety of blue light vs topical application of 1% clindamycin solution in the treatment of mild to moderate inflammatory acne vulgaris. Study Design: Comparative interventional study done in Dermatology Outpatient Department Unit-II, KEMU/ Mayo Hospital, Lahore six months i.e. 1-06-2014 – 30-11-2014 Methodology: After an informed and written consent, 130 patients fulfilling the selection criteria were enrolled in the study and divided in two study groups A & B by balloting method. At first visit, a detailed history and clinical examination was recorded on a specially designed proforma. The acne was graded according to the acne grading scale of American Academy of Dermatology.4,13 Group A was exposed to blue light for twenty minutes twice weekly for eight weeks. Group B was given 1% clindamycin to apply twice daily for a period of eight weeks. Post- treatment follow up was done for next four weeks. Patients were assessed at 2nd, 4th, 6th, 8th, 10th, and 12th week. All findings and side effects were recorded on a predesigned proforma. To determine the efficacy of treatment, Acne Severity Index (ASI) was used.5 Result: Efficacy of treatment [≥ 50% improvement in ASI score] was seen in 39(60%) patients in blue light group while in clindamycin group it was achieved in 8 (12.3%) patients only. Blue light group had significantly less number of side effects observed in 35 (37.23%) patients while clindamycin group had a higher number of side effects observed in 59 (62.77%) patients, p-value= 0.013. Conclusion: Blue light is more efficacious and safer than topical 1% clindamycin in the treatment of mild to moderate inflammatory acne vulgaris. Keywords: Blue light, 1% Clindamycin, Acne vulgaris

scholarly journals A comparative study between nifedipine and isoxsuprine in the suppression of preterm labor pain

2020 ◽  
Vol 9 (7) ◽  
pp. 2886
Author(s):  
Susheela Khoiwal ◽  
Vandana Patidar ◽  
Radha Rastogi ◽  
Bharat Tailor
Keyword(s):  
Preterm Labor ◽  
Preterm Labour ◽  
Neonatal Morbidity ◽  
Labour Pain ◽  
Labor Pain ◽  
Morbidity And Mortality ◽  
Medical College ◽  
Uterine Contractions ◽  
High Incidence ◽  
A Prospective Study

Background: A prospective study was conducted to compare the effectiveness of Nifedipine and Isoxsuprine in suppression of preterm labour pain as tocolytics drug. As preterm labour pain is major contributor for perinatal morbidity and mortality. The aims of this study were to assess the effect of nifedipine and isoxsuprine in threatened preterm labour with the aim of preventing preterm birth and its sequelae.Methods: This study was conducted on 100 patients coming to Pannadhay Rajkiya Mahila Chikitsalaya, RNT Medical College, Udaipur and attending OPD and IPD with complain of uterine contractions between 28-36 weeks of gestation.Results: Nifedipine was more effective than isoxsuprine hydrochloride as tocolytic agent.Conclusions: There is high incidence of preterm labour in India which leads to neonatal morbidity and mortality. Nifedipine is a better tocolytic drug compared to isoxsuprine hydrochloride.

scholarly journals Efficacy of Tamsulosin and Alfuzosin in Management of Distal Ureteral Stones

Med Phoenix ◽  
2021 ◽  
Vol 6 (1) ◽  
pp. 10-13
Author(s):  
Bimochan Piya ◽  
Abhishek Bhattarai
Keyword(s):  
Urinary Tract ◽  
Side Effects ◽  
Diclofenac Sodium ◽  
Study Groups ◽  
Ureteral Stones ◽  
Control Group ◽  
P Value ◽  
Expulsion Rate ◽  
Group A ◽  
Group B

Introduction: Urinary tract calculi are the most frequent condition in urology clinics worldwide. The overall prevalence is about 5 % and lower urinary tract stones account for 70% among them. Medical expulsive therapy has been used to treat distal ureteric stone as it reduces symptoms and facilitates stone expulsion. The aim of this study is to evaluate and compare the efficacy of tamsulosin and alfuzosin as medical therapy in ureteric stones. Materials and Methods: A total of 87 patients with distal ureteral stones of size ≤10 mm were randomly divided into 3 groups. Group A patients (n-30) received 0.4 mg of tamsulosin daily, group B patients (n-29) received 10 mg of alfuzosin daily and group C patients (n-28) received 75 mg of diclofenac sodium. Patients in all groups received diclofenac sodium for one week and then as required. Follow-up was done on a weekly basis for 4 weeks. The stone expulsion rate, time for stone expulsion, and side-effects were recorded in each group. Results: The mean stone size (5.66, 5.79, 5.67) mm and age (29.1, 30.31, 29.4) were comparable in each group. The stone expulsion rate was 83.3%, 79.3%, and 50% in groups A, B, and C respectively.  It showed that both the study groups (Group A and Group B) were effective than the control group (p-value 0.006 and 0.02 respectively) but there was no difference between tamsulosin and alfuzosin (p-value 0.69). The duration of stone expulsion was 11.5 days, 11.8 days, and 17.3 days for Group A, B, and C respectively. The drugs related side effects reported by patients were mild and transient. Conclusion:  The use of tamsulosin and alfuzosin for the medical treatment of ureteric stones proved to be safe and effective and neither did have any significant benefits over the other.

scholarly journals Comparison between Allopurinol and Febuxostat in management of gout patients - a prospective study

2012 ◽  
Vol 10 (4) ◽  
pp. 257-259 ◽  
Author(s):  
KK Singal ◽  
S Goyal ◽  
P Gupta ◽  
BK Aggawal
Keyword(s):  
Side Effects ◽  
Serum Urate ◽  
End Point ◽  
Daily Dose ◽  
Group A ◽  
Baseline Values ◽  
Group B ◽  
A Prospective Study ◽  
Gout Flare

Aim:To assesses the efficacy of a relatively new drug-Febuxostat in management of gout and its comparison with allopurinol. Method: A comparative study of both Allopurinol and Febuxostat was done on 100 patients of gout. Both were studied for efficacy. side effects and for gout flare up. Results: Primary efficacy end point (baseline values) - a serum urate concentration of less than 6.0mg per deciliter at the last three measurements was reached by 54 %( 27/50) of group A patients taking 80mgs of febuxostat and 25 %( 12/50) of group B patients taking allopurinol 300mgs per day (P<0.001) Secondary efficacy end point(follow up values)- At first visit( after 2 weeks of onset of study), the proportions of subjects with serum urate concentration of less than 6.0mg/dl was significantly higher in the group A receiving febuxostat than the group B receiving allopurinol(P<0.001)[Tableno-1]. Conclusion: Febuxostat, at a daily dose was more effective than allopurinol at the commonly used fixed daily dose of 300 mg in lowering serum urate. Results of side effects and gout flare up were similar in both groups. Key words: Allopurinol; febuxostat; uric acid; goutDOI: http://dx.doi.org/10.3329/bjms.v10i4.7522 BJMS 2011; 10 (4): 257-259

scholarly journals Study on role of magnesium Sulphate as a Tocolytic agent in preventing preterm labour

2015 ◽  
Vol 22 (2) ◽  
pp. 179-184
Author(s):  
Lutfa Begum Lipi ◽  
Nasima Begum ◽  
Ummum Khair Alam ◽  
Rounak Jahan ◽  
Mohammed Mizanur Rahman ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Preterm Birth ◽  
Magnesium Sulphate ◽  
Preterm Labour ◽  
Medical College ◽  
Uterine Contractions ◽  
Tocolytic Agent ◽  
Study Population ◽  
A Prospective Study

A prospective study was done to assess the effectiveness of magnesium sulphate therapy given to women in preterm labour with the aim preventing preterm birth and its sequel. The place of study was the Department of Obstetrics & Gynecology, Sir Salimullah Medical College & Mitford Hospital, Dhaka. The study population were all primi and multigravida with preterm labour admitted in the above mentioned hospital, from January to December, 2009. Gestational age, maternal pulse, blood pressure, temperature, urine output, respiratory rate, uterine contractions, cervical effacement, dilatation and amniotic membrane status were elicited. Data were collected by questionnaire and analyzed with SPSS version 12.0. The results showed that magnesium sulphate injection is an effective method for tocolysis and appears to be safe for the mother and fetus and is a promising option for the treatment of preterm labour in a low resourced setting. DOI: http://dx.doi.org/10.3329/jdmc.v22i2.21538 J Dhaka Medical College, Vol. 22, No.2, October, 2013, Page 179-184

scholarly journals Sublingual Misoprostol for labour augmentation

2019 ◽  
Vol 8 (4) ◽  
pp. 1300
Author(s):  
Aruna Verma ◽  
Abhilasha Gupta ◽  
Monika Kashyap
Keyword(s):  
Side Effects ◽  
Effective Drug ◽  
Control Group ◽  
Study Group ◽  
Uterine Contractions ◽  
Sublingual Misoprostol ◽  
Group A ◽  
Maternal And Neonatal Outcomes ◽  
Foetal Outcome ◽  
Group B

Background: Labour dystocia is associated with a number of adverse maternal and neonatal outcomes. Augmentation of labour is a commonly used intervention in cases of labour dystocia. Misoprostol is an inexpensive and stable prostaglandin E1analogue. Present study was done to see the effectiveness of sublingual misoprostol for labour augmentation and foeto-maternal outcome.Methods: Total 100 labouring women of term gestation were taken and divided in two groups: group A (study group) and group B (control group). In study group 25mcg sublingual misoprostol given 4 hourly till adequate uterine contractions developed, i.e. >3 contractions in 10 minutes, each lasting for 40-45 seconds. A maximum of 200mcg of misoprostol or 8 doses were used and in group B no drug was given for augmentation of labour. Maternal and foetal outcome were observed in both groups.Results: Augmentation to delivery interval was very short in group A in comparison to group B. Maternal and foetal outcome were almost same in both groups.Conclusions: Sublingual misoprostol is a safe and effective drug for augmentation of labour leading to early delivery without any major side effects.

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