scholarly journals A comparative study between nifedipine and isoxsuprine in the suppression of preterm labor pain

2020 ◽  
Vol 9 (7) ◽  
pp. 2886
Author(s):  
Susheela Khoiwal ◽  
Vandana Patidar ◽  
Radha Rastogi ◽  
Bharat Tailor
Keyword(s):  
Preterm Labor ◽  
Preterm Labour ◽  
Neonatal Morbidity ◽  
Labour Pain ◽  
Labor Pain ◽  
Morbidity And Mortality ◽  
Medical College ◽  
Uterine Contractions ◽  
High Incidence ◽  
A Prospective Study

Background: A prospective study was conducted to compare the effectiveness of Nifedipine and Isoxsuprine in suppression of preterm labour pain as tocolytics drug. As preterm labour pain is major contributor for perinatal morbidity and mortality. The aims of this study were to assess the effect of nifedipine and isoxsuprine in threatened preterm labour with the aim of preventing preterm birth and its sequelae.Methods: This study was conducted on 100 patients coming to Pannadhay Rajkiya Mahila Chikitsalaya, RNT Medical College, Udaipur and attending OPD and IPD with complain of uterine contractions between 28-36 weeks of gestation.Results: Nifedipine was more effective than isoxsuprine hydrochloride as tocolytic agent.Conclusions: There is high incidence of preterm labour in India which leads to neonatal morbidity and mortality. Nifedipine is a better tocolytic drug compared to isoxsuprine hydrochloride.

scholarly journals Study on role of magnesium Sulphate as a Tocolytic agent in preventing preterm labour

2015 ◽  
Vol 22 (2) ◽  
pp. 179-184
Author(s):  
Lutfa Begum Lipi ◽  
Nasima Begum ◽  
Ummum Khair Alam ◽  
Rounak Jahan ◽  
Mohammed Mizanur Rahman ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Preterm Birth ◽  
Magnesium Sulphate ◽  
Preterm Labour ◽  
Medical College ◽  
Uterine Contractions ◽  
Tocolytic Agent ◽  
Study Population ◽  
A Prospective Study

A prospective study was done to assess the effectiveness of magnesium sulphate therapy given to women in preterm labour with the aim preventing preterm birth and its sequel. The place of study was the Department of Obstetrics & Gynecology, Sir Salimullah Medical College & Mitford Hospital, Dhaka. The study population were all primi and multigravida with preterm labour admitted in the above mentioned hospital, from January to December, 2009. Gestational age, maternal pulse, blood pressure, temperature, urine output, respiratory rate, uterine contractions, cervical effacement, dilatation and amniotic membrane status were elicited. Data were collected by questionnaire and analyzed with SPSS version 12.0. The results showed that magnesium sulphate injection is an effective method for tocolysis and appears to be safe for the mother and fetus and is a promising option for the treatment of preterm labour in a low resourced setting. DOI: http://dx.doi.org/10.3329/jdmc.v22i2.21538 J Dhaka Medical College, Vol. 22, No.2, October, 2013, Page 179-184

scholarly journals Association of vaginal infections in Preterm labour

2018 ◽  
Vol 7 (6) ◽  
pp. 2174
Author(s):  
Srilakshmi Yarlagadda ◽  
Sajana G. ◽  
Prasuna J. L. Narra
Keyword(s):  
High Risk ◽  
Preterm Labor ◽  
Preterm Labour ◽  
Neonatal Morbidity ◽  
Vaginal Swab ◽  
Morbidity And Mortality ◽  
Vaginal Infections ◽  
Increased Risk ◽  
Culture And Sensitivity ◽  
Genitourinary Infections

Background: Preterm labour is defined as onset of regular uterine contractions associated with cervical changes between 28-37 completed weeks of gestation. Prematurity is the cause of 85% neonatal morbidity and mortality. Preterm labour has multiple etiologies. Vaginal infections have been associated with increased risk for preterm labour. Screening for genitourinary infections antenatally, especially in high risk cases, prompt recognition and treatment decrease the incidence of preterm labour.Methods: Ours was a prospective and retrospective observational study done at Dr. Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation from April 2016 to February 2018 in the Department of Obstetrics and Gynaecology. The aim is to study the association of vaginal infections in preterm labour. A total of 116 women in preterm labor were studied. After clinical examination, CBP, CUE, Ultrasound, urine culture and sensitivity were done. Vaginal swab was taken from posterior fornix and sent for culture and sensitivity and gram staining .Culture and sensitivity were done in the Department of Microbiology at our Institute.Results: Out of 116 women in preterm labour, urinary tract infection was seen in 27.58% women. E. Coli was the commonest microorganism isolated in urine (15.51%). Vaginal infections were seen in 33.62% women. Candida was the commonest microorganism isolated in HVS cultures.Conclusions: Screening for genitourinary infections in pregnancy is necessary, especially in high risk cases. Early detection and prompt treatment of genitourinary infections decrease the incidence of preterm labor, thereby decreasing the neonatal morbidity and mortality associated with prematurity.

scholarly journals Butorphanol in Labour Analgesia

2018 ◽  
Vol 56 (214) ◽  
pp. 940-944 ◽  
Author(s):  
Jyotsna Yadav ◽  
Mohan Chandra Regmi ◽  
Pritha Basnet ◽  
K.M. Guddy ◽  
Balkrishna Bhattarai ◽  
...  
Keyword(s):  
Neonatal Outcome ◽  
Labour Pain ◽  
Cross Sectional Study ◽  
Labour Analgesia ◽  
Labor Pain ◽  
Inclusion Criteria ◽  
Cross Sectional ◽  
Fetal Heart Rate Monitoring ◽  
Uterine Contractions ◽  
Pain Scores

Introduction: Labour is the process where uterine contractions lead to expulsion of product of conception through the vagina into the outer world. Labour pain is one of the most severe pains which has ever been evaluated and its fear is one of the reasons women wouldn’t go for natural delivery. Delivery is a painful experience for all of the women except a few of them. The labor pain results from some physiological-psychological causes. Different pharmacological and non-pharmacological methods have been tried for pain relief in labour. The objective of this study is to see the effect of butorphanol injection in labour pain. Methods: It is a descriptive cross-sectional study conducted in B.P. Koirala institute of health sciences. We observed 200 pregnant women meeting the inclusion criteria and giving the informed consent who were on 1 mg butorphanol i.m. at the onset of active stage of labour every 4 hourly and on demand. Pain assessment was done by Numerical Pain analogue scale measured from 1 to 10. Fetal heart rate monitoring was done according to the hospital protocol. Caesarean section was performed for obstetrical indication. Neonatal outcome was evaluated by on duty pediatrician and APGAR score were noted at 1 and 5 min.Results: The pain scores in first, second, third, fourth hour were (8.83±0.773), (9.84±0.544), (9.94±0.338), (9.6±0.298) respectively, where 1st and 2nd hour is statistically significant.Conclusions: Butorphanol is an effective labour analgesia without significant adverse effects on women and the neonatal outcome.

scholarly journals Correlation of Thompson Score in Predicting Early Outcome of Newborn with Birth Asphyxia

2020 ◽  
Vol 18 (3) ◽  
pp. 406-410
Author(s):  
Sabina Shrestha ◽  
Sangita Puree Dhungana ◽  
Sujit Shrestha ◽  
Gentle Sunder Shrestha
Keyword(s):  
Neurodevelopmental Outcome ◽  
Birth Asphyxia ◽  
Neonatal Morbidity ◽  
Clinical Score ◽  
Hypoxic Ischemic Encephalopathy ◽  
Early Outcome ◽  
Medical College ◽  
A Prospective Study ◽  
Ischemic Encephalopathy

Background: Birth asphyxia is one of the important causes of neonatal morbidity and mortality, accounting up to 30% of neonatal death in Nepal. It is also an important cause of long term neurological disability and impairment. Thompson encephalopathy score is a clinical score which can be used to assess the newborn with hypoxic ischemic encephalopathy for the prognosis and their neurodevelopmental outcome. The aim of the study was to assess the role of Thompson score in predicting the early outcome of neonates with birth asphyxia. Methods: A prospective study was conducted from May 2019 to April 2020 in Nepal Medical College. All the term babies during the period with Apgar score of less than seven at five minutes were considered to have birth asphyxia and included in the study. Neurological examination was done on first, second and third day using HIE score proposed by Thompson and severity of hypoxic ischemic encephalopathy was classified accordingly. Outcome was measured as normal, morbidity with encephalopathy, seizure, organ dysfunction and death. Results: Out of 391 newborn admitted to neonatal unit, 84 (21.4%) had birth asphyxia. Mild Thompson score on day 1,2,3 were 49(58.3%), 49 (58.3%), 51(60.7%); moderate Thompson score on day 1,2,3 were 21 (25%), 21 (25%), 18(21.4%) and severe Thompson score on day 1, 2, 3 were 14 (16.7%), 14 (16.7%), 15(17.9%) respectively. Out of 14 babies who had severe Thompson score on day 1, 11(91.7%) expired and 3 (16.7%) developed encephalopathy. Conclusions: There was strong correlation of severity of Thompson score with the outcome. Keywords: Birth asphyxia; hypoxic ischemic encephalopathy; thompson score

scholarly journals UMA ANÁLISE INTEGRAL DO TRABALHO DE PARTO PREMATURO

2019 ◽  
Vol 6 (1) ◽  
pp. 54-57
Author(s):  
Renata dos Santos Oliveira ◽  
Maria Luiza Silva Brito ◽  
Delcides Bernardes da Costa Neto
Keyword(s):  
Risk Factors ◽  
Preterm Birth ◽  
Early Diagnosis ◽  
Preterm Labor ◽  
Transvaginal Ultrasound ◽  
Treatment Options ◽  
Neonatal Morbidity ◽  
Morbidity And Mortality ◽  
Fetal Fibronectin ◽  
Appropriate Treatment

A prematuridade é um dos mais significativos desafios da obstetrícia, constituindo a principal causa de morbimortalidade neonatal. A presença de fatores de risco, tanto maternos quanto fetais, geram maior vigilância durante o decorrer da gestação, entretanto cada gravidez ocorre de forma singular e seus fatores devem ser analisados individualmente, motivo que nos leva ao estudo profundo e integral de cada um deles. O diagnóstico do trabalho de parto prematuro é eminentemente clínico e, muitas vezes, de difícil estabelecimento precoce. Para auxiliar na obtenção de um diagnóstico em estágio inicial, tem-se empregado métodos complementares, como o ultrassom transvaginal e a fibronectina fetal. Existem várias opções de tratamento com suas particularidades para a indicação, porém a escolha deve ser feita prontamente a fim de prolongar a gestação, evitando os desfechos desfavoráveis do parto prematuro. Palavras-chave: trabalho de parto prematuro; diagnóstico precoce; tratamento adequado ABSTRACT Prematurity is one of the most significant challenges of obstetrics, being the main cause of neonatal morbidity and mortality. The presence of risk factors, both maternal and fetal, generate greater vigilance during the course of gestation, however each pregnancy occurs in a singular way and its factors must be analyzed individually, reason that leads us to the deep and integral study of each one of them. The diagnosis of preterm labor is eminently clinical and often difficult to establish early. To assist in obtaining an early diagnosis, complementary methods have been employed, such as transvaginal ultrasound and fetal fibronectin. There are several treatment options with their particularities for the indication, but the choice must be made promptly in order to prolong the gestation, avoiding the unfavorable outcomes of the preterm birth. Keywords: preterm labor; early diagnosis; appropriate treatment.

scholarly journals Outcome of Preterm Labour in SSMC Mitford Hospital, Dhaka.

2021 ◽  
Vol 33 (2) ◽  
pp. 143-146
Author(s):  
Mamata Manjari ◽  
Lipika Ghosh ◽  
Rokhshana Khatun ◽  
Jahanara Akter ◽  
Md Mohim Ibn Sina ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Perinatal Mortality ◽  
Preterm Labour ◽  
Neonatal Morbidity ◽  
Labour Pain ◽  
Clinical Problem ◽  
Cross Sectional Study ◽  
Intrauterine Fetal Death ◽  
Childhood Disability ◽  
Cross Sectional

Introduction: : Preterm birth as a consequence of preterm labour is the major clinical problem associated with perinatal mortality, serious neonatal morbidity and moderate to severe childhood disability and two-thirds of all perinatal deaths. Moreover, preterm labour comprises a large number of low birth weight babies. Global incidence of preterm labour is 5-10% of all births. The aim of this study was to determine the clinical profile and to find out pregnancy outcomes of preterm labour. Materials & Methods: This cross-sectional study was conducted in Sir Salimullah Medical College Mitford Hospital, Dhaka from January 2005 to December 2005. A total 103 gravid women who got admitted with established premature labour pain were included as study patients. Preterm labour associated with severe pre-eclampsia, eclampsia, antepartum haemorrhage and intrauterine fetal death were excluded. Data were collected in a pre-designed questionnaire and analyzed by SPSS software. Results: Incidence of preterm labour was found 6.3%. Among maternal morbidities, puerperal sepsis found to be highest (14.56%) followed by UTI (7.77%), PPH (6.80%), wound infection (5.83%) and retained placenta (3.88%). This study found perinatal mortality 32.0% and morbidity 49.5% of which RDS contributed highest (24.27%) followed by neonatal jaundice (11.65%), septicemia (8.73%), neonatal convulsion (2.91%) and umbilical sepsis (1.94%). Conclusion: Preterm labor followed by preterm birth significantly contributes to maternal morbidity and perinatal morbidity and mortality. Medicine Today 2021 Vol.33(2): 143-146

scholarly journals Comparative study of efficacy of nifedipine, nitroglycerin dermal patches and isoxsuprine as tocolytic agents in suppression of preterm labour 1-year study at navodaya medical college hospital and research centre Raichur

2021 ◽  
Vol 10 (7) ◽  
pp. 2806
Author(s):  
Rita D. ◽  
V. Haripriya
Keyword(s):  
Side Effects ◽  
Preterm Labour ◽  
Research Centre ◽  
College Hospital ◽  
Treatment Groups ◽  
Medical College ◽  
Uterine Contractions ◽  
Significant Difference ◽  
Tocolytic Agent ◽  
Tocolytic Agents

Background: Tocolytic agents are used to reduce preterm deliveries. Very few studies documenting the comparison of tocolytic agents viz. nifedipine, nitroglycerin dermal patches and isoxsuprine. Other drugs are not used due to their adverse effects. Objective was to study and compare the safety efficacy of nifedipine, nitroglycerin dermal patches and isoxsuprine as tocolytic agents in suppression of preterm labour 1 year study.Methods: This was a prospective case control study was conducted for a period of 1 year. Total 90 cases selected to study were randomly distribute in to three treatment groups viz. A, B, and C nifedipine, nitroglycerin and isoxsuprine respectively. Subjects in all three groups were evaluated for maternal pulse rate, palpitation uterine contractions and fetal heart rate in order to assess efficacy of each drug under investigation.Results: There was no statistically significant difference in age of woman’s in three different groups. Among (100%) subjects, majority of the cases i.e. (27.8%) primi gravida followed by multi (72.2%). Side effects of nifedipine was less when compared to nitroglycerine dermal patch and isoxsuprine i/v/o of headache (8.9%), nausea (1.1%), vomiting (1.1%), tachycardia (3.3%), palpitation (3.3%), hypotension (1.1%). side effects were statistically significant different between the treatment groups. There was no statistically significant difference with respect to APGAR score at 1 minute and 5 minutes.Conclusions: Oral nifedipine was found to be superior and efficacious as tocolytic agent as compared to transdermal nitroglycerin and intravenous isoxsuprine.

scholarly journals Weight does Matter! A Study of Effect of Obesity on Pregnancy and its Outcome

2013 ◽  
Vol 5 (3) ◽  
pp. 107-110
Author(s):  
Laxmi Maru ◽  
Shraddha Daksha ◽  
Anupama Dave ◽  
Neeta Natu
Keyword(s):  
Pregnant Women ◽  
South Asian ◽  
Significant Risk ◽  
Shoulder Dystocia ◽  
Medical College ◽  
Increased Risk ◽  
High Incidence ◽  
A Prospective Study ◽  
Maternal Bmi

ABSTRACT Objectives To analyze the significant risk associated with obesity and its consequences on obstetrics management and perinatal outcome. Materials and methods A prospective study was carried out in the Department of Obstetric and Gynecology, MGM Medical College and My Hospital, Indore. The study enrolled 200 pregnant women with body mass index (BMI) >25 and equal number of women with normal BMI (18-24.9) as control. Results A total of 76 (38%) out of 200 pregnant women were overweight, 70 (35%) were obese type 1 (BMI: 30-34.9), 44 (22%) had BMI (35-39.9) and 10 (5%) had BMI >40. In comparison to normal BMI pregnant women, women with BMI >25 had significant risk of gestation hypertension (p = 0.004), pre-eclampsia (p = 0.04) gestational diabetes mellitus and shoulder dystocia (p = 0.021), cesarean section (0.0001), induced labor (0.0001) and decreased incidence of VBAC (p = 0.037) with postoperative wound infection. Neonates of these women were mostly macrosomic (p = 0.021) and had high incidence of shoulder dystocia. Conclusion High maternal BMI at booking is associated with increased risk of pregnancy complications. Achieving a normal BMI prior to conception with the institution of healthy eating and exercise regimens may represent an ideal option. How to cite this article Dave A, Maru L, Daksha S, Natu N. Weight does Matter! A Study of Effect of Obesity on Pregnancy and its Outcome. J South Asian Feder Obst Gynae 2013;5(3): 107-110.

MECONIUM STAINED LIQOUR AND ITS IMPACT ON PERINATAL OUTCOME

2021 ◽  
pp. 47-49
Author(s):  
Ranjana Sharma ◽  
Manju Agarwal
Keyword(s):  
Prospective Observational Study ◽  
Perinatal Asphyxia ◽  
Birth Asphyxia ◽  
Neonatal Morbidity ◽  
Meconium Aspiration Syndrome ◽  
Morbidity And Mortality ◽  
Medical College ◽  
Increased Risk ◽  
Nicu Admission ◽  
One Year

Background- The occurrence of meconium-stained amniotic uid (MSAF) during labor has long been considered the predictor of adverse fetal outcomes such as meconium aspiration syndrome and perinatal asphyxia, which leads to perinatal and neonatal morbidity and mortality Methods- A Prospective observational study was carried out in Smt. Hira Kunwar Ba Mahila Hospital, Jhalawar attached to Jhalawar Medical College,over one year from January 2020 to January 2021. Total 278 cases taken at random basis having following inclusion criteria Result- MSL is responsible for neonatal morbidity in 15.1% of cases. Rate of neonatal morbidity was higher in thick meconium group (24.9%) as compared to thin meconium group (6.2%) and this difference was statistically signicant. In our study birth asphyxia (5.8%) was the most common complication followed by MAS (4%), Pneumonitis (3.6%) and Sepsis (1.8%). Conclusion- Passage of meconium still remains as an enigma to the obstetrician and equally worries the paediatrician. As shown in the study, thick meconium is associated with increased operative intervention, low apgar score, increased rate of NICU admission and increased risk of neonatal morbidity and mortality as compared to thin meconium.

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