scholarly journals Comparative study of efficacy of nifedipine, nitroglycerin dermal patches and isoxsuprine as tocolytic agents in suppression of preterm labour 1-year study at navodaya medical college hospital and research centre Raichur

2021 ◽  
Vol 10 (7) ◽  
pp. 2806
Author(s):  
Rita D. ◽  
V. Haripriya
Keyword(s):  
Side Effects ◽  
Preterm Labour ◽  
Research Centre ◽  
College Hospital ◽  
Treatment Groups ◽  
Medical College ◽  
Uterine Contractions ◽  
Significant Difference ◽  
Tocolytic Agent ◽  
Tocolytic Agents

Background: Tocolytic agents are used to reduce preterm deliveries. Very few studies documenting the comparison of tocolytic agents viz. nifedipine, nitroglycerin dermal patches and isoxsuprine. Other drugs are not used due to their adverse effects. Objective was to study and compare the safety efficacy of nifedipine, nitroglycerin dermal patches and isoxsuprine as tocolytic agents in suppression of preterm labour 1 year study.Methods: This was a prospective case control study was conducted for a period of 1 year. Total 90 cases selected to study were randomly distribute in to three treatment groups viz. A, B, and C nifedipine, nitroglycerin and isoxsuprine respectively. Subjects in all three groups were evaluated for maternal pulse rate, palpitation uterine contractions and fetal heart rate in order to assess efficacy of each drug under investigation.Results: There was no statistically significant difference in age of woman’s in three different groups. Among (100%) subjects, majority of the cases i.e. (27.8%) primi gravida followed by multi (72.2%). Side effects of nifedipine was less when compared to nitroglycerine dermal patch and isoxsuprine i/v/o of headache (8.9%), nausea (1.1%), vomiting (1.1%), tachycardia (3.3%), palpitation (3.3%), hypotension (1.1%). side effects were statistically significant different between the treatment groups. There was no statistically significant difference with respect to APGAR score at 1 minute and 5 minutes.Conclusions: Oral nifedipine was found to be superior and efficacious as tocolytic agent as compared to transdermal nitroglycerin and intravenous isoxsuprine.

scholarly journals An experience of workshop on introduction to statistical methods and SPSS hands-on training to enhance analytical skills among research professionals

2017 ◽  
Vol 4 (11) ◽  
pp. 4337
Author(s):  
Laxmi Tellur ◽  
Vijaya Sorganvi ◽  
M. C. Yadavannavar
Keyword(s):  
Statistical Methods ◽  
Research Centre ◽  
Teaching Methodology ◽  
Multiple Choice Questions ◽  
College Hospital ◽  
Medical College ◽  
Significant Difference ◽  
Hands On ◽  
Post Test ◽  
The Impact

Background: In a current scenario, research project and writing a thesis is one of the most important components of PG and Ph.D. studies and a potential area where the students are challenged by lack of structured guidance. Thus the workshop on “Introduction to Statistical Methods & ‘SPSS’ Hands-on Training” was conducted with the objectives, to know the impact of workshop and to obtain suggestions for improvement.Methods: The workshop on “Introduction to Statistical Methods & ‘SPSS’ Hands-on Training” conducted during 7-9 November, 2016 by the Department of Community Medicine, Shri B. M. Patil Medical College, Hospital and Research Centre in collaboration with University of Manitoba, Canada. The effectiveness of the workshop was assessed by pre-and-post tests using Multiple-Choice Questions (MCQ). Analysis was done using paired t test and Wilcoxon signed rank test.Results: A total of thirty six participants attended the sessions. The overall participant opinion about the workshop was positive. Majority of the participants were female. Majority of the participants were in the age group of 30-35 years (33%), followed by 25-30 years (28%). Majority of participants were MBBS (31%), MD (28%), other degree faulty members (22%) and PhD (22%). The mean score in pre-and-post-test was 12.52±6.17 and 13.98±6.50 respectively (Range=2-27) and was found significant difference in the scores between pre-and-post-tests (p=0.002).Conclusions: The recommendations and suggestions given by workshop participants were to increase the duration of the workshop. Participants were satisfied with the teaching methodology in the workshops. 

scholarly journals Comparison of safety, efficacy and perinatal outcome of isoxsuprine and nifedipine in women with preterm labour

2017 ◽  
Vol 6 (2) ◽  
pp. 400
Author(s):  
Seema BN ◽  
Tejaswi V. Pujar
Keyword(s):  
Side Effects ◽  
Neonatal Outcome ◽  
Preterm Labour ◽  
Study Groups ◽  
Research Centre ◽  
Maternal Complications ◽  
Uterine Contractions ◽  
Group B ◽  
A Prospective Study ◽  
Maternal Side

Background: Over the last 50 years, extensive research has been conducted with the objective of preventing, predicting and optimizing the outcome of patients with preterm labour. Currently, the therapeutic foundation for treating preterm labour involves the use of tocolysis. An attempt is made to study the tocolytic effect of Isoxsuprine and nifedipine in suppression of preterm labour.Methods: This is a prospective study, carried out in the department of Obstetrics and Gynaecology of S S institute of medical sciences and research centre, Davangere, over a period of 15 months- from October 2014 to January 2016.Results: 60 antenatal cases with 28-36 weeks of gestation with painful intermittent uterine contractions were considered for the study. Subjects were randomly allotted into two groups - Group A (Isoxsuprine) and Group B (Nifedipine) 30 patients each. Main outcomes include prolongation of pregnancy, maternal side effects and neonatal outcome were compared. Baseline characteristics were well matched in both study groups. Mean prolongation of pregnancy was 31.68 days in Nifedipine and 27.54 days in Isoxsuprine group which was statistically significant. Success rate with Nifedipine was found to be 96% as compared to Isoxsuprine which was 75%. Maternal side effects like hypotension (13.33%) and tachycardia (6.66%) were common in Isoxsuprine group, while facial flushing was seen in16.66% patients in Nifedipine group. Neonatal outcome was similar in the both groups.Conclusions: Nifedipine is a safe and effective tocolytic agent than Isoxsuprine with less maternal complications.

scholarly journals Study on role of magnesium Sulphate as a Tocolytic agent in preventing preterm labour

2015 ◽  
Vol 22 (2) ◽  
pp. 179-184
Author(s):  
Lutfa Begum Lipi ◽  
Nasima Begum ◽  
Ummum Khair Alam ◽  
Rounak Jahan ◽  
Mohammed Mizanur Rahman ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Preterm Birth ◽  
Magnesium Sulphate ◽  
Preterm Labour ◽  
Medical College ◽  
Uterine Contractions ◽  
Tocolytic Agent ◽  
Study Population ◽  
A Prospective Study

A prospective study was done to assess the effectiveness of magnesium sulphate therapy given to women in preterm labour with the aim preventing preterm birth and its sequel. The place of study was the Department of Obstetrics & Gynecology, Sir Salimullah Medical College & Mitford Hospital, Dhaka. The study population were all primi and multigravida with preterm labour admitted in the above mentioned hospital, from January to December, 2009. Gestational age, maternal pulse, blood pressure, temperature, urine output, respiratory rate, uterine contractions, cervical effacement, dilatation and amniotic membrane status were elicited. Data were collected by questionnaire and analyzed with SPSS version 12.0. The results showed that magnesium sulphate injection is an effective method for tocolysis and appears to be safe for the mother and fetus and is a promising option for the treatment of preterm labour in a low resourced setting. DOI: http://dx.doi.org/10.3329/jdmc.v22i2.21538 J Dhaka Medical College, Vol. 22, No.2, October, 2013, Page 179-184

scholarly journals Evaluation of effectiveness of rupatadine and olopatadine in patients of allergic rhinitis at Indore: a randomized control trial

2017 ◽  
Vol 6 (7) ◽  
pp. 1753
Author(s):  
Jay Shah ◽  
Poonam Patel
Keyword(s):  
Allergic Rhinitis ◽  
Cost Effective ◽  
Nasal Symptom ◽  
Research Centre ◽  
Differential Count ◽  
Double Blind ◽  
College Hospital ◽  
Treatment Groups ◽  
Medical College ◽  
Parallel Group

Background: Allergic rhinitis (AR) is one of the most prevalent atopic disorders that affect productivity and quality of life. Although individually olopatadine and rupatadine are efficacious in AR, data on the head to head study of these drugs in Indian population are scanty, so present study was undertaken with an aim to compare the efficacy, safety, and cost effectiveness of rupatadine and olopatadine in patients’ of allergic rhinitis.Methods: A prospective, randomized, double blind, parallel group, comparative 2 weeks clinical study conducted in eighty patients of AR in the Department of Pharmacology, Index Medical College Hospital and Research Centre, Indore. Following inclusion and exclusion criteria, 67 patients were recruited and randomized to two treatment groups and received the respective drugs for 2 weeks. At follow-up, parameters assessed were total nasal symptom score (TNSS), change in total and differential count of eosinophil.Results: In olopatadine group, there was a significantly higher reduction in TNSS (P < 0.05) than that of rupatadine. Both the drugs significantly reduced the absolute eosinophil count, but olopatadine (P <0.001) was found to be superior. The incidence of adverse effects was found to be less in olopatadine group when compared with rupatadine group.Conclusions: Both rupatadine and olopatadine provide effective relief of the symptoms of AR. However, clinical benefit occurs significantly more with olopatadine. However, rupatadine was more cost‑effective than olopatadine in treating the patients of AR in term of effectiveness.

scholarly journals A clinicopathological study of multinodular goitre

2019 ◽  
Vol 6 (3) ◽  
pp. 892
Author(s):  
Virendra S. Athavale ◽  
Saurabh M. Thakkar ◽  
Debabrata D. Gope ◽  
Akriti R. Tulsian ◽  
Sree Kumar B. ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Diagnostic Accuracy ◽  
Benign Lesion ◽  
Histopathological Finding ◽  
Research Centre ◽  
Multinodular Goitre ◽  
College Hospital ◽  
Medical College ◽  
Significant Difference ◽  
Operative Findings

Background: Multinodular goitre (MNG) is a clinicopathological entity characterized by an increased volume of the thyroid gland with formation of nodules. The present study has been planned to study the various clinical presentations and diagnostic accuracy between operative findings and histopathological findings in a case of multinodular goitre.Methods: The present study was a hospital-based prospective study conducted in Dr D.Y. Patil Medical College, Hospital and Research Centre, Pune between July 2016 to September 2018. 100 patients aged between 15 to 75 yrs. clinically diagnosed as multinodular goitre were included.Results: FNAC finding of multinodular goitre in the study group showed colloid goitre was seen in 62 cases, 27 cases had multinodular goitre. 6 cases had neoplastic etiology, 3 cases had Hashimoto’s thyroiditis and 2 cases had papillary carcinoma of thyroid. HPE finding wise distribution showed that 10 cases were malignant, and 90 cases were benign. FNAC finding was significantly associated with histopathological finding in detecting malignant or benign lesion of multinodular thyroid gland and diagnostic accuracy of FNAC is 92%. Clinical finding comparison with operative finding showed that diagnostic accuracy of detecting malignant or benign lesion was only 35%. There was no significant difference among the two methods for detecting type of lesion in multinodular thyroid.Conclusions: Females are predominantly affected. About 8% cases of MNG are malignant. Considering the histopathological report as a gold standard, correlation of FNAC finding with histopathological finding was very much accurate and significant for detecting malignant and benign lesion of multinodular thyroid.

scholarly journals A Study of the Safety and Efficacy of Alternate Day vs. Daily Rosuvastatin Dosing in Hypercholesterolemia Patients at Tertiary Care Hospital

2021 ◽  
Vol 10 (2) ◽  
pp. 33-37
Author(s):  
Rajesh Yadav ◽  
Gaurav Chhetri
Keyword(s):  
Side Effects ◽  
Tertiary Care ◽  
Care Hospital ◽  
Treatment Groups ◽  
Medical College ◽  
Parallel Group ◽  
Lipid Panel ◽  
Lipid Fractions ◽  
Significant Difference ◽  
The Cost

Background: Many of the patients with coronary heart disease require lifelong statin administration. Patients usually discontinue the medicine either due to side effects like myalgia, hepatotoxicity or due to the cost of the medicine.  The aim of this study is to see the scope of adjustment of the regimen to alternate-day dosing as an option to be considered in patients for whom adverse effects or cost are issues. Materials and Methods: A comparative, prospective, parallel group and open study was performed on forty- two patients of both genders with dyslipidaemia within the age group of 30 to 60 years attending the out – patients department of Medicine of Nobel Medical College and Teaching Hospital from February 2020 to March 2020. Mean reductions in different lipid fractions in the two treatment groups over the eight-week study period was calculated and then compared. Frequencies of patients developing different side effects was also calculated and compared between the two groups. Results: Baseline characters of both the groups were well balanced. Low density lipoprorein-C was reduced by 33.8 % in once-daily group and 31.3 % in alternate-day group, respectively. Changes were also recorded for the other lipid parameters. Such changes were found to be of no significant difference when compared between the two groups (p>0.05). Conclusion: An alternate-day regimen of statin in patients of hyperlipidaemia showed similar effect on the lipid panel compared to daily regimen.

SIGNIFICANCE OF PLACENTAL HISTOPATHOLOGICAL FINDINGS IN PRETERM/TERM BIRTH

2020 ◽  
Vol 4 (5) ◽  
Author(s):  
Monika Kushwaha ◽  
Sanjeev Narang
Keyword(s):  
Preterm Birth ◽  
Comparative Study ◽  
Pregnancy Outcome ◽  
Neonatal Morbidity ◽  
Research Centre ◽  
College Hospital ◽  
Cross Sectional ◽  
Chorionic Villi ◽  
Term Birth ◽  
Medical College

Background: This study is cross-sectional, observational and comparative study, at Index Medical College, Hospital & Research Centre, Indore, Madhya Pradesh from July 2017 to July 2019 with sample size 100 placentae. Method: The placenta received was evaluated blinded of maternal pregnancy outcome. The pattern of morphology was evaluated both qualitatively (type of lesion) and quantitatively (number of lesions). Result: In Present study 79% of the deliveries were term deliveries and 21% were preterm deliveries. On placental macroscopy, placenta weight was significantly low among the neonates of preterm deliveries (370.00±60.49) as compared to term deliveries (440.89±55.22). Preterm placenta had higher number of abnormal placental lesion compared to term pregnancies. Conclusion: The uteroplacental insufficiency defined as placental infarct, fibrosis of chorionic villi, thickening of blood vessels, and poor vascularity of chorionic villi. Placental histopathological lesions are strongly associated with maternal under perfusion and uteroplacental insufficiency. These are the reasons for preterm birth. Thus, knowledge of the etiological factor can be use to reduce maternal and neonatal morbidity and mortility. Keywords: Placenta, Term & Preterm.

scholarly journals Evaluation of the Severity of Major Depression Using a Voice Index for Emotional Arousal

Sensors ◽  
2020 ◽  
Vol 20 (18) ◽  
pp. 5041
Author(s):  
Shuji Shinohara ◽  
Hiroyuki Toda ◽  
Mitsuteru Nakamura ◽  
Yasuhiro Omiya ◽  
Masakazu Higuchi ◽  
...  
Keyword(s):  
Rating Scale ◽  
Area Under The Curve ◽  
Emotional Arousal ◽  
Arousal Level ◽  
National Defense ◽  
College Hospital ◽  
Medical College ◽  
National Defense Medical College ◽  
Significant Difference ◽  
The Relationship

Recently, the relationship between emotional arousal and depression has been studied. Focusing on this relationship, we first developed an arousal level voice index (ALVI) to measure arousal levels using the Interactive Emotional Dyadic Motion Capture database. Then, we calculated ALVI from the voices of depressed patients from two hospitals (Ginza Taimei Clinic (H1) and National Defense Medical College hospital (H2)) and compared them with the severity of depression as measured by the Hamilton Rating Scale for Depression (HAM-D). Depending on the HAM-D score, the datasets were classified into a no depression (HAM-D < 8) and a depression group (HAM-D ≥ 8) for each hospital. A comparison of the mean ALVI between the groups was performed using the Wilcoxon rank-sum test and a significant difference at the level of 10% (p = 0.094) at H1 and 1% (p = 0.0038) at H2 was determined. The area under the curve (AUC) of the receiver operating characteristic was 0.66 when categorizing between the two groups for H1, and the AUC for H2 was 0.70. The relationship between arousal level and depression severity was indirectly suggested via the ALVI.

TO COMPARE THE EFFECTIVENESS OF NEBULISATION WITH ADRENALINE, 3% HYPERTONIC SALINE AND NORMAL SALINE IN BRONCHIOLITIS IN CHILDREN OF 2 TO 24 MONTHS OF AGE BASED ON CLINICAL SEVERITY SCORE AND NEBULISATION FREQUENCY.

2021 ◽  
Vol 5 (2) ◽  
Author(s):  
Priyanka Jain ◽  
Rakesh Jain
Keyword(s):  
Hypertonic Saline ◽  
Normal Saline ◽  
Mean Difference ◽  
Clinical Severity ◽  
Research Centre ◽  
P Value ◽  
College Hospital ◽  
Mean Values ◽  
Significant Difference ◽  
The Mean

Background & Method: We conducted a double blinded study at Index Medical College Hospital & Research Centre, Indore. The sample size was determined to be minimum of 120 cases as based upon previous years admission due to acute bronchiolitis. Initially, 146 cases were included in the study out of which 23 cases dropped out of the study after giving consent by guardian for participation in the study as they left against medical advice from the hospital. Result: The mean difference of CSS between 0 minutes to 60 minutes of nebulisation between groups in all cases was 0.4 ± 0.6, between 60 minutes and 4 hours was 0.8 ± 0.6, between 4 to 8 hours was 0.7 ± 0.6, between 8-12 hours was 0.6 ± 0.4, between 12-24 hours was 1.6 ± 0.9 and between 24-48 hours was 1.9 ± 0.9.The mean values and resultant p-value of ANOVA of various nebulising agents used for improvement in CSS shows significant association between various nebulising agents used along with improvement in CSS at the end of assessment at 48 hours of treatment. Conclusion: This study was conducted to establish the efficacy of each nebulisation agent (i.e.  adrenaline, 3% hypertonic saline and normal saline) currently used and compare the outcomes as there is not enough evidence amongst Indian population on level of efficacy of each drug in causing improvement in symptoms and signs in various severities of bronchiolitis in early childhood. Comparison of significant improvement in mean difference in CSS at various intervals in all cases compared between groups by post hoc test revealed non-significant difference (p-value 0.700) between 3% hypertonic saline and normal saline. Keywords: nebulisation, adrenaline, bronchiolitis & clinical.

scholarly journals Occupational Stress among Nurses in a Public Medical College Hospital

2018 ◽  
Vol 6 (2) ◽  
pp. 86-89
Author(s):  
Shila Rani Das ◽  
Chinmay Biswas ◽  
Sharmina Afrin
Keyword(s):  
Occupational Stress ◽  
Family Income ◽  
High Stress ◽  
Clinical Work ◽  
Medical College Hospital ◽  
College Hospital ◽  
Cross Sectional ◽  
Medical College ◽  
Work Related ◽  
Significant Difference

Background: Now a days, there is increased demand and progress in the nursing profession. Along with these stress among the nurses has also increased.Objective: Purpose of the study was to assess the extent of perceived occupational stress and its association with work-related and non-work related causes among nurses.Materials and method: This Cross-sectional study was carried out among 197 nurses of Shaheed Suhrawardy Medical College hospital (ShSMCH), Dhaka, Bangladesh, from the period of 1st July 2015 to 30th June 2016. Sampling method was simple random sampling. Data was collected by face to face interview with the help of semi-structured questionnaire and finally all data were analyzed using SPSS software version 21.Results: It was found that 69% nurses were between the age of 21 to 39 years, 94.9% were female, 68% were married, 79.2% were Muslim, 84.3% had diploma, family income of 91.4% were equal to more than 40,000 Tk. and 95.5% used to do clinical work. Only 5.1% found to experience high stress. Statistically significant difference was found between sex, occupational stress and religion, educational status, and type of work (p < 0.05). Few nurses suffered from high stress but high level of stress were more in male, non Muslim, post graduate nurse and those who were engaged in administrative work.Conclusion: Nurse Managers should take appropriate actions to decrease stress helping their nurses to work efficiently and effectively.Delta Med Col J. Jan 2018 6(2): 86-89

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