FETO-MATERNAL OUTCOME OF INTRAVENOUS LABETALOLAND ORAL NIFEDIPINE IN SEVERE PRE-ECLAMPSIA- A COMPARATIVE STUDY

Introduction: Pre-eclampsia (PE) is a disorder of pregnancy characterized by the onset of high blood pressure and often a significant amount of protein in the urine. When it arises, the condition begins after 20 weeks of pregnancy. Aims and objectives: 1. to determine the efficacy and safety of oral nifedipine for treatment of severe hypertension of pregnancy compared with intravenous labetalol. 2. To compare the time taken to reach the therapeutic goal blood pressure after using intravenous labetalol & oral nifedipine in severe pregnancy induced hypertension. 3. The time taken to achieve a blood pressure of less than 150/100 mmHg. 4. To compare the maternal and perinatal outcome among the subjects using nifedepine over labetalo. Material and method: PROSPECTIVE RANDOMISED INTERVENTIONAL COMPARITIVE TRAIL. One and half year. Conclusion: Our present study compares the efficacy of oral Nifedipine and IV Labetalol in reaching the therapeutic goal. From the results of our study we can conclude that nifedipine required less time for reaching target BP as compare to labetalol. Less no of dose of nifedipine was used for the rapid control of blood pressure in severe hypertension in pregnancy. So, Nifedipine may be preferable as it is a simple, less time and is an oral regimen.

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Pregnancy-induced hypertension and the neonatal outcome

Acta Paulista de Enfermagem ◽

10.1590/s0103-21002008000100008 ◽

2008 ◽

Vol 21 (1) ◽

pp. 53-58 ◽

Cited By ~ 8

Author(s):

Solange Regina Perfetto Chaim ◽

Sonia Maria Junqueira Vasconcellos de Oliveira ◽

Amélia Fumiko Kimura

Keyword(s):

Blood Pressure ◽

Perinatal Outcome ◽

Neonatal Outcome ◽

Maternity Hospital ◽

Cross Sectional Study ◽

Pregnancy Induced Hypertension ◽

Sectional Study ◽

Cross Sectional ◽

Normal Birth ◽

Induced Hypertension

OBJECTIVES:This cross-sectional study were to identify the prevalence of pregnancy-induced hypertension and to verify diastolic blood pressure (DBP) association with type of birth and perinatal outcome. METHODS: The data were collected from the mothers' records, in the governmental maternity hospital indicated for high-risk pregnancies, in São Paulo city. RESULTS: During hospitalization, 62.1% had systolic blood pressure > 160 mmHg and 49.6% had a DBP < 110 mmHg. There was no significant association of DBP (p=0.799). The frequency of caesarean section was 64.5%, 28.9% for normal birth, and 6.6% for forceps; 93.4% were live born, 81.0% weighed > 2,500 g, 10.6% were premature, 68.1% were born with adequate gestational age, 84.0% and 99.2% had APGAR score > 7 at 1st and 5th minutes, respectively. CONCLUSION: The DBP e" 110 mmHg was associated with low birth weight (p=0.002) and prematurity (p=0.013).

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Managing high blood pressure in pregnancy

Drug and Therapeutics Bulletin ◽

10.1136/dtb.31.14.53 ◽

1993 ◽

Vol 31 (14) ◽

pp. 53-56

Keyword(s):

Blood Pressure ◽

Arterial Blood Pressure ◽

High Blood Pressure ◽

Chronic Hypertension ◽

Pregnancy Induced Hypertension ◽

Hypertension In Pregnancy ◽

Arterial Blood ◽

Induced Hypertension ◽

In Pregnancy

Raised arterial blood pressure is common in pregnancy. Usually it is due solely to the pregnancy and resolves within days or weeks of delivery (pregnancy-induced hypertension – PIH). Occasionally it is chronic hypertension which predates or begins during pregnancy; it persists after delivery. In some women it is a mixture of both, with pregnancy-induced hypertension superimposed on existing chronic hypertension. In this article we discuss the risks to mother and fetus of hypertension in pregnancy and review its prevention and management.

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Systolic blood pressure and fatty acid-binding protein 4 predict pregnancy-induced hypertension in overweight nulliparous women

Endocrine Abstracts ◽

10.1530/endoabs.35.p637 ◽

2014 ◽

Author(s):

Anna Tuuri ◽

Matti Jauhiainen ◽

Risto Kaaja

Keyword(s):

Blood Pressure ◽

Fatty Acid ◽

Systolic Blood Pressure ◽

Fatty Acid Binding Protein ◽

Binding Protein ◽

Pregnancy Induced Hypertension ◽

Fatty Acid Binding ◽

Acid Binding Protein ◽

Nulliparous Women ◽

Induced Hypertension

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Serum Uric Acid Level as a Predictive Biomarker of Gestational Hypertension Severity; A Prospective Observational Case-Control Study

Reviews on Recent Clinical Trials ◽

10.2174/1574887115666200709142119 ◽

2020 ◽

Vol 15 (3) ◽

pp. 227-239 ◽

Cited By ~ 1

Author(s):

Hader I. Sakr ◽

Akef A. Khowailed ◽

Reham S. Al-Fakharany ◽

Dina S. Abdel-Fattah ◽

Ahmed A. Taha

Keyword(s):

Blood Pressure ◽

Pregnant Women ◽

Case Control Study ◽

Serum Urate ◽

Interleukin 1Β ◽

Pregnancy Induced Hypertension ◽

C Reactive Protein ◽

Reactive Protein ◽

Induced Hypertension ◽

Control Study

Background: Pre-eclampsia poses a significant potential risk of hypertensive disorders during pregnancy, a leading cause of maternal deaths. Hyperuricemia is associated with adverse effects on endothelial function, normal cellular metabolism, and platelet aggregation and adhesion. This study was designed to compare serum urate levels in normotensive pregnant women to those with pregnancy-induced hypertension, and to evaluate its value as a potential predictive marker of hypertension severity during pregnancy. Methods: A prospective, observational, case-control study conducted on 100 pregnant women in their third trimester. Pregnant women were classified into two groups (n=50) according to arterial blood pressure measurements: group I had normal blood pressure, and group II had a blood pressure of ≥ 140/90, which was further subdivided according to hypertension severity into IIa (pregnancy- induced hypertension, IIb (mild pre-eclampsia), and IIc (severe pre-eclampsia). Blood samples were obtained on admission. Serum urate, high sensitive C-reactive protein, and interleukin-1β levels, and lipid profile were compared among the groups. Results: A significant increase in the mean values of serum urate, C-reactive protein, and interleukin- 1β levels was detected in gestational hypertensives. In addition, there was a positive correlation between serum urate levels and C-reactive protein and interleukin-1β, as well as between serum urate levels and hypertension severity. Conclusion: Hyperuricemia and increased C-reactive protein and interleukin-1β serum levels correlate with the severity of pregnancy-induced hypertension, and these biomarkers may play a role in the pathogenesis of pre-eclampsia. Serum urate measurement is sensitive, reliable markers that correlate well with the severity of hypertension in pregnant females with pre-eclampsia.

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Incidence of Pregnancy Induced Hypertensive Women and its Associated Factors

10.53350/pjmhs2115123307 ◽

2021 ◽

Vol 15 (12) ◽

pp. 3307-3309

Author(s):

Samia Saifullah ◽

Maryam Shoaib ◽

Muhammad Sohail Tareen ◽

Nosheen Sikander Baloch

Keyword(s):

Blood Pressure ◽

Family History ◽

Pregnant Women ◽

Cross Sectional Study ◽

Mean Value ◽

Renal Diseases ◽

Pregnancy Induced Hypertension ◽

Cross Sectional ◽

Induced Hypertension ◽

Keywords Pregnancy

Background: Pregnancy induced hypertension is a fetal disease resulting into morbidity and mortality of female as well as its neonate. Objective: To find the incidence of pregnancy induced hypertension in Pakistani women. Study Design: Cross sectional study Place and Duration of the Study: Department of Obstetrics & Gynaecology, Sandeman Provincial Hospital, Quetta from 1st March 2019 to 31st March 2021. Methodology: Seven hundred and twenty eight females were identified with pregnancy induced hypertension from all the pregnant women attending the outdoor were enrolled. Each female was checked for their protein urea as well as systolic and diastolic blood pressure according to standard operating protocol. Socio-demographic, clinical and family history were documented. Results: Among all pregnant women, 150 were identified as pregnancy induced hypertensive with a 20.6% incidence of pregnancy induced hypertension. The mean value systolic blood pressure value was 144.3±5.2 and of diastolic as 83.1±5.2 in pregnancy induced hypertension women. Conclusion: Family history, obesity and renal diseases are the main factors associated with pregnancy induced hypertension with an incidence of 20.6% among pregnant women. Keywords: Pregnancy induced hypertension, Body mass index, Pregnant women, Hypertension

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Twenty-four hour blood pressure monitoring in early pregnancy: is it predictive of pregnancy-induced hypertension and preeclampsia?

Acta Obstetricia Et Gynecologica Scandinavica ◽

10.1080/00016349808565804 ◽

1998 ◽

Vol 77 (1) ◽

pp. 14-21 ◽

Cited By ~ 8

Author(s):

Chiara Benedetto ◽

Luca Marozio ◽

Maurizio Giarola ◽

Luciano Chiarolini ◽

Vincenza Maulà ◽

...

Keyword(s):

Blood Pressure ◽

Early Pregnancy ◽

Blood Pressure Monitoring ◽

Pregnancy Induced Hypertension ◽

Pressure Monitoring ◽

Induced Hypertension

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Significance of obstetric Doppler studies in prediction of perinatal outcome in pregnancy induced hypertension

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20172312 ◽

2017 ◽

Vol 6 (6) ◽

pp. 2354 ◽

Cited By ~ 1

Author(s):

Pradip R. Gaikwad ◽

Manisha R. Gandhewar ◽

Nity Rose ◽

Vidyadhar Suryakar

Keyword(s):

Diagnostic Accuracy ◽

Doppler Ultrasound ◽

Predictive Value ◽

Perinatal Outcome ◽

Uterine Artery ◽

Pregnancy Induced Hypertension ◽

Doppler Studies ◽

Uterine Artery Doppler ◽

Adverse Perinatal Outcome ◽

Induced Hypertension

Background: Pregnancy induced hypertension (PIH) is associated with adverse perinatal outcome. Multi vessel color Doppler studies are useful in these cases for timely intervention. The aim of present study was to know the significance of umbilical, middle cerebral and uterine artery Doppler studies in PIH and to analyse its role in predicting perinatal outcome.Methods: This was a prospective study of 106 singleton pregnancies in the third trimester with PIH. The results of last Doppler ultrasound within one week of delivery were used for analysis. Adverse perinatal outcome was studied in the form of emergency cesarean section for fetal distress, meconium stained amniotic fluid, Apgar at 5 min <7, NICU admission and perinatal mortality (stillbirths and neonatal death). Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy of various Doppler parameters were calculated after comparing with standard.Results: In the present study specificity and diagnostic accuracy of all Doppler ultrasound parameters was high in predicting adverse perinatal outcome. Cerebroplacental ratio showed highest specificity (98.55%), PPV (94.44%) and diagnostic accuracy (80.19%) in predicting adverse perinatal outcome and it is better than MCA PI and UA PI alone. Uterine artery Doppler evaluation also gives additional information in predicting adverse perinatal outcome.Conclusions: Amongst various Doppler parameters cerebroplacental index (MCA/UA PI) is best predictor of adverse perinatal outcome.

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Roll-over test in primigravidae attending a public primary care service

Sao Paulo Medical Journal ◽

10.1590/s1516-31801997000500004 ◽

1997 ◽

Vol 115 (5) ◽

pp. 1533-1536

Author(s):

Luiz Francisco Marcopito

Keyword(s):

Blood Pressure ◽

Primary Care ◽

Roc Curve ◽

Operating Characteristic ◽

Care Setting ◽

Care Service ◽

Primary Care Service ◽

Pregnancy Induced Hypertension ◽

Predictive Values ◽

Induced Hypertension

OBJECTIVE:To determine the roll-over test (ROT) performance in predicting pregnancy-induced hypertension (PIH) in primigravidae aged 15-29 years in a public primary care service. METHOD: Prospective cohort study enrolling 369 consecutive and initially normotensive primigravidae. The ROT was applied within 28-32 weeks of pregnancy. PIH was defined as diastolic blood pressure (DBP) 90 mm Hg or systolic blood pressure (SBP) 140 mm Hg, or a rise in DBP 15 mm Hg or a rise in SBP 30 mm Hg. The ROT prognostic properties were calculated, and a receiver operating characteristic (ROC) curve was constructed. RESULTS: For the 20 mm Hg cutoff point, sensitivity was 20% and specificity was 93%. Positive and negative predictive values were, respectively, 23% and 92%, for a PIH cumulative incidence of 9.5%. With other cutoff points, the ROC curve showed a poor discriminatory value of the test. CONCLUSION: The ROT was not useful for predicting PIH in a primary prenatal care setting.

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