Immunosuppression Improves Blood Pressure and Endothelial Function in a Rat Model of Pregnancy-Induced Hypertension

Background: Pre-eclampsia poses a significant potential risk of hypertensive disorders during pregnancy, a leading cause of maternal deaths. Hyperuricemia is associated with adverse effects on endothelial function, normal cellular metabolism, and platelet aggregation and adhesion. This study was designed to compare serum urate levels in normotensive pregnant women to those with pregnancy-induced hypertension, and to evaluate its value as a potential predictive marker of hypertension severity during pregnancy. Methods: A prospective, observational, case-control study conducted on 100 pregnant women in their third trimester. Pregnant women were classified into two groups (n=50) according to arterial blood pressure measurements: group I had normal blood pressure, and group II had a blood pressure of ≥ 140/90, which was further subdivided according to hypertension severity into IIa (pregnancy- induced hypertension, IIb (mild pre-eclampsia), and IIc (severe pre-eclampsia). Blood samples were obtained on admission. Serum urate, high sensitive C-reactive protein, and interleukin-1β levels, and lipid profile were compared among the groups. Results: A significant increase in the mean values of serum urate, C-reactive protein, and interleukin- 1β levels was detected in gestational hypertensives. In addition, there was a positive correlation between serum urate levels and C-reactive protein and interleukin-1β, as well as between serum urate levels and hypertension severity. Conclusion: Hyperuricemia and increased C-reactive protein and interleukin-1β serum levels correlate with the severity of pregnancy-induced hypertension, and these biomarkers may play a role in the pathogenesis of pre-eclampsia. Serum urate measurement is sensitive, reliable markers that correlate well with the severity of hypertension in pregnant females with pre-eclampsia.

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Incidence of Pregnancy Induced Hypertensive Women and its Associated Factors

10.53350/pjmhs2115123307 ◽

2021 ◽

Vol 15 (12) ◽

pp. 3307-3309

Author(s):

Samia Saifullah ◽

Maryam Shoaib ◽

Muhammad Sohail Tareen ◽

Nosheen Sikander Baloch

Keyword(s):

Blood Pressure ◽

Family History ◽

Pregnant Women ◽

Cross Sectional Study ◽

Mean Value ◽

Renal Diseases ◽

Pregnancy Induced Hypertension ◽

Cross Sectional ◽

Induced Hypertension ◽

Keywords Pregnancy

Background: Pregnancy induced hypertension is a fetal disease resulting into morbidity and mortality of female as well as its neonate. Objective: To find the incidence of pregnancy induced hypertension in Pakistani women. Study Design: Cross sectional study Place and Duration of the Study: Department of Obstetrics & Gynaecology, Sandeman Provincial Hospital, Quetta from 1st March 2019 to 31st March 2021. Methodology: Seven hundred and twenty eight females were identified with pregnancy induced hypertension from all the pregnant women attending the outdoor were enrolled. Each female was checked for their protein urea as well as systolic and diastolic blood pressure according to standard operating protocol. Socio-demographic, clinical and family history were documented. Results: Among all pregnant women, 150 were identified as pregnancy induced hypertensive with a 20.6% incidence of pregnancy induced hypertension. The mean value systolic blood pressure value was 144.3±5.2 and of diastolic as 83.1±5.2 in pregnancy induced hypertension women. Conclusion: Family history, obesity and renal diseases are the main factors associated with pregnancy induced hypertension with an incidence of 20.6% among pregnant women. Keywords: Pregnancy induced hypertension, Body mass index, Pregnant women, Hypertension

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Twenty-four hour blood pressure monitoring in early pregnancy: is it predictive of pregnancy-induced hypertension and preeclampsia?

Acta Obstetricia Et Gynecologica Scandinavica ◽

10.1080/00016349808565804 ◽

1998 ◽

Vol 77 (1) ◽

pp. 14-21 ◽

Cited By ~ 8

Author(s):

Chiara Benedetto ◽

Luca Marozio ◽

Maurizio Giarola ◽

Luciano Chiarolini ◽

Vincenza Maulà ◽

...

Keyword(s):

Blood Pressure ◽

Early Pregnancy ◽

Blood Pressure Monitoring ◽

Pregnancy Induced Hypertension ◽

Pressure Monitoring ◽

Induced Hypertension

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Roll-over test in primigravidae attending a public primary care service

Sao Paulo Medical Journal ◽

10.1590/s1516-31801997000500004 ◽

1997 ◽

Vol 115 (5) ◽

pp. 1533-1536

Author(s):

Luiz Francisco Marcopito

Keyword(s):

Blood Pressure ◽

Primary Care ◽

Roc Curve ◽

Operating Characteristic ◽

Care Setting ◽

Care Service ◽

Primary Care Service ◽

Pregnancy Induced Hypertension ◽

Predictive Values ◽

Induced Hypertension

OBJECTIVE:To determine the roll-over test (ROT) performance in predicting pregnancy-induced hypertension (PIH) in primigravidae aged 15-29 years in a public primary care service. METHOD: Prospective cohort study enrolling 369 consecutive and initially normotensive primigravidae. The ROT was applied within 28-32 weeks of pregnancy. PIH was defined as diastolic blood pressure (DBP) 90 mm Hg or systolic blood pressure (SBP) 140 mm Hg, or a rise in DBP 15 mm Hg or a rise in SBP 30 mm Hg. The ROT prognostic properties were calculated, and a receiver operating characteristic (ROC) curve was constructed. RESULTS: For the 20 mm Hg cutoff point, sensitivity was 20% and specificity was 93%. Positive and negative predictive values were, respectively, 23% and 92%, for a PIH cumulative incidence of 9.5%. With other cutoff points, the ROC curve showed a poor discriminatory value of the test. CONCLUSION: The ROT was not useful for predicting PIH in a primary prenatal care setting.

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Direct laboratory evidence that pregnancy-induced hypertension might be associated with increased catecholamines and decreased renalase concentrations in the umbilical cord and mother’s blood

Journal of Laboratory Medicine ◽

10.1515/labmed-2018-0185 ◽

2019 ◽

Vol 43 (2) ◽

pp. 77-85

Author(s):

Yakup Baykus ◽

Sefer Ustebay ◽

Rulin Deniz ◽

Kader Ugur ◽

Şeyda Yavuzkir ◽

...

Keyword(s):

Blood Pressure ◽

Pregnant Women ◽

Umbilical Cord ◽

Enzyme Linked Immunosorbent Assay ◽

Pregnancy Induced Hypertension ◽

Induced Hypertension ◽

Healthy Control ◽

C 30 ◽

Body Mass Indexes ◽

Umbilical Cord Vein

Abstract Background Renalase (RNL) is a controversial enzyme as to whether it oxidizes catecholamines (CAs) (as is generally accepted) in the blood or not. CAs (dopamine [DPMN], epinephrine [EPI] and norepinephrine [NEPI]) are associated with hypertension, including pregnancy-induced hypertension, which occurs in 8–10% of all pregnancies. Therefore, the aim of the study was to compare CAs and renalase concentration in (i) normotensive controls (C), (ii) patients with preeclampsia (PE) and (iii) patients with severe preeclampsia (SPE), which is one of the well-known symptoms of hypertension. Methods This case-control study involved 90 women divided into three groups – 30 C, 30 PE and 30 SPE – whose age and body mass indexes (BMIs) were similar. A total of 270 blood samples (90 maternal samples, 90 umbilical cord artery samples and 90 umbilical cord vein samples) were obtained. CAs and RNL concentrations of the biological samples were measured by enzyme-linked immunosorbent assay (ELISA). Results Comparing the amounts of CAs, RNL and systolic blood pressure (SBP)/diastolic blood pressure (DBP) between healthy control pregnant women and pregnant women with PE and SPE (SBP/DBP was 120/80 mm Hg for C, above 140/90 mm Hg for PE and above 160/110 mm Hg for SPE), the levels of CAs were significantly increased whereas RNL was reduced. The correlation between SBP/DBP and the amount of RNL in pregnant women with PE and SPE was negative. Conclusions These novel results are evidence that hypertension seen in PE and SPE is directly related to increased levels of CAs and reduced RNL concentrations. The use of RNL preparations may be preferred in future to prevent maternal and perinatal morbidity and mortality due to pregnancy-induced hypertension.

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Abnormalities of peripheral venous tone in women with pregnancy-induced hypertension

Clinical Science ◽

10.1042/cs0700155 ◽

1986 ◽

Vol 70 (2) ◽

pp. 155-157 ◽

Cited By ~ 10

Author(s):

Karen Stainer ◽

Rachel Morrison ◽

C. Pickles ◽

A. J. Cowley

Keyword(s):

Blood Pressure ◽

Pregnant Women ◽

Inverse Correlation ◽

The Other ◽

Normal Blood ◽

Pregnancy Induced Hypertension ◽

Normal Blood Pressure ◽

Venous Tone ◽

Arterial Blood ◽

Induced Hypertension

1. Forearm venous tone was measured in two groups of pregnant women: one group with pregnancy-induced hypertension and the other group with normal blood pressure. 2. The women with pregnancy-induced hypertension were venoconstricted in the forearm (P < 0.01) compared with the pregnant women with normal blood pressure. However, there was no difference in venous tone between the women with pregnancy-induced hypertension and nonpregnant women. 3. There was an inverse correlation between mean arterial blood pressure and forearm venous tone (r = −0.581, P < 0.001) for all the pregnant women studied. Further evaluation of peripheral venous tone may provide valuable information about the pathophysiology and treatment of women with pregnancy-induced hypertension.

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