scholarly journals Role of Nepafenac 0.1% Ophthalmic Solution in Preventing Intraoperative Miosis during Phacoemulsification

2020 ◽  
Vol 37 (1) ◽  
Author(s):  
Sairam Ahmed ◽  
Iqra Ghazanfar ◽  
Fuad Ahmad Khan Niazi ◽  
Ali Raza
Keyword(s):  
Placebo Group ◽  
Cataract Surgery ◽  
Pupil Size ◽  
Ophthalmic Solution ◽  
Eye Drops ◽  
Department Of Ophthalmology ◽  
Quasi Experimental ◽  
Group A ◽  
Group B

Purpose:  To compare 0.1% Nepafenac ophthalmic solution with placebo in terms of decreasing mean intraoperative miosis in patients undergoing cataract surgery. Study Design:  Quasi experimental study. Place and Duration of Study:  Department of Ophthalmology, Holy-Family Hospital Rawalpindi from September 2017 to March 2018. Methods:  A total of 150 eyes with senile cataract of patients between 40-80 years of age and of both genders, undergoing uneventful cataract surgery and fulfilling the inclusion criteria were included. Patients were divided into 2 equal groups. Group A received Nepafenac eye drops and group B received placebo drops (Preservative free artificial tears). The diameter of pupil as viewed through the operating microscope was measured with Castroviejo Caliper at following steps; immediately before the start of surgery (baseline), after complete nucleus removal and at the end of surgery. Results:  Mean decrease in pupil size from the start of surgery to the end of phacoemulsification in Group A (nepafenac group) was 0.48 ± 0.26 mm while in Group B (placebo group) it was 1.40 ± 0.49 mm (P = 0.0001). Mean decrease in pupil size from start to end in Group A (Nepafenac group) was 0.75 ± 0.32 mm while in Group B (placebo group) was 2.02 ± 0.62 mm (P = 0.0001). Conclusion:  Intraoperative miosis in terms of mean decrease in pupils size (both from start of surgery till phacoemulsification and also from start of surgery till end of surgery) was lower in 0.1% Nepafenac group as compared to placebo group. Key Words:  Phacoemulsification, Miosis, Nepafenac.

scholarly journals To Study the Safety of Multi-dose Topical Anaesthetic Eye Drops One Month after Opening

2019 ◽  
Vol 35 (3) ◽  
Author(s):  
Mehr-un-Nisa Irfan Qayyum Malik Muhammad Wasif Irshad
Keyword(s):  
Fungal Growth ◽  
Eye Drops ◽  
Topical Anaesthetic ◽  
Dry Eyes ◽  
Study Results ◽  
Department Of Ophthalmology ◽  
Quasi Experimental ◽  
Organism Growth ◽  
Group A ◽  
Group B

Purpose: To determine the risk of ocular infections due to topical multi-dose anaesthetic eye drops in patients one month after opening the bottle. Study Design: Quasi experimental study. Place and duration of study: Department of Ophthalmology DHQ Teaching Hospital, Gujranwala from 22nd May 2018 to 22nd June 2018. Materials and Methods: In this study topical anaesthetic eye drops containing proparacaine hydrochloride 0.5% as main ingredient and benzalkonium choride as preservative (Alcaine�) were tested daily to see if any bacterial/fungal growth occurs in the bottle containing eye drops or not. Same bottle was used in patients presenting in outdoor and indoor departments. Samples taken from the bottle contents were cultured on different media to see growth of fungi or bacteria. Patients who already had keratitis, conjunctivitis, corneal opacities, thin corneas and having dry eyes which were prone to get infected were excluded from this study. Results: There were 60 patients included in our study and they were divided in two groups. Group A included those who presented in the outdoor department and group B comprised of those admitted for various operative procedures. There were 30 patients in each group. All patients were adults (18-60 years). After 1 month of daily culturing on agar plates, no micro-organism growth was seen in both groups. Conclusion: Topical anaesthetic eye drops can be used safely for 1 month in different patients after opening the bottle without any risk of causing infectious keratitis, conjunctivitis or endophthalmitis. Keywords: Proparacaine, Culture medium, Endophthalmitis.

scholarly journals Comparison of anti-inflammatory effects of eye drops formulations after uncomplicated cataract surgery

2020 ◽  
Vol 12 ◽  
pp. 251584142092430
Author(s):  
Carlo Cagini ◽  
Adriana Pellegrino ◽  
Alessia Iannone ◽  
Alessio Cerquaglia ◽  
Antonella Modugno ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Cataract Surgery ◽  
Aqueous Humour ◽  
Corneal Thickness ◽  
Macular Thickness ◽  
Eye Drops ◽  
Significant Difference ◽  
Group A ◽  
Group B

Aim: The aim of this study is to compare the efficacy of different dexamethasone eye drops formulations in controlling postoperative inflammation. Methods: Cataract surgery was carried out in 72 patients (35 males) divided into two groups: group A (36 patients, mean age = 78.0 ± 5.6) received four times daily for 2 weeks a suspension containing tobramycin 0.3% mg/ml + dexamethasone 0.1% mg/ml, and group B (36 patients, mean age = 76.2 ± 6.8) a solution containing tobramycin 0.3% mg/ml + dexamethasone 0.1% mg/ml. Both groups received ofloxacin 0.5% four times daily for 7 days, and nepafenac 0.1% three times daily for 3 weeks. Best-corrected visual acuity, intraocular pressure, corneal thickness, endothelial cells count, aqueous flare and macular thickness were evaluated preoperatively and at 1 day, 15 days, 1 and 2 months. Results: In group A, intraocular pressure, corneal thickness and aqueous humour flare values preoperatively and at the end of follow-up were 14.3 ± 1.8 and 13.2 ± 1.8 mmHg, 546.4 ± 34.6 and 539.6 ± 36.1 µm, 11.84 ± 4.44 and 13.52 ± 5.54 ph/ms, respectively, with no statistically significant difference. In group B, intraocular pressure, corneal thickness and aqueous humour flare values preoperatively and at the end of follow-up were 14.3 ± 1.5 and 13.1 ± 1.7 mmHg, 552.9 ± 37.4 and 548.1 ± 39.3 µm, 11.45 ± 4.06 and 13.73 ± 4.99 ph/ms, respectively, with no statistically significant difference. No difference was detected in the macular thickness values in the parafoveal area preoperatively and at 2 months follow-up in group A (332.18 ± 16.19 and 337.71 ± 16.33 µm) and group B (329.11 ± 18.28 and 334.37 ± 20.86 µm), respectively. Conclusion: The two different formulations of dexamethasone eye drops reached the same anti-inflammatory effects.

scholarly journals Hyaluronic Acid/Trehalose Ophthalmic Solution in Reducing Post-Cataract Surgery Dry Eye Signs and Symptoms: A Prospective, Interventional, Randomized, Open-Label Study

2021 ◽  
Vol 10 (20) ◽  
pp. 4699
Author(s):  
Rita Mencucci ◽  
Eleonora Favuzza ◽  
Giulia Decandia ◽  
Michela Cennamo ◽  
Fabrizio Giansanti
Keyword(s):  
Hyaluronic Acid ◽  
Cataract Surgery ◽  
Dry Eye ◽  
Ophthalmic Solution ◽  
Signs And Symptoms ◽  
Ocular Surface Disease Index ◽  
Open Label ◽  
Open Label Study ◽  
Group A ◽  
Group B

The purpose of this prospective study was to evaluate the efficacy of the perioperative use of a hyaluronic acid (HA) and trehalose ophthalmic solution (Thealoz® Duo) in reducing post-cataract surgery dry eye signs and symptoms in patients with mild/moderate dry eye disease (DED). One hundred and twenty patients, scheduled for unilateral cataract surgery, were randomized into three groups: (1) group A: HA/trehalose three times/day in the preoperative week and for 5 postoperative weeks; (2) group B: HA/trehalose for only 5 postoperative weeks; (3) group C: no artificial tears. In groups A and B, OSDI (Ocular Surface Disease Index) questionnaire scores were significantly lower than group C at all the postoperative visits; in group A they were significantly lower than group B on the day of surgery, with similar results in the first and fifth weeks after surgery. In groups A and B, break-up time (BUT) was significantly higher than group C during the postoperative period (p ≤ 0.001). In comparison to the preoperative values, BUT in group A remained stable 7 days after surgery; however, in groups B and C, it significantly decreased. In conclusion, the HA/trehalose ophthalmic solution effectively reduced post-cataract surgery DED signs and symptoms in patients with mild/moderate DED, particularly if also administered in the preoperative period.

scholarly journals Sildenafil is Safe and Effective for the Treatment of Lower Ureteric Stone with no Major Side Effect

2019 ◽  
Vol 3 (3) ◽  
pp. 560-564
Author(s):  
Sudeep Raj KC ◽  
Bhusan Raj Timilsina ◽  
Hari Prasad Upadhyay ◽  
Gaurav Devkota ◽  
Rajiv Shah ◽  
...  
Keyword(s):  
Placebo Group ◽  
Standard Deviation ◽  
Treatment Group ◽  
Early Time ◽  
Life Time ◽  
Urinary Stones ◽  
Expulsion Rate ◽  
Quasi Experimental ◽  
Group A ◽  
Group B

INTRODUCTION: Urolithiasis is one of the most common diseases of the urinary tract. Prevalence of urinary stones in a life time is approximately 1% to 15%.Peak age of incidence is 30 years. Male are more commonly affected than female about 2 to 3 times. At the time of presentation 20 % of the calculi are found in the ureter, among which 70% are located in the distal third of the ureter. OBJECTIVE: To study the effect of sildenafil citrate on passage of stone from distal ureter. METHODOLOGY: This is the Quasi experimental study performed in College Of Medical Sciences, Chitwan, Nepal, from February 2017 to February 2018 for a period of one year. First 100 patients of urolithiasis were selected and divided into two groups with the help of lotiery method Group A and Group B. In group A we had patient on placebo and in group B we had patient receiving sildenafil 50 mg once daily and for the period of two weeks. RESULTS: The mean ± standard deviation of stone size was 7.01±1.70mm for treatment group and 6.85±1.56mm for placebo group (p> 0.64) .The stone expulsion rate was 74.5% for treatment group and 41.7% for placebo group (P<0.001). Mean ± standard deviation of expulsion time was 7.6 ±3.49 days for treatment group and 10.25±3.12 days for placebo group (P<0.008). Mean ± standard deviation of VAS was 3.49±1.300for treatment group and 6.77±1.308 for placebo group (P<0.0001). CONCLUSION: Medical Expulsive Therapy (MET) for lower ureterolithiasis with sildenafil during conservative treatment period is safe and effective as demonstrated by the absence of serious side effects and increased stone expulsion rate with early time.

scholarly journals A comparative analysis of morphometric changes in the angle of anterior chamber after cataract surgery

2021 ◽  
Vol 9 (8) ◽  
pp. 2296
Author(s):  
Mahsa Jamil ◽  
Anupam . ◽  
Ramanuj Samanta ◽  
Sanjeev Kumar Mittal
Keyword(s):  
Cataract Surgery ◽  
Anterior Chamber ◽  
Anterior Chamber Depth ◽  
Cataract Extraction ◽  
Anterior Chamber Angle ◽  
Small Incision Cataract Surgery ◽  
Common Causes ◽  
Quasi Experimental ◽  
Group A ◽  
Group B

Background: Cataract surgery brings about certain changes in the angle of anterior chamber and we aimed at understanding the morphometric changes occurring in the angle at the site of incision (SOI) and the site opposite to it (OSOI) after two types of cataract surgeries viz. phacoemulsification and manual small incision cataract surgery (SICS) at two postoperative follow-ups.Methods: A quasi-experimental study was conducted at AIIMS, Rishikesh and a minimum of 60 patients were enrolled. They were divided into two groups based on the surgery performed, 30 patients had undergone phacoemulsification (group A) and 30 patients had undergone SICS (group B). The patients were evaluated using optical coherence tomography (OCT), the parameters measured were central anterior chamber depth (ACD), anterior chamber angle (ACA), angle opening distance (AOD), and trabecular iris surface area (TISA). The subjects were assessed preoperatively, post-operatively at 1 week and 6 weeks.Results: The increase in the angle parameters at 1 week and 6 weeks post-operatively was found to be statistically significant in the two groups (p<0.05). The increase in the parameters was also compared between the two surgeries and was found to have no statistical difference.Conclusions: We were able to conclude that a simple cataract extraction can help treat two most common causes of blindness, cataract and glaucoma and the technique of cataract surgery used does not influence the change brought about in the angle.

scholarly journals Comparison between intracameral ceftazidime & cefuroxime for the prevention of post-operative endophthalmitis

2019 ◽  
Vol 34 (2) ◽  
Author(s):  
Arooj Amjad ◽  
Muhammad Moin
Keyword(s):  
Cataract Surgery ◽  
Anterior Chamber ◽  
Cell Counts ◽  
C Cell ◽  
Intracameral Antibiotics ◽  
Quasi Experimental ◽  
Group A ◽  
A Cell ◽  
Grade 3 ◽  
Group B

Purpose: To compare the efficacy and safety of intracameral injection of ceftazidime and cefuroxime during cataract surgery for the prevention of post-operative endophthalmitis. Study Design: Quasi experimental study. Place and Duration of Study: Ophthalmology Department Unit-1, Lahore General Hospital, Lahore. From November 2016 to March 2018. Material and Methods: Patients undergoing cataract surgery in the eye department were selected by convenient sampling to receive prophylactic intracameral antibiotics at the end of routine cataract surgery. Patients were divided into two groups; group A received Cefuroxime and group B received Ceftazidime both as 1 mg /0.1ml intracameral injections at the end of the surgery after wound hydration and before chamber formation. The patients were examined pre and post operatively on slit lamp and the number of cells in the anterior chamber (A/C) were counted on day 1, week 1 and week 6 after surgery. Results: Out of total 260 patients 130 were allocated to each group. On first post-operative day in Group A, A/C cell counts were grade 1 in 22 patients, grade 2 in 93 patients, grade 3 in 14 patients and Grade 4 in 1 patient. In group B, A/C cell counts were grade 1 in 11 patients, grade 2 in 96 patients, grade 3 in 20 patients and grade 4 in 3 patients. After one week, in group A, cell counts were grade 0 in 27 patients, grade 1 in 100 patients, grade 2 in 2 patients and grade 4 in 1 patient. While in group B, A/C cell counts were Grade 0 in 23 patients, grade 1 in 102 patients, grade 2 in 3 patients and grade 3 in 2 patients. After 6 weeks no patient in any group showed any activity in the anterior chamber. Conclusion: There is little difference in efficacy of intracameral ceftazidime antibiotic prophylaxis as compared to the intracameral cefuroxime.

scholarly journals A comparison of the efficacy of Olopatadine hydrochloride 0.1% ophthalmic solution and Sodium Chromoglycate ophthalmic solution in the treatment of allergic conjunctivitis

1970 ◽  
Vol 18 (2) ◽  
pp. 136-139
Author(s):  
AIMA Uddin ◽  
GM Faruque ◽  
AQMO Sharif
Keyword(s):  
Allergic Conjunctivitis ◽  
Ophthalmic Solution ◽  
Eye Drops ◽  
Blinded Study ◽  
Group A ◽  
The Difference ◽  
Group B ◽  
Double Blinded ◽  
Symptoms And Signs ◽  
Olopatadine Hydrochloride

Aim: To find out an effective drug for the treatment of allergic conjunctivitis and to compare the efficacy of Sodium chromoglycate ophthalmic solution and Olopatadine Hydrochloride 0.1% ophthalmic solution in the treatment of allergic conjunctivitis. Materials and methods: This randomized double blinded study was conducted in National Institute of Ophthalmology and Hospital, Sher-E-BangIa Nagar, Dhaka, from January, 2005 to May, 2009. 100 Patients with ocular allergies attending OPD of NIO&H were included. Each of the patient was randomly included in either of the following two groups by simple lottery method; Group A: 50 Patients receiving olopatadine hydrochloride 0.1% eye drops and Group B: 50 Patients receiving sodium chromoglycate 2% eye drops. Itching score, Redness score, Discharge score, Evaluator's score - baseline and after 21 days of treatment with olopatadine and sodium chromoglycate 2% ophthalmic solution were evaluated following Aguilar (2000). For the relieving of symptoms and signs olopatadine was found to be superior over sodium chromoglycate 2% but the difference was not statistically significant. Conclusion: This clinical study concludes that the relieving of symptoms and signs olopatadine was found to be superior over sodium chromoglycate 2% but the difference was not statistically significant. DOI: 10.3329/jdmc.v18i2.6274 J Dhaka Med Coll. 2009; 18(2) : 136-139

scholarly journals Comparison of Steroid with Cyclosporine Eye Drops in Epidemic Keratoconjunctivitis

2020 ◽  
Vol 36 (4) ◽  
Author(s):  
Abdul Rafe ◽  
Muhammad Tariq Munawar
Keyword(s):  
Topical Steroid ◽  
Corneal Opacity ◽  
Eye Drops ◽  
Epidemic Keratoconjunctivitis ◽  
Exclusion Criteria ◽  
Quasi Experimental ◽  
Group A ◽  
Group B ◽  
Corneal Infiltrates

Purpose:  To compare the effect of topical steroid with cyclosporine eye drops in recurrence of sub-epithelial corneal infiltrates in epidemic keratoconjunctivitis. Study Design:  Quasi Experimental study. Place and Duration of Study:  CMH Kharian from Jan 2017 to June 2018. Methods:  Eighty eight patients with epidemic keratoconjunctivitis were divided into two groups. Group A included patients who received topical steroid drops and group B received topical Cyclosporine eye drops. The inclusion criteria comprised of fresh cases of SEIs, between the ages of 20 to 50 years, having a vision of 6/6 before the illness. The exclusion criteria included patients suffering from allergic conjunctivitis, ocular surface disease like Sjogren syndrome, corneal ulcer, blepharitis, old corneal opacity, glaucoma and those who had been using steroids in the past e.g. uveitis. The patients were followed up at 2, 4, 8 and 12 weeks. On resolution of sub-epithelial infiltrates (SEIs), both regimen were tapered off in next two weeks. The patients were advised to continue monthly follow up for two months to see any recurrence. Results:  SEIs resolved in both the groups by week 12, however the resolution was slightly quicker in group A. SEIs resolved in 84.1% of cases in group A and in 70.4% cases in group B at the end of 4 weeks. Recurrence was higher in group A (11.3%) while it was 4.5% in group B. Conclusion:  Cyclosporine eye drops are a safe and equally effective treatment of epidemic keratoconjunctivitis related SEIs, with an added advantage of reduced recurrence rate. Key Words:  Epidemic, Keratoconjunctivitis (EKC), Cornea, Subepithelial Infiltrates, Cyclosporine.

scholarly journals INHIBITION OF SURGICALLY INDUCED MIOSIS WITH NEPAFENAC

2021 ◽  
Vol 71 (3) ◽  
pp. 801-04
Author(s):  
Rabbia Mirza ◽  
Imran Basit ◽  
Summaya Khan ◽  
Zahid Ullah ◽  
Shahid Tarar ◽  
...  
Keyword(s):  
Experimental Study ◽  
Cataract Surgery ◽  
Pupil Size ◽  
Armed Forces ◽  
Control Group ◽  
Eye Drops ◽  
Post Surgery ◽  
Quasi Experimental ◽  
The Mean ◽  
Surgically Induced

Objective: To assess the efficacy of prophylactic administration of 0.1% nepafenac in the maintenance of trans-operative mydriasis following cataract surgery. Study Design: Quasi-experimental study. Place and Duration of Study: Armed Forces Institute of Ophthalmology, Rawalpindi, from Oct 2018 to Mar 2019. Methodology: A total of 70 patients undergoing cataract surgery phacoemulsification were randomly placed in either the control group or the nepafenac group. Nepafenac eye drops were administered as one drop 8 hourly, 3 days before surgery. Control group didn’t receive any medication preoperatively Mydriasis was measured trans-operatively before surgery, after aspiration of the cortex, and then at the end of surgery. Patients of both groups received tobradex 2 weeks post-surgery. Results: Post-surgery statistically significant (0.001) difference was observed in the mean pupil size between the nepafenac group (7.88 ± 0.49) and the control group (6.57 ± 0.92 mm). Conclusion: Use of nepafenac prophylactically was very effective in maintenance of trans-operative mydriasis in cataract surgery.

scholarly journals THERAPEUTIC ROLE OF ZINC

2010 ◽  
Vol 17 (03) ◽  
pp. 472-478
Author(s):  
AISHA SAJID ◽  
SURRIYA SAJID ◽  
MAQBOOL AHMAD
Keyword(s):  
Zinc Supplementation ◽  
Stool Frequency ◽  
Stool Consistency ◽  
Control Group ◽  
P Value ◽  
Adequate Nutrition ◽  
Quasi Experimental ◽  
Group A ◽  
Group B

OBJECTIVES: To evaluate the efficacy of zinc supplementation in patients with diarrheal illnesses. Study Design: Quasi Experimental study. Setting: The study was conducted at the pediatrics department of Madina Teaching Hospital, Sargodha road, Faisalabad, Period: 6 months period from November 2008 to April 2009. Material and Methods: Two hundred children suffering from diarrhea with mild to moderate dehydration were included in the study and divided into two groups, A and B. Group A was given zinc supplementation along with ORS and adequate nutrition according to age. In group B 100 children were taken as control to whom only ORS and adequate nutrition for age was given. Results: Baseline clinical parameters were comparable in both groups at admission. The effect observed on stool consistency was more marked in 72 hours i.e. 71% patients were improved in group A versus 40% in group B, as compared to stool frequency in 72 hours i.e. 56% in group A versus 39% in group B. Although in 7 days, 99% patients showed improvement in stool consistency in group A,70% in group B(p value 0.037) and stool frequency showed improvement of 96% in group A as compared to 77% in group B(p value 0.037). Duration of hospital stay on the average was about 2 days less in case of zinc supplemented group as compared to control group. Conclusion: Zinc supplementation reduced the duration and severity of mild to moderate diarrheal illness and treatment was well tolerated with no significant side effects. 

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