E/E Inverter Using Four-Terminal Poly-GexSn1-x TFTs on Glass

2019 ◽  
pp. 624
Author(s):  
Ryo Miyazaki ◽  
Akito Hara
Keyword(s):  
Terminal Poly

scholarly journals Cricket Paralysis Virus RNA has a 3' Terminal Poly(A)

1980 ◽  
Vol 50 (1) ◽  
pp. 167-171 ◽  
Author(s):  
B. T. Eaton ◽  
A. D. Steacie
Keyword(s):  
Virus Rna ◽  
Terminal Poly ◽  
Paralysis Virus

scholarly journals The effect of polyamines on the poly(adenylic acid)-induced inhibition of ribonuclease activity

1981 ◽  
Vol 193 (1) ◽  
pp. 325-337 ◽  
Author(s):  
T P Karpetsky ◽  
K K Shriver ◽  
C C Levy
Keyword(s):  
Human Plasma ◽  
Segment Length ◽  
Side Chain ◽  
Amino Groups ◽  
Human Spleen ◽  
Low Concentrations ◽  
Degradation Rates ◽  
Adenylic Acid ◽  
Bovine Pancreas ◽  
Terminal Poly

Segments of poly(A) at the 3′-termini of 5 S rRNA inhibit the activities of ribonucleases from Citrobacter, Enterobacter, bovine pancreas, human spleen and human plasma. Certain polyamines, or compounds containing polyamine substructures, mediate reversal of this inhibition. Effective compounds contain three amino groups, at least two of which are charged and are separated from the others by no less than three carbon atoms. Spermidine and 9-aminoacridines, which contain substituted propyl- or butylamino moieties at the 9-amino position and which bear two positive charges per molecule, are efficacious at low concentrations (5 microM). A decrease in effectiveness is associated with the removal of one aromatic ring from the 9-aminoacridines. However, the resulting 4-aminoquinolines, unlike the acridines, do not inhibit enzyme activity when present in concentrations above 30 microM. Relocating the diamino side chain from the 4- to the 8-position of the quinoline nucleus causes a decrease in charge density to +1, with the result that such compounds are ineffective. The orders of polyamine efficacy of reversal of inhibition were similar for enzymes from Citrobacter, bovine pancreas, and human plasma, and paralleled the order of binding of polyamines to either poly(A) or 5 S rRNA. This was not the case with Enterobacter and human spleen RNAases, indicating that the identity of the most effective polyamines depends on the RNAase studied. The combination of variable 3′-terminal poly(A) segment length and polyamine identity and concentration constitutes a system by which RNAase activities, and, therefore, substrate-degradation rates, may be easily varied.

scholarly journals Southern bean mosaic viral RNA has a 5′-linked protein but lacks 3′ terminal poly(A)

1979 ◽  
Vol 7 (8) ◽  
pp. 2137-2146 ◽  
Author(s):  
Amit Ghosh ◽  
Ranjit Dasgupta ◽  
Terry Salerno-Rife ◽  
Tineke Rutgers ◽  
Paul Kaesberg
Keyword(s):  
Viral Rna ◽  
Terminal Poly

scholarly journals Addition of an N-Terminal Poly-Glutamate Fusion Tag Improves Solubility and Production of Recombinant TAT-Cre Recombinase in Escherichia coli

2020 ◽  
Vol 30 (1) ◽  
pp. 109-117
Author(s):  
A-Hyeon Kim ◽  
Soohyun Lee ◽  
Suwon Jeon ◽  
Goon-Tae Kim ◽  
Eun Jig Lee ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Cre Recombinase ◽  
Fusion Tag ◽  
Terminal Poly

scholarly journals Research Progress of circRNAs in Glioblastoma

2021 ◽  
Vol 9 ◽  
Author(s):  
Xu Guo ◽  
Haozhe Piao
Keyword(s):  
Biological Properties ◽  
Research Progress ◽  
Migration And Invasion ◽  
Circular Rnas ◽  
Specific Expression ◽  
New Ideas ◽  
The Central Nervous System ◽  
Non Coding Rnas ◽  
New Biomarkers ◽  
Terminal Poly

Circular RNAs (circRNAs) are a class of single-stranded covalently closed non-coding RNAs without a 5′ cap structure or 3′ terminal poly (A) tail, which are expressed in a variety of tissues and cells with conserved, stable and specific characteristics. Glioblastoma (GBM) is the most aggressive and lethal tumor in the central nervous system, characterized by high recurrence and mortality rates. The specific expression of circRNAs in GBM has demonstrated their potential to become new biomarkers for the development of GBM. The specific expression of circRNAs in GBM has shown their potential as new biomarkers for GBM cell proliferation, apoptosis, migration and invasion, which provides new ideas for GBM treatment. In this paper, we will review the biological properties and functions of circRNAs and their biological roles and clinical applications in GBM.

scholarly journals Crystal structure of the FERM-folded talin head reveals the determinants for integrin binding

2020 ◽  
Vol 117 (51) ◽  
pp. 32402-32412 ◽  
Author(s):  
Pingfeng Zhang ◽  
Latifeh Azizi ◽  
Sampo Kukkurainen ◽  
Tong Gao ◽  
Mo Baikoghli ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Adapter Proteins ◽  
Integrin Receptors ◽  
Integrin Activation ◽  
Domain Sequence ◽  
Fundamental Understanding ◽  
Β3 Integrin ◽  
Tight Association ◽  
Terminal Poly

Binding of the intracellular adapter proteins talin and its cofactor, kindlin, to the integrin receptors induces integrin activation and clustering. These processes are essential for cell adhesion, migration, and organ development. Although the talin head, the integrin-binding segment in talin, possesses a typical FERM-domain sequence, a truncated form has been crystallized in an unexpected, elongated form. This form, however, lacks a C-terminal fragment and possesses reduced β3-integrin binding. Here, we present a crystal structure of a full-length talin head in complex with the β3-integrin tail. The structure reveals a compact FERM-like conformation and a tightly associated N-P-L-Y motif of β3-integrin. A critical C-terminal poly-lysine motif mediates FERM interdomain contacts and assures the tight association with the β3-integrin cytoplasmic segment. Removal of the poly-lysine motif or disrupting the FERM-folded configuration of the talin head significantly impairs integrin activation and clustering. Therefore, structural characterization of the FERM-folded active talin head provides fundamental understanding of the regulatory mechanism of integrin function.

Wheat embryo ribonucleates. X. Metabolism of 3′-hydroxyl termini in the conserved mRNA and tRNA of imbibing wheat embryos

1978 ◽  
Vol 56 (3) ◽  
pp. 197-202 ◽  
Author(s):  
T. D. Kennedy ◽  
B. G. Lane
Keyword(s):  
Ribosomal Rna ◽  
Messenger Rna ◽  
Insoluble Fraction ◽  
Wheat Embryo ◽  
Selective Labelling ◽  
Wheat Embryos ◽  
Chain Lengths ◽  
Hydroxyl Termini ◽  
Terminal Poly ◽  
Mass Component

There are conserved complements of ribosomal RNA (rRNA), transfer RNA (tRNA), and messenger RNA (mRNA) in dry wheat embryos. Although early labelling of RNA is largely directed toward the synthesis of complete molecules of nascent rRNA and mRNA, there is also selective labelling at 3′-hydroxyl termini in conserved polynucleotides when dry wheat embryos are subjected to short-term (0.5 h) imbibition in a medium that contains tritium-labelled adenosine, guanosine, cytidine, and uridine. Conserved tRNA is the principal mass component in NaCl-soluble RNA (sRNA) and most of the 'rapid labelling' of sRNA (rl-sRNA) is a result of labelling at 3′-hydroxyl termini in conserved tRNA. By contrast, although conserved rRNA is the principal mass component in NaCl-insoluble RNA (iRNA), most of the labelled 3′-hydroxyl termini in 'rapidly labelled' iRNA (rl-iRNA) do not appear to derive from rRNA. Although about 10% of the labelled 3′-hydroxyl termini in rl-iRNA originates in conserved poly(A)-rich mRNA, the available evidence leads to the conclusion that most of the labelled 3′-hydroxyl termini in rl-iRNA originates in an unusual NaCl-insoluble fraction of conserved tRNA. During the course of extended imbibition, between 0.5 and 5 h, there are characteristic changes in the chain lengths and labelling patterns for 3′-hydroxyl terminal poly(A) sequences in mRNA. Analytical and physiological implications of these data are subjects of discussion.

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