A Comprehensive Study of the Neuropharmacological Profile of Methanol Leaf Extract of Aloe vera and Identification of Associated Neuroprotective Compounds through Gas chromatography-mass spectrometry Analysis

ABSTRACTObjective: The aim of this study was to investigate the presence of bioactive compounds in the methanolic leaf extract of Syzygium jambos.Methods: Collected leaves were shade dried and made into fine powder, extracted with methanol, and the methanolic extract was prepared andanalyzed for the presence of bioactive compounds by gas chromatography-mass spectrometry (GC-MS). The mass spectrum of the chromatographywas matched with NIST and WILEY Libraries.Results: The GC-MS analysis revealed the presence of 45 active compounds in the extract. From the GC-MS investigation, 1-Deoxy-d-mannitol3-methyl-2-methylsulfanyl-5-nitro-6-pyridin-4-ylpyrimidin-4-one, 3-Pentadecylphenol, 2-biphenylene carboxylic acid, Quinoline-3-carboxylic acid,and Stigmast-5-en-3-ol are important phytoconstituents which have antipyretic and antiparasitic activities.Conclusion: The present investigation revealed preliminary information on phytocompounds presented in S. jambos leaf extract which is very usefulfor the human community.Keywords: Syzygium jambos, Gas chromatography-mass spectrometry analysis, 1-Deoxy-d-mannitol, Phytoconstituents, Methanolic leaf extract.

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GAS CHROMATOGRAPHY-MASS SPECTROMETRY ANALYSIS OF METHANOLIC LEAF EXTRACT OF CASSIA ANGUSTIFOLIA VAHL.

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2016.v9s3.14512 ◽

2016 ◽

Vol 9 (9) ◽

pp. 111 ◽

Cited By ~ 4

Author(s):

Shahina Parveen ◽

Anwar Shahzad ◽

Anamica Upadhyay ◽

Vikas Yadav

Keyword(s):

Mass Spectrometry ◽

Gas Chromatography ◽

Vitamin E ◽

Leaf Extract ◽

Methanolic Extract ◽

Mass Spectrometry Analysis ◽

Gas Chromatography Mass Spectrometry ◽

Spectrometry Analysis ◽

Cassia Angustifolia ◽

Chromatography Mass Spectrometry

ABSTRACTObjective: The leaves of Cassia angustifolia Vahl. are employed for the treatment of several human diseases. Therefore, the present study wasundertaken to determine the phytocomponents present in the methanolic extract of the leaves by gas chromatography-mass spectrometry (GC-MS)Methods: The collected leaf samples were dried and extracted in methanol. Screening of the extract was done by GC-MS which is an importanttechnique for the separation and identification of different phytochemicals.Results: The methanolic extract of the leaves of C. angustifolia revealed the presence of 45 different phytochemicals. The prevailing compounds were1 butanol, 3 methyl acetate (area % 7.47), 6, 6-dideutero-nonen-1-Ol-3 (area % 10.45), pentadecanoic acid (area % 9.22), and squalene (area %12.30). Vitamin E (area % 3.85) has also been found in the leaf extract. Some of the compounds possess biological activities.Conclusions: It can be concluded from the present study that some of the identified phytochemicals could be responsible for the medicinal value orbiological activity of the plant leaves.Keywords: Senna, Leaf extract, Methanol, Gas chromatography-mass spectrometry, Phytochemicals, Vitamin E.

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