IMPACT OF INFECTIOUS DISEASES ON PUBERTAL TIMING IN UKRAINIAN GIRLS: RESULTS A MULTICENTER STUDY

2021 ◽  
Vol 74 (10) ◽  
pp. 2392-2399
Author(s):  
Aidyn G. Salmanov ◽  
Orusia A. Kovalyshyn ◽  
Roman S. Scoreiko ◽  
Victor M. Zinchenko ◽  
Serhiy M. Baksheev ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Bacterial Infections ◽  
Viral Infections ◽  
Age Of Onset ◽  
Final Height ◽  
Pubertal Development ◽  
Age At Onset ◽  
Peak Height ◽  
Height Velocity ◽  
Peak Height Velocity

The aim: To determine current age at the initiation of puberty for Ukrainian school-aged girls and infections impact to puberty. Materias and methods: We performed a multicentre cohort study. The analyses are based on data that were collected and evaluated biannually on Ukrainian school girls aged 6-17 years from 5 regions of Ukraine. Pubertal development was classified according to the Marshall and Tanner criteria. Results: Overall, 2,784 girls have been included in the study. Mean age of onset of puberty in Ukrainian girls was 10.1±1.0 yrs. Age of onset of pubic hair was 11.0±1.0 yrs and that of axillary hair was 11.6±1.0 yrs. Mean age in girls of menarche was 12.2±0.9 yrs. There were no significant correlations between age at onset of puberty and body mass index, final height, total peak height velocity, duration of puberty, and peak height velocity. A total of 2,420 infectious diseases were diagnosted. Of these, 64.8% were viral and 35.2% bacterial infections, respectively. Ukrainian girls with infectious diseases (especially viral infections) had older age at pubertal onset and positive association of infections in childhood with late age of menarche. Conclusions: Infectious morbidity (especially viral infections) in girls may be associated with later puberty. The lowering of the number of infections in childhood could be an additional factor that contributes to earlier puberty. To reduce infectious diseases, more attention should be paid to the vaccination of children.

Growth and Normal Puberty

PEDIATRICS ◽  
1998 ◽  
Vol 102 (Supplement_3) ◽  
pp. 507-511 ◽  
Author(s):  
Val Abbassi
Keyword(s):  
Adult Height ◽  
Average Rate ◽  
Final Height ◽  
Peak Height ◽  
Height Velocity ◽  
Peak Height Velocity ◽  
Pubertal Stage ◽  
Pubertal Growth ◽  
Velocity Peak ◽  
The Mean

We reviewed the growth characteristics of American boys and girls from published studies, including age at takeoff, age at peak height velocity, peak height velocity, duration of puberty, and the magnitude of the pubertal contribution to adult height. Age at takeoff is highly variable and sex-dependent. The mean takeoff age in children growing at an average rate is ∼11 years in boys and 9 years in girls, and peak height velocity occurs at a mean age of 13.5 years and 11.5 years, respectively, in these children. Whole-year peak height velocity is 9.5 cm/y in boys and 8.3 cm/y in girls, with slight variations in the different studies. The contribution of pubertal growth to final height is ∼30 to 31 cm in boys, accounting for 17% to 18% of the final height, and 27.5 to 29 cm in girls, accounting for 17% of the final height. The magnitude of pubertal growth has a negative correlation with age at takeoff, but no correlation with final height. Age at takeoff, however, correlates highly with pubertal stage, but correlates negatively with duration of puberty.

scholarly journals Biological maturation of Portuguese rhythmic gymnasts in different competition levels of performance

2019 ◽  
Vol 8 (1) ◽  
pp. 38-48
Author(s):  
Amanda Batista ◽  
Rui Garganta ◽  
Lurdes Ávila-Carvalho
Keyword(s):  
Pearson Correlation ◽  
Pubertal Development ◽  
Peak Height ◽  
Height Velocity ◽  
Chronological Age ◽  
Training Volume ◽  
Competitive Performance ◽  
Peak Height Velocity ◽  
Biological Maturation ◽  
Competition Level

The aims of the present study were: (1) identify and compare the biological maturity in Portuguese gymnasts across competitive levels; (2) investigate how morphological variables and training volume behave in the different status and indicators of maturity and (3) determinate if the maturity status influences the competitive performance. The sample (n=164) consisted of three competition levels (Base, 1st division and Elite) from Portugal. Anthropometric measurements and body composition were performed. For analysis of biological maturation, the sexual and somatic maturation were evaluated. For the statistical analysis, Mann-Whitney and Kruskal-Wallis tests, Pearson correlation and Linear Regression were used. In total, 63.4% of gymnasts had not yet reached menarche and the higher competition level, lower the number of gymnasts with menarche. On mean, all groups had reached the age at peak height velocity. The higher the competition level, higher the chronological age and age at peak height velocity. Thus, the maturation indicators showed a delay in pubertal development in all competition levels and the elite gymnasts seem present a later pubertal development. The chronological age, the values of body mass, height, BMI and body fat increased with the maturity status according all maturity indicators. However, gymnasts with different maturity status revealed similar training volume. Finally, the maturational status explained 11.5% of competition success with higher advantage in the competitive performance to prepubertal gymnasts. Thus, the premenarcheal status and a higher age at peak height velocity contribute to performance in Rhythmic Gymnastics.

scholarly journals Association Between Paternal Separation During Early Childhood and Pubertal Timing Among Girls Using Longitudinal Birth Cohort in Japan

2021 ◽  
Vol 12 ◽  
Author(s):  
Aomi Katagiri ◽  
Nobutoshi Nawa ◽  
Takeo Fujiwara
Keyword(s):  
Early Childhood ◽  
Confidence Interval ◽  
Pubertal Timing ◽  
Pubertal Development ◽  
Divorce Rate ◽  
Peak Height ◽  
Longitudinal Survey ◽  
Height Velocity ◽  
Peak Height Velocity ◽  
Paternal Absence

IntroductionPrevious studies have shown that paternal absence leads to earlier pubertal timing among girls in high-income countries. Despite the low divorce rate in Japan, paternal separation is commonly seen due to a unique corporation system, tanshin funin, where employees relocate with their spouses and children. We examined paternal separation, including paternal absence (due to divorce or paternal death) and paternal tanshin funin, during early childhood as a predictor of earlier girl’s pubertal development, assessed as age at peak height velocity (PHV).MethodsThis study examined 15 214 girls from a longitudinal survey conducted in Japan from 2001 to 2016 by the Ministry of Health, Labor and Welfare. Paternal separation was determined by the occurrence through annual surveys conducted at ages 0.5 to 4.5 years. Outcome was defined as age at PHV between ages 6 to 15 years. We conducted linear regression, adjusted for potential confounders and other covariates.ResultsContinuous father cohabitation was seen in 88.7% of households, while paternal separation was experienced 1-2, 3-4 and 5 times (always) among 7.4%, 2.8% and 1.1% of households, respectively. Girls who confronted continuous paternal separation (5 times) experienced 0.42 years earlier [95% confidence interval (CI): -0.75, -0.10] age at PHV compared to their peers who always lived with their fathers.ConclusionGirls who experienced paternal separation throughout ages 0.5 to 4.5 years experienced PHV earlier.

Non-classical 21-hydroxylase deficiency in infancy and childhood: the effect of time of initiation of therapy on puberty and final height

1997 ◽  
Vol 136 (2) ◽  
pp. 188-195 ◽  
Author(s):  
Naomi Weintrob ◽  
Zvi Dickerman ◽  
Elliot Sprecher ◽  
Avinoam Galatzer ◽  
Atalia Pertzelan
Keyword(s):  
Final Height ◽  
Bone Age ◽  
Peak Height ◽  
Height Velocity ◽  
Peak Height Velocity ◽  
Hydroxylase Deficiency ◽  
Group A ◽  
Parental Height ◽  
Group B ◽  
21 Hydroxylase Deficiency

Abstract Objective: To review the characteristics of children with non-classical 21-hydroxylase deficiency (NC-21-OHD) diagnosed during infancy and childhood, and to evaluate the relationship of pubertal and bone age maturation at initiation of glucocorticoid therapy with the course of puberty and final height. Design: We retrospectively compared the course of puberty, growth pattern and final height in two groups of patients: group A (two males, six females), hydrocortisone (HC) treatment 7·5–15 mg/m2 per 24 h, initiated ≥1 year before onset of true puberty and group B (seven females), treatment started with the first signs of true puberty present. Participants: Thirteen girls and two boys with NC-21-OHD diagnosed at age range 0·5–10·6 years were followed-up for 9·0 ± 3·8 years (mean±s.d.). Therapy with HC was initiated because of signs of hyperandrogenism, accelerated growth and bone maturation, or true precocious puberty. The HC dose was adjusted according to linear growth and basal plasma androgen levels. Results: Puberty and peak height velocity developed significantly earlier in the girls of group B: gonadarche at 7·9 ± 1·4 years and peak height velocity at 9·2 ± 1·4 years vs 10·2 ± 0·4 years (P = 0·002) and 11·5 ± 0·7 years (P = 0·006) in group A. Menarche, however, occurred only slightly earlier in group B (12·0 ± 1·1 vs 12·8 ±0·5 years, P = 0·068). All eight children in group A achieved a final height within the range of their mean parental height standard deviation scores (SDS) in comparison with only 1/7 in group B (P = 0·0014). Seven of eight patients who started therapy before a bone age of 9 years achieved a final height within the parental height SDS range, compared with 2/7 who started therapy later (P = 0·041). The final height SDS was significantly better for group A (0·05 ± 0·19, mean ± s.e.m.) than group B (−1·63 ± 0·23, P = 0·0007), even when adjusted for a significant effect of the mean parental height SDS (A, −0·63 ± 0·28; B, −0·89 ± 0·31, P = 0·0245, ANCOVA). Conclusion: Every child with signs of excess androgen activity or early puberty should be studied for the possibility of NC-21-OHD. Screening programs for populations with a high frequency of the gene for NC-21-OHD would facilitate early diagnosis and treatment. Pubertal stage and bone age at the introduction of therapy dictate height prognosis. Initiation of therapy before puberty with careful follow-up and HC dose adjustment can assure the achievement of genetic adult height. European Journal of Endocrinology 136 188–195

scholarly journals Geographical differences in the effects of age and height at peak height velocity on final body height: An analysis of a population-based cross-sectional growth curve in Japan

2017 ◽  
Author(s):  
Masana Yokoya
Keyword(s):  
Growth Curve ◽  
Final Height ◽  
Body Height ◽  
Population Based ◽  
Peak Height ◽  
Height Velocity ◽  
Average Height ◽  
Peak Height Velocity ◽  
Geographical Differences ◽  
Cross Sectional

Background. The aim of this study was to elucidate the effect of geographical differences in the age at peak height velocity (APHV) and height at peak height velocity (HPHV) on final height, at a prefectural level, and to evaluate the current average height status of 47 prefectures in Japan. Methods. We elucidated the association between the geographical differences in a prefectural-level cross-sectional population-based infancy-childhood-puberty (ICP) growth curve, derived from prefectural mean height data (age: 5-17 years, 2006-2013), APHV and HPHV, for final height. Results. The correlation between the APHV and final height was very weak; however, the results of a multiple regression analysis showed that the final height of each prefecture can be accurately predicted based on the APHV and HPHV. This result showed that the earlier the APHV and higher the HPHV, the higher the final height. An earlier APHV reduced the height gain in the puberty component; however, this did not reduce the final height. Discussion. From the perspective of the average value of each prefecture, in the present situation, the effect of an earlier APHV in increasing the amount of growth of the childhood component exceeded its effect in reducing the growth of the puberty component. In short, the final height of the prefectures depends on how large the height growth is in the early stages of childhood. However, the HPHV tended to be region-specific, and it is unlikely that it can increase the average height in this population in the future.

scholarly journals Estimation of Pubertal Growth Spurt Parameters in Children and Adolescents Living at Moderate Altitude in Colombia

2021 ◽  
Vol 12 ◽  
Author(s):  
Marco Antonio Cossio-Bolaños ◽  
Ruben Vidal-Espinoza ◽  
Juan Minango-Negrete ◽  
Pedro R. Olivares ◽  
Luis Urzua-Alul ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Final Height ◽  
Peak Height ◽  
Height Velocity ◽  
Growth Spurt ◽  
Moderate Altitude ◽  
Biological Parameters ◽  
Pubertal Growth Spurt ◽  
Peak Height Velocity ◽  
Pubertal Growth

ObjectiveKnowledge of the biological parameters of pubertal growth spurt allows verification of secular changes and exploration of the timing of puberty. The aim of the study was to estimate final height, age at peak height velocity (APHV), and peak height velocity PHV (cm/y) in children and adolescents living at moderate altitude in Colombia.MethodsA cross-sectional study was designed in 2.295 schoolchildren from Bogotá (Colombia) with an age range from 5.0 to 18.9 years. Height (cm) was assessed. Preece–Baines model 1 (1PB) was used to make inferences about mathematical and biological parameters.ResultsThe five mathematical parameters estimated in general have reflected quality in the fit to the model, reflecting a small residual error. Final height was reached in boys at 170.8 ± 0.4 cm and in girls at 157.9 ± 0.2 cm. APHV was estimated at 12.71 ± 0.1 years in boys and 10.4 ± 0.2 years in girls. Girls reached APHV 2.2 years earlier than boys. In relation to PHV (cm/y), boys reached higher growth speed in height (7.4 ± 0.4 cm/y), and in girls it was (7.0 ± 0.2 cm/y).ConclusionIt was determined that final height was reached at 170.8 ± 0.4 cm in boys and 157.9 ± 0.2 cm in girls, and APHV (years) and PHV (cm/ye) were reached relatively early and with average peak velocity similar to Asian and Western populations. A large-scale longitudinal study is needed to confirm these findings.

scholarly journals Pubertal course of persistently short children born small for gestational age (SGA) compared with idiopathic short children born appropriate for gestational age (AGA)

2003 ◽  
Vol 149 (5) ◽  
pp. 425-432 ◽  
Author(s):  
L Lazar ◽  
U Pollak ◽  
O Kalter-Leibovici ◽  
A Pertzelan ◽  
M Phillip
Keyword(s):  
Gestational Age ◽  
Small For Gestational Age ◽  
Final Height ◽  
Pubertal Development ◽  
Height Velocity ◽  
Peak Height Velocity ◽  
Bone Maturation ◽  
Pubertal Growth ◽  
Short Children ◽  
Appropriate For Gestational Age

OBJECTIVE: Few data are available on the pubertal development of children born small for gestational age (SGA) who fail to show catch-up growth. DESIGN: A longitudinal analysis compared the pubertal course of persistently short children born SGA compared to children with idiopathic short stature who were appropriate for gestational age (AGA). One hundred and twenty-eight short children (height SDS<-1.7), including 76 (31 boys) born SGA and 52 (22 boys) born AGA, were regularly followed from early childhood to completion of puberty. RESULTS: Puberty was attained at normal age (10.5-14 Years in boys, 9.5-13 Years in girls) for most children in both the SGA and AGA groups (boys, 80% and 77%; girls, 76% and 78% respectively). The duration of puberty was similar in the SGA and AGA groups. Menarche occurred at normal age range but was significantly earlier in the SGA girls (P<0.01 by ANOVA). Despite the similar total pubertal growth, the patterns of growth differed significantly: SGA group - accelerated growth and bone maturation rates from onset of puberty with peak height velocity at Tanner stages 2-3, followed by a decelerated growth rate and earlier fusion of the epiphyses; AGA group - steady progression of bone elongation and maturation throughout puberty (pubertal growth, P<0.05 in both sexes; bone maturation, P<0.001 in both sexes). Final height in the SGA group was compromised compared with their target height (P<0.001). CONCLUSION: Children born SGA have a normal pubertal course with a distinct pubertal growth pattern. This pattern may represent an altered regulation of their growth modalities.

scholarly journals A Longitudinal Study of Growth, Sex Steroids, and IGF-1 in Boys With Physiological Gynecomastia

2015 ◽  
Vol 100 (10) ◽  
pp. 3752-3759 ◽  
Author(s):  
Mikkel G. Mieritz ◽  
Lars L. Rakêt ◽  
Casper P. Hagen ◽  
John E. Nielsen ◽  
Maj-Lis M. Talman ◽  
...  
Keyword(s):  
Pubertal Development ◽  
Free Testosterone ◽  
Serum Levels ◽  
Median Number ◽  
Peak Height ◽  
Height Velocity ◽  
Peak Height Velocity ◽  
Serum Hormone ◽  
Longitudinal Part ◽  
Igf Binding

Context: Physiological gynecomastia is common and affects a large proportion of otherwise healthy adolescent boys. It is thought to be caused by an imbalance between estrogen and testosterone, although this is rarely evident in analyses of serum. Objective: This study aimed to describe the frequency of physiological gynecomastia and to determine possible etiological factors (eg, auxology and serum hormone levels) in a longitudinal setup. Design, Settings, and Participants: A prospective cohort study of 106 healthy Danish boys (5.8–16.4 years) participated in the longitudinal part of the COPENHAGEN Puberty Study. The boys were examined every 6 months during an 8-year follow-up. Median number of examinations was 10 (2–15). Main outcome measurements: Blood samples were analyzed for FSH, LH, testosterone, estradiol, SHBG, inhibin B, anti-Müllerian hormone, IGF-1, and IGF binding protein-3 by immunoassays. Auxological parameters, pubertal development, and the presence of gynecomastia were evaluated at each visit. Results: Fifty-two of 106 boys (49%) developed gynecomastia, of which 10 (19%) presented with intermittent gynecomastia. Boys with physiological gynecomastia reached peak height velocity at a significantly younger age than boys who did not develop gynecomastia (13.5 versus 13.9 years, P = .027), and they had significantly higher serum levels of IGF-1 (P = .000), estradiol (P = .013), free testosterone (P &lt; .001), and FSH (P = .030) during pubertal transition. However, no differences in serum LH or in the estradiol to testosterone ratio were found. Conclusions: Gynecomastia is frequent in pubertal boys. Increased IGF-1 levels and pubertal growth appear to be associated, whereas changes in estrogen to testosterone ratio seem negligible.

Pubertal Development of Young Association Football Players: A Longitudinal Study

1994 ◽  
Vol 6 (2) ◽  
pp. 140-148
Author(s):  
William Bell
Keyword(s):  
Pubertal Development ◽  
Normal Growth ◽  
Peak Height ◽  
Pubic Hair ◽  
Height Velocity ◽  
Control Group ◽  
Football Players ◽  
Peak Height Velocity ◽  
Association Football ◽  
Pubertal Stages

The purpose of the present study was to investigate the pubertal characteristics of a group of specialist association football (soccer) players (N = 22) between the ages of 12.3 and 15.3 years. Pubertal status was assessed by direct observation of pubic hair (PH), and peak height velocity (PHV) was assessed using graphic procedures. The ages at which the various stages of PH were reached did not differ between playing positions or between players as a whole and the control group. The length of the interval between sequential stages of PH was about a year and between PH2 and PH5 was 2.5 years. Correlations between the age at PHV and each of the pubertal stages were generally high. It was concluded that the influence of participation in competitive association football had no significant effect on the attainment and progress of pubertal development beyond that expected by normal growth.

scholarly journals Geographical differences in the effects of age and height at peak height velocity on final body height: An analysis of a population-based cross-sectional growth curve in Japan

2017 ◽  
Author(s):  
Masana Yokoya
Keyword(s):  
Growth Curve ◽  
Final Height ◽  
Body Height ◽  
Population Based ◽  
Peak Height ◽  
Height Velocity ◽  
Average Height ◽  
Peak Height Velocity ◽  
Geographical Differences ◽  
Cross Sectional

Background. The aim of this study was to elucidate the effect of geographical differences in the age at peak height velocity (APHV) and height at peak height velocity (HPHV) on final height, at a prefectural level, and to evaluate the current average height status of 47 prefectures in Japan. Methods. We elucidated the association between the geographical differences in a prefectural-level cross-sectional population-based infancy-childhood-puberty (ICP) growth curve, derived from prefectural mean height data (age: 5-17 years, 2006-2013), APHV and HPHV, for final height. Results. The correlation between the APHV and final height was very weak; however, the results of a multiple regression analysis showed that the final height of each prefecture can be accurately predicted based on the APHV and HPHV. This result showed that the earlier the APHV and higher the HPHV, the higher the final height. An earlier APHV reduced the height gain in the puberty component; however, this did not reduce the final height. Discussion. From the perspective of the average value of each prefecture, in the present situation, the effect of an earlier APHV in increasing the amount of growth of the childhood component exceeded its effect in reducing the growth of the puberty component. In short, the final height of the prefectures depends on how large the height growth is in the early stages of childhood. However, the HPHV tended to be region-specific, and it is unlikely that it can increase the average height in this population in the future.

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