Microwave Assisted Synthesis of 3-Chloro-N-(2-(5-chloro-1-tosyl-1Hbenzo [d] Imidazol-2-yl) ethyl)-N-Substituted Quinoxalin-2-Amine Derivatives Using DCQX

Organic Chemistry Plus ◽

10.37256/ocp.122020287 ◽

2020 ◽

pp. 39-45

Author(s):

K.Shashikala ◽

E.Laxminarayana ◽

M.Ramesh ◽

M.Thirumala Chary

Keyword(s):

Conventional Method ◽

Alkylating Agent ◽

Microwave Assisted Synthesis ◽

Propargyl Bromide ◽

Microwave Assisted ◽

Starting Compound

The microwave assisted synthesis of 3-Chloro-N-(2-(5-chloro-1-tosyl-1H-benzo [d] imidazol-2-yl) ethyl)-N-substituted quinoxalin-2-amine derivatives is described. 2,3-dichloro quinoxaline (DCQX), as a starting compound and propargyl bromide, as an efficient alkylating agent are used in the synthesis of N-substituted quinoxalin-2-amine derivatives. We realized that microwave assisted synthesis is efficiently replacing conventional method of synthesis.

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Microwave Assisted Improved Method for the Synthesis of Pyrazole Containing 2,4,-Disubstituted Oxazole-5-one and their Antimicrobial Activity

E-Journal of Chemistry ◽

10.1155/2008/265131 ◽

2008 ◽

Vol 5 (1) ◽

pp. 120-129 ◽

Cited By ~ 10

Author(s):

N. D. Argade ◽

B. K. Kalrale ◽

C. H. Gill

Keyword(s):

Conventional Method ◽

Antimicrobial Agents ◽

Biological Activities ◽

Microwave Assisted Synthesis ◽

Antifungal Activities ◽

Microwave Assisted ◽

Antibacterial And Antifungal Activities ◽

Microwave Assistance ◽

Antibacterial And Antifungal

Disubstituted oxazol-5-one and pyrazoles are known to exhibit various biological activities. Therefore, in this work, we designed pyrazole containing 2,4-disubstituted oxazol-5-one(3a-g)as a new class of antimicrobial agents. Synthesis of titled compounds was carried out by two different methods. In the first method (conventional Method A), disubstituted oxazol-5-one(3a-g)was prepared by reacting 1-phenyl-3-p-tolyl-1H-pyrazole-4-carbaldehyde(1a-g)with hippuric acid(2)and sodium acetate, in an acetic anhydride for 2.5 - 4 h. In the second method (Method B), the above reaction was carried out under microwave assistance. Compared to the conventional method, the microwave-assisted synthesis of 3,4,5-trisubstituted imidazoles demonstrate several advantages, in terms of reaction time and overall yield. All the test compounds were evaluated forin vitroantibacterial and antifungal activities. In general, compounds with electron withdrawing groups showed good antibacterial and antifungal activities. Among the compound tested, compound(3d)showed highest activity.

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Microwave-Assisted Synthesis of 3,5-Dibenzyl-4-amino-1,2,4-triazole and its Diazo Ligand, Metal Complexes Along with Anticancer Activity

E-Journal of Chemistry ◽

10.1155/2010/569605 ◽

2010 ◽

Vol 7 (4) ◽

pp. 1571-1577 ◽

Cited By ~ 4

Author(s):

Anjali Jha ◽

Y. L. N. Murthy ◽

G. Durga ◽

T. T. Sundari

Keyword(s):

Microwave Irradiation ◽

Metal Complexes ◽

Anticancer Activity ◽

Cell Lines ◽

Conventional Method ◽

Ruthenium Complexes ◽

Microwave Assisted Synthesis ◽

Microwave Irradiation Method ◽

Anticancer Activities ◽

Microwave Assisted

Synthesis of 3,5-dibenzyl-4-amino-1,2,4-triazole was accomplished via a conventional method as well as microwave irradiation method, followed by diazotization and coupling with 2,4-pentanedione. The dinucleating ligand was isolated and complexed with Ni(II), Cu(II) and Ru(III) chlorides. These complexes were screened on Jurkat, Raji & PBMC cell lines for anticancer activity. Ruthenium complexes showed potential anticancer activities.

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Microwave-Assisted Synthesis of Some New Mixed Ligand Ni(II) Complexes Its Characterization and Its Antimicrobial Study

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i31b31700 ◽

2021 ◽

pp. 143-152

Author(s):

Jitendra M. Pawara ◽

Sunil S. Patil

Keyword(s):

Thermal Analysis ◽

Conventional Method ◽

Mixed Ligand ◽

High Yield ◽

Microwave Assisted Synthesis ◽

Microwave Method ◽

Preparation Time ◽

Microwave Assisted ◽

Microwave Assisted Method ◽

Very High

Nickel(II) complexes of the type [Ni(P)(L).2H2O] has been synthesized by using 2-amino-6-methyl pyrimidine-4-ol (HP) and amino acids (HL). Complexes synthesized by conventional as well as microwave methods. Results indicate that complexes synthesized by the microwave method are more efficient than the conventional method. In the microwave method preparation time is short (4-7 min.) compared to the conventional method (45 min.). Moreover, the microwave Assisted method gives a very high yield (90%) of the complexes. The microwave method used for the synthesis of the complexes has been found easier, convenient and eco-friendly. Complexes have been characterized by FTIR, Elemental analysis, Gouy experiment, Thermogravimetric Analysis (TGA) and Differential Thermal Analysis (DTA). Complexes have shown significant antimicrobial activity.

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Microwave Assisted Synthesis of some Novel Sulphonamide Bearing Pyrazolone Core Structure

International Letters of Chemistry Physics and Astronomy ◽

10.18052/www.scipress.com/ilcpa.30.116 ◽

2014 ◽

Vol 30 ◽

pp. 116-126

Author(s):

Dipti L. Namera ◽

Khushal M. Kapadiya ◽

Mitesh M. Chhatrola ◽

Umed C. Bhoya

Keyword(s):

Experimental Data ◽

Conventional Method ◽

Mass Spectroscopy ◽

Elemental Analysis ◽

Microwave Assisted Synthesis ◽

H Nmr ◽

Microwave Assisted ◽

Pyrazolone Derivatives ◽

Ft Ir ◽

Microwave Assisted Method

We have described some novel Sulphonamide bearing pyrazoline derivatives synthesized by conventional method as well as microwave assisted method of synthesis. The reaction of 4-(3-methyl-5-oxo-4,5-dihydro-1-H-pyrazol-1-yl)benzenesulphonamide with substituted benzaldehyde in the presence of Methanol as solvent and piperidine as catalyst, generated a series of substituted pyrazolone derivatives 4a-m. The structures of all synthesized compounds are well characterized by Mass spectroscopy, FT-IR, 1H NMR and elemental analysis. After obtaining experimental data regarding the yield and the time taken for the synthesis by both the approaches, convenient and microwave assisted method, it was ascertained that the microwave assisted method is more suitable for synthesis of pyrazolone derivatives 4a-m.

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Microwave Assisted Synthesis of 5-hydroxymethylfurfural Using Mild Reaction Conditions

Revista de Chimie ◽

10.37358/rc.17.3.5471 ◽

2017 ◽

Vol 68 (3) ◽

pp. 435-438 ◽

Cited By ~ 1

Author(s):

Adina Ionuta Gavrila ◽

Ioana Asofiei ◽

Adrian Trifan ◽

Petre Chipurici ◽

Edina Rusen

Keyword(s):

Reaction Time ◽

Conventional Method ◽

Industrial Development ◽

High Performance ◽

Heterogeneous Catalysts ◽

Microwave Assisted Synthesis ◽

Reaction Conditions ◽

Microwave Assisted ◽

Catalyst Temperature ◽

Exchange Resins

5-Hydroxymethylfurfural (5-HMF) is an important platform molecules, being a green precursor for a variety of high performance fuels and valuable chemicals. The production of 5-HMF from fructose under microwave-assisted heating conditions by varying different parameters (catalyst, temperature, stirring rate and reaction time) was studied. Microwave assisted synthesis leads to a shorter reaction time (40 min versus 150 min for conventional method) and the energy consumption is lower compared with the conventional method. Homogeneous and heterogeneous catalysts were tested. Although homogeneous catalysis produced the highest conversion of fructose to 5-HMF, ion exchange resins are preferable for industrial development and the best results were obtained for Dowex resin.

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