scholarly journals In Vitro Antioxidative Potential of Lactoferrin and Black Tea Polyphenols and Protective Effects In Vivo on Carcinogen Activation, DNA Damage, Proliferation, Invasion, and Angiogenesis During Experimental Oral Carcinogenesis

2008 ◽  
Vol 17 (5) ◽  
pp. 193-203 ◽  
Author(s):  
P. Vidjaya Letchoumy ◽  
K. V. P. Chandra Mohan ◽  
J. J. Stegeman ◽  
H. V. Gelboin ◽  
Y. Hara ◽  
...  
Keyword(s):  
Dna Damage ◽  
Black Tea ◽  
Tea Polyphenols ◽  
Protective Effects ◽  
Oral Carcinogenesis ◽  
Black Tea Polyphenols

Prevention of diet-induced obesity by dietary black tea polyphenols extract in vitro and in vivo

Nutrition ◽  
2011 ◽  
Vol 27 (3) ◽  
pp. 287-292 ◽  
Author(s):  
Satoshi Uchiyama ◽  
Yoshimasa Taniguchi ◽  
Akiko Saka ◽  
Aruto Yoshida ◽  
Hiroaki Yajima
Keyword(s):  
Black Tea ◽  
Tea Polyphenols ◽  
Diet Induced Obesity ◽  
Black Tea Polyphenols

scholarly journals Colon Bioaccessibility and Antioxidant Activity of White, Green and Black Tea Polyphenols Extract after In Vitro Simulated Gastrointestinal Digestion

Nutrients ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1711 ◽  
Author(s):  
Giuseppe Annunziata ◽  
Maria Maisto ◽  
Connie Schisano ◽  
Roberto Ciampaglia ◽  
Patricia Daliu ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Inflammatory Diseases ◽  
Black Tea ◽  
Tea Polyphenols ◽  
Array Detector ◽  
Total Phenol Content ◽  
Beneficial Effects ◽  
Polyphenolic Extract

The beneficial effects of the tea beverage are well-known and mainly attributed to polyphenols which, however, have poor bioaccessibility and bioavailability. The purpose of the present study was the evaluation of colon bioaccessibility and antioxidant activity of tea polyphenolic extract. An 80% methanolic extract (v/v) of tea polyphenols was obtained from green (GT), white (WT) and black tea (BT). Simulated gastrointestinal (GI) digestion was performed on acid-resistant capsules containing tea polyphenolic extract. The main tea polyphenols were monitored by HPLC-diode-array detector (DAD) method; in addition, Total Phenol Content (TPC) and antioxidant activity were evaluated. After GI digestion, the bioaccessibility in the colon stage was significantly increased compared to the duodenal stage for both tea polyphenols and TPC. Similarly, the antioxidant activity in the colon stage was significantly higher than that in the duodenal stage. Reasonably, these results could be attributable in vivo to the activity of gut microbiota, which is able to metabolize these compounds, generating metabolites with a greater antioxidant activity. Our results may guide the comprehension of the colon digestion of polyphenols, suggesting that, although poorly absorbed in the duodenum, they can exert their antioxidant and anti-inflammatory activities in the lower gut, resulting in a novel strategy for the management of gut-related inflammatory diseases.

scholarly journals Toxicological Studies of Czech Beers and Their Constituents

Foods ◽  
2019 ◽  
Vol 8 (8) ◽  
pp. 328 ◽  
Author(s):  
Tania Merinas-Amo ◽  
Rocío Merinas-Amo ◽  
Victoria García-Zorrilla ◽  
Alejandro Velasco-Ruiz ◽  
Ladislav Chladek ◽  
...  
Keyword(s):  
Dna Damage ◽  
Raw Materials ◽  
Methylation Status ◽  
Human Cell Line ◽  
Protective Effects ◽  
Toxicological Effects ◽  
Freeze Dried ◽  
Toxicological Studies

Background: Czech beers are unique because they are brewed using specific technology at a particular latitude and for being entirely produced in the area of the Czech Republic. The purpose of this work is the evaluation of toxicological effects of a variety of freeze-dried Czech beers, their raw materials (malts, hops and yeast) and processed-beer (wort, hopped wort and young beer). Methods: In vivo assays to evaluate the safety and protective effects in the Drosophila melanogaster eukaryotic system, and the in vitro evaluations of chemopreventive and DNA damage activity using the HL-60 tumour human cell line were carried out. Results: The safe effects for all the analysed substances and general protective effects against H2O2 were shown both at the individual and genomic level in the Drosophila animal model, with some exceptions. Moreover, all the substances were able to inhibit the tumour cell growth and to induce DNA damage in the HL-60 cells at different levels (proapoptotic, single/double strands breaks and methylation status). Conclusions: The promising effects shown by freeze-dried Czech beers due to their safety, protection against a toxin, chemopreventive potential and the induction of DNA damage in tumour cells, allow the proposition of Czech beer as a beverage with nutraceutic potential.

Sign in / Sign up

Export Citation Format

Share Document