Efektifitas Panax Ginseng terhadap Alopecia

Aspek fungsional rambut pada kepala tidak hanya untuk melindungi dari radiasi matahari dan paparan panas / dingin, tetapi juga untuk berkontribusi pada penampilan dan kepribadian seseorang. Kerontokan rambut progresif memiliki dampak kosmetik dan sosial. Rambut mengalami tiga tahap siklus rambut: fase anagen, catagen, dan telogen. Melalui kehilangan siklus dan pertumbuhan rambut baru, jumlah rambut tetap relatif konstan. Berbagai faktor, seperti hormon, status gizi, dan paparan radiasi, racun lingkungan, dan obat-obatan, dapat memengaruhi pertumbuhan rambut. Androgen adalah faktor terpenting yang menyebabkan alopesia androgenik. Bentuk lain dari kerontokan rambut termasuk kerontokan rambut imunogenik, yaitu alopecia areata. Meskipun sejumlah terapi, seperti finasteride dan minoxidil, adalah obat yang disetujui pencarian terhadap obat obatan alami atau tradisional tetap diperhitungkan salah satunya adalah ginseng. Sejumlah produk - produk sampo dan kondisioner memsukan bagian ginseng, telah menunjukkan pertumbuhan rambut - mempromosikan efek dalam sejumlah besar studi praklinis. Penelitian ini merupakan studi literature review.Tujuan dari tinjauan ini adalah melihat potensi ginseng dan metabolitnya pada pencegahan rambut rontok dan mekanisme yang mendasarinya. Kata kunci: alopecia, kerontokan rambut, ginseng EFFECTIVENESS OF PANAX GINSENG ON ALOPECIA ABSTRACT The functional aspect of hair on the head is not only to protect from sun radiation and heat / cold exposure, but also to contribute to one's appearance and personality. Progressive hair loss has cosmetic and social effects. Hair experiences three stages of the hair cycle: anagen, catagen, and telogen phases. Through cycle loss and new hair growth, the amount of hair remains relatively constant. Various factors, such as hormones, nutritional status, and radiation exposure, environmental toxins, and medications, can affect hair growth. Androgens are the most important factor causing androgenic alopecia. Other forms of hair loss include immunogenic hair loss, namely alopecia areata. Although a number of therapies, such as finasteride and minoxidil, are drugs that are approved by the search for natural or traditional medicines, one of which is still considered ginseng. A number of shampoo and conditioner products, which have a part of ginseng, have shown hair growth - promoting effects in a large number of preclinical studies. This study used literatur review. The purpose of this review is to look at the potential of ginseng and its metabolites in the prevention of hair loss and the underlying mechanisms. Keywords:alopecia, hair loss, ginseng

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Hair-Growth Potential of Ginseng and Its Major Metabolites: A Review on Its Molecular Mechanisms

International Journal of Molecular Sciences ◽

10.3390/ijms19092703 ◽

2018 ◽

Vol 19 (9) ◽

pp. 2703 ◽

Cited By ~ 9

Author(s):

Bu Choi

Keyword(s):

Hair Loss ◽

Hair Growth ◽

Social Impact ◽

Molecular Mechanisms ◽

Growth Potential ◽

Environmental Toxicants ◽

Androgenic Alopecia ◽

Three Stages ◽

Growth Promoting ◽

Underlying Mechanisms

The functional aspect of scalp hair is not only to protect from solar radiation and heat/cold exposure but also to contribute to one’s appearance and personality. Progressive hair loss has a cosmetic and social impact. Hair undergoes three stages of hair cycle: the anagen, catagen, and telogen phases. Through cyclical loss and new-hair growth, the number of hairs remains relatively constant. A variety of factors, such as hormones, nutritional status, and exposure to radiations, environmental toxicants, and medications, may affect hair growth. Androgens are the most important of these factors that cause androgenic alopecia. Other forms of hair loss include immunogenic hair loss, that is, alopecia areata. Although a number of therapies, such as finasteride and minoxidil, are approved medications, and a few others (e.g., tofacitinib) are in progress, a wide variety of structurally diverse classes of phytochemicals, including those present in ginseng, have demonstrated hair growth-promoting effects in a large number of preclinical studies. The purpose of this review is to focus on the potential of ginseng and its metabolites on the prevention of hair loss and its underlying mechanisms.

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Hair Growth in a Patient with Alopecia Areata on Tocilizumab

Skin Appendage Disorders ◽

10.1159/000516300 ◽

2021 ◽

pp. 1-5

Author(s):

Chloe J. Walker ◽

Kelly E. Flanagan ◽

James T. Pathoulas ◽

Isabel Pupo Wiss ◽

Maryanne M. Senna

Keyword(s):

Monoclonal Antibody ◽

Autoimmune Disease ◽

Hair Loss ◽

Alopecia Areata ◽

Interleukin 6 ◽

Hair Growth ◽

Posterior Uveitis ◽

Case Presentation ◽

Antibody Targeting ◽

Growth Changes

Introduction: Tocilizumab (TCZ), a recombinant humanized antihuman monoclonal antibody targeting interleukin-6 (IL-6) signaling, is often utilized in the management of autoimmune disease. Few reports have demonstrated hair growth changes in patients on TCZ. Case Presentation: Herein, we review the literature and report a 21-year-old woman with progressive alopecia areata (AA) presenting with AA improvement while on TCZ for concomitant posterior uveitis. Discussion: Our case demonstrates the potential ability of TCZ to disrupt IL-6 signaling involved in AA, leading to hair loss and regrowth.

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Hair growth promoting effect of white wax and policosanol from white wax on the mouse model of testosterone-induced hair loss

Biomedicine & Pharmacotherapy ◽

10.1016/j.biopha.2017.02.036 ◽

2017 ◽

Vol 89 ◽

pp. 438-446 ◽

Cited By ~ 10

Author(s):

Zhan-di Wang ◽

Ying Feng ◽

Li-yi Ma ◽

Xian Li ◽

Wei-feng Ding ◽

...

Keyword(s):

Mouse Model ◽

Hair Loss ◽

Hair Growth ◽

Promoting Effect ◽

Growth Promoting

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Disorders of Hair

10.2310/fm.1107 ◽

2013 ◽

Author(s):

James Q Del Rosso

Keyword(s):

Hair Loss ◽

Alopecia Areata ◽

Hair Growth ◽

Growth Cycle ◽

Hair Follicles ◽

Common Type ◽

Diagnosis And Treatment ◽

Basic Knowledge ◽

Androgenetic Alopecia ◽

Broad Overview

A basic knowledge of the hair growth cycle is needed to evaluate disorders of hair growth. This chapter presents a broad overview of the physiology and evaluation of hair growth, as well as discussions of specific types of alopecia. The epidemiology, pathogenesis, diagnosis, and treatment of androgenetic alopecia, the most common type of nonscarring hair loss, are covered. Diffuse hair shedding is generalized hair loss over the entire scalp. Diagnosis and treatment of telogen effluvium, anagen arrest (anagen effluvium), and other causes of diffuse hair shedding are covered in detail. Alopecia areata, typically characterized by patchy hair loss; cicatricial alopecia, which results from permanent scarring of the hair follicles; and miscellaneous causes of hair loss are also discussed. Tables list the causes of diffuse and cicatricial alopecia, telogen effluvium, and miscellaneous chemicals and categories of drugs that can cause alopecia, as well as miscellaneous causes of hair loss. Included is an algorithm outlining the approach to diagnosing nonscarring alopecia, as well as a variety of clinical photographs. This review contains 9 highly rendered figures, 6 tables, and 42 references.

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Hair Growth Activity of Three Plants of the Polynesian Cosmetopoeia and Their Regulatory Effect on Dermal Papilla Cells

Molecules ◽

10.3390/molecules25194360 ◽

2020 ◽

Vol 25 (19) ◽

pp. 4360

Author(s):

Kristelle Hughes ◽

Raimana Ho ◽

Stéphane Greff ◽

Edith Filaire ◽

Edwige Ranouille ◽

...

Keyword(s):

Hair Loss ◽

Hair Growth ◽

Dermal Papilla ◽

Hair Cycle ◽

Bidens Pilosa ◽

Dermal Papilla Cells ◽

Qpcr Analysis ◽

Chemical Content ◽

Growth Activity ◽

Gene Expression Levels

Hair loss is becoming increasingly prevalent as dietary and living habits change. The search for natural products to limit hair loss has led to tapping into traditional cosmetic knowledge. We studied three plants of the Polynesian cosmetopoeia, Bidens pilosa, Calophyllum inophyllum and Fagraea berteroana, to determine their ability to promote hair growth. Their chemical content was characterized by liquid chromatography coupled to mass spectrometry (LC-MS). Their proliferative activity on dermal papilla cells (DPCs) was assessed via MTT assay and molecular targets were evaluated by RT-qPCR analysis of seven factors involved in the modulation of the hair cycle, CCND1, LEF1, DKK1, WNT5A PPARD, TGFΒ1, PPARD and RSPO2. Our results show that our extracts significantly increased proliferation of dermal papilla cells. Furthermore, LC-MS/MS analysis revealed a diversity of molecules, flavonoids, iridoids and organic acids, some known for hair-inducing properties. Finally, specific extracts and fractions of all three plants either upregulated CCND1, LEF1 and PPARD involved in stimulating hair follicle proliferation and/or lowered the gene expression levels of hair growth inhibiting factors, DKK1 and TGFB1. Our findings suggest that extracts from B. pilosa, C. inophyllum and F. berteroana are interesting candidates to stimulate hair growth.

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Comparative Hair Restorer Efficacy of Medicinal Herb on Nude (Foxn1nu) Mice

BioMed Research International ◽

10.1155/2014/319795 ◽

2014 ◽

Vol 2014 ◽

pp. 1-9 ◽

Cited By ~ 3

Author(s):

Shahnaz Begum ◽

Mi Ra Lee ◽

Li Juan Gu ◽

Md. Jamil Hossain ◽

Hyun Kyoung Kim ◽

...

Keyword(s):

Panax Ginseng ◽

Nude Mice ◽

Hair Loss ◽

Hair Growth ◽

Growth Promotion ◽

Hair Follicles ◽

Growth Potential ◽

Eclipta Alba ◽

Growth Area ◽

Brdu Labeling

Eclipta alba(L.) Hassk,Asiasarum sieboldii(Miq.) F. Maek (Asiasari radix), andPanax ginsengC. A. Mey (red ginseng) are traditionally acclaimed for therapeutic properties of various human ailments. Synergistic effect of each standardized plant extract was investigated for hair growth potential on nude mice, as these mutant mice genetically lack hair due to abnormal keratinization. Dried plant samples were ground and extracted by methanol. Topical application was performed on the back of nude mice daily up to completion of two hair growth generations. The hair density and length ofEclipta albatreated mice were increased significantlyP>0.001than control mice. Hair growth area was also distinctly visible inEclipta albatreated mice. On the other hand,Asiasari radixandPanax ginsengtreated mice developing hair loss were recognized from the abortive boundaries of hair coverage. Histomorphometric observation of nude mice skin samples revealed an increase in number of hair follicles (HFs). The presence of follicular keratinocytes was confirmed by BrdU labeling, S-phase cells in HFs. Therefore,Eclipta albaextract and/or phytochemicals strongly displayed incomparability of hair growth promotion activity than others. Thus, the standardizedEclipta albaextract can be used as an effective, alternative, and complementary treatment against hair loss.

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What Can Complex Dietary Supplements Do for Hair Loss and How Can It Be Validly Measured—A Review

Applied Sciences ◽

10.3390/app10144996 ◽

2020 ◽

Vol 10 (14) ◽

pp. 4996

Author(s):

Nicole Braun ◽

Ulrike Heinrich

Keyword(s):

Hair Follicle ◽

Dietary Supplements ◽

Hair Loss ◽

Hair Growth ◽

Hair Cycle ◽

Active Growth ◽

Widespread Occurrence ◽

Non Invasive ◽

Anagen Phase

Hair plays a major role in perception within a society. It provides information about gender, age, health, and social status. It is therefore not surprising that those affected are exposed to great suffering due to the widespread occurrence of hair loss. As a result, the demand for new products to remedy this problem is not diminishing. Hair grows in cycles, and a hair follicle goes through several phases called the hair cycle. The active growth phase (anagen phase) lasts 2–6 years. In this state a hair follicle shows a growth of about 1 cm per month. In order to improve the existing hair status, hair should be kept in the active anagen phase as long as possible, or the transition to anagen should be stimulated. A number of reviews already describe the influence of individual active ingredients on hair growth. However, the following review describes existing studies of complex dietary supplements with their experimental weaknesses and strengths and their influence on hair loss. Also, for the determination of hair loss, it is important to use a valid method with high acceptance by the test persons. In this context, the TrichoScale® is a validated and non-invasive tool for quantifying hair loss/hair growth. Thus, it is an ideal measuring instrument to objectively quantify the effectiveness of a hair loss treatment.

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Efficacy of plum blossom acupuncture on alopecia areata – A case report

Indian Journal of Case Reports ◽

10.32677/ijcr.v7i9.3024 ◽

2021 ◽

pp. 395-397

Author(s):

Sujithra Sreekumari Thanudhas

Keyword(s):

Case Report ◽

Hair Loss ◽

Alopecia Areata ◽

Pharmacological Treatment ◽

Hair Growth ◽

Genetic Factors ◽

The Past ◽

Autoimmune Condition

Alopecia areata (AA) is a complex autoimmune condition that causes non-scarring hair loss and may present at any age. It typically presents with sharply demarcated round patches of hair loss. AA presents heterogeneously and is influenced by both environmental and genetic factors. There is no effective pharmacological treatment currently available for this disorder so far. We had an opportunity to treat a patient with AA using acupuncture. The patient was a 23-year-old male who presented to us with a complaint of sudden hair loss in patches in two demarcated round areas in a diameter of 2–3 cm on the back of the head for the past year. He was diagnosed as AA by AA progression index. After a long treatment course of about 3 months with acupuncture, this patient showed significant hair growth.

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