Good Glycemic Control for a Low Cardiovascular Risk in Children Suffering from Diabets

2017 ◽  
Vol 68 (2) ◽  
pp. 358-361
Author(s):  
Camelia Busila ◽  
Mariana Cretu Stuparu ◽  
Aurel Nechita ◽  
Camelia Ana Grigore ◽  
Gabriela Balan
Keyword(s):  
Glycosylated Hemoglobin ◽  
Control Group ◽  
Sex Distribution ◽  
Good Glycemic Control ◽  
Rural And Urban ◽  
Lipid Panel ◽  
Patients With Diabetes ◽  
Kolmogorov Smirnov ◽  
Low Cardiovascular Risk

The study is a prospective and operational one, ant its was conducted on 58 patients with diabetes type 1 and 2. The patients sex distribution was homogenious and they come from both rural and urban environment. The statistical analisys was carried out using the programme SPSS 17.0 for Windows. The distribution normality was cheked using the Kolmogorov - Smirnov Z test. he values of glycemia, glycosylated hemoglobin, lipid panel, blood pressure have been measured and compared to the ones belonging to the control group.

scholarly journals Volume rendered 3D OCTA assessment of macular ischemia in patients with type 1 diabetes and without diabetic retinopathy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Enrico Borrelli ◽  
Domenico Grosso ◽  
Mariacristina Parravano ◽  
Eliana Costanzo ◽  
Maria Brambati ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Diabetic Retinopathy ◽  
Healthy Subjects ◽  
Diabetic Group ◽  
Control Group ◽  
Diabetic Patients ◽  
Vascular Volume ◽  
Patients With Diabetes ◽  
Perfusion Density

AbstractThe aim of this study was to measure macular perfusion in patients with type 1 diabetes and no signs of diabetic retinopathy (DR) using volume rendered three-dimensional (3D) optical coherence tomography angiography (OCTA). We collected data from 35 patients with diabetes and no DR who had OCTA obtained. An additional control group of 35 eyes from 35 healthy subjects was included for comparison. OCTA volume data were processed with a previously presented algorithm in order to obtain the 3D vascular volume and 3D perfusion density. In order to weigh the contribution of different plexuses’ impairment to volume rendered vascular perfusion, OCTA en face images were binarized in order to obtain two-dimensional (2D) perfusion density metrics. Mean ± SD age was 27.2 ± 10.2 years [range 19–64 years] in the diabetic group and 31.0 ± 11.4 years [range 19–61 years] in the control group (p = 0.145). The 3D vascular volume was 0.27 ± 0.05 mm3 in the diabetic group and 0.29 ± 0.04 mm3 in the control group (p = 0.020). The 3D perfusion density was 9.3 ± 1.6% and 10.3 ± 1.6% in diabetic patients and controls, respectively (p = 0.005). Using a 2D visualization, the perfusion density was lower in diabetic patients, but only at the deep vascular complex (DVC) level (38.9 ± 3.7% in diabetes and 41.0 ± 3.1% in controls, p = 0.001), while no differences were detected at the superficial capillary plexus (SCP) level (34.4 ± 3.1% and 34.3 ± 3.8% in the diabetic and healthy subjects, respectively, p = 0.899). In conclusion, eyes without signs of DR of patients with diabetes have a reduced volume rendered macular perfusion compared to control healthy eyes.

scholarly journals Urinary excretion of type IV collagen as an early marker of renal fibrosis in patients with diabetes mellitus

2011 ◽  
Vol 14 (4) ◽  
pp. 29-31 ◽  
Author(s):  
Irina Arkad'evna Bondar' ◽  
Vadim Valer'evich Klimontov ◽  
Ekaterina Mikhailovna Parfent'eva ◽  
Vyacheslav Vital'evich Romanov ◽  
Alexander Petrovich Nadeev
Keyword(s):  
Type 1 Diabetes ◽  
Urinary Excretion ◽  
Renal Fibrosis ◽  
Type Iv Collagen ◽  
Diagnostic Value ◽  
Control Group ◽  
Type Iv ◽  
Patients With Diabetes

Aim. To determine the diagnostic value of urinary excretion of type IV collagen in patients with type 1 diabetes with different stages of nephropathy.Methods. Urinary type IV collagen was determined in 60 patients with type 1 diabetes (23 with normal albuminuria, 28 with microalbuminuriaand 9 with macroalbuminuria) by an enzyme immunoassay. 10 healthy individuals were acted as the control group. Renal biopsy was performedin 22 patients. Deposits of type IV collagen were revealed by 11 individuals by immunohistochemistry. Results. The urinary excretion of type IV collagen increased with severety of diabetic nephropathy, correlating with the urinary albumin/creatinineratio, serum creatinine and parameters of daytime and nighttime systolic and diastolic blood pressure. Patients with excessive accumulation of typeIV collagen in the glomeruli had significantly higher level of type IV collagen in the urine. Conclusion. The determination of urinary type IV collagen can be used for early detection of renal fibrosis in patients with type 1 diabetes.

Assessment of human cartilage glycoprotein 39 (YKL-40), preptin, and nitric oxide in adolescent patients with type 1 diabetes and its relation to cardiorenal affection

2015 ◽  
Vol 0 (0) ◽  
Author(s):  
Soha M. Abd El Dayem ◽  
Ahmed A. Battah ◽  
Amal El Shehaby ◽  
Nagwa Abd Allah
Keyword(s):  
Nitric Oxide ◽  
Type 1 Diabetes ◽  
Diastolic Dysfunction ◽  
Negative Correlation ◽  
Glycosylated Hemoglobin ◽  
Creatinine Ratio ◽  
Human Cartilage ◽  
Albumin Creatinine Ratio ◽  
Patients With Diabetes

AbstractTo evaluate new biomarkers such as YKL-40, preptin, and nitric oxide (NO) in patients with diabetes and to assess its relation to cardiorenal injury.The study included 62 patients with type 1 diabetes and 30 healthy volunteers. Blood sample was taken for assessment of glycosylated hemoglobin, lipid profile, YKL-40, preptin, and NO. Also, urine sample was taken for analysis of albumin/creatinine ratio. Echocardiography was also done.NO was lower, whereas YKL-40, preptin, and albumin/creatinine ratio were significantly higher in patients with diabetes. NO had a significant negative correlation with LVEDD, LVESD, PWT, LV mass, YKL-40, preptin, and albumin/creatinine ratio. YKL-40 had a significant positive correlation with waist/height ratio, preptin and negative correlation with E/A ratio. Stepwise multiple regression revealed that E/A ratio is the only parameter related to YKL-40. On the contrary, NO and systolic blood pressure are related to preptin.A significant reduction of NO and elevation of YKL-40 and preptin was found in patients with diabetes. A decrease in NO is associated with diastolic dysfunction, LV hypertrophy, and renal impairment, whereas YKL-40 is associated with diastolic dysfunction. An increase in preptin level was associated with hypertension.

Depression and the Reporting of Diabetes Symptoms

1989 ◽  
Vol 18 (4) ◽  
pp. 295-303 ◽  
Author(s):  
Patrick J. Lustman ◽  
Ray E. Clouse ◽  
Robert M. Carney
Keyword(s):  
Metabolic Control ◽  
Glycosylated Hemoglobin ◽  
Blood Glucose Control ◽  
Depressive Mood ◽  
Diabetes Mellitus Type 1 ◽  
Patients With Diabetes ◽  
Relationship Of ◽  
The Relationship

The relationship of diabetes symptoms to current mood and general metabolic control was studied. Symptoms commonly associated with poorly controlled diabetes (e.g., thirst, polyuria, weight loss) were measured in 114 patients with diabetes mellitus (type 1 = 57, type 2 = 57). Scores for these individual symptoms were correlated with glycosylated hemoglobin (HbA1) and depression as measured by the Beck Depression Inventory (BDI). HbA1 was poorly correlated ( r < 0.2) with nine of the eleven symptoms and made a significant independent contribution only to the reporting of polyuria ( p = 0.04). In contrast, depression was moderately correlated with nine symptoms and had a significant effect on the reporting of two of three hyperglycemic symptoms, five of six hypoglycemic symptoms, and both nonspecific symptoms of poor control ( p < 0.05 for each). We conclude that many reported symptoms often attributed to diabetes are more related to depressive mood than to a conventional clinical measure of blood glucose control. Diabetes symptoms may be unreliable indicators of poor metabolic control when features suggestive of depression are present.

Clinical and Dynamic Range-of-Motion Techniques in Subjects With and Without Diabetes Mellitus

2002 ◽  
Vol 92 (3) ◽  
pp. 136-142 ◽  
Author(s):  
Paul Tinley ◽  
Michael Taranto
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Range Of Motion ◽  
Dynamic Range ◽  
Control Group ◽  
Limited Joint Mobility ◽  
Study Results ◽  
Patients With Diabetes ◽  
Female Subjects

Thirty subjects with type 1 diabetes, 30 subjects with type 2 diabetes, and 30 age- and sex-matched controls were evaluated through clinical goniometry and two-dimensional motion analysis systems to determine the dynamic and static range of motion of the knee, ankle, and hallux joints. The purpose of this study was to determine if the knee and ankle joints of patients with diabetes mellitus are affected by limited joint mobility syndrome. The study results support previous medical literature showing significant reduction of range of motion of the hallux in subjects with type 1 diabetes. Significant differences were found between the range of motion of male and female subjects in all lower-limb joints for both subject groups with diabetes compared to the control group, and male subjects in all groups recorded less range of motion than female subjects. (J Am Podiatr Med Assoc 92(3): 136-142, 2002)

scholarly journals Erectile dysfunction in patients with diabetes mellitus: results of epidemiological monitoring

2009 ◽  
Vol 12 (2) ◽  
pp. 51-54 ◽  
Author(s):  
Roman Viktorovich Rozhivanov ◽  
Yury Ivanovich Suntsov ◽  
Dmitriy Gennad'evich Kurbatov
Keyword(s):  
Diabetes Mellitus ◽  
Erectile Dysfunction ◽  
Questionnaire Survey ◽  
Lower Extremities ◽  
Control Group ◽  
Measurement Evaluation ◽  
Epidemiological Monitoring ◽  
Patients With Diabetes ◽  
Hba1c Measurement

Aim. Screening for erectile dysfunction (ED) in patients with type 1 and 2 diabetes mellitus. Materials and methods. The study included 611 patients with type 1 (n=276) and 2 (n=335) diabetes mellitus. The control group comprised 70 patients.The methods used were a questionnaire survey, HbA1c measurement, evaluation of renal and cardiovascular function, examination of ocularfundus, lower extremities and genital organs. Differences were considered significant at p

scholarly journals Study of the Association Between Diabetes and Helicobacter Pylori Infection in a Tunisian Population

2020 ◽  
Vol 2 (4) ◽  
Author(s):  
Chaima Jemai ◽  
Rim Rachdi ◽  
Sonia Bellamine ◽  
Lamia Bouallegue ◽  
Faika Ben Mami
Keyword(s):  
Helicobacter Pylori ◽  
Medical Records ◽  
Tunisian Population ◽  
Control Group ◽  
Patients With Diabetes ◽  
And Gender ◽  
H Pylori ◽  
Control Study

Introduction: The association between diabetes and Helicobacter Pylori (H. Pylori) infection remains controversial in the literature. The aim of our study was to search an association between diabetes and H. Pylori infection. Methods: This is a case-control study carried out in 2017 over 3 months (September-October-November), collecting 120 patients with dyspepsia, matched for age and gender into two groups: a group of 77 patients with diabetes, and a group of control cases made of 43 non-diabetics. Diabetes was defined according to the American Diabetes Association (ADA) of 2017. Clinical, biological, endoscopic and anatomopathological data were collected from medical records. Results: The average age of the patients was 50±2,1 year. The sex ratio was 0.51. 34.2% (n=41) patients were male. Diabetes was type 2 in the majority of cases (88.31%) and type 1 in 11.68% only. H. Pylori infection was more prevalent in diabetics (19.48%, 11.63%, p=0.27). H. Pylori infection was more prevalent in type 1 diabetics (44.44%, 16.18%, p= 0.04). The frequency of upper endoscopic lesions in diabetics and controls was 70.13% and 74.42%, respectively. Chronic gastritis, gastric atrophy, and intestinal metaplasia were found in 61%, 3.9% and 2.6% of the cases in the group of diabetics and 62.79%, 6.98% and 4.65% respectively in the control group (p= not significant (NS)). Conclusion: Our study shows the absence of a significant association between diabetes and H. Pylori infection, as well as the absence of endoscopic and histological specificities of this infection in patients with diabetes.

scholarly journals Predictors of Early Retinal Changes in Diabetes Mellitus

2020 ◽  
Vol 17 (1) ◽  
pp. 88-95
Author(s):  
V. S. Kulybysheva ◽  
I. A. Ronzina ◽  
A. A. Gamidov ◽  
V. G. Motalov ◽  
V. N. Nikolenko
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Dynamic Control ◽  
Clinical Manifestations ◽  
Light Sensitivity ◽  
Control Group ◽  
Patients With Diabetes ◽  
Almost All

Purpose. Determining the functional state of the outer and inner retina’s layers in patients with diabetes mellitus (DM) type 1 and 2 before the clinical manifestations and in the early stages of diabetic retinopathy (DR) using the methods of multifocal electroretinography (mfERG) and microperimetry (MP).Patients and methods. 91 patients were examined (182 eyes). The patients were divided into 4 groups: 1st — 23 people (46 eyes) with diabetes without DR (the duration of the disease is up to 2 years); 2nd — 22 people (44 eyes) with diabetes without DR (diabetes from 2 to 8 years); 3rd — 24 people (48 eyes) with NPDR on the background of diabetes; 4th — 22 people (44 eyes) of the control group (healthy eyes). In addition to the standard ophthalmologic examination, all patients were registered mfERG (FOK1) on the diagnostic equipment EP-1000 Multifocal (Tomey, Germany) and carried out MP using the device “MAIA” (CenterVue, Italy).Results. According to mfERG, it has been established that the components of mfERG, the biopotential density and the amplitude of P1, are most sensitive to diabetic changes. In groups with type 1 and type 2 diabetes, there is a significant decrease in the density of P1 in comparison with the control group (p < 0.005, Mann-Whitney test), as well as a decrease in the amplitude of P1 on almost all tested rings (p < 0.005). In all groups, there is an increase in the latency of P1 in the central ring (0–2.3°). According to MP data, it was found that patients with type 1 and type 2 diabetes showed a decrease in the average light sensitivity in comparison with the control group, however, our data are within the reference values, regardless of the presence or absence of clinical manifestations of PD.Conclusion. As a result of the study, early functional and morphological disorders of the neurosensory apparatus of the eye in diabetes were identified. It is proved that mfER and MP allow to detect violations at the preclinical stage of DR and are necessary studies for the dynamic control of the progression of DR.

scholarly journals Renal dysfunction markers in patients with diabetes mellitus type 1 after kidney or simultaneous kidney-pancreas transplantation

2016 ◽  
Vol 62 (5) ◽  
pp. 14-16
Author(s):  
Alexandra M. Glazunova ◽  
Larisa V. Nikankina ◽  
Alexandr V. Ilin ◽  
Minara S. Shamkhalova ◽  
Gulya M. Musaeva ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Renal Transplant ◽  
Renal Dysfunction ◽  
Cystatin C ◽  
Pancreas Transplantation ◽  
Diabetes Mellitus Type 1 ◽  
Diabetes Mellitus Type ◽  
Control Group ◽  
Patients With Diabetes

Objective. To examine kidney transplant dysfunction markers in patients with diabetes mellitus type 1 (T1DM) after kidney transplantation (KT) and simultaneous kidney-pancreas transplantation (SPK).Materials and methods. The study included 20 patients after successful SPK (group 1) and 41 patients after KT (21 received insulin pump therapy (group 2), 20 –multiple daily injections of insulin (group 3). Post transplantation period at the time of inclusion in the KT group was 8 months [7;8], in SPK-11 months [8;18]. The control group consisted of 15 patients with DM1 without diabetic nephropathy (group 4). Sex, age and duration of T1DM were comparable. Donors of SPK were younger than KT: 29 [25; 33] vs 46[30; 51] years p<0,01 and transplant cold ischemia time was less 8[7;10] vs 11,5 [1; 17] hours respectively, p<0,01. After 9 months of observation biomarkers of dysfunction of renal transplant: Cystatin C (serum, urine); NGAL, KIM-1, podocin, nephrin, IL-18, IP-10 (urine), TGF-β1, MMP-9, VEGF-A, Osteopontin – (OPN) (serum) were defined.Results. the level of GFR in patients after transplantation was C2 stage, albuminuria A1 of chronic kidney disease. In the group of patients with T1DM after successful SPK and KT revealed a significant increase in markers of renal dysfunction (cystatin C (serum), NGAL, Podocin, OPN) compared with the control group despite of carbohydrate metabolism compensation (Tabl.1). High level and a negative associated of blood cystatin C with GFR (r = - 0,36, p<0.05) and positive with albuminuria (r=0,40, p<0,05), as well as a direct link of podocin urine-with blood creatinine (r = 0,35, p<0.05) and NGAL with albuminuria (r = 0,35, p<0.05) in recipients after transplantation were defined. Association between podocin with MMP-9 (r = 0,46, p<0,05) and NGAL (r = 0,33, p<0,05) indicated correlation of stress factors of renal microstructures in posttransplantation patients.Conclusion. High levels of renal graft dysfunction biomarkers in the examined patients (including those after SPK) show the persistence of damage to the microstructures with stable graft function and demonstrate the need to control all factors in the preservation of renal function.Table 1. Renal transplant dysfunction markersParametrsGroup 1Group 2Group 3Group 4TGF b1 (serum, pg/ml)32999[24514;3917]24473[21752;33330]25139[11367;2862]26986[17347;4266]VEGF A (serum, pg/ml)471,9[296;530,6]#407,6[301,6;522,2] #226,6[177,8;367,4]467,4[288,3;474,8]CYS C, (serum, ng/ml)1047[985;1295]*∞1252,9[1151;1540]#∞1113,32[986;1257] §728,8[592,9;765,3]Osteopontin (serum, ng/ml)3,51[2,7;4,9] #∞4,28[2,8;8,2] ∞4,71[3,6;12,7] §2,86[2,2;3,1]MMP-9 (urine, ng/ml)1,15[1,1;1,7]1,30[1,2;1,9] #1,10[0,9;1,3]1,22[1,0;1,3]IP-10 (urine, ng/ml)17,83[17,32;18,36]17,83[17,32;18,36]18,36[17,83;18,90]18,36[17,83;18,90]CYS C (urine, ng/ml)10407[5812;16306]15574[7518;28397]13329[7006;24624]14701[3643;26666]Podocin (urine, ng/ml)0,41[0,18;0,51] #0,49[0,26;0,69]0,56[0,38;0,79]§0,36[0,1;0,51]Nephrin (urine, ng/ml)0,0[0,0;0,1]0,0[0,0;01]0,0[0,0;0,07]0,07[0,0;0,1]KIM-1 (urine, ng/ml)211,8[83,3;368,4]314,9[152,1;508,6]338,7[191,3;594,0]359,2[204,4;494,5]NGAL (urine, ng/ml)2,4[1,7;6,7] *7,8[2,8;14,5] ∞2,9[1,8;12,0]§2,3[1,7;7,3]* р<0,01 (1-2); # р<0,01 (1,2-3); ∞ р<0,01 (1,2-4); § р<0,01 (3–4)

What Breathing Insulin Means for Diabetes Treatment

2006 ◽  
Vol 00 (02) ◽  
Author(s):  
Marc Rendell
Keyword(s):  
Glycosylated Hemoglobin ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Severe Deficiency ◽  
Patients With Diabetes ◽  
Insufficient Response ◽  
Relative Deficiency ◽  
Insulin Secretory Capacity

Type 1 diabetes is a disease of severe deficiency of endogenously secreted insulin. When introduced in the late 1920s, injected insulin treatment proved to be a lifesaving treatment for type 1 patients. The primary abnormality in type 2 diabetes is a relative deficiency of insulin secretory capacity resulting in insufficient response to tissue insulin resistance. Normalization of blood glucose levels is the goal of diabetes treatment.Yet, a large proportion of patients with diabetes fail to meet recommended glycemic goals. Two-thirds of patients (67%) in one survey conducted by the American College of Clinical Endocrinologists failed to meet the target goal of 6.5% glycosylated hemoglobin (HbA1c).1

Sign in / Sign up

Export Citation Format

Share Document