Serum Lipid Profile in Diffuse versus Limited Systemic Sclerosis Data from the SASS cohort

2018 ◽  
Vol 69 (2) ◽  
pp. 403-406
Author(s):  
Codrina Ancuta ◽  
Cristina Pomirleanu ◽  
Cristina Iordache ◽  
Magda Ecaterina Antohe ◽  
Rodica Chirieac ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Total Cholesterol Level ◽  
Cross Sectional Study ◽  
Serum Lipid Profile ◽  
Serum Triglycerides ◽  
Cross Sectional ◽  
Topoisomerase 1

Data about lipoprotein changes and their link with cardiovascular disease and atherosclerosis in systemic sclerosis (SSc) are still challenging. We aimed to evaluate serum lipid profile of patients with SSc and to identify potential relation with different disease specific characteristics (clinical, serological, inflammatory tests) in a cross-sectional study. Standard assessments comprised SSc-related parameters (disease subtype, clinical spectrum, immunological tests) and lipid metabolism (total cholesterol and fractions, triglycerides). Impaired lipid profile (low serum HDL- and high LDL-cholesterol, increased serum triglycerides, slightly modification in total cholesterol level) significantly correlated with diffuse SSc, activity (EUSTAR) and severity (MEDSGER), as well as seropositivity for specific antibodies (anti-centromere and anti-topoisomerase 1). The dyslipidemic profile might represent a pathobiological pathway for atherosclerosis in SSc.

Periodontal Diseases and Lipid Profile in Systemic Sclerosis: an EUSTAR Cohort Experience

2017 ◽  
Vol 68 (4) ◽  
pp. 890-893
Author(s):  
Codrina Ancuta ◽  
Cristina Pomirleanu ◽  
Cristina Iordache ◽  
Ana Maria Fatu ◽  
Eugenia Popescu ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Systemic Sclerosis ◽  
Periodontal Disease ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Periodontal Diseases ◽  
Total Cholesterol Level ◽  
Pocket Depth ◽  
Serum Triglycerides ◽  
Cross Sectional

Dental pathology is commonly described among patients with systemic sclerosis (SSc), a multisystem autoimmune disorder, and assumed to be multifactorial. We aimed to evaluate the periodontal status and to identify potential relation with SSc-specific parameters as well as serum lipid profile in a cross-sectional study on consecutive SSc. Standard assessments comprised dual, rheumatologic (disease subtype, clinical spectrum, inflammatory, immunological, lipid metabolism - total cholesterol and fractions, triglycerides), and dental evaluation (plaque index, bleeding on probing, pocket depth, clinical attachment level). 70.96% SSc developed oral manifestations, 51.61% periodontal disease, while one third severe aggressive periodontitis, particularly in diffuse SSc (p[0.05). Abnormal lipid pattern (low serum HDL- and high LDL-cholesterol, increased serum triglycerides, without significant modification in total cholesterol level) significantly correlated with diffuse SSc and skin involvement, disease duration, anti-topoisomerase 1 positivity, SSc activity and severity, as well as periodontitis (p[0.05). Our results clearly define an association between the presence and severity of periodontal disease and lipid anomalies in SSc, suggesting a potential link with early atherosclerosis via gingival inflammation and altered lipid metabolism.

scholarly journals Recent suicide attempts and serum lipid profile in subjects with mental disorders: A cross-sectional study

2018 ◽  
Vol 270 ◽  
pp. 611-615 ◽  
Author(s):  
Enrico Capuzzi ◽  
Francesco Bartoli ◽  
Cristina Crocamo ◽  
Maria Rosaria Malerba ◽  
Massimo Clerici ◽  
...  
Keyword(s):  
Mental Disorders ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Suicide Attempts ◽  
Cross Sectional Study ◽  
Serum Lipid Profile ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Association of Hypertensive Retinopathy with different serum lipid parameters in patients of Essential Hypertension: A Hospital Based Study

2018 ◽  
Vol 7 (2) ◽  
pp. 50-57
Author(s):  
Bishwa Nath Adhikari ◽  
Pramod Sharma Gautam ◽  
Binod Bekoju ◽  
Sadhana Basnet ◽  
Himlal Bhandari
Keyword(s):  
Essential Hypertension ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Cross Sectional Study ◽  
Serum Lipid Profile ◽  
Hypertensive Retinopathy ◽  
Cross Sectional ◽  
Hypertensive Patients ◽  
Medical College ◽  
Department Of Ophthalmology

Introduction: Abnormalities in serum lipid and lipoprotein levels are recognized as major modifiable risk factors for cardiovascular disease and essential hypertension and retinopathy. So this study was conducted to evaluate the role of dyslipidemia on development of retinopathy in hypertensive patients and to establish the association of parameters of serum lipid profile with hypertensive retinopathy. Materials and Methods: A cross-sectional study was conducted in Ophthalmology Department among 135 patients in Nobel Medical College and Teaching Hospital (NoMCTH), Biratnagar who were diagnosed with essential hypertension. Patients having diabetes mellitus, myopia, hazy ocular media and other posterior segment disorders were excluded from the study. The detailed ophthalmic examination was carried out in department of ophthalmology, NoMCTH, Biratnagar and all the study population were investigated for fasting serum lipid profile. Result: Out of 135 patients with essential hypertension, 65.44% had retinopathy and remaining had no signs of retinopathy. Mean age of patients were 60.24 (±15.14) years. Although no gender preponderance was found with retinopathy but this study showed that hypertensive retinopathy increases significantly with increase in age and its incidence increases after the age of 60 years. Conclusion: The duration of hypertension was found to be strongly associated with development of hypertensive retinopathy. The increase in all the lipid profile parameters (Serum TG, TC, and LDL and LDL:HDL) and the obesity were found to be strongly associated with retinopathy in hypertensive patients.

scholarly journals ASSESSMENT OF SERUM LIPID PROFILE AS PROGNOSTIC MARKER IN CIRRHOSIS OF LIVER - A CROSS SECTIONAL STUDY

2017 ◽  
Vol 4 (58) ◽  
pp. 3531-3534
Author(s):  
Sudhir Kumar Verma ◽  
Vivek Kumar ◽  
Purshottam Singh Yadav ◽  
Nikhil Kumar P Joge ◽  
Ravi Misra
Keyword(s):  
Lipid Profile ◽  
Prognostic Marker ◽  
Serum Lipid ◽  
Cross Sectional Study ◽  
Serum Lipid Profile ◽  
Sectional Study ◽  
Cross Sectional ◽  
Cirrhosis Of Liver

scholarly journals Differences in Serum Lipid Profile Value in Pregnancy and Postpartum on Severe Preeclampsia

2019 ◽  
pp. 9
Author(s):  
I Putu F I White ◽  
John J E Wantania ◽  
Maya E Mewengkang
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Mean Value ◽  
Severe Preeclampsia ◽  
Serum Lipid Profile ◽  
Cross Sectional ◽  
Pregnancy And Postpartum ◽  
Medium Correlation ◽  
In Pregnancy

Abstract                     Objective:Uncovering the connection of serum lipid profile (total cholesterol, triglyceride, HDL, LDL, VLDL) with preeclampsia in pregnancy and postpartum, and its outcome. Method:This is a cross-sectional comparative analytic study Result:From 28 preeclampsia subject were found, mean value of systole 165.36 mmHg and 105.71 diastole. Serum lipid profile in pregnancy and postpartum has a significant differences and correlated with preeclampsia, total cholesterol 234.5 mg/dl and 192.71 mg/dl, p=0.000; medium positive in pregnancy with systole r=0.461; p=0.013, weak positive with diastole r=0.380; p=0.046; postpartum with systole medium positive r=0.615; p=0.001, and weak positive with diastole r=0.317; p=0.100. LDL 140.5 mg/dl and 102.5 mg/dl, p=0.000; pregnancy and systole r=0.446; p=0,017; and postpartum were medium positive r=0.546; p=0.003. HDL 51.5 mg/dl and 43.5 mg/dl, p=0.003; not correlated with BP. Triglyceride 268.89 mg/dl and 208.96 mg/dl, p=0.000; pregnancy r=0.516; p=0.005; postpartum r= 0.515; p=0.005 has medium correlation with systole. VLDL 53.78 mg/dl and 41.79, p=0.000; pregnancy r=0.461; p=0.013 systole medium positive; r=0.380; p=0.046 diastole weak positive; postpartum r=0,615; p=0,001 systole strong positive. Conclusion:All parameter of serum lipid profile in pregnancy and postpartum has significant differences and related with severe preeclampsia. Total cholesterol, LDL, triglyceride, and VLDL correlated with BP in severe preeclampsia. Key word:endothelial dysfunction, lipid profile, preeclampsia.   Abstrak Tujuan: Untuk mengetahui hubungan profil lipid serum (kolesterol total, trigliserida, HDL, LDL, VLDL) dengan preeklampsia dan luarannya dalam kehamilan dan postpartum. Metode: Penelitian ini merupakan studi potong lintang analitik komparatif Hasil: Dari 28 subjek dengan preeklamsia, ditemukan rerata systole 165,36 mmHg dan 105,71 diastole. Profil lipid serum dalam kehamilan dan postpartum ditemukan berbeda bermakna dan berhubungan dengan preeklampsia berat, kolesterol total 234,5 mg/dl dan 192,71 mg/dl, p=0,000; kehamilan dengan sistole positif sedang  r=0,461; p=0,013, diastole positif lemah r=0,380; p=0,046; postpartum dengan sistole positif sedang r=0,615; p=0,001,  dan diastole postitif lemah r=0,317; p=0,100. LDL 140,5 mg/dl dan 102,5 mg/dl, p=0,000; dalam kehamilan dengan sistole r=0,446; p=0,017;  dan postpartum positif sedang r=0,546; p=0,003. HDL 51,5 mg/dl dan 43,5 mg/dl, p=0,003; tidak berkorelasi dengan TD. Trigliserida 268,89 mg/dl dan 208,96 mg/dl, p=0,000; kehamilan r=0,516; p=0,005; postpartum  r= 0,515; p = 0,005 korelasi positif sedang dengan sistole.  VLDL 53,78 mg/dl dan  41,79, p=0,000; kehamilan r=0,461; p=0,013 positif sedang dengan sistole; r=0,380; p=0,046 positif lemah dengan diastole; postpartum r=0,615; p=0,001 positif kuat dengan sistole. Kesimpulan: Seluruh parameter profil lipid serum kehamilan dan postpartum ditemukan memiliki perbedaan bermakna dan berhubungan dengan preeklampsia berat. Kolesterol total, LDL, trigliserida, dan VLDL ditemukan berhubungan dengan TD pada PEB. Kata kunci: disfungsi endothel, lipid, preeklampsia.

scholarly journals A study of serum lipid profile in smokers and non-smokers: evaluation of role of smoking on lipid profile

2019 ◽  
Vol 7 (4) ◽  
pp. 1016
Author(s):  
Chandrashekar V. Kubihal ◽  
Hemalatha D. Naik
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Serum Triglyceride ◽  
Blood Cholesterol ◽  
Serum Lipid Profile ◽  
Serum Triglyceride Level ◽  
Cross Sectional ◽  
Cholesterol Levels ◽  
Increased Risk

Background: Several studies have reported elevated blood cholesterol levels among persons who regularly smoke cigarettes and lowered blood cholesterol levels among persons quitting smoking. Other studies have also shown that smoking lowers high density lipoprotein level, resulting in an increased risk of coronary heart disease. Smoking also leads to increase in LDL cholesterol and triglyceride levels. The objective was to study serum lipid profile in smokers and non-smokers.Methods: A cross sectional comparative study was carried in 100 subjects. The subjects were divided into two groups. First group consisted of 25 nonsmokers and second group of 75 smokers. The group of 75 smokers was again divided into three equal sub groups of 25 each depending upon the duration and intensity of smoking. Concentration of serum total cholesterol and HDL was determined by Zak’s method. Concentration of serum LDL and VLDL cholesterol was determined by Friedwald’s formula. Concentration of serum triglyceride level was determined by enzymatic end point peroxidase coupled method.Results: All the values of lipid profile i.e., total cholesterol, triglycerides, LDL, VLDL were found to be significantly higher among the smokers compared to the non-smokers. HDL value was significantly lower among smokers. As the degree of smoking increased from mild to heavy smokers, the values of total cholesterol, triglycerides, LDL and VLDL increased. The degree of smoking was inversely proportional to HDL values i.e., the HDL value decreased as the smoking degree increased.Conclusions: Thus, it can be said based on the present study that smoking affects and deranges the lipid profile of the person.

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