Periodontal Diseases and Lipid Profile in Systemic Sclerosis: an EUSTAR Cohort Experience

2017 ◽  
Vol 68 (4) ◽  
pp. 890-893
Author(s):  
Codrina Ancuta ◽  
Cristina Pomirleanu ◽  
Cristina Iordache ◽  
Ana Maria Fatu ◽  
Eugenia Popescu ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Systemic Sclerosis ◽  
Periodontal Disease ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Periodontal Diseases ◽  
Total Cholesterol Level ◽  
Pocket Depth ◽  
Serum Triglycerides ◽  
Cross Sectional

Dental pathology is commonly described among patients with systemic sclerosis (SSc), a multisystem autoimmune disorder, and assumed to be multifactorial. We aimed to evaluate the periodontal status and to identify potential relation with SSc-specific parameters as well as serum lipid profile in a cross-sectional study on consecutive SSc. Standard assessments comprised dual, rheumatologic (disease subtype, clinical spectrum, inflammatory, immunological, lipid metabolism - total cholesterol and fractions, triglycerides), and dental evaluation (plaque index, bleeding on probing, pocket depth, clinical attachment level). 70.96% SSc developed oral manifestations, 51.61% periodontal disease, while one third severe aggressive periodontitis, particularly in diffuse SSc (p[0.05). Abnormal lipid pattern (low serum HDL- and high LDL-cholesterol, increased serum triglycerides, without significant modification in total cholesterol level) significantly correlated with diffuse SSc and skin involvement, disease duration, anti-topoisomerase 1 positivity, SSc activity and severity, as well as periodontitis (p[0.05). Our results clearly define an association between the presence and severity of periodontal disease and lipid anomalies in SSc, suggesting a potential link with early atherosclerosis via gingival inflammation and altered lipid metabolism.

Serum Lipid Profile in Diffuse versus Limited Systemic Sclerosis Data from the SASS cohort

2018 ◽  
Vol 69 (2) ◽  
pp. 403-406
Author(s):  
Codrina Ancuta ◽  
Cristina Pomirleanu ◽  
Cristina Iordache ◽  
Magda Ecaterina Antohe ◽  
Rodica Chirieac ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Total Cholesterol Level ◽  
Cross Sectional Study ◽  
Serum Lipid Profile ◽  
Serum Triglycerides ◽  
Cross Sectional ◽  
Topoisomerase 1

Data about lipoprotein changes and their link with cardiovascular disease and atherosclerosis in systemic sclerosis (SSc) are still challenging. We aimed to evaluate serum lipid profile of patients with SSc and to identify potential relation with different disease specific characteristics (clinical, serological, inflammatory tests) in a cross-sectional study. Standard assessments comprised SSc-related parameters (disease subtype, clinical spectrum, immunological tests) and lipid metabolism (total cholesterol and fractions, triglycerides). Impaired lipid profile (low serum HDL- and high LDL-cholesterol, increased serum triglycerides, slightly modification in total cholesterol level) significantly correlated with diffuse SSc, activity (EUSTAR) and severity (MEDSGER), as well as seropositivity for specific antibodies (anti-centromere and anti-topoisomerase 1). The dyslipidemic profile might represent a pathobiological pathway for atherosclerosis in SSc.

scholarly journals Interplay between glycaemic status, lipid peroxidation and hyperlipidaemia in subjects with varying glucose metabolism

2019 ◽  
pp. 13
Author(s):  
Remva Paul ◽  
J.K. Mukkadan
Keyword(s):  
Lipid Peroxidation ◽  
Glucose Metabolism ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Total Cholesterol Level ◽  
Pearson Correlation ◽  
Density Lipoprotein ◽  
Diabetic Patients ◽  
Sod Activity ◽  
Cross Sectional

Background: Diabetes is one of the largest global health emergencies of the 21st century. About 425 million people worldwide or 8.8% of adults between the ages of 20-79 years are estimated to have diabetes. There are evidences which show that higher blood glucose and cholesterol levels have an association with free radical-mediated lipid peroxidation. The aim of the study was to compare and correlate glycosylated haemoglobin (HbA1c), lipid peroxidation marker malondialdehyde (MDA), lipid profile, and antioxidant enzyme superoxide dismutase (SOD) activity in subjects with varying levels of glucose metabolism. Materials and methods: This was a cross sectional study. Based on fasting plasma glucose and HbA1c, subjects were divided into diabetic patients (n= 40), pre-diabetic patients (n=38) and normal patients (n=41). Subjects were tested for lipid profile, MDA, and SOD activity. The comparison of parameter between the groups was carried out using one-way ANOVA followed by tukey’s multiple comparison test. The correlation between parameter was analyzed by Karl Pearson correlation coefficient using SPSS 20.0. Results: The serum MDA levels (nmol/ml) were significantly higher in pre-diabetes (3.11±0.40) and diabetes mellitus (3.55±0.88) compared to normal controls (2.04±0.99). The SOD activity(U/ml) were lower in diabetes (7.69±3.83) and pre-diabetic subjects (8.13±2.15) compared to normal subjects (11.16±3.61). MDA has significant positive correlation with HbA1c and total cholesterol level. SOD has significant negative correlation with HbA1c and Total cholesterol/High Density Lipoprotein (TC/ HDL) ratio. Conclusion: The findings strongly confirmed that there is a continuous interplay between glycemic status, lipid peroxidation and hyperlipidemia in which one factor perpetuates another leading to the progression of disease.

scholarly journals ABO Blood Group System and Periodontal Disease Indices: A Cross-Sectional Study in Greek Adults

2021 ◽  
Vol 4 (2) ◽  
pp. 132-144
Author(s):  
Nikolaos Chrysanthakopoulos
Keyword(s):  
Periodontal Disease ◽  
Blood Group ◽  
Periodontal Diseases ◽  
Blood Groups ◽  
Blood Group System ◽  
Abo Blood Groups ◽  
Analysis Model ◽  
Pocket Depth ◽  
Cross Sectional ◽  
Attachment Loss

Introduction: Periodontal disease (PD) development has been associated with the presence of causative microorganisms, host immunity and risk factors, whereas the types of periodontal diseases are characterized by interactions between host and bacteria. Moreover, ABO blood groups are the most investigated erythrocyte antigen system. However, a small number of researches have been focused on the possible associations between ABO blood groups and periodontal diseases. Methods: A cross-sectional, epidemiological study was carried out on 854 individuals, 404 males and 450 females, aged 45 to 77. The study sample was interviewed and underwent an oral and dental clinical examination. The assessment of the possible associations between several indices of PD, such as Probing Pocket Depth (PPD), Clinical Attachment Loss (CAL) and Bleeding on Probing (BOP) as dependent variables and ABO blood groups A, B, AB, and O as independent ones was carried out by using a multiple regression analysis model. Results: Individuals with blood group A [OR= 2.94, 95% CI = 1.27-3.96] and B [OR= 2.66, 95% CI = 1.11-3.87] were significantly associated with the risk of developing deeper periodontal pockets (PPD) and worse values of attachment loss (CAL) [OR= 2.42, 95% CI= 1.37-3.85] and [OR= 2.31,95% CI=1.25-3.68], respectively. However, no significant associations were recorded between ABO blood groups and BOP [OR= 1.04, 95% CI= 0.92-1.18]. Conclusion: A significant association was revealed between A and B blood groups and deeper periodontal pockets and worse attachment loss, whereas no associations were observed between ABO blood groups and bleeding of probing.

scholarly journals Clinical Investigations of the Effect of Citrus unshiu Peel Pellet on Obesity and Lipid Profile

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Seongil Kang ◽  
Sangyeol Song ◽  
Joosang Lee ◽  
Hyekyung Chang ◽  
Sanghun Lee
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Cholesterol Level ◽  
Weight Control ◽  
Large Scale ◽  
Total Cholesterol Level ◽  
Experimental Studies ◽  
Density Lipoprotein ◽  
Citrus Unshiu ◽  
The Impact

Objectives. Several experimental studies have reported antiobesity and lipid-improving effects of Citrus unshiu. However, clinical studies on its effects are lacking. This study was designed to evaluate the impact of Citrus unshiu peel pellet (CUPP) on obesity and lipid profile. Methods. For 118 patients with body mass index (BMI) > 23 who took Citrus unshiu peel pellet (CUPP) for 4 weeks in a Public Health Center, laboratory and biometric readings before and after CUPP administration were analyzed. Results. Mean age of these subjects was 53.8±10.6 years (range: 18-75 years). There were 88 (74.6%) females in the study sample (n = 118). A significant (p < 0.01) decrease in BMI from 27.47±2.24 to 27.27±2.22 was observed in all subjects after CUPP treatment and 65.3% (N = 77) of them lost 1.03±0.83 kg of weight after 4 weeks of treatment. Total cholesterol level was significantly (p < 0.01) decreased from 204.0±37.4 mg/dL to 193.5±36.5 mg/dL. Significant (p < 0.05) decreases in levels of low-density lipoprotein, cholesterol, and triglyceride were also observed. Conclusions. These results suggest that CUPP in practice could help weight control and improve total cholesterol level. Findings of this study provide clinical foundation for future large-scale trials to establish clinical benefits of CUPP.

scholarly journals Validating gingival surface temperature as an alternative tool in the diagnosis of periodontal disease activity: An observational clinical trial

2019 ◽  
Vol 13 (2) ◽  
pp. 123-127
Author(s):  
Sumanth Gunupati ◽  
Hasya Sappiti ◽  
Sreenivas Nagarakanti ◽  
BV Ramesh Reddy ◽  
Vijay Kumar Chava
Keyword(s):  
Pilot Study ◽  
Periodontal Disease ◽  
Surface Temperature ◽  
Disease Activity ◽  
Diagnostic Tool ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Cross Sectional ◽  
Probing Pocket Depth ◽  
Pilot Clinical Study

Background. Elevated temperature has been recognized as an inflammatory sign. It is the only indication that can be both objectively and quantitatively evaluated and is considered as a potential indicator of periodontal disease. Assessing gingival surface temperature (GST) could be a diagnostic parameter to determine periodontal health. This pilot clinical study aimed to validate gingival surface temperature (GST) as a clinical diagnostic tool to measure periodontal disease activity by correlating with the periodontal inflamed surface area (PISA). Methods. A cross-sectional mono-center pilot study was conducted with a convenient sample of 50 participants with a mean age of 34.14±13.7 years. Clinical parameters such as probing pocket depth (PPD) clinical attachment loss (CAL) and bleeding on probing (BOP) were measured. GST was recorded with a single lead of the bedside patient monitor and correlated with PISA. Results. The results showed a positive correlation between PISA and GST (P=0.46). Conclusion. This study showed a rise in GST of inflamed sites, but the results did not support the hypothesis that increased GST is an indicator of periodontal disease. As this is a pilot study, further studies with more larger sample sizes need to be undertaken to confirm its use as a diagnostic tool in clinical trials.

scholarly journals Oxidative stress and plasma lipoproteins in cancer patients

2014 ◽  
Vol 12 (4) ◽  
pp. 480-484 ◽  
Author(s):  
Fernanda Maria Machado Maia ◽  
Emanuelly Barbosa Santos ◽  
Germana Elias Reis
Keyword(s):  
Oxidative Stress ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Cancer Patients ◽  
Thiobarbituric Acid ◽  
Plasma Lipoproteins ◽  
Cross Sectional ◽  
Patients With Cancer ◽  
Group 2 ◽  
Group 1

Objective To evaluate the relation between oxidative stress and lipid profile in patients with different types of cancer.Methods This was an observational cross-sectional. A total of 58 subjects were evaluated, 33 males, divided into two groups of 29 patients each: Group 1, patients with cancer of the digestive tract and accessory organs; Group 2 patients with other types of cancers, all admitted to a public hospital. The plasma levels (lipoproteins and total cholesterol, HDL, and triglycerides, for example) were analyzed by enzymatic kits, and oxidative stress based on thiobarbituric acid-reactive substances, by assessing the formation of malondialdehyde.Results In general the levels of malondialdehyde of patients were high (5.00μM) as compared to 3.31μM for healthy individuals. The median values of lipids exhibited normal triacylglycerol (138.78±89.88mg/dL), desirable total cholesterol values (163.04±172.38mg/dL), borderline high LDL (151.30±178.25mg/dL) and low HDL (31.70±22.74mg/dL). Median HDL levels in Group 1 were lower (31.32mg/dL) than the cancer patients in Group 2 (43.67mg/dL) (p=0.038). Group 1 also showed higher levels of oxidative stress (p=0.027).Conclusion The lipid profile of patients with cancer was not favorable, which seems to have contributed to higher lipid peroxidation rate, generating a significant oxidative stress.

STUDY OF SERUM LIPID PROFILE IN BETA-THALASSEMIA MAJOR PATIENTS

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Lokesh Kumar Meena
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Density Lipoprotein ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Age Group ◽  
Cross Sectional ◽  
Beta Thalassemia Major ◽  
Low Levels

Background: To study lipid profile in Beta-Thalassemia Major Patients. Methods: A cross-sectional was done on 50 diagnosed Cases of beta-thalassemia major in the age group of 1 year to 18 years receiving regular blood transfusions; not suffering from any ailment or any other disease leading to deranged lipid profile were included. Results: Lipid analyses of controls and thalassemic children. It is clear from the results that beta thalassemia major patients had significantly lower total cholesterol (TC), high-density lipoprotein cholesterol (HDL) and low-density lipoprsotein cholesterol (LDL) compared with controls. Conclusion: Lipid profile in Beta thalassmia patients show significantly low levels of total cholesterol, LDLC and HDL-C. Keywords:  Beta Thalassemia Major, Lipid Profile, Hypocholesterolemia.

scholarly journals Efek ekstrak daun sirsak (Annona muricata Linn) terhadap profil lipid tikus putih jantan (Rattus Norvegicus)

2014 ◽  
Vol 3 (1) ◽  
pp. 7-12 ◽  
Author(s):  
Indrawati Wurdianing ◽  
SA Nugraheni ◽  
Zen Rahfiludin
Keyword(s):  
Treatment Group ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Cholesterol Level ◽  
Ldl Cholesterol ◽  
Total Cholesterol Level ◽  
Wilcoxon Test ◽  
Control Group ◽  
Annona Muricata ◽  
The Mean

Background: Lipid profile effects is a risk factor for Coronary Heart Disease. Soursop leaves (Annona muricata L) isa traditional medicine plant containing metabolic compounds that contribute to the improvement of the lipid profile.Objective: To determine the effects of soursop leaves extract on lipid profile (total cholesterol, LDL cholesterol, HDLcholesterol and triglyceride).Methods: An experimental study using randomized pre-posttest with control group design. Sample consisted of 28 maleWistar rats, were divided into four groups. The control group (K) was only given High Fat High Cholesterol (HFHC)diet and treatment groups (P1, P2, P3) were given a HFHC diet plus Annona muricata L extract with doses of 100, 200and 300 mg/kgBB per day for 28 days respectively. Data were analyzed by Wilcoxon test, Kruskal-Wallis and MannWhitney.Results: The mean total cholesterol level significantly decreased in the treatment group P1 (p = 0.028) from 60.7 mg/dl(47.6-75.3) to 45.5 mg/dl (38.4-62.4). Mean HDL cholesterol level significantly increased in the treatment group P2(p=0.043) from 26.0 mg/dl (19.7-35.3) to 27.9 mg/dl (18.8-38.0). The mean levels of LDL cholesterol and triglyceridedecreased but not significantly.Conclusion: The administration of Annona muricata L extract can decrease total cholesterol and increase HDLcholesterol significantly.

scholarly journals Psychosocial Stress and its Effect on Periodontal Tissues using Malondialdehyde as Oxidative Stress Biomarker

2018 ◽  
Vol 2 (2) ◽  
pp. 34-39
Author(s):  
Anuradha Mokashi ◽  
Keshava Abbayya ◽  
Siddhartha Varma ◽  
Sameer Zope ◽  
Girish Sugarimath ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Psychosocial Stress ◽  
Inflammatory Diseases ◽  
Periodontal Diseases ◽  
Stress Index ◽  
Pocket Depth ◽  
Cross Sectional ◽  
Periodontal Tissues ◽  
Stress Biomarker ◽  
Oxidative Stress Biomarker

Background: Stress is playing a major role as an aetiologic factor in the initiation of many systemic diseases. Similarly, it is also thought to be an aetiologic factor in the progression of periodontal diseases. Aim: The production of free radical species is associated with various inflammatory diseases and also during stressful conditions. Hence, an effort in the present study is done to correlate psychosocial stress and periodontitis using serum MDA as an oxidative stress biomarker. Materials and Methods: A current cross-sectional study included 201 individuals between 20 to 60 years of age. A periodontal examination included Probing Pocket Depth, CAL, Plaque Index, and Gingival Index. According to CAL individuals were divided into four groups i.e. healthy, slight (CAL = 1-2 mm), moderate (CAL = 3-4 mm) and severe (CAL = ≥5 mm) periodontitis. Psychosocial stress of the individuals was evaluated using occupational stress index. Serum MDA level was evaluated using spectrochromatometer. Results: Patients with stress demonstrated increased levels of MDA along with a higher loss of attachment. Conclusion: The results revealed statistically significant association between psychosocial stress and periodontitis indicating psychosocial stress as a risk factor for developing periodontitis.

scholarly journals Effect of Nonsurgical Periodontal Therapy on Crevicular Fluid and Serum Glutathione Peroxidase Levels

2012 ◽  
Vol 32 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Swati Pradeep Patel ◽  
Nishanth S. Rao ◽  
A. R. Pradeep
Keyword(s):  
Oxidative Stress ◽  
Glutathione Peroxidase ◽  
Periodontal Disease ◽  
Chronic Periodontitis ◽  
Periodontal Diseases ◽  
Periodontal Therapy ◽  
Enzyme Linked Immunosorbent Assay ◽  
Pocket Depth ◽  
Nonsurgical Periodontal Therapy ◽  
Crevicular Fluid

Background: Plasma glutathione peroxidase (eGPx) is an important selenium containing antioxidant in human defense against oxidative stress. While crevicular fluid (GCF) eGPx levels and its association with periodontal disease is well documented, there is no data on correlation of GCF and serum eGPx levels in chronic periodontitis. Hence this study was undertaken to further probe into the role of oxidative stress in periodontal diseases and effect of nonsurgical periodontal therapy (NSPT) by correlating GCF and serum levels of eGPx.Materials and methods: Thirty subjects (16-Males and 14-Females; age: 30–38 years) participated in the study. The subjects were divided, based on gingival index, probing pocket depth and clinical attachment level into: Healthy (group-1,n=10), Gingivitis (group-2,n=10) and Periodontitis (group-3,n=10). Chronic periodontitis patients after NSPT constituted group 4. GCF and serum samples collected from each subject were quantified for eGPx levels using Enzyme linked Immunosorbent Assay.Results: The mean eGPx concentrations increased from health (14.01 ng/μl and 78.26 ng/ml) to gingivitis (22.86 ng/μl and 90.44 ng/ml) and then to periodontitis (29.89 ng/μl and 103.43 ng/ml), in GCF and serum respectively. After NSPT, there was statistically significant reduction in eGPx concentration in GCF and serum (19.41 ng/μl and 85.21 ng/ml). Further, all the GCF eGPx values showed a positive correlation to that of serum eGPx level.Conclusion: Thus, increased eGPx concentration in GCF can be considered as an indicator of local increase in oxidative stress. While, increase in serum eGPx levels indicates that periodontal disease can also lead to increased oxidative stress at the systemic level.

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