scholarly journals A study of serum lipid profile in smokers and non-smokers: evaluation of role of smoking on lipid profile

2019 ◽  
Vol 7 (4) ◽  
pp. 1016
Author(s):  
Chandrashekar V. Kubihal ◽  
Hemalatha D. Naik
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Serum Triglyceride ◽  
Blood Cholesterol ◽  
Serum Lipid Profile ◽  
Serum Triglyceride Level ◽  
Cross Sectional ◽  
Cholesterol Levels ◽  
Increased Risk

Background: Several studies have reported elevated blood cholesterol levels among persons who regularly smoke cigarettes and lowered blood cholesterol levels among persons quitting smoking. Other studies have also shown that smoking lowers high density lipoprotein level, resulting in an increased risk of coronary heart disease. Smoking also leads to increase in LDL cholesterol and triglyceride levels. The objective was to study serum lipid profile in smokers and non-smokers.Methods: A cross sectional comparative study was carried in 100 subjects. The subjects were divided into two groups. First group consisted of 25 nonsmokers and second group of 75 smokers. The group of 75 smokers was again divided into three equal sub groups of 25 each depending upon the duration and intensity of smoking. Concentration of serum total cholesterol and HDL was determined by Zak’s method. Concentration of serum LDL and VLDL cholesterol was determined by Friedwald’s formula. Concentration of serum triglyceride level was determined by enzymatic end point peroxidase coupled method.Results: All the values of lipid profile i.e., total cholesterol, triglycerides, LDL, VLDL were found to be significantly higher among the smokers compared to the non-smokers. HDL value was significantly lower among smokers. As the degree of smoking increased from mild to heavy smokers, the values of total cholesterol, triglycerides, LDL and VLDL increased. The degree of smoking was inversely proportional to HDL values i.e., the HDL value decreased as the smoking degree increased.Conclusions: Thus, it can be said based on the present study that smoking affects and deranges the lipid profile of the person.

scholarly journals Evaluation of Serum Triglyceride and Total Cholesterol Status in Adolescent Smoker

1970 ◽  
Vol 1 ◽  
pp. 14-18
Author(s):  
L Afrin ◽  
R Sultana ◽  
S Ferdousi ◽  
A Ahmed ◽  
MR Amin
Keyword(s):  
Total Cholesterol ◽  
Serum Lipid ◽  
Serum Triglyceride ◽  
Adolescent Male ◽  
Serum Triglyceride Level ◽  
Cross Sectional ◽  
Cholesterol Levels ◽  
Increased Risk ◽  
The Mean ◽  
Dose Response Effect

Objectives: A cross sectional comparative study was performed to evaluate the changes of the serum lipid profile in apparently healthy adolescent male non smokers and smokers’ subjects. Method: This study was carried out in the department of Physiology of Dhaka Medical College from January to December 2005. For this purpose, total 80 subjects with age range 12-19 years were selected, of whom 20 were non smokers (control) and 60 were smokers (experimental) who smoked for at least one year. Again smokers were grouped according to the number of cigarettes smoked per week, ( mild < 19, moderate 20-59, heavy >60). Fasting serum Triglyceride and total Cholesterol levels of all subjects were measured. Data were compared between smokers and non smokers and between non smoker and mild moderate and heavy smokers and analyzed statistically by unpaired t test. Result: Mean ±SD Triglyceride levels were136.80mg/dl ± 42.18 vs. 153.12mg/dl ± 26.66 and Mean ±SD Total Cholesterol levels were 165.20mg/dl ± 15.13 vs165.36mg/dl ± 10.12 in non smokers and smokers respectively. there were no significant changes in the mean serum total cholesterol levels in adolescent smokers but the mean serum triglyceride level in smokers were significantly higher (p<0.01 )than that of non smokers. hyper Triglyceridemia (TG level> 150mg/dl) were observed in 56% of smoker subjects whereas 36% in non smokers. The dose response effect of smoking was observed in serum triglyceride levels of smoker subgroups. Mean ±SD TG levels in mild, moderate, heavy groups were 148.15mg/dl± 21.32,152.8mg/dl± 29.49,154.12mg/dl± 23.75 respectively. Conclusion: From the result of the present study it may be concluded that, cigarette smoking during adolescent period induces alteration in serum lipid levels in the direction of increased risk for coronary artery disease. J Bangladesh Soc Physiol. 2006 Dec;(1):14-18

scholarly journals Effect of lisinopril and perindopril on serum lipid profile in Albino rabbits

2018 ◽  
Vol 7 (6) ◽  
pp. 1136
Author(s):  
Shruti Chandra ◽  
S. P. Singh ◽  
Rashmi Singh ◽  
Neeraj Kumar Agarwal
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Serum Triglyceride ◽  
Serum Lipid Profile ◽  
Favourable Effect ◽  
Serum Triglyceride Level ◽  
Group I ◽  
Group Ii ◽  
Significant Change

Background: Hypertension with dislipidemia is becoming a common morbidity, since ACE inhibitors are the first line of antihypertensive drugs so present study was undertaken with the aim to evaluate the possible effects of ACE inhibitor on lipid profile in albino rabbits.Methods: The study was conducted in the Department of Pharmacology and Therapeutics, GSVM Medical College, Kanpur. Rabbits were divided into 2 groups with 6 in each group. Rabbits of Group I was given Lisinopril in dose of 0.25mg/kg and of group II was given Perindopril in dose of 0.20mg/kg for a period of 6 weeks. Lipid profile estimation (Serum Total cholesterol, serum HDL, serum LDL, serum Triglycerides and serum VLDL) was done at day 0, 7, 21 and 45 respectively.Results: After analysis Rabbits of group-I (Lisinopril) showed 3.1% decrease in serum cholesterol level at 45th day (P<0.001). Serum HDL level increased by 6.4% and 14.3% at day 21 and 45 respectively (P<0.05). Increase in serum Triglyceride level was 2.6% at day 45 (P>0.05). Serum LDL level decreases by 4.4% and 8.6% at day 21 and 45 respectively (P<0.001). There was no significant change in Serum VLDL level. Rabbits of group- II (Perindopril) showed decreased total cholesterol levels by 2.6% (P<0.05). There was an increase in HDL level by 6.8 % at day 45(P<.05). Triglycerides and VLDL levels were not significantly altered while serum LDL level decreases by 6.7% at day 45 (P<0.01).Conclusions: From our study it was concluded that Lisinopril had a favourable effect on serum lipid profile by decreasing total cholesterol, increasing serum HDL level. It may increase triglycerides, decrease LDL. Perindopril increase serum HDL and decreases LDL, there is no significant change in cholesterol, TG and VLDL levels.

Serum Lipid Profile in Diffuse versus Limited Systemic Sclerosis Data from the SASS cohort

2018 ◽  
Vol 69 (2) ◽  
pp. 403-406
Author(s):  
Codrina Ancuta ◽  
Cristina Pomirleanu ◽  
Cristina Iordache ◽  
Magda Ecaterina Antohe ◽  
Rodica Chirieac ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Total Cholesterol Level ◽  
Cross Sectional Study ◽  
Serum Lipid Profile ◽  
Serum Triglycerides ◽  
Cross Sectional ◽  
Topoisomerase 1

Data about lipoprotein changes and their link with cardiovascular disease and atherosclerosis in systemic sclerosis (SSc) are still challenging. We aimed to evaluate serum lipid profile of patients with SSc and to identify potential relation with different disease specific characteristics (clinical, serological, inflammatory tests) in a cross-sectional study. Standard assessments comprised SSc-related parameters (disease subtype, clinical spectrum, immunological tests) and lipid metabolism (total cholesterol and fractions, triglycerides). Impaired lipid profile (low serum HDL- and high LDL-cholesterol, increased serum triglycerides, slightly modification in total cholesterol level) significantly correlated with diffuse SSc, activity (EUSTAR) and severity (MEDSGER), as well as seropositivity for specific antibodies (anti-centromere and anti-topoisomerase 1). The dyslipidemic profile might represent a pathobiological pathway for atherosclerosis in SSc.

scholarly journals Differences in Serum Lipid Profile Value in Pregnancy and Postpartum on Severe Preeclampsia

2019 ◽  
pp. 9
Author(s):  
I Putu F I White ◽  
John J E Wantania ◽  
Maya E Mewengkang
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Mean Value ◽  
Severe Preeclampsia ◽  
Serum Lipid Profile ◽  
Cross Sectional ◽  
Pregnancy And Postpartum ◽  
Medium Correlation ◽  
In Pregnancy

Abstract                     Objective:Uncovering the connection of serum lipid profile (total cholesterol, triglyceride, HDL, LDL, VLDL) with preeclampsia in pregnancy and postpartum, and its outcome. Method:This is a cross-sectional comparative analytic study Result:From 28 preeclampsia subject were found, mean value of systole 165.36 mmHg and 105.71 diastole. Serum lipid profile in pregnancy and postpartum has a significant differences and correlated with preeclampsia, total cholesterol 234.5 mg/dl and 192.71 mg/dl, p=0.000; medium positive in pregnancy with systole r=0.461; p=0.013, weak positive with diastole r=0.380; p=0.046; postpartum with systole medium positive r=0.615; p=0.001, and weak positive with diastole r=0.317; p=0.100. LDL 140.5 mg/dl and 102.5 mg/dl, p=0.000; pregnancy and systole r=0.446; p=0,017; and postpartum were medium positive r=0.546; p=0.003. HDL 51.5 mg/dl and 43.5 mg/dl, p=0.003; not correlated with BP. Triglyceride 268.89 mg/dl and 208.96 mg/dl, p=0.000; pregnancy r=0.516; p=0.005; postpartum r= 0.515; p=0.005 has medium correlation with systole. VLDL 53.78 mg/dl and 41.79, p=0.000; pregnancy r=0.461; p=0.013 systole medium positive; r=0.380; p=0.046 diastole weak positive; postpartum r=0,615; p=0,001 systole strong positive. Conclusion:All parameter of serum lipid profile in pregnancy and postpartum has significant differences and related with severe preeclampsia. Total cholesterol, LDL, triglyceride, and VLDL correlated with BP in severe preeclampsia. Key word:endothelial dysfunction, lipid profile, preeclampsia.   Abstrak Tujuan: Untuk mengetahui hubungan profil lipid serum (kolesterol total, trigliserida, HDL, LDL, VLDL) dengan preeklampsia dan luarannya dalam kehamilan dan postpartum. Metode: Penelitian ini merupakan studi potong lintang analitik komparatif Hasil: Dari 28 subjek dengan preeklamsia, ditemukan rerata systole 165,36 mmHg dan 105,71 diastole. Profil lipid serum dalam kehamilan dan postpartum ditemukan berbeda bermakna dan berhubungan dengan preeklampsia berat, kolesterol total 234,5 mg/dl dan 192,71 mg/dl, p=0,000; kehamilan dengan sistole positif sedang  r=0,461; p=0,013, diastole positif lemah r=0,380; p=0,046; postpartum dengan sistole positif sedang r=0,615; p=0,001,  dan diastole postitif lemah r=0,317; p=0,100. LDL 140,5 mg/dl dan 102,5 mg/dl, p=0,000; dalam kehamilan dengan sistole r=0,446; p=0,017;  dan postpartum positif sedang r=0,546; p=0,003. HDL 51,5 mg/dl dan 43,5 mg/dl, p=0,003; tidak berkorelasi dengan TD. Trigliserida 268,89 mg/dl dan 208,96 mg/dl, p=0,000; kehamilan r=0,516; p=0,005; postpartum  r= 0,515; p = 0,005 korelasi positif sedang dengan sistole.  VLDL 53,78 mg/dl dan  41,79, p=0,000; kehamilan r=0,461; p=0,013 positif sedang dengan sistole; r=0,380; p=0,046 positif lemah dengan diastole; postpartum r=0,615; p=0,001 positif kuat dengan sistole. Kesimpulan: Seluruh parameter profil lipid serum kehamilan dan postpartum ditemukan memiliki perbedaan bermakna dan berhubungan dengan preeklampsia berat. Kolesterol total, LDL, trigliserida, dan VLDL ditemukan berhubungan dengan TD pada PEB. Kata kunci: disfungsi endothel, lipid, preeklampsia.

scholarly journals Contribution of Eggs and Other Cholesterol-containing Foods to Total Dietary Cholesterol Intake, and Their Influence on Serum Lipid Profile of Adults in Calabar, Nigeria

2019 ◽  
pp. 329-340
Author(s):  
Eridiong O. Onyenweaku ◽  
Henrietta N. Ene-Obong ◽  
Gregory E. Oko ◽  
Ima O. Williams
Keyword(s):  
Lipid Profile ◽  
Serum Cholesterol ◽  
Serum Lipid ◽  
Dietary Cholesterol ◽  
Serum Lipid Profile ◽  
Cross Sectional ◽  
Dietary Recall ◽  
Cholesterol Levels ◽  
Cholesterol Intake

Aim: Eggs have sometimes been regarded as unhealthy foods due to their relatively high cholesterol content. The aim of this study is to determine contribution of eggs and other    cholesterol containing food to total dietary cholesterol and their influence on serum lipid profile of adults. Study Design: Cross sectional and experimental. Place and Duration of Study: Department of Biochemistry, University of Calabar, Calabar. February to July 2017. Methodology: A cross-sectional survey to determine consumption pattern was carried out on 400 respondents using food frequency questionnaire (FFQ) and 24 hour dietary recall. The respondents were further grouped into four based on their reported weekly egg consumption. A detailed follow-up study was conducted on 50 participants selected from across the 4 groups, using a 3-day repeated 24 hour dietary recall to determine their consumption of egg and other cholesterol-containing foods. Serum blood lipid profile of these 50 participants was also determined using Randox cholesterol test kits. Food composition tables were used to calculate dietary cholesterol intake (DCI). The mean DCI of the 4 groups were cross-tabulated with mean serum cholesterol levels. Percentage contribution of eggs and other frequently consumed cholesterol-containing foods (such as milk and fish) to total DCI was calculated. Statistical significance was accepted at p = .05. Results: For the follow-up participants, it was observed that results of correlations between DCI and the lipid profile parameters showed negative correlation (at p = .01) in both males and females, except slight positive correlations between cholesterol intake and HDL-c (r=0.191) among the males, and cholesterol with TC (r=0.265) among the females. Apart from this, no association was observed between DCI and the lipid profile parameters. Furthermore, the > 5eggs/week group had the lowest TC and LDL-c (4.23±0.19 mmol/L and 2.38±0.10 mmol/L). Based on the respondents’ consumption patterns, eggs (boiled and fried) contributed the highest- 34.8% to total DCI, followed by milk (15.9%); salad cream contributed lowest (0.3%) to total DCI. Conclusion: Increased DCI from cholesterol-containing foods (such as eggs), did not cause an adverse increase in serum cholesterol levels of normocholesterolemic people.

scholarly journals Recent suicide attempts and serum lipid profile in subjects with mental disorders: A cross-sectional study

2018 ◽  
Vol 270 ◽  
pp. 611-615 ◽  
Author(s):  
Enrico Capuzzi ◽  
Francesco Bartoli ◽  
Cristina Crocamo ◽  
Maria Rosaria Malerba ◽  
Massimo Clerici ◽  
...  
Keyword(s):  
Mental Disorders ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Suicide Attempts ◽  
Cross Sectional Study ◽  
Serum Lipid Profile ◽  
Sectional Study ◽  
Cross Sectional

STUDY OF SERUM LIPID PROFILE IN BETA-THALASSEMIA MAJOR PATIENTS

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Lokesh Kumar Meena
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Density Lipoprotein ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Age Group ◽  
Cross Sectional ◽  
Beta Thalassemia Major ◽  
Low Levels

Background: To study lipid profile in Beta-Thalassemia Major Patients. Methods: A cross-sectional was done on 50 diagnosed Cases of beta-thalassemia major in the age group of 1 year to 18 years receiving regular blood transfusions; not suffering from any ailment or any other disease leading to deranged lipid profile were included. Results: Lipid analyses of controls and thalassemic children. It is clear from the results that beta thalassemia major patients had significantly lower total cholesterol (TC), high-density lipoprotein cholesterol (HDL) and low-density lipoprsotein cholesterol (LDL) compared with controls. Conclusion: Lipid profile in Beta thalassmia patients show significantly low levels of total cholesterol, LDLC and HDL-C. Keywords:  Beta Thalassemia Major, Lipid Profile, Hypocholesterolemia.

scholarly journals Association of Hypertensive Retinopathy with different serum lipid parameters in patients of Essential Hypertension: A Hospital Based Study

2018 ◽  
Vol 7 (2) ◽  
pp. 50-57
Author(s):  
Bishwa Nath Adhikari ◽  
Pramod Sharma Gautam ◽  
Binod Bekoju ◽  
Sadhana Basnet ◽  
Himlal Bhandari
Keyword(s):  
Essential Hypertension ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Cross Sectional Study ◽  
Serum Lipid Profile ◽  
Hypertensive Retinopathy ◽  
Cross Sectional ◽  
Hypertensive Patients ◽  
Medical College ◽  
Department Of Ophthalmology

Introduction: Abnormalities in serum lipid and lipoprotein levels are recognized as major modifiable risk factors for cardiovascular disease and essential hypertension and retinopathy. So this study was conducted to evaluate the role of dyslipidemia on development of retinopathy in hypertensive patients and to establish the association of parameters of serum lipid profile with hypertensive retinopathy. Materials and Methods: A cross-sectional study was conducted in Ophthalmology Department among 135 patients in Nobel Medical College and Teaching Hospital (NoMCTH), Biratnagar who were diagnosed with essential hypertension. Patients having diabetes mellitus, myopia, hazy ocular media and other posterior segment disorders were excluded from the study. The detailed ophthalmic examination was carried out in department of ophthalmology, NoMCTH, Biratnagar and all the study population were investigated for fasting serum lipid profile. Result: Out of 135 patients with essential hypertension, 65.44% had retinopathy and remaining had no signs of retinopathy. Mean age of patients were 60.24 (±15.14) years. Although no gender preponderance was found with retinopathy but this study showed that hypertensive retinopathy increases significantly with increase in age and its incidence increases after the age of 60 years. Conclusion: The duration of hypertension was found to be strongly associated with development of hypertensive retinopathy. The increase in all the lipid profile parameters (Serum TG, TC, and LDL and LDL:HDL) and the obesity were found to be strongly associated with retinopathy in hypertensive patients.

scholarly journals Alterations in the Serum Lipid Profile in Patients with Oral Cancer, Oral Precancerous Lesions/Conditions associated with the Habit of Tobacco Consumption

2011 ◽  
Vol 2 (3) ◽  
pp. 130-133 ◽  
Author(s):  
Sonal Vahanwala ◽  
Sandeep Pagare ◽  
Shilpa Dua
Keyword(s):  
Lipid Profile ◽  
Serum Lipid ◽  
Precancerous Lesions ◽  
Precancerous Lesion ◽  
Tobacco Consumption ◽  
Serum Lipid Profile ◽  
Cell Integrity ◽  
Increased Risk ◽  
Membrane Components ◽  
Risk Of Cancer

ABSTRACT The changes in lipid profile have long been associated with cancer because lipids play a key role in maintenance of cell integrity. Lipids are the major cell membrane components essential for various biological functions including cell growth and division of normal and malignant tissues. Lower blood lipids have been associated with the etiology of breast and colorectal cancer, and relation has also been reported between low cholesterol and increased risk of cancer occurrence and mortality. The present study was designed to evaluate the serum lipid profile in patients with oral precancerous lesion/condition and squamous cell carcinoma to see whether there are any alterations in the lipid levels during the pathogenesis of these lesions and also to evaluate significance of lipid profile as biochemical marker, if any.

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