scholarly journals Antimicrobial Activity of Biosynthesized Silver Nanoparticles Compared to Standard Antibiotics Used in ORL Infections

2019 ◽  
Vol 70 (7) ◽  
pp. 2571-2573
Author(s):  
Alina Andreea Tischer (Tucuina) ◽  
Delia Berceanu Vaduva ◽  
Nicolae Balica ◽  
Alina Heghes ◽  
Adelina Cheveresan ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Silver Nanoparticles ◽  
Antibiotic Resistance ◽  
Adverse Effects ◽  
Infectious Diseases ◽  
Broad Spectrum ◽  
Bacterial Infections ◽  
New Antibiotics ◽  
Recorded Data

In recent years, bacterial infections in hospitals have grown particularly due to the development of antibiotic resistance. Recent research targets the discovery of new antibiotics that exhibit broad spectrum of action without adverse effects or minimizing adverse effects. In this study, the activity of biosynthesized silver nanoparticles against three bacteria commonly found in infectious diseases in the ORL sphere was evaluated. The recorded data revealed an activity comparable to that of the standard antibiotics used in these types of infections, with the observation that the activity of the nanoparticles could also be observed in the particular cases of antibiotic resistance.

Antimicrobial carbon-dot-stabilized silver nanoparticles

2022 ◽  
Author(s):  
Jin-Liang Ma ◽  
Kexin Li ◽  
Shaobin Gu ◽  
Ying Wu ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Antibiotic Resistance ◽  
Human Health ◽  
Bacterial Infections ◽  
Carbon Dot ◽  
Excellent Candidate

Bacterial infections have posed an emerging threaten to human health. The overuse of various antibiotics is unavoidable to cause antibiotic resistance. Silver nanoparticles (AgNPs) provide an excellent candidate for combating...

Ampicillin-augmented silver nanoparticles for synergistic antimicrobial response: A promising therapeutic approach

2021 ◽  
Vol 22 ◽  
Author(s):  
Kashan Khan ◽  
Mohd Aamir Qureshi ◽  
Ameer Azam ◽  
Moinuddin ◽  
Javed Musarrat ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Silver Nanoparticles ◽  
Zeta Potential ◽  
Bacterial Infections ◽  
Colloidal Stability ◽  
Resistant Bacteria ◽  
Antimicrobial Drugs ◽  
Vis Spectroscopy ◽  
Microbial Infections ◽  
Ft Ir

Aims: Globally Scientists are working to find more efficient antimicrobial drugs to treat microbial infections and kill drug-resistant bacteria. Background: Despite the availability of numerous antimicrobial drugs bacterial infections still poses a serious threat to global health. Due to a constant decline in the effectiveness of antibiotics owing to their repeated exposure as well as shortlasting antimicrobial activity, led to the demand for developing novel therapeutic agents capable of controlling microbial infections. Objective: In this study, we report antimicrobial activity of chemically synthesized silver nanoparticles (cAgNPs) augmented with ampicillin (amp) in order to increase antimicrobial response against Escherichia coli (gram –ve), Staphylococcus aureus (gram +ve) and Streptococcus mutans (gram +ve). Methods: Nanostructure, colloidal stability, morphology and size of cAgNPs before and after functionalization were explored by UV-vis spectroscopy, FT-IR, zeta potential and TEM. The formation and functionalization of cAgNPs was confirmed from UV-vis spectroscopy and FT-IR patterns. From TEM the average sizes of cAgNPs and cAgNP-amp were found to be 13 and 7.8 nm respectively, and change in colloidal stability after augmentation was confirmed from zeta potential values. The antimicrobial efficacies of cAgNP-amp and cAgNPs against E. coli S. aureus and S. mutans were studied by determining minimum inhibitory concentrations (MICs), zone of inhibition, assessment of viable and non-viable bacterial cells and quantitative assessment of biofilm. Results & Discussion: Our results revealed cAgNP-amp to be highly bactericidal compared to cAgNPs or amp alone. The nano-toxicity studies indicated cAgNP-amp to be less toxic compared to cAgNPs alone. Results: This study manifested that cAgNPs show synergistic antimicrobial effect when they get functionalized with amp suggesting their application in curing long-term bacterial infections.

scholarly journals Thinking Outside the Bug: Molecular Targets and Strategies to Overcome Antibiotic Resistance

2019 ◽  
Vol 20 (6) ◽  
pp. 1255 ◽  
Author(s):  
Ana Monserrat-Martinez ◽  
Yann Gambin ◽  
Emma Sierecki
Keyword(s):  
Antibiotic Resistance ◽  
Bacterial Infections ◽  
Rational Design ◽  
Disease Onset ◽  
Resistant Bacteria ◽  
Antibiotic Resistant ◽  
New Antibiotics ◽  
Resistant Strains ◽  
Vancomycin Resistant ◽  
Antibiotic Discovery

Since their discovery in the early 20th century, antibiotics have been used as the primary weapon against bacterial infections. Due to their prophylactic effect, they are also used as part of the cocktail of drugs given to treat complex diseases such as cancer or during surgery, in order to prevent infection. This has resulted in a decrease of mortality from infectious diseases and an increase in life expectancy in the last 100 years. However, as a consequence of administering antibiotics broadly to the population and sometimes misusing them, antibiotic-resistant bacteria have appeared. The emergence of resistant strains is a global health threat to humanity. Highly-resistant bacteria like Staphylococcus aureus (methicillin-resistant) or Enterococcus faecium (vancomycin-resistant) have led to complications in intensive care units, increasing medical costs and putting patient lives at risk. The appearance of these resistant strains together with the difficulty in finding new antimicrobials has alarmed the scientific community. Most of the strategies currently employed to develop new antibiotics point towards novel approaches for drug design based on prodrugs or rational design of new molecules. However, targeting crucial bacterial processes by these means will keep creating evolutionary pressure towards drug resistance. In this review, we discuss antibiotic resistance and new options for antibiotic discovery, focusing in particular on new alternatives aiming to disarm the bacteria or empower the host to avoid disease onset.

A moisturizing chitosan-silk fibroin dressing with silver nanoparticles-adsorbed exosomes for repairing infected wounds

2020 ◽  
Vol 8 (32) ◽  
pp. 7197-7212 ◽  
Author(s):  
Zhiyong Qian ◽  
Yating Bai ◽  
Jin Zhou ◽  
Linhao Li ◽  
Jing Na ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Wound Healing ◽  
Silver Nanoparticles ◽  
Silk Fibroin ◽  
Broad Spectrum ◽  
Electrolyte Balance ◽  
Infected Wounds ◽  
Multifunctional Properties

The CTS-SF/SA/Ag-Exo dressing possessed multifunctional properties including broad-spectrum antimicrobial activity, promoting wound healing, retaining moisture and maintaining electrolyte balance.

scholarly journals Limitations of Recent Studies Dealing with the Antibacterial Properties of Silver Nanoparticles: Fact and Opinion

Nanomaterials ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 1775 ◽  
Author(s):  
Raphaël E. Duval ◽  
Jimmy Gouyau ◽  
Emmanuel Lamouroux
Keyword(s):  
Silver Nanoparticles ◽  
Infectious Diseases ◽  
Metallic Nanoparticles ◽  
Bacterial Infections ◽  
Antibacterial Agents ◽  
Therapeutic Option ◽  
Antibacterial Properties ◽  
Antimicrobial Activities ◽  
Synthetic Process ◽  
Great Heterogeneity

Due to the constant increase in the number of infectious diseases and the concomitant lack of treatment available, metallic nanoparticles (e.g., silver nanoparticles) have been of particular interest in the last decades. Indeed, several studies suggest that silver nanoparticles have valuable antimicrobial activities, especially against bacteria, which may lead us to think that these nanoparticles may one day be an attractive therapeutic option for the treatment of bacterial infections. Unfortunately, when we look a little closer to these studies, we can see a very great heterogeneity (e.g., in the study design, in the synthetic process of nanoparticles, in the methods that explore the antibacterial properties of nanoparticles and in the bacteria chosen) making cross-interpretation between these studies impossible, and significantly limiting the interest of silver nanoparticles as promising antibacterial agents. We have selected forty-nine international publications published since 2015, and propose to discuss, not the results obtained, but precisely the different methodologies developed in these publications. Through this discussion, we highlighted the aspects to improve, or at least to homogenize, in order to definitively establish the interest of silver nanoparticles as valuable antibacterial agents.

The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa

2017 ◽  
Vol 15 (2) ◽  
pp. 306-310 ◽  
Author(s):  
Rachel Shanahan ◽  
F. Jerry Reen ◽  
Rafael Cano ◽  
Fergal O'Gara ◽  
Gerard P. McGlacken
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antibiotic Resistance ◽  
Bacterial Infections ◽  
Innovative Strategies ◽  
Bacterial Antibiotic Resistance ◽  
New Antibiotics ◽  
Perfect Storm

The ‘perfect storm’ of increasing bacterial antibiotic resistance and a decline in the discovery of new antibiotics, has made it necessary to search for new and innovative strategies to treat bacterial infections.

scholarly journals Can Bees Help us Find New Antibiotics?

2021 ◽  
Vol 9 ◽  
Author(s):  
Kirstie A. Goggin ◽  
Les Baillie
Keyword(s):  
Antibiotic Resistance ◽  
Bacterial Infections ◽  
Antibiotic Activity ◽  
Antibacterial Compounds ◽  
Improper Use ◽  
New Antibiotics ◽  
University Buildings

Antibiotics are very important for treating bacterial infections in humans, pets, and livestock. However, improper use of antibiotics has resulted in antibiotic resistance, making it difficult to treat some infections. There is an urgent need to discover new antibiotics, but how do we find them? The answer potentially lies with bees and the honey they produce. Bees who feed on unique plants produce honey with high levels of antibiotic activity, due to the presence of antibacterial compounds in the nectar that the bees collect to make honey. In addition to nectar, the bees also collect pollen, which contains a sample of each visited plant’s unique DNA. By studying this DNA, we have identified plants that are sources of the antibacterial compounds found in honey. We are now working to develop new antibiotics from this honey, and we have installed beehives on university buildings to create our own super honey.

scholarly journals Upregulation of gluconeogenesis leads to increased tolerance to antibiotics targeting the MreB elongosome in E. coli

2020 ◽  
Author(s):  
Brody Barton ◽  
Addison Grinnell ◽  
Randy M. Morgenstein
Keyword(s):  
Antibiotic Resistance ◽  
Minimal Inhibitory Concentration ◽  
Bacterial Infections ◽  
Inhibitory Concentration ◽  
Resistance Mechanism ◽  
Tca Cycle ◽  
Resistant Bacteria ◽  
Antibiotic Development ◽  
New Antibiotics ◽  
Global Threat

AbstractAntibiotic resistant bacteria are a global threat to human health. One way to combat the rise of antibiotic resistance is to make new antibiotics that target previously ignored proteins. The bacterial actin homolog, MreB, is highly conserved among rod-shaped bacteria and essential for growth, making MreB a good focus for antibiotic targeting. Therefore, it is imperative to understand mechanisms that can give rise to resistance to MreB targeting drugs. Using the MreB targeting drug, A22, we show that changes to central metabolism through deletion of TCA cycle genes, leads to the upregulation of gluconeogenesis resulting in cells with an increased minimal inhibitory concentration to A22. This phenotype can be recapitulated through the addition of glucose to the media. Finally, we show that this increase in minimal inhibitory concentration is not specific to A22 but can be seen in other cell wall targeting antibiotics, such as mecillinam.ImportanceThe spread of antibiotic resistance has made bacterial infections harder to treat. Finding new targets for antibiotic development is critical to overcoming the variety of resistance mechanism that are already crippling our ability to treat infections with current antibiotics. The bacterial actin homolog MreB is a good target for new antibiotic development because it is essential for growth and highly conserved among rod-shaped pathogens. The significance of this research is in understanding the mechanisms cells can develop toward the inhibition of MreB to better understand how to make MreB targeting antibiotics in the future.

scholarly journals Applications of Raman Spectroscopy in Bacterial Infections: Principles, Advantages, and Shortcomings

2021 ◽  
Vol 12 ◽  
Author(s):  
Liang Wang ◽  
Wei Liu ◽  
Jia-Wei Tang ◽  
Jun-Jiao Wang ◽  
Qing-Hua Liu ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Antibiotic Resistance ◽  
Infectious Diseases ◽  
Bacterial Infections ◽  
Bacterial Pathogens ◽  
Basic Research ◽  
Label Free ◽  
Clinical Implementation ◽  
Label Free Detection

Infectious diseases caused by bacterial pathogens are important public issues. In addition, due to the overuse of antibiotics, many multidrug-resistant bacterial pathogens have been widely encountered in clinical settings. Thus, the fast identification of bacteria pathogens and profiling of antibiotic resistance could greatly facilitate the precise treatment strategy of infectious diseases. So far, many conventional and molecular methods, both manual or automatized, have been developed for in vitro diagnostics, which have been proven to be accurate, reliable, and time efficient. Although Raman spectroscopy (RS) is an established technique in various fields such as geochemistry and material science, it is still considered as an emerging tool in research and diagnosis of infectious diseases. Based on current studies, it is too early to claim that RS may provide practical guidelines for microbiologists and clinicians because there is still a gap between basic research and clinical implementation. However, due to the promising prospects of label-free detection and noninvasive identification of bacterial infections and antibiotic resistance in several single steps, it is necessary to have an overview of the technique in terms of its strong points and shortcomings. Thus, in this review, we went through recent studies of RS in the field of infectious diseases, highlighting the application potentials of the technique and also current challenges that prevent its real-world applications.

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