scholarly journals Correlations of the Mechanisms Involved in Diabetes Mellitus, Peripheral Arterial Disease and Gangrene Leading to Amputations-a Retrospective Study Over the Non-traumatic Amputations Performed in the Emergency Clinical County Hospital of Arad Between 2014- 2018

2019 ◽  
Vol 70 (9) ◽  
pp. 3309-3314
Author(s):  
Roxana Furau ◽  
Amorin Remus Popa ◽  
Cristian Furau ◽  
Cringu Ionescu ◽  
Mihai Dimitriu ◽  
...  

Diabetes mellitus (DM) is, undoubtedly, an important risk factor of peripheral artery disease (PAD), leading to increased and severe complications, as well as for primary or associated dermatological lesions, all of which leading to radical therapeutic measures, as amputations are. DM and its complications have an important effect on life expectancy and quality of life, which can be quantified using disability-adjusted life year (DALY) as universal metric that allows researchers and policymakers to compare very different populations and health conditions across time. In the last five years these medical conditions have had a detrimental effect on the whole Arad County society, with a magnitude of premature deaths (YLL ) of 1,779 years and a value for Years Lost due to Disability (YLD) of 20,795, DALY reaching 22,574. These figures have to change completely the existent DM control measures for better protection of patients� health and improving their quality of life.

ESC CardioMed ◽  
2018 ◽  
pp. 2844-2845
Author(s):  
Mariana Garcia

Atherosclerotic disease involving the lower extremities, also known as peripheral arterial disease (PAD), has an estimated prevalence of 27 million adults in Europe and North America. PAD is now known to be associated with morbidity and mortality equal to coronary artery disease and stroke, and is associated with a significantly reduced quality of life. Awareness of PAD, both in women and men, is remarkably low compared to knowledge of other cardiovascular diseases.


Author(s):  
Susan Matthews ◽  
Martin Fox ◽  
Sarah Coy ◽  
Jane Whittaker ◽  
Gail Brough ◽  
...  

Background/Aims Peripheral arterial disease is common among those aged 60 years or above and can cause debilitating intermittent claudication. This impacts quality of life and is a marker for increased morbidity and mortality, mainly from cardiovascular disease. Access to recommended exercise programmes for people with symptomatic peripheral arterial disease is poor in most areas of the UK. This study aimed to evaluate the benefits of expanding an established cardiac rehabilitation service to accommodate supervised exercise for people with peripheral arterial disease Methods The study evaluated 11 participants peripheral arterial disease and intermittent claudication who were referred by the Manchester leg circulation service. Participants underwent the programme involving eight weekly 1.5 hour sessions of supervised exercise and cardiovascular education with support, reassurance and motivation. The participants' blood pressure, walking impairment, quality of life, anxiety and depression were monitored and reviewed. Results Overall, the participants' walking distance, intermittent claudication, quality of life and blood pressure had improved. The participants' overall satisfaction with the programme was excellent. The programme also demonstrated clinical and cost-effectiveness. Conclusions A structured, supervised exercise programme can have considerable benefits for people with peripheral arterial disease, improving their symptoms and quality of life. It may also help to reduce the morbidity and mortality risks associated with inactivity in this patient group.


2019 ◽  
Vol 20 (9) ◽  
pp. 2233 ◽  
Author(s):  
Federico Biscetti ◽  
Nicola Bonadia ◽  
Elisabetta Nardella ◽  
Andrea Leonardo Cecchini ◽  
Raffaele Landolfi ◽  
...  

Vascular complications of diabetes mellitus are an important issue for all clinicians involved in the management of this complex pathology. Although many therapeutic advances have been reached, peripheral arterial disease is still an unsolved problem that each year compromises the quality of life and life span of affected patients. Oftentimes, patients, after ineffective attempts of revascularization, undergo greater amputations. At the moment, there is no effective and definitive treatment available. In this scenario, the therapeutic use of stem cells could be an interesting option. The aim of the present review is to gather all the best available evidence in this regard and to define a new role of the stem cells therapy in this field, from biomarker to possible therapeutic target.


2010 ◽  
Vol 22 (5-6) ◽  
pp. 395-405 ◽  
Author(s):  
Leena Remes ◽  
Raimo Isoaho ◽  
Tero Vahlberg ◽  
Matti Viitanen ◽  
Markku Koskenvuo ◽  
...  

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