scholarly journals DESCRIPTIVE STUDY OF HYDATIDIFORM MOLE ACCORDING TO TYPE AND AGE AMONG PATIENTS IN WASIT PROVINCE, IRAQ

2020 ◽  
Vol 2 (1) ◽  
pp. 118-124
Keyword(s):  
Teaching Hospital ◽  
Hydatidiform Mole ◽  
Clinical Information ◽  
Study Data ◽  
Age Group ◽  
Partial Hydatidiform Mole ◽  
Trophoblastic Diseases ◽  
Gestational Trophoblastic Diseases ◽  
Collection Period ◽  
Histopathological Parameter

Introduction: Hydatidiform mole is the most common among gestational trophoblastic diseases in women, which characterized by abnormal gestation, and subdivide to complete and partial hydatidiform mole. It continues to be a significant problem among women, because of complete H mole has a tendency to be a malignant. The diagnosis of this disease is very important because it has the potential to be transformed into choriocarcinoma and to differentiate it to a complete or partial. Methods: In this study, data was collected from fifty-two patients selected randomly from Al-Karama Teaching Hospital and Al-Zahraa Teaching Hospital in Wasit Province. Specialized histopathologists examined the sections with haematoxylin and eosin (H & E) to confirm the diagnosis. Clinical information, clinical examination and histopathological parameter include type and age were obtained. The data collection period was from October 2018 to April 2019. Results: The descriptive data showed that forty-eight percent of patients have a complete hydatidiform mole (CHM) and fifty-two percent have a partial hydatidiform mole (PHM). Moreover, the same results demonstrated that the age group of patients between (14-21) and )22-29) years were more common than the other groups. Conclusion: The age group under 30 years is the most common hydatidiform mole infected and Partial hydatidiform mole was the most common type of hydatiform mole.

scholarly journals Study of gestational trophoblastic diseases at a tertiary care hospital in India

2018 ◽  
Vol 7 (4) ◽  
pp. 1622
Author(s):  
Ramalingappa C. Antaratani ◽  
Shruthi M.
Keyword(s):  
Hydatidiform Mole ◽  
Local Population ◽  
Tertiary Care ◽  
Spontaneous Remission ◽  
Standard Of Care ◽  
Gestational Trophoblastic Disease ◽  
Care Hospital ◽  
Case Record ◽  
Trophoblastic Diseases ◽  
Gestational Trophoblastic Diseases

Background: Gestational trophoblastic disease refers to the heterogeneous group of interrelated lesions that arises from abnormal proliferation of placental trophoblasts. GTNs are among the rare human tumours that can be cured even in the presence of widespread dissemination. Although GTNs commonly follow a molar pregnancy, they can occur after any gestational event, including induced or spontaneous abortion, ectopic pregnancy, or term pregnancy. The study was conducted to know the incidence of different types of gestational trophoblastic diseases in the local population and the percentage of people ultimately requiring chemotherapy.Methods: The retrospective analysis of case record of 124 women with a diagnosis of GTD admitted to Karnataka Institute of Medical Sciences Hubli between November 2008 to November 2017.Results: A total of 124 cases of GTD were reviewed. Hydatidiform mole was diagnosed in 91 patients; of those experienced spontaneous remission after evacuation. 04 patients had persistent gestational trophoblastic Neoplasia and 13 cases of invasive mole (GTN) 1 case of epitheloid trophoblastic tumors and 15 cases of choriocarcinoma 99 (80%) had low-risk GTN, 25 (20%) had high-risk GTN.Conclusions: Hydatidiform mole was found to be the most common form of gestational trophoblastic diseases. Majority of the cases got cured by simple surgical evacuation. During the course of our study some rare cases of gestational trophoblastic diseases were noted. Patients’ compliance for serial follow up is a highly challenging task in developing countries. Registration of women with GTD represents a minimum standard of care.

scholarly journals Gestational Trophoblastic Diseases: A Review of the Clinical Presentation and Management at the Alex Ekwueme Federal University Teaching Hospital Abakaliki

2019 ◽  
Vol 08 (06) ◽  
pp. 164-171
Author(s):  
Nwafor Johnbosco Ifunanya ◽  
Obi Vitus Okwuchukwu ◽  
Ibo Chukwunenye Chukwu ◽  
Obi Chuka Nobert ◽  
Onwe Blessing ◽  
...  
Keyword(s):  
Teaching Hospital ◽  
Clinical Presentation ◽  
University Teaching ◽  
Trophoblastic Diseases ◽  
Gestational Trophoblastic Diseases

scholarly journals Gestational trophoblastic diseases: an observational study at a tertiary care teaching hospital in Jharkhand, India

2020 ◽  
Vol 9 (8) ◽  
pp. 3138
Author(s):  
Archana Kumari ◽  
Nikita Chauhan
Keyword(s):  
Observational Study ◽  
Teaching Hospital ◽  
Tertiary Care ◽  
Molar Pregnancy ◽  
Tertiary Care Teaching Hospital ◽  
Care Teaching ◽  
Disease Spectrum ◽  
Trophoblastic Diseases ◽  
Gestational Trophoblastic Diseases

Background: Gestational Trophoblastic Diseases (GTD) encompass a wide spectrum of proliferative disorders of trophoblast tissue, which hold a good prognosis if diagnosed and treated on time. A close understanding of the disease spectrum is therefore needed to reduce morbidity and mortality.Methods: This is an observational study (both prospective and retrospective analysis) conducted in Rajendra Institute of Medical Sciences, a tertiary care teaching hospital in Ranchi, Jharkhand over a period of 2 years from 1st January 2017 to 31st December 2018.Results: A total of 162 cases of GTD were identified during the study period. Disease spectrum comprised of complete molar pregnancy in 146 (90.12%) and partial molar pregnancy in 7 (4.3%), GTN in 9 out of 162 cases (5.5%). Bleeding per vaginum preceded by amenorrhea was the most common symptom, observed in 95.4% of the cases. Uterine size was more than period of amenorrhea in almost 50% of the cases. Theca lutein cysts were found in 39.8% of the cases, hypertension in 21.5%, hyperthyroidism in 6.5% cases. Overall, there were nine (5.56%) cases of choriocarcinoma and six (3.7%) cases of Invasive mole. Remission rate in GTN was 86.7% with chemotherapy.Conclusions: Women complaining of vaginal bleeding in first half of pregnancy with uterine size more than period of amenorrhea must be evaluated for GTD by ultrasound and serum beta HCG. For cases of molar pregnancies, suction and evacuation remains the treatment of choice but need for regular follow-up and strict compliance to contraception during entire follow up has to be emphasized. Cases of GTN have excellent remission with chemotherapy.

scholarly journals Clinical study of gestational trophoblastic disease in a tertiary care hospital

2020 ◽  
Vol 9 (7) ◽  
pp. 2964
Author(s):  
Jayashree Mulik ◽  
Archana Choudhary
Keyword(s):  
Histopathological Examination ◽  
Hydatidiform Mole ◽  
Tertiary Care ◽  
Gestational Trophoblastic Disease ◽  
Care Hospital ◽  
Complete Mole ◽  
Trophoblastic Diseases ◽  
Study Centre ◽  
Gestational Trophoblastic Diseases ◽  
Chest X Ray

Background: Gestational trophoblastic diseases (GTDs) had been associated with significant morbidity and mortality till recently. Wide variation in incidences have been reported worldwide. The present study was planned with the objective of determination of incidence, assessment of risk factors, clinical presentation, management protocols and outcomes in GTD cases in Indian population at a tertiary care centre.Methods: All the diagnosed cases of GTD reporting to study centre during study period of 1.5 years were included. Detailed history taking, examination and relevant investigations (Hb%, blood grouping, thyroid functions, serum ß-hCG, USG and chest X-ray) were undertaken. Suction and evacuation were done for all patients as primary mode of management and samples were sent for histopathological examination. Comprehensive follow ups were done, including weekly ß-hCG until normal for 3 consecutive weeks followed by monthly determination until the levels were normal for 6 consecutive months.Results: Total 22 cases out of 19500 deliveries were diagnosed as GTD (incidence rate-1.13/1000 deliveries). Mean age was 23.64±3.89 years with 50% participants being primigravida. The commonest symptom after amenorrhea 22 (100%) was bleeding per-vaginum 15 (68.2%). Maximum cases were of complete hydatidiform mole histopathology 16 (72.73%), USG 19 (86.4%). Clinical characteristics were statistically comparable between patients of complete mole and partial mole. Out of 22 cases, 1 (4.5%) was diagnosed as GTN.Conclusions: Early diagnosis and treatment along with regular follow up is the key in GTD. There is need to establish a centralized disease specific registry in future.

scholarly journals GESTATIONAL TROPHOBLASTIC DISEASES;

2012 ◽  
Vol 19 (02) ◽  
pp. 159-161
Author(s):  
SYED MEHMOOD HASSAN ◽  
SHOAIB NAYYER I HASHM ◽  
BUSHRA AYAZ ◽  
Faisal Rashid Lodhi ◽  
Kanwal Sohail
Keyword(s):  
Hydatidiform Mole ◽  
Age Groups ◽  
Gestational Trophoblastic Disease ◽  
Trophoblastic Disease ◽  
Complete Mole ◽  
Trophoblastic Diseases ◽  
Partial Mole ◽  
Gestational Trophoblastic Diseases ◽  
Data Source ◽  
Naval Hospital

Objective: The study was carried out to evaluate the frequency and types of gestational. Trophoblastic diseases (GTD) inendometrial curettings received for histopathology examination. Data Source: Pathology Department, Shifa Naval Hospital Karachi. Design ofStudy: It was a Retrospective Descriptive Observational study. Setting: Department of Pathology, Pakistan Naval Ship; Shifa Naval HospitalKarachi. Period: From 2009 till 2010. Material & Methods: A total of 170 cases of endometrial curettage were examined. All specimensreceived with a diagnosis of product of conceptions (POC) or with the clinical suspicion of a gestational trophoblastic disease were included.Results: It was observed that partial mole identified in 57.1 % cases followed by complete mole 21.4%, choriocarcinoma 14.2% and placentalsite Trophoblastic disease 7.1% cases. Nearly half of the cases were diagnosed as having a gestational trophoblastic disease; these were fromthe age groups of 26-30 years followed by 21-25 years. Conclusions: Hydatidiform mole is the commonest gestational trophoblastic disease.Most complete moles are detected clinically but partial moles are misdiagnosed as abortions therefore all cases of abortions should be sent forhistopathological examinations.

scholarly journals Partial Hydatidiform Mole with Alive Term IUGR Foetus

2017 ◽  
Vol 34 (3) ◽  
pp. 164-167 ◽  
Author(s):  
Rowshan Ara ◽  
Jahanara Begum ◽  
Setara Binte Kasem ◽  
Shadiqul Hoque ◽  
Shamim Fatema Nargis
Keyword(s):  
Intrauterine Growth Retardation ◽  
Hydatidiform Mole ◽  
Stage Iv ◽  
Molar Pregnancy ◽  
Fetal Abnormality ◽  
Intrauterine Growth ◽  
Trophoblastic Diseases ◽  
Spontaneous Labour ◽  
Gestational Trophoblastic Diseases ◽  
Live Fetus

Gestational Trophoblastic diseases consist of a broadspectrum of conditions ranging from an uncomplicated partial hydatidiform molar pregnancy to stage -IV choriocarcinoma with cerebral metastasis. Incidence of hydatidiform mole with a co-existing live fetus varies between 0.005 to 0.01 % of all pregnancies. We report a case of partial molar pregnancy with alive term IUGR (intrauterine growth retardation) foetus. Diagnosis was made by sonographic findings of molar changes at her 28 weeks of gestation. Anomaly scan showed no fetal abnormality. At 40 weeks of pregnancy patient went to spontaneous labour and delivered a severely IUGR baby weighing 1.5 kg and it was morphologically normal. There was a single placenta; one third of it was replaced by molar tissue. As the singletone alive pregnancy with partial molar changes is extremely rare occurrence we reported the case here.J Bangladesh Coll Phys Surg 2016; 34(3): 164-167

INCIDENCE OF TROPHOBLASTIC TUMORS: A RETROSPECTIVE CASE STUDY AT RIMS RANCHI

2021 ◽  
pp. 26-27
Author(s):  
Sona Pathak ◽  
Suraj Sinha ◽  
Md Raihan Md Raihan ◽  
M. A. Ansari
Keyword(s):  
Clinical Presentation ◽  
Hydatidiform Mole ◽  
Gestational Trophoblastic Disease ◽  
Retrospective Case ◽  
Trophoblastic Diseases ◽  
Wide Range ◽  
Gestational Trophoblastic Diseases ◽  
Common Clinical Presentation ◽  
Abnormal Vaginal Bleeding ◽  
Retrospective Case Study

Background: The gestational trophoblastic diseases encompass a wide range of conditions that vary in their clinical presentation, their propensity for spontaneous resolution, local invasion and metastasis and their overall prognosis. Advanced or adolescent maternal age has consistently correlated with higher rates of complete Hydatidiform mole. Material and Methods: It is a retrospective record based study, performed in Department of pathology RIMS, Ranchi. Study population included all cases which were clinically suspected of gestational trophoblastic disease, with common clinical presentation of abnormal vaginal bleeding, amenorrhea, pain abdomen, from January 2017- December 2020. Results: Hydatidiform mole was found to be the most common form of gestational trophoblastic diseases. Our study shows maximum cases of GTD falls in the age group of 20-29 years followed by 30-39 years.

scholarly journals Clinicopathological analysis of ovarian tumors in perimenopausal women: A study in a rural teaching hospital of eastern India

2013 ◽  
Vol 12 (3) ◽  
pp. 263-268
Author(s):  
Jyoti Prakash Phukan ◽  
Anuradha Sinha ◽  
Rakhi Sardar ◽  
Paulami Guha
Keyword(s):  
Teaching Hospital ◽  
Malignant Tumors ◽  
Medical Science ◽  
Clinical Information ◽  
Serous Cystadenoma ◽  
Ovarian Tumors ◽  
Age Group ◽  
Common Benign Tumor ◽  
Perimenopausal Women ◽  
Rural Teaching

Introduction: Ovarian tumors are important in perimenopausal women as they are more likely to be malignant. Aim: The aim was to study the various histological pattern of ovarian tumors and their clinical presentation in perimenopausal age group. Materials and Methods: The study was carried out in the departments of Gynaecology and Obstetrics and Pathology in a teaching hospital for two years from June 2007 to May 2009. All patients presented with ovarian tumors of perimenopausal age group (40-50 years) were included. Detailed clinical information, radiological findings and histopathological reports were recorded. Results: A total 52 ovarian tumors were included in this study. Most common histological types were surface epithelial tumors (92.3%), out of which 54.2% were benign, 41.7% were malignant and 4.2% were borderline. Serous cystadenoma was the most common benign tumor and serous cystadenocarcinoma was the commonest malignant tumor. Abdominal discomfort was the commonest presenting symptom both in benign and malignant tumors (85.7% and 45.4% respectively). Most of the malignant tumors were presented in stage III (50%), followed by stage II (27.3%). Conclusion: In this study, we found a relatively higher proportion of ovarian malignancies. So, any ovarian tumor in perimenopausal age group is more likely to be malignant and that require a thorough evaluation and management. Further research should be advocated in this field. Bangladesh Journal of Medical Science Vol. 12 No. 03 July ’13 Page 263-268 DOI: http://dx.doi.org/10.3329/bjms.v12i3.12232 

scholarly journals Predictivity of inflammatory cell counts in early diagnosis of hydatidiform mole

2019 ◽  
Vol 7 (2) ◽  
pp. 363
Author(s):  
Hüseyin Avni Eroğlu ◽  
Yasemen Adalı
Keyword(s):  
Early Diagnosis ◽  
Inflammatory Cell ◽  
Pregnancy Termination ◽  
Statistical Significance ◽  
Hydatidiform Mole ◽  
Control Group ◽  
Cell Counts ◽  
Trophoblastic Diseases ◽  
Gestational Trophoblastic Diseases ◽  
The Mean

Background: Hydatidiform mole (HM) is the most frequently encountered disease among gestational trophoblastic diseases. HM can invade myometrium and result in hysterectomy and because of the absence of any predictive method, the disease  can  be lately diagnosed in the periphery. Author aimed to evaluate predictive value of  the inflammatory cell counts in molar pregnancies in this study.Methods: Nineteen (19) cases with histopathologic HM diagnosis and 19 cases of control group with pregnancy termination or abortion material reached to a university hospital's pathology department on the same day were included in the study. The data on the same day or the day before the operation was used as the hemogram data.Results: The mean age of the cases were 33.84±8.477. The mean of neutrophil, lymphocyte, monocyte, basophil and eosinophil numbers of the HM group and control group were compared in the 95% confidence interval with the independent t test. No statistical significance was observed in any of the inflammatory cell means  (p>0.05). The ratio of lymphocyte means was statistically significant (p=0.006).Conclusions: In this study, author assessed whether the inflammatory cell counts were a predictive in detecting HM. The statistically significant results that author founded in the means of lymphocyte, suggests that this finding may be predictive of early diagnosis. They concluded that this result can be routinely used after the confirmation of the results in larger series of cases.

scholarly journals Analysis of Pap smears in a cytopathology lab of a teaching hospital

2020 ◽  
Vol 15 (1) ◽  
pp. 72-75
Author(s):  
Reetu Sharma Baral
Keyword(s):  
Teaching Hospital ◽  
Pap Smear ◽  
Descriptive Analysis ◽  
Age Distribution ◽  
College Teaching ◽  
Clinical Information ◽  
Pap Smears ◽  
Age Group ◽  
Abnormal Cytology ◽  
Pap Smear Screening

Aims: This study was done to find out age wise distribution pattern, cellular abnormality and adequacy of Pap smears. Methods: A retrospective study of 470 Pap smears based on laboratory record was done from September 2019 to April 2020 at B and C Medical College Teaching Hospital, Birtamod, Jhapa, Nepal. Descriptive analysis performed using MS Excel and SPSS 16. Results: Out of 470 analyzable data 2.55% had abnormal cytology, all high-grade lesions were in 30-49 age group and 0.21% were detected as carcinoma. Mean age of women was 39.2±10.5 years. Age distribution follows the normal Gaussian curve. Age group of 30-60 years consists of four-fifth (75.5%, n=355) and Two-third of cases (66.4%, n=312) were of age group 30-49 years. Conclusions: Pap samples were normally distributed by age. Test requisition forms lack adequate clinical information. Even the inadequately sampled Pap smears were satisfactory for evaluation. Keywords: cancer, cervix, intraepithelial lesion, Pap smear, screening

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