scholarly journals Continuous gas/liquid–liquid/liquid flow synthesis of 4-fluoropyrazole derivatives by selective direct fluorination

2011 ◽  
Vol 7 ◽  
pp. 1048-1054 ◽  
Author(s):  
Jessica R Breen ◽  
Graham Sandford ◽  
Dmitrii S Yufit ◽  
Judith A K Howard ◽  
Jonathan Fray ◽  
...  
Keyword(s):  
Liquid Flow ◽  
Flow Process ◽  
Flow Synthesis ◽  
Direct Fluorination

4-Fluoropyrazole systems may be prepared by a single, sequential telescoped two-step continuous gas/liquid–liquid/liquid flow process from diketone, fluorine gas and hydrazine starting materials.

Continuous flow synthesis of amine oxides by oxidation of tertiary amines

2019 ◽  
Vol 4 (7) ◽  
pp. 1270-1276
Author(s):  
Tobias Baumeister ◽  
Stefan Zikeli ◽  
Hannes Kitzler ◽  
Paul Aigner ◽  
Piotr P. Wieczorek ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Continuous Flow ◽  
Tertiary Amines ◽  
Flow Process ◽  
Flow Synthesis ◽  
Amine Oxides ◽  
Continuous Flow Process

An efficient, safe and scalable continuous flow process for the synthesis of amine oxides with hydrogen peroxide is described.

scholarly journals Continuous flow synthesis of α-aryl-α-aminophosphonates

2019 ◽  
Vol 91 (1) ◽  
pp. 67-76 ◽  
Author(s):  
Erika Bálint ◽  
Ádám Tajti ◽  
Katalin Ladányi-Pára ◽  
Nóra Tóth ◽  
Béla Mátravölgyi ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Reaction Times ◽  
Primary Amines ◽  
Flow Process ◽  
Flow Synthesis ◽  
Microwave Reactor ◽  
Dialkyl Phosphites ◽  
Benzaldehyde Derivatives

AbstractThe synthesis of α-aryl-α-aminophosphonates was performed by the three-component Kabachnik-Fields reaction of primary amines, benzaldehyde derivatives and dialkyl phosphites in a continuous flow microwave reactor. The target compounds could be obtained in high (~90%) yields without any catalyst in simple alcohols as the solvent. The flow process elaborated required shorter reaction times and lower excess of the reagent, as compared to the “traditional” batch reactions, and allowed the synthesis of the α-aminophosphonates on a somewhat larger scale.

Continuous-Flow Synthesis of (–)-Oseltamivir Phosphate (Tamiflu)

Synlett ◽  
2020 ◽  
Vol 31 (19) ◽  
pp. 1925-1929 ◽  
Author(s):  
Paul Watts ◽  
Cloudius R. Sagandira
Keyword(s):  
Residence Time ◽  
Continuous Flow ◽  
Shikimic Acid ◽  
Flow Process ◽  
Flow Synthesis ◽  
Continuous Flow Process ◽  
The Individual ◽  
Total Residence Time ◽  
Oseltamivir Phosphate

Herein the anti-influenza drug (–)-oseltamivir phosphate is prepared in continuous flow from ethyl shikimate with 54% overall yield over nine steps and total residence time of 3.5 min from the individual steps. Although the procedure involved intermediate isolation, the dangerous azide chemistry and intermediates involved were elegantly handled in situ. It is the first continuous-flow process for (–)-oseltamivir phosphate involving azide chemistry and (–)-shikimic acid as precursor.

A Two-Stage Continuous-Flow Synthesis of Spirooxazine Photochromic Dyes

2013 ◽  
Vol 66 (2) ◽  
pp. 172 ◽  
Author(s):  
Mark York ◽  
Adriana Edenharter
Keyword(s):  
Continuous Flow ◽  
Hydroxylamine Hydrochloride ◽  
Preliminary Evaluation ◽  
Substituted Anilines ◽  
Two Stage ◽  
Flow Process ◽  
Flow Synthesis ◽  
Continuous Flow Process

A continuous-flow process for the synthesis of several known and previously unreported spirooxazine photochromic dyes is reported. The process proceeds via an initial copper catalysed addition of substituted anilines to naphthalene-1,2-dione. This is followed by reaction with 1,3,3-trimethyl-2-methyleneindoline in the presence of hydroxylamine hydrochloride to give the desired spirooxazine products. The photochromic dyes were then cast into lenses to allow a preliminary evaluation of their properties.

Simulation of Nanoimprint Based on PSQ-L Polymer

2014 ◽  
Vol 609-610 ◽  
pp. 1498-1502
Author(s):  
Xin Guo ◽  
Ming Zhu Sun ◽  
Ming Shan Zhao ◽  
Xin Zhao
Keyword(s):  
Finite Element Method ◽  
Finite Element ◽  
Layer Thickness ◽  
Liquid Flow ◽  
Static Model ◽  
Simulation System ◽  
Flow Process ◽  
Static State ◽  
Simulation Process ◽  
Waveguide Fabrication

A method of simulating nanoimprint process dynamically is proposed and a software program has been made to complete the simulation process automatically. Finite element method (FEM) is used to reveal mechanism of how the liquid flow in the imprint process by every static state. By means of static model iteration,we make a software to simulate the flow process dynamically and it can be used to forecast the result of the nanoimprint. The simulation system is used to predict residual layer thickness in the waveguide fabrication process.

scholarly journals Continuous Flow Synthesis of Propofol

Molecules ◽  
2021 ◽  
Vol 26 (23) ◽  
pp. 7183
Author(s):  
Romain Mougeot ◽  
Philippe Jubault ◽  
Julien Legros ◽  
Thomas Poisson
Keyword(s):  
Intensive Care ◽  
Intensive Care Medicine ◽  
Continuous Flow ◽  
Intravenous Anesthesia ◽  
Flow Process ◽  
Short Acting ◽  
Flow Synthesis ◽  
Step Procedure ◽  
Continuous Flow Process

Herein, we report a continuous flow process for the synthesis of 2,6-diisopropylphenol—also known as Propofol—a short-acting intravenous anesthesia, widely used in intensive care medicine to provide sedation and hypnosis. The synthesis is based on a two-step procedure: a double Friedel–Crafts alkylation followed by a decarboxylation step, both under continuous flow.

scholarly journals Flow synthesis of a versatile fructosamine mimic and quenching studies of a fructose transport probe

2013 ◽  
Vol 9 ◽  
pp. 2022-2027 ◽  
Author(s):  
Matthew B Plutschack ◽  
D Tyler McQuade ◽  
Giulio Valenti ◽  
Peter H Seeberger
Keyword(s):  
High Throughput ◽  
Photophysical Properties ◽  
Flow Process ◽  
Flow Synthesis ◽  
Throughput Enhancement ◽  
Fluidic Devices ◽  
Uptake Studies

We describe the synthesis of 1-amino-2,5-anhydro-D-mannose (“mannitolamine”), a key intermediate to the 7-nitro-1,2,3-benzadiazole conjugate (NBDM), using commercially available fluidic devices to increase the throughput. The approach is the first example of a flow-based Tiffeneau–Demjanov rearrangement. Performing this step in flow enables a ~64-fold throughput enhancement relative to batch. The flow process enables the synthesis to be accomplished three times faster than the comparable batch route. The high throughput enabled the production of larger quantities of the fluorescent fructose transport probe NBDM, enabling us to measure key photophysical properties that will facilitate future uptake studies.

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