scholarly journals A PRIVATE MODEL OF INDEX IS A HINDRANCE OF STABILITY OF THE STATION OF ACCOMPANIMENT OF AIM OF ZENITHAL ROCKET COMPLEX OF SHORTER-RANGE

2020 ◽  
pp. 56-66
Author(s):  
V. Kudryashov ◽  
A. Artemenko ◽  
O. Kolomiitsev ◽  
R. Oliynik ◽  
Y. Zhivetc ◽  
...  
Keyword(s):  
Standard Deviation ◽  
Analytical Method ◽  
High Efficiency ◽  
Modern Approach ◽  
Partial Model ◽  
Informative Parameters ◽  
Location Channel ◽  
Radio Location ◽  
Mathematical Design

Protecting from the action of radio of hindrances on the elements of zenithal rocket complex of shorter-range is one of important problems, that requires modern approach for her decision. Presently, influence of active hindrances is certain yet not enough on possibilities of armament on the defeat of air aims. In the article the analysis of influence of hindrances of different closeness is conducted on the station of accompaniment of aims of fighting machine of zenithal rocket complex shorter-range. The partial model of determination of index is offered hindrance of stability of the station of accompaniment of aim of zenithal rocket complex of shorter-range. The brought partial model over allows an analytical method to conduct the evaluation of values of conditional hit of model aim probabilities under various conditions. Mathematical calculations are conducted for: amplification of aerial of accompaniment of aim of fighting machine and aerials factors hindrance of producer; powers of hindrances on the entrance of accompaniment of aim of fighting machine; to the maximum sensitiveness of accompaniment of aim of fighting machine and relations hindrance/noise in the radio-location channel of accompaniment of aim; standard deviation of error of aiming of rocket depending on distance to the point of meeting of rocket with an aim in the zone of defeat taking into account influence of hindrances on the radio-location channel of accompaniment of aim of fighting machine; probabilities of passing of rocket in the «tube» of the set radius and conditional hit of aim probability at firing by one rocket; coefficient of зпомеха stability of accompaniment of aim of fighting machine; to conditional hit of aim probability hindrance of producer at firing by two rockets. On the accepted entry informative parameters and technical descriptions of accompaniment of aim of fighting machine certainly her maximum sensitiveness and relation hindrance/noise in this radio-location channel. On results mathematical calculations (mathematical design) corresponding charts that over is brought are got. From charts it is possible to define high efficiency of firing rockets on a model (air) aim.

Colorimetric Determination of Arprinocid in Feed

1978 ◽  
Vol 61 (5) ◽  
pp. 1078-1082
Author(s):  
David W Fink ◽  
Kobert P Martin ◽  
James V Pivnichny ◽  
Jung-Sook K Shim
Keyword(s):  
Standard Deviation ◽  
Reaction Time ◽  
Analytical Method ◽  
Acidic Solution ◽  
Feed Additives ◽  
Colorimetric Determination ◽  
Colorimetric Measurement ◽  
Relative Standard ◽  
Zinc Reduction

Abstract An analytical method has been developed for the determination of arprinocid (9-(2-chloro- fluorophenylmethyl) -9ff-purin-6-amine) in feed, based upon measurement of the absorbance of the diazo chromophore formed from product of zinc reduction of the drug in acidic solution. The analyte is extracted from the feed into chloroform in the presence of a pH 7 phosphate buffer and isolated by adsorption chromatography on alumina, followed by partitioning between hexane and 0.15M HC1. The reduction product in the aqueous phase is then treated for colorimetric measurement. This procedure has been applied to determining 0.0010-0.0080% arprinocid in feed with precision of <5% relative standard deviation near the middle of this concentration range. Of 32 feed additives examined, only zoalene and sulfamethazine were serious interferences. study and discussion of several factors, e.g., reaction time, pH, and amount of zinc metal, that affect the analytical reactions are also included.

scholarly journals SIMULTANEOUS DETERMINATION OF PARACETAMOL AND IBUPROFENE MIXTURES BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY

2010 ◽  
Vol 3 (1) ◽  
pp. 9-13 ◽  
Author(s):  
Sophi Damayanti ◽  
Slamet Ibrahim ◽  
Kurnia Firman ◽  
Daryono H Tjahjono
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Standard Deviation ◽  
Retention Time ◽  
Analytical Method ◽  
Phosphate Buffer ◽  
Mobile Phase ◽  
High Performance ◽  
Relative Standard

Analytical method for the determination of paracetamol and ibuprofene mixtures has been developed by High Performance Liquid Chromatography using C-18 column and acetinitrile - phosphate buffer pH = 4.5 (75:25) containing 0.075% sodium hexanesulfunate as a mobile phase. The detector was set at 215 nm. Using such conditions, retention time for paracetamol and ibuprofen was 4.89 and 7.11 min, respectively. The recovery for paracetamol and ibuprofen was found to be 101.07± 0.73% and 102.02 ± 1.58%, respectively. The detector limits of the method was 1.30 and 1.60 μg/mL with the relative standard deviation (RSD) 0.74 and 1.52% for paracetamol and ibuprofen, respectively.   Keywords: paracetamol, ibuprofen, multi-component, validation, HPLC.

scholarly journals Determination of a Two-Tailed 100(1-α)% Upper Limit on the Relative Error in the Laboratory-to-Laboratory Standard Deviation Obtained from an Interlaboratory Study

2009 ◽  
Vol 92 (5) ◽  
pp. 1593-1601 ◽  
Author(s):  
Foster D McClure ◽  
Jung K Lee
Keyword(s):  
Monte Carlo ◽  
Standard Deviation ◽  
Relative Error ◽  
Analytical Method ◽  
Interlaboratory Study ◽  
Chi Square ◽  
True Value ◽  
Upper Limit ◽  
Interlaboratory Studies

Abstract For some classes of analytical methods, it is assumed that the error in the laboratory-to-laboratory standard deviation (sL) is appreciable. To demonstrate the magnitude of this error in sL for such methods, formulas were derived to obtain a two-tailed 100(1-α)% upper limit on the relative error in sL obtained from an interlaboratory study, assuming that the laboratory-to-laboratory variance (sL2) obtained in the validation of an analytical method is approximately normal and/or Chi-square distributed. This 100(1-α)% upper limit is referred to as a margin of relative error in sL (MRE(sL)). Monte Carlo simulations were performed, and the results compared satisfactorily with the formula calculations. To aid in designing future interlaboratory studies in which concern is focused on the magnitude of the uncertainty in sL, expressed as a proportion of the true value (σL), a formula was derived to determine the number of laboratories needed to attain a given MRE in sL for a stated number of replicates per laboratory.

scholarly journals Development and Statistical Validation of a Quantitative Method for the Determination of Steroid Hormones in Environmental Water by Column Liquid Chromatography/Tandem Mass Spectrometry

2008 ◽  
Vol 91 (1) ◽  
pp. 237-246 ◽  
Author(s):  
Christophe Stavrakakis ◽  
Ronan Colin ◽  
Valrie Hquet ◽  
Catherine Faur ◽  
Pierre Le Cloirec
Keyword(s):  
Steroid Hormones ◽  
Analytical Method ◽  
High Efficiency ◽  
Solid Phase ◽  
Treatment Plant ◽  
Tandem Mass ◽  
Statistical Validation ◽  
Water And Wastewater Treatment ◽  
Tandem Mass Spectrometric

Abstract This paper presents an analytical method applied to the determination of 3 natural steroid hormones, estrone, 17 -estradiol, and 16 -hydroxyestrone, and the contraceptive estrogen, 17 -ethynylestradiol, at the sub-ng/L level in water samples [surface water and wastewater treatment plant (WWTP) samples]. The solid-phase extraction conditions were optimized using C18 cartridges. Identification and quantification were performed using a column liquid chromatographic/tandem mass spectrometric system with electrospray ionization in the negative mode. Before analyzing steroids in complex matrixes, statistical tools permitted a fine validation of the analytical method, and performance was evaluated for spring water in terms of recovery, specificity, trueness, repeatability, and intralaboratory reproducibility. The results showed the accuracy of the method, and limits of detection (LOD) ranged between 0.02 and 0.21 ng/L. The determination of steroids in WWTP effluents, which contain high levels of organic matter, required an additional purification step on silica cartridges. The high efficiency of the purification was proved with LOD <0.3 ng/L from 200 mL sample. Specificity of the entire analytical procedure was shown by repeatable recoveries at low and high levels of the calibration range.

scholarly journals Method Validation for Determination of Alkaloid Content in Goldenseal Root Powder

2003 ◽  
Vol 86 (3) ◽  
pp. 476-483 ◽  
Author(s):  
Holly A Weber ◽  
Matthew K Zart ◽  
Andrew E Hodges ◽  
Kellie D White ◽  
Sarah M Barnes ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Standard Deviation ◽  
Relative Standard Deviation ◽  
Analytical Method ◽  
Hydrastis Canadensis ◽  
Extraction Solvent ◽  
Relative Standard ◽  
Oregon Grape

Abstract A fast, practical ambient extraction methodology followed by isocratic liquid chromatography (LC) analysis with UV detection was validated for the determination of berberine, hydrastine, and canadine in goldenseal (Hydrastis canadensis L.) root powder. The method was also validated for palmatine, a major alkaloid present in the possible bioadulterants Coptis, Oregon grape root, and bar-berry bark. Alkaloid standard solutions were linear over the evaluated concentration ranges. The analytical method was linear for alkaloid extraction using 0.3–2 g goldenseal root powder/100 mL extraction solvent. Precision of the method was demonstrated using 10 replicate extractions of 0.5 g goldenseal root powder, with percent relative standard deviation for all 4 alkaloids ≤1.6. Alkaloid recovery was determined by spiking each alkaloid into triplicate aliquots of neat goldenseal root powder. Recoveries ranged from 92.3% for palmatine to 101.9% for hydrastine. Ruggedness of the method was evaluated by performing multiple analyses of goldenseal root powder from 3 suppliers over a 2-year period. The method was also used to analyze Coptis root, Oregon grape root, barberry bark, and celandine herb, which are possible goldenseal bioadulterants. The resulting chromato-graphic profiles of the bioadulterants were significantly different from that of goldenseal. The method was directly transferred to LC with mass spectrometry, which was used to confirm the presence of goldenseal alkaloids tetrahydro-berberastine, berberastine, canadaline, berberine, hydrastine, and canadine, as well as alkaloids from the bioadulterants, including palmatine, jatrorrhizine, and coptisine.

Concentrations of booster biocides in sediment and clams from Vietnam

2006 ◽  
Vol 86 (5) ◽  
pp. 1163-1170 ◽  
Author(s):  
Hiroya Harino ◽  
Sayaka Midorikawa ◽  
Takaomi Arai ◽  
Madoka Ohji ◽  
Nguyen Duc Cu ◽  
...  
Keyword(s):  
Standard Deviation ◽  
Simultaneous Determination ◽  
Analytical Method ◽  
Degradation Product ◽  
Detection Limits ◽  
Recovery Rates ◽  
Irgarol 1051 ◽  
Central Vietnam ◽  
Relative Standard

An analytical method for the simultaneous determination of five booster biocides (Sea-Nine 211, Dichlofluanid, Duiron, Irgarol 1051 and Pyrithiones) and degradation product of Irgarol 1051 (M1) in sediment from Vietnam was developed by LC/MS-MS. The recovery rates and relative standard deviation of the booster biocides in the sediment were in the range of 71–108% and 1.5–12%, respectively, and the detection limits were in the range of 0.04–2 μg kg−1 dry. An analytical method for the simultaneous determination of three booster biocides (Sea-Nine 211, Duiron and Irgarol 1051) and M1 in clams was also developed by LC/MS-MS. The recovery rates and relative standard deviations of the booster biocides in the biological samples were in the range of 60–99% and 3.4–6.8%, respectively, and the detection limits were in the range of 0.24–1.1 μg kg−1.The booster biocides in sediment from the coastal area of northern and central Vietnam were measured using this analytical method. Sea-Nine 211, Dichlofluanid, Duiron, Irgarol 1051, M1 and Pyrithiones were detected in the range of 0.09–1.3 μg kg−1 dry, <0.10–13 μg kg−1 dry, 0.11–3.0 μg kg−1 dry, 0.05–4.0 μg kg−1 dry, <0.1–0.43 μg kg−1 dry and <2–420 μg kg−1 dry, respectively. The detection frequencies of Dichlofluanid, M1 and Pyrithiones were low. The species and levels of detected booster biocides varied between sampling stations.Irgarol 1051 and its degradation product M1 were not detected in clams.

scholarly journals Multielemental Screening and Analytical Method Validation for Determination of Elemental Impurity in Sucroferric Oxyhydroxide by Using (ICP-MS)

2021 ◽  
pp. 273-280
Author(s):  
Vikas Kumar Singh ◽  
Santosh Kumar Verma ◽  
Sudhanshu Ranjan Swain
Keyword(s):  
Standard Deviation ◽  
Relative Standard Deviation ◽  
Analytical Method ◽  
Drug Product ◽  
Individual Element ◽  
Elemental Impurities ◽  
Acceptable Range ◽  
Icp Ms ◽  
Relative Standard

A highly selective, specific, precise sensitive and reliable ICPMS method has been developed and validated by using ICP-MS for the determination of multielement in Sucroferric oxyhydroxide. The described ICP-MS method provides specific detection and quantification of minor and trace elements from 0.3J(30%) to 2J(200%) of its individual specification of each element i.e Ag, As, Au, Ba, Cd, Co, Cr, Cu, Hg, Ir, Li, Mo, Ni, Os, Pb, Pd, Pt, Rh, Ru, Sb, Se, Sn, Tl,  and V.The analytical method found to be Linear for each individual element with working concentration range from 30%, 50%, 100%, 150% and 200% i.e 0.3J, 0.5J, 1J, 1.5J and 2J with correlation coefficient not less than 0.990.The % recoveries of elemental impurities of each individual elements at three different concentrations with spiking in samples were found to be an acceptable range as 70% to 150%.The method was found to be precise and robust and its relative standard deviation was below 20%.The actual observed relative standard deviation in Precision was found to be in an acceptable range. Therefore developed method can be use for routine quantitative analysis of elemental impurities like Ag, As, Au, Ba, Cd, Co, Cr, Cu, Hg, Ir, Li, Mo, Ni, Os, Pb, Pd, Pt, Rh, Ru, Sb, Se, Sn, Tl, and V to ensure the quality of drug product.

scholarly journals Desenvolvimento de um método analítico rápido e eficiente para a determinação de corticosteróides plasmáticos por injeção direta em coluna cromatográfica ISRP-C18 por CLAE.

2018 ◽  
Vol 35 (2) ◽  
pp. 51
Author(s):  
Eliane Aparecida Toledo-Pinto ◽  
Manoel Lima de Menezes ◽  
O. C. M. Pereira
Keyword(s):  
Analytical Method ◽  
Mobile Phase ◽  
High Efficiency ◽  
Direct Injection ◽  
Wave Length ◽  
Internal Surface ◽  
Previous Treatment ◽  
Ultraviolet Detector ◽  
On Line

The present work had as aim the development of simple an analytical method, fast efficient and the determination of corticosteroids (cortisone, corticosterone, acetate of hidrocortisone and acetate of dexametasone) in sanguine samples of rats using an isocratic system of liquid chromatography of high efficiency (CLAE) with ultraviolet detention. The methodinvolved direct injection of sanguine sample in a chromatographic column with internal surface of phase reverse (ISRP-C18), using the composed mobile phase for drain plug phosphate pH 4,0: acetonitrile (65:35 v/v). The detention the analytes was obtained using an ultraviolet detector of changeable wave length (Varian Model 2550) adjusted in 240 nm and a 4400 integratorSP Chromaject (Varian Associates, Inc., Sunnyvale, CA, USA). The extraction of the analyte resulted in recovery values between 90% and 108%, and variation coefficient enter 1,1% and 2.5%. The detention and quantification limits of the method were 0,02 and 0,04 μg mL-1, respectively. In conclusion, the analytical method possible the direct injection (on-line) of the sample without previous treatment also presenting some advantages, such as: fast, exactness, precision and specific.

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